Clinical bacteriology automationClinical applications

Envisioning a Full microbiology Lab Automation.

Clinical bacteriology automation

Express your lab's full potential by automating your routine.

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Our comprehensive approach to preanalytics

Collection

Transport

Processing

Artificial Intelligence

We envision e�cient labs where the quality of results is sky-high. At

Copan, automation is the core of this dream. From the Greek αùτόµατος –

acting of itself, moving or acting on its own – automation etymological

sense is too limiting: even though our set of advanced AI and hardware

modules are in the service of the lab's daily tasks, your sta�, needs, and

rules are still at the center of every process.

What is automation?

Technology in service of people

Laboratory challenges

A demanding daily routine

Data – patient individual information, protocols, results from

previous analyses.

Processes – handle samples and reagents, aliquot,

transport, incubate and interpret data.

Decisions – lab management decisions and the diagnosis.

To keep these data, processes, and decisional inaccuracies as negligible as

possible and ensure a precise, reproducible diagnosis, laboratory sta� must

adopt time-consuming measures every day.

Automation is undoubtedly one of the most important

advancements that occurred in clinical laboratories over the past

decade. Its evolution, digital automation, o�ers now the

opportunity to connect multiple lab instruments, multiple

specialty labs, and even multiple labs scattered across the globe.

While providing significant long-term cost savings and sta�

requalification, automation enables improved e�ciency,

organization, standardization, and laboratory testing safety.

Laboratory automation is only a part of Copan's comprehensive

approach to preanalytics; our line of liquid-based microbiology

collection and transport systems can be paired with our

automation solutions, unlocking your lab's real potential

and accompanying you from sample collection to data

interpretation in a smoother and more e�cient way.

From sample collection to image analysis and automated colony picking

Our comprehensive approach to preanalytics

Each day, in every clinical laboratory, thousands of data and processes

intertwine with each other in constant cooperation, leading to

therapy-driving results. It is crucial to tackling this complex operational

weave in the most e�cient way possible, in all its parts:

Microbiology labs criticalities are the same as any other lab. In the same way, they can enormously benefit from FLA

implementation. According to a recent multicenter study4, Full Lab Automation can almost double microbiology labs'

productivity and halve the cost per specimen – regardless of the lab size, load, and location – reducing the median

turnaround time of 14 h (Figure 1)4.

FLA in microbiology

Get prepared for what's next!

Full Lab Automation enables a 24/7

processing and culture workup schedule, and

AI interpretative algorithms allow

technologists to review images in batch

mode for a more e�cient release of

significant cultures or interpret plates and

antibiotic sensitivity results in a flash.

Even if human and economic resources

decline in the future, incorporating these and

new tools will empower the microbiology

community – and your lab – to provide

high-quality results ever more rapidly.

Full laboratory Automation (FLA) combines into an integrated system the complete automatization of preanalytics, analytics,

and data interpretation, with minimal human intervention and many advantages. Automation performs repetitive tasks

rapidly and accurately, reducing process errors for unparalleled precision and reproducibility.

Also, machines never sleep, enabling laboratories to switch to a 24/7 schedule.

Can you imagine?

You could enter the lab in the morning with all the routines already performed autonomously during the night: more time for

you to focus on essential tasks and reduced time to results.

Labs worldwide – from large to small, low to high throughput, reference to hospital-based laboratories – are exploring or

deploying various degrees of FLA with unquestionable benefits – including error reduction – from clinical chemistry to

immunology and molecular biology1,2,3.

Full Laboratory Automation

A sleepless and accurate assistant

20%

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40%

60%

80%

100%

Pre WASP® 2015

WASP® 2015

WASPLab®

2016WASPLab® 2018

24 hr 24-42 hr 42 hr

Figure 1: TAT frequency distribution with WASP® and Full Lab Automation

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We started our microbiology automation journey back in 2007 when it was still far from most people's thoughts.

Over these years, we built a preanalytical automation system that begins at the streaking phase and – combining hardware

modules with integrated image analysis software – takes care of streaking, reading, interpreting and picking activities: a real

Full Lab Automation4!

Copan approach to Full Lab Automation

From sample processing to image analysis

Innovation

New ideas, creativity, internal and external know-how are the

engine of our work. We strive every day to bring you

something unique.

Productivity

We believe in automatization as the solution to reduce time

to results and increase your lab's throughput.

Modularity

All our automation solutions are designed to be flexible and

meet any workflow, volume, or protocol need.

Quality

As volumes rise and the laboratory grows, our automation

systems are designed to boost the quality and level of service.

Traceability

When processing loads of samples per day, it is crucial to keep

everything under control. For this, we design our products to

integrate seamlessly with your LIS.

Valorization

The expertise, experience, and commitment of your sta� are

your most valuable assets. By automating routine tasks, we

aim to give value to your personnel by letting them focus on

tasks that matter, for them as for patients.

The WASPLab® world

The leading microbiology ecosystem

WASP-FLO™Moving microbiology

PhenoMATRIX®

and PhenoMATRIX® TAGMicrobiology brain

Colibrí™Precision microbiology

MIcrohub®

Precision microbiology

WASP®

Microbiology core

Radian®

WASPLab®

Digital microbiology

Automated AST

Copan Walk-Away Specimen Processor™ is a truly revolutionary instrument with more than ten years of continuous

evolution. WASP® provides a comprehensive and modular system, encompassing all aspects of automated

specimen processing as plate planting and streaking, microscope slide preparation, broth inoculation.

WASP®

The microbiology core

Reduces consumables, management, and

environmental costs

Modular and scalable, adapts to every workflow

Increases the quality of streaking, minimizing

human errors

Ensures traceability through labeling and reading

systems

Advantages

The microbiology core

Loads samples without interrupting the

instrument or disrupting the lab workflow

Sample entry conveyor

Automatically print and apply barcodes to plates,

broths, and microscope slides

Label printers

Decaps and recaps automatically sample tubes

Universal decapper [a]

Ensures the homogeneity of each sample

Onboard vortex

Guarantees full traceability of every sample

Smart barcode readerChecks the sample presence in the loop

Inoculation verification camera

Holds up to 370 plates into nine di�erent columns

Plate carousel

Avoids cross-contaminations and ensure a clean

and safe environment

Incinerator and hepa filter

Tech-based quality

Slide prep evo™

Slide smear, barcode laser

print, and slide dry out.

Pipettor module Customizable volume inoculations

and multiple broth management.

WASP® modules

Broth module Broth inoculation and

automatic tube labeling.

WASPLab® is the natural evolution of WASP® redefining the state-of-the-art of FLA. WASPLab® takes care of the

incubation and imaging of the plates, bringing the lab into the world of Digital Bacteriