Pharmacology and Therapeutics Publications 2011 Alaoui-Jamali, Moulay (see Department of Medicine) Allen, Bruce Vaniotis G, Allen BG, Hébert TE. (2011) Nuclear GPCRs in cardiomyocytes: an insider's view of β-adrenergic receptor signaling. Am J Physiol Heart Circ Physiol. 301(5):H1754-64. Review. Rivard K, Grandy SA, Douillette A, Paradis P, Nemer M, Allen BG, Fiset C. (2011) Overexpression of type 1 angiotensin II receptors impairs excitation-contraction coupling in the mouse heart. (2011) Am J Physiol Heart Circ Physiol. 301(5):H2018-27. Dee DL, Bensyl DM, Gindler J, Truman BI, Allen BG, D'Mello T, Pérez A, Kamimoto L, Biggerstaff M, Blanton L, Fowlkes A, Glover MJ, Swerdlow DL, Finelli L. (2011) Racial and ethnic disparities in hospitalizations and deaths associated with 2009 pandemic Influenza A (H1N1) virus infections in the United States. Ann Epidemiol. 21(8):623-30. Lauzier B, Merlen C, Vaillant F, McDuff J, Bouchard B, Beguin PC, Dolinsky VW, Foisy S, Villeneuve LR, Labarthe F, Dyck JR, Allen BG, Charron G, Des Rosiers C. (2011) Post-translational modifications, a key process in CD36 function: lessons from the spontaneously hypertensive rat heart. J Mol Cell Cardiol. 51(1):99-108. Ascah A, Khairallah M, Daussin F, Bourcier-Lucas C, Godin R, Allen BG, Petrof BJ, Des Rosiers C, Burelle Y. (2011) Stress-induced opening of the permeability transition pore in the dystrophin-deficient heart is attenuated by acute treatment with sildenafil. Am J Physiol Heart Circ Physiol. 300(1):H144-53. Lavoie V, Kernaleguen AE, Charron G, Farhat N, Cossette M, Mamarbachi AM, Allen BG, Rhéaume E, Tardif JC. (2011) Functional effects of adiponectin on endothelial progenitor cells. Obesity (Silver Spring). 19(4):722-8. Vaniotis G, Del Duca D, Trieu P, Rohlicek CV, Hébert TE, Allen BG. (2011) Nuclear β-adrenergic receptors modulate gene expression in adult rat heart. Cell Signal. 23(1):89-98. Almazan, Guillermina Mimouni-Rongy M, White JH, Weinstein DE, Desbarats J, Almazan G. (2011) Fas ligand acts as a counter-receptor in Schwann cells and induces the secretion of bioactive nerve growth factor. J Neuroimmunol. 230(1-2):17-25. Huang J, Vogel G, Yu Z, Almazan G, Richard S. (2011) Type II Arginine Methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation. J Biol Chem. 286(52):44424-32. Batist, Gerald (See Department of Oncology)

Pharmacology and Therapeutics Publications 2011 Bernard, Daniel Ho CC, Zhou X, Mishina Y, Bernard DJ (2011) Mechanisms of bone morphogenetic protein 2 (BMP2) stimulated inhibitor of DNA binding 3 (Id3) transcription. Molecular and Cellular Endocrinology 332(1-2): 242-252. Bowie, Derek Maclean DM, Bowie D. (2011) Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretation. J Physiol. 589(Pt 22):5383-90. Lachance-Touchette P, Brown P, Meloche C, Kinirons P, Lapointe L, Lacasse H, Lortie A, Carmant L, Bedford F, Bowie D, Cossette P. (2011) Novel α1 and γ2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy. Eur J Neurosci. ;34(2):237-49. Bowie D. (2011) Choosing the right pain relief for patients with soft-tissue injuries. Emerg Nurse. 19(2):28-30. Review. Maclean DM, Wong AY, Fay AM, Bowie D. (2011) Cations but not anions regulate the responsiveness of kainate receptors. J Neurosci. 31(6):2136-44. Čapek, Radan

Sylvestre MP, Abrahamowicz M, Capek R, Tamblyn R. (2011) Assessing the cumulative effects of exposure to selected benzodiazepines on the risk of fall-related injuries in the elderly.Int Psychogeriatr. 8:1-10. Han L, McCusker J, Cole M, Capek R, Abrahamowicz M. (2011) Antidepressant use and cognitive functioning in older medical patients with major or minor depression: a prospective cohort study with database linkage. J Clin Psychopharmacol. 31(4):429-35. Chemtob, Sylvain Rivera JC, Sapieha P, Joyal JS, Duhamel F, Shao Z, Sitaras N, Picard E, Zhou E, Lachapelle P, Chemtob S. (2011) Understanding retinopathy of prematurity: update on pathogenesis. Neonatology. 100(4):343-53. Kermorvant-Duchemin E, Sennlaub F, Behar-Cohen F, Chemtob S. (2011) [Epidemiology and pathophysiology of retinopathy of prematurity]. Arch Pediatr. 18 Suppl 2:S79-85. French. Bourguet CB, Goupil E, Tassy D, Hou X, Thouin E, Polyak F, Hébert TE, Claing A, Laporte SA, Chemtob S, Lubell WD. (2011) Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics. J Med Chem. 54(17):6085-97. Zaniolo K, Sapieha P, Shao Z, Stahl A, Zhu T, Tremblay S, Picard E, Madaan A, Blais M, Lachapelle P, Mancini J, Hardy P, Smith LE, Ong H, Chemtob S. (2011) Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a. Invest Ophthalmol Vis Sci. 52(8):5376-86. Shao Z, Dorfman AL, Seshadri S, Djavari M, Kermorvant-Duchemin E, Sennlaub F, Blais M, Polosa A, Varma DR, Joyal JS, Lachapelle P, Hardy P, Sitaras N, Picard E, Mancini J, Sapieha

Pharmacology and Therapeutics Publications 2011 P, Chemtob S. (2011) Choroidal involution is a key component of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 52(9):6238-48. Lavalette S, Raoul W, Houssier M, Camelo S, Levy O, Calippe B, Jonet L, Behar-Cohen F, Chemtob S, Guillonneau X, Combadière C, Sennlaub F. (2011) Interleukin-1β inhibition prevents choroidal neovascularization and does not exacerbate photoreceptor degeneration. Am J Pathol. 178(5):2416-23. Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma DR, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P. (2011) Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood. 117(22):6024-35. Boutard N, Turcotte S, Beauregard K, Quiniou C, Chemtob S, Lubell WD. (2011) Examination of the active secondary structure of the peptide 101.10, an allosteric modulator of the interleukin-1 receptor, by positional scanning using β-amino γ-lactams. J Pept Sci. 17(4):288-96. Shah NA, Hills NK, Waleh N, McCurnin D, Seidner S, Chemtob S, Clyman R. (2011) Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment. J Pediatr. 158(6):919-923. Zhu T, Mancini JA, Sapieha P, Yang C, Joyal JS, Honoré JC, Leduc M, Zaniolo K, Hardy P, Shao Z, Fan L, Hou X, Rivard GE, Chemtob S. (2011) Cortactin activation by FVIIa/tissue factor and PAR2 promotes endothelial cell migration. Am J Physiol Regul Integr Comp Physiol. 300(3):R577-85. Dorfman AL, Cuenca N, Pinilla I, Chemtob S, Lachapelle P. (2011) Immunohistochemical evidence of synaptic retraction, cytoarchitectural remodeling, and cell death in the inner retina of the rat model of oygen-induced retinopathy (OIR). Invest Ophthalmol Vis Sci. 52(3):1693-708. Clarke, Paul

No publications in 2011. Cuello, A. Claudio Ferretti, MT, Cuello AC. (2011) Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment? Curr Alzheimer Res. 8(2):164-74. S. Allard, V. Gosein, AC. Cuello and A. Ribeiro-da-Silva (2011) Changes with aging in the dopaminergic and noradrenergic innervation of rat neocortex. Neurobiology of the Aging 32(12):2244-53. Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello AC. (2011) Transgenic mice as a model of pre-clinical Alzheimer's disease. Curr Alzheimer Res. 8(1):4-23. Culty, Martine (See Department of Medicine)

Pharmacology and Therapeutics Publications 2011 De Koninck, Yves Doyon N, Prescott SA, Castonguay A, Godin AG, Kröger H, De Koninck Y. (2011) Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis. PLoS Comput Biol. 7(9):e1002149. Laffray S, Pagès S, Dufour H, De Koninck P, De Koninck Y, Côté D. (2011) Adaptive movement compensation for in vivo imaging of fast cellular dynamics within a moving tissue. PLoS One. 6(5):e19928. Mesnage B, Gaillard S, Godin AG, Rodeau JL, Hammer M, Von Engelhardt J, Wiseman PW, De Koninck Y, Schlichter R, Cordero-Erausquin M. (2011) Morphological and functional characterization of cholinergic interneurons in the dorsal horn of the mouse spinal cord. J Comp Neurol. 519(16):3139-58. Swift JL, Godin AG, Doré K, Freland L, Bouchard N, Nimmo C, Sergeev M, De Koninck Y, Wiseman PW, Beaulieu JM. (2011) Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells. Proc Natl Acad Sci U S A. 108(17):7016-21. Godin AG, Costantino S, Lorenzo LE, Swift JL, Sergeev M, Ribeiro-da-Silva A, De Koninck Y, Wiseman PW. (2011) Revealing protein oligomerization and densities in situ using spatial intensity distribution analysis. Proc Natl Acad Sci U S A. 108(17):7010-5. Bonin RP, Labrakakis C, Eng DG, Whissell PD, De Koninck Y, Orser BA. (2011) Pharmacological enhancement of δ-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice. Pain. 152(6):1317-26. LeChasseur Y, Dufour S, Lavertu G, Bories C, Deschênes M, Vallée R, De Koninck Y. (2011) A microprobe for parallel optical and electrical recordings from single neurons in vivo. Nat Methods. 8(4):319-25. Di Battista, Giovanni (John) (See Department of Anatomy and Cell Biology) Fellows, Lesley (See Department of Neurology and Neurosurgery) Fiset, Pierre (See Department of Anesthesia) Gauthier, Serge (See Departments of Neurology and Neurosurgery, Psychiatry) Geary, Timothy (See Department of Parasitology) Hales, Barbara

Pharmacology and Therapeutics Publications 2011 Bardai, G. K., Hales, B. F. and Sunahara, G. I. (2011) The Developmental Toxicity of Glyceryl Trinitrate in Quail Embryos. Birth Defects Res A Clin Mol Teratol. 91:230-240. Grenier L, Robaire B, Hales BF. (2011) Paternal cyclophosphamide exposure induces the formation of functional micronuclei during the first zygotic division. PLoS One. 6:e27600. Marcon, L., Zhang, X., Hales, B., Robaire, B., and Nagano, M.C. (2011) Effects of Chemotherapeutic Agents for Testicular Cancer on Rat Spermatogonial Stem/Progenitor Cells. J Androl. 32:432-43. Hales BF, Grenier L, Lalancette L, Robaire B. (2011) Epigenetic programming: from gametes to blastocyst. Birth Defects Res A Clin Mol Teratol. 91:652-65.

Hales BF, Robaire B. (2011) Paternally-Mediated Effects On Development. In: Developmental

and Reproductive Toxicology, a practical approach. (R.D. Hood, ed.) CRC Taylor & Francis,

Boca Raton, pp. 125-146. Chapter. Hébert, Terrence Bourguet, C.B., Goupil, E., Tassy, D., Hou, X., Thouin, E., Polyak, F. Hébert, T.E., Claing, A., Laporte, S.A., Chemtob, S. and Lubell, W. (2011) New allosteric ligands for FP as tocolytic agents. Journal of Medicinal Chemistry 54:6085-6097. Glazkova, I., Altosaar, K. and Hébert, T.E. (2011) Organizational complexity of b-adrenergic receptor signalling systems Current Topics in Membranes- Advances in Adrenergic Receptor Biology 67:19-49. Pétrin, D., Robitaille, M., and Hébert, T.E. (2011) Real-time BRET assays to measure G protein/effector interactions. Methods in Molecular Biology 756:245-261. Pétrin, D. and Hébert, T.E. (2011) Imaging-based approaches to understanding G protein-coupled receptor signalling complexes Methods in Molecular Biology 756:37-60. Vaniotis, G., Del Duca, D., Trieu, P. Rohlicek, C.V., Hébert, T.E. and Allen, B.G. (2011) Nuclear β-adrenergic receptors modulate gene expression in adult rat heart. Cellular Signalling 23(1):89-98. Vaniotis, G., Allen, B.G. and Hébert, T.E. (2011) Nuclear GPCRs in cardiomyocytes-putting adrenergic receptors in their place. Am. J. Physiol. Heart and Circulatory Physiol. 301:H1754-H1764. Bourguet CB, Goupil E, Tassy D, Hou X, Thouin E, Polyak F, Hébert TE, Claing A, Laporte SA, Chemtob S, Lubell WD. (2011) Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics. J Med Chem. 54(17):6085-97. Jean-Claude, Bertrand (See Department of Medicine) Kimmins, Sarah (See Department of Animal Science)

Pharmacology and Therapeutics Publications 2011 Laird, Jennifer Martino G, Puma C, Yu XH, Gilbert AK, Coupal M, Markoglou N, McIntosh FS, Perkins MN, Laird JM. (2011) The M1/M4 preferring agonist xanomeline is analgesic in rodent models of chronic inflammatory and neuropathic pain via central site of action. Pain. 152(12):2852-60. Gu X, Zhang W, Choi J, Li W, Chen X, Laird JM, Salomon RG. (2011) An (1)O2 route to γ-hydroxyalkenal phospholipids by vitamin E-induced fragmentation of hydroperoxydiene-derived endoperoxides. Chem Res Toxicol. 24(7):1080-93. Choi J, Laird JM, Salomon RG. (2011) An efficient synthesis of γ-hydroxy-α,β-unsaturated aldehydic esters of 2-lysophosphatidylcholine. Bioorg Med Chem. 19(1):580-7. Choi J, Zhang W, Gu X, Chen X, Hong L, Laird JM, Salomon RG. (2011) Lysophosphatidylcholine is generated by spontaneous deacylation of oxidized phospholipids. Chem Res Toxicol. 24(1):111-8. Laporte, Stéphane (See Division of Experimental Medicine) Mancini, Joseph Zhu T, Mancini JA, Sapieha P, Yang C, Joyal JS, Honoré JC, Leduc M, Zaniolo K, Hardy P, Shao Z, Fan L, Hou X, Rivard GE, Chemtob S. (2011) Cortactin activation by FVIIa/tissue factor and PAR2 promotes endothelial cell migration. Am J Physiol Regul Integr Comp Physiol. 300(3):R577-85. Maysinger, Dusica Hutter E, Maysinger D. (2011) Gold nanoparticles and quantum dots for bioimaging. Microsc Res Tech. 74(7):592-604. McKinney, R. Anne Schätzle P, Ster J, Verbich D, McKinney RA, Gerber U, Sonderegger P, Mateos JM. (2011) Rapid and reversible formation of spine head filopodia in response to muscarinic receptor activation in CA1 pyramidal cells. J Physiol. 589(Pt 17):4353-64. McLeod, Peter McLeod PJ, Steinert Y, Boillat M. (2011) How faculty development research can inform practice. Med Educ. 45(11):1150-1. Miller, Gregory

Wang H, Wang F, Jones K, Miller GJ. (2011) Chemical pressure and rare-earth orbital contributions in mixed rare-earth silicides La(5-x)Y(x)Si4 (0 ≤ x ≤ 5). Inorg Chem. 50(24):12714-23.

Pharmacology and Therapeutics Publications 2011 Wang F, Miller GJ. (2011) Revisiting the Zintl-Klemm concept: alkali metal trielides. Inorg Chem. 50(16):7625-36. Goerens C, Brgoch J, Miller GJ, Fokwa BP. (2011) Scaffolding, ladders, chains, and rare ferrimagnetism in intermetallic borides: synthesis, crystal chemistry and magnetism. Inorg Chem. 50(13):6289-96. Brgoch J, Goerens C, Fokwa BP, Miller GJ. (2011) Scaffolding, ladders, chains, and rare ferrimagnetism in intermetallic borides: electronic structure calculations and magnetic ordering. J Am Chem Soc. 133(17):6832-40. Nattel, Stanley Comtois P, Nattel S. (2011) Interactions between cardiac fibrosis spatial pattern and ionic remodeling on electrical wave propagation. Conf Proc IEEE Eng Med Biol Soc. 2011:4669-72. Iwasaki YK, Nishida K, Kato T, Nattel S. (2011) Atrial fibrillation pathophysiology: implications for management. Circulation. 124(20):2264-74. Review. Nattel S. (2011) Dronedarone in atrial fibrillation--Jekyll and Hyde? N Engl J Med. 365(24):2321-2. Farid TA, Nair K, Massé S, Azam MA, Maguy A, Lai PF, Umapathy K, Dorian P, Chauhan V, Varró A, Al-Hesayen A, Waxman M, Nattel S, Nanthakumar K. (2011) Role of KATP channels in the maintenance of ventricular fibrillation in cardiomyopathic human hearts. Circ Res. 109(11):1309-18. Makary S, Voigt N, Maguy A, Wakili R, Nishida K, Harada M, Dobrev D, Nattel S. (2011) Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling. Circ Res. 109(9):1031-43. Wakili R, Voigt N, Kääb S, Dobrev D, Nattel S. (2011) Recent advances in the molecular pathophysiology of atrial fibrillation. J Clin Invest. 121(8):2955-68. Nattel S. (2011) A focus on hypertension: a modest condition of enormous significance. Can J Cardiol. 27(4):394-6. Nattel S, Antzelevitch C, Noble D. (2011) Resolving the M-cell debate: why and how. Heart Rhythm. 8(8):1293-5. Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RA, Cerbai E, Chen PS, Delmar M, Difrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding SE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varró A, Volders PG, Wang K, Weiss JN, Wettwer E, White E, Wilders R, Winslow RL, Kohl P. (2011) Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. Prog Biophys Mol Biol. 107(1):4-10.

Pharmacology and Therapeutics Publications 2011 Datino T, Macle L, Chartier D, Comtois P, Khairy P, Guerra PG, Fernandez-Aviles F, Nattel S. (2011) Differential effectiveness of pharmacological strategies to reveal dormant pulmonary vein conduction: a clinical-experimental correlation. Heart Rhythm. 8(9):1426-33. Lemoine MD, Duverger JE, Naud P, Chartier D, Qi XY, Comtois P, Fabritz L, Kirchhof P, Nattel S. (2011) Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model. Cardiovasc Res. 92(1):67-74. Le Quang K, Naud P, Qi XY, Duval F, Shi YF, Gillis MA, Comtois P, Tardif JC, Li D, Levesque PC, Dobrev D, Charpentier F, Nattel S. (2011) Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice. Cardiovasc Res. 91(3):420-8. Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K. (2011) Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm. Circulation. 123(20):2192-203. Comtois P, Nattel S. (2011) Impact of tissue geometry on simulated cholinergic atrial fibrillation: a modeling study. Chaos. 21(1):013108. Thomas J, Epshtein Y, Chopra A, Ordog B, Ghassemi M, Christman JW, Nattel S, Cook JL, Levitan I. (2011) Anthrax lethal factor activates K(+) channels to induce IL-1β secretion in macrophages. J Immunol. 186(9):5236-43. Nattel S, Van Wagoner DR. (2011) Atrial fibrillation: therapy with omega-3 fatty acids-is the case closed? Nat Rev Cardiol. 8(3):126-8. Gillis AM, Verma A, Talajic M, Nattel S, Dorian P; CCS Atrial Fibrillation Guidelines Committee. (2011) Canadian Cardiovascular Society atrial fibrillation guidelines 2010: rate and rhythm management. Can J Cardiol. 27(1):47-59. Nattel S. (2011) From guidelines to bench: implications of unresolved clinical issues for basic investigations of atrial fibrillation mechanisms. Can J Cardiol. 27(1):19-26. Review. Nattel S. (2011) A proud tradition and a new beginning with a theme issue on atrial fibrillation. Can J Cardiol. 27(1):5-6. Dobrev D, Nattel S. (2011) New insights into the molecular basis of atrial fibrillation: mechanistic and therapeutic implications. Cardiovasc Res. 89(4):689-91. Yeh YH, Kuo CT, Chan TH, Chang GJ, Qi XY, Tsai F, Nattel S, Chen WJ. (2011) Transforming growth factor-β and oxidative stress mediate tachycardia-induced cellular remodelling in cultured atrial-derived myocytes. Cardiovasc Res. 91(1):62-70. Nishida K, Qi XY, Wakili R, Comtois P, Chartier D, Harada M, Iwasaki YK, Romeo P, Maguy A, Dobrev D, Michael G, Talajic M, Nattel S. (2011) Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model. Circulation. 123(2):137-46.

Pharmacology and Therapeutics Publications 2011 Benito B, Gay-Jordi G, Serrano-Mollar A, Guasch E, Shi Y, Tardif JC, Brugada J, Nattel S, Mont L. (2011) Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training. Circulation. 123(1):13-22. Yue L, Xie J, Nattel S. (2011) Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res. 89(4):744-53. Nishida K, Maguy A, Sakabe M, Comtois P, Inoue H, Nattel S. (2011) The role of pulmonary veins vs. autonomic ganglia in different experimental substrates of canine atrial fibrillation. Cardiovasc Res. 89(4):825-33. O’Flaherty, Cristian (See Department of Urology) Papadopoulos, Vassilios (See Department of Medicine) Prichard, Roger (See Department of Parasitology) Quirion, Remi (See Department of Psychiatry) Ribeiro-da-Silva, Alfredo S. Allard, V. Gosein, A.C. Cuello and A. Ribeiro-da-Silva (2011) Changes with aging in the dopaminergic and noradrenergic innervation of rat neocortex. Neurobiology of the Aging 32(12):2244-53. Robaire, Bernard Carroll M, Luu T, Robaire B. (2011) Null mutation of the transcription factor inhibitor of DNA binding 3 (Id3) affects spermatozoal motility parameters and epididymal gene expression. Biol Reprod. 84:765-74. Marcon, L., Zhang, X., Hales, B., Robaire, B., and Nagano, M.C. (2011) Effects of Chemotherapeutic Agents for Testicular Cancer on Rat Spermatogonial Stem/Progenitor Cells. J Androl. 32:432-43. Hamzeh M, Robaire B. (2011) Androgens Activate Mitogen-Activated Protein Kinase via Epidermal Growth Factor Receptor/Insulin-Like Growth Factor 1 Receptor in the Mouse PC-1 Cell Line. J Endo. 209:55-64. Hales BF, Grenier L, Lalancette L, Robaire B. (2011) Epigenetic programming: from gametes to blastocyst. Birth Defects Res A Clin Mol Teratol. 91:652-65. Paul C, Nagano M, Robaire B. (2011) Aging results in differential regulation of DNA repair pathways in pachytene spermatocytes in the Brown Norway rat. Biol Reprod. 85:1269-78.

Robaire B, Murphy BD. (2011) From the Editors: BOR launches the “World of Reproductive

Biology”. Biol Reprod. 85:1.

Pharmacology and Therapeutics Publications 2011

Robaire B, Hamzeh H. (2011) Androgen action in the epididymis. J Androl. 32:592-9. Review.

Hales BF, Robaire B. (2011) Paternally-Mediated Effects On Development. In: Developmental

and Reproductive Toxicology, a practical approach. (R.D. Hood, ed.) CRC Taylor & Francis,

Boca Raton, pp. 125-146. Chapter.

Chan P, Robaire B. (2011) Cancer in males: implications for sperm quality, fertility and progeny

outcome. In: Sperm Chromatin: Biological and Clinical Applications in Male Infertility and

Assisted Reproduction. (A. Zini and A. Agarwal, eds.) Humana Press-Springer Science, Chapter

24, pp. 354-60. Chapter.

Grenier L, Robaire B, Hales BF. (2011) Paternal cyclophosphamide exposure induces the

formation of functional micronuclei during the first zygotic division. PLoS One. 6(11):e27600. Rousseau, Simon (See Department of Medicine) Saragovi, H. Uri Jain P, Li R, Lama T, Saragovi HU, Cumberlidge G, Meerovitch K. (2011) An NGF mimetic, MIM-D3, stimulates conjunctival cell glycoconjugate secretion and demonstrates therapeutic efficacy in a rat model of dry eye. Exp Eye Res. 93(4):503-12. Bai Y, Sivori D, Woo SB, Neet KE, Lerner SF, Saragovi HU. (2011) During glaucoma, alpha2-macroglobulin accumulates in aqueous humor and binds to nerve growth factor, neutralizing neuroprotection. Invest Ophthalmol Vis Sci. 52(8):5260-5. Aboulkassim T, Tong XK, Tse YC, Wong TP, Woo SB, Neet KE, Brahimi F, Hamel E, Saragovi HU. (2011) Ligand-dependent TrkA activity in brain differentially affects spatial learning and long-term memory. Mol Pharmacol. 80(3):498-508. Shir, Yoram (See MUHC Pain Center) Stone, Laura (See Faculty of Dentistry) Szyf, Moshe Chik F, Szyf M, Rabbani SA. (2011) Role of epigenetics in cancer initiation and progression. Adv Exp Med Biol. 720:91-104. Review. Tajerian M, Alvarado S, Millecamps M, Dashwood T, Anderson KM, Haglund L, Ouellet J, Szyf M, Stone LS. (2011) DNA methylation of SPARC and chronic low back pain. Mol Pain. 7:65. Szyf M. (2011) The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life. Epigenetics. 6(8):971-8. Review.

Pharmacology and Therapeutics Publications 2011 Stefanska B, Huang J, Bhattacharyya B, Suderman M, Hallett M, Han ZG, Szyf M. (2011) Definition of the landscape of promoter DNA hypomethylation in liver cancer. Cancer Res. 71(17):5891-903. Szyf M. (2011) DNA methylation, the early-life social environment and behavioral disorders. J Neurodev Disord. 3(3):238-49. McGowan PO, Suderman M, Sasaki A, Huang TC, Hallett M, Meaney MJ, Szyf M. (2011) Broad epigenetic signature of maternal care in the brain of adult rats. PLoS One. 6(2):e14739. Szyf M. (2011) The implications of DNA methylation for toxicology: toward toxicomethylomics, the toxicology of DNA methylation. Toxicol Sci. 120(2):235-55. Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello AC. (2011) Transgenic mice as a model of pre-clinical Alzheimer's disease. Curr Alzheimer Res. 8(1):4-23. Chik F, Szyf M. (2011) Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors. Carcinogenesis. 32(2):224-32. Hochberg Z, Feil R, Constancia M, Fraga M, Junien C, Carel JC, Boileau P, Le Bouc Y, Deal CL, Lillycrop K, Scharfmann R, Sheppard A, Skinner M, Szyf M, Waterland RA, Waxman DJ, Whitelaw E, Ong K, Albertsson-Wikland K. (2011) Child health, developmental plasticity, and epigenetic programming. Endocr Rev. 32(2):159-224. Review. Tanny, Jason No publications in 2011. Trasler, Jacquetta Niles KM, Chan D, La Salle S, Oakes CC, Trasler JM.(2011) Critical period of nonpromoter DNA methylation acquisition during prenatal male germ cell development. PLoS One. 6(9):e24156. Goupil S, La Salle S, Trasler JM, Bordeleau LJ, Leclerc P.(2011) Developmental expression of SRC-related tyrosine kinases in the mouse testis. J Androl. 32(1):95-110. Varma, Daya Krishnan SS, Panigrahi M, Jayalakshmi S, Varma DR. (2011) Neuroplasticity in hemispheric syndrome: an interesting case report. Neurol India. 59(4):601-4. Shao Z, Dorfman AL, Seshadri S, Djavari M, Kermorvant-Duchemin E, Sennlaub F, Blais M, Polosa A, Varma DR, Joyal JS, Lachapelle P, Hardy P, Sitaras N, Picard E, Mancini J, Sapieha P, Chemtob S. (2011) Choroidal involution is a key component of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 52(9):6238-48. Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma DR, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P.

Pharmacology and Therapeutics Publications 2011 (2011) Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood. 117(22):6024-35 Yang, Xiang-Jiao (See McGill University Rosaline & Morris Goodman Cancer Center) Zingg, Hans No publications in 2011. Zorychta, Edith (See Department of Pathology)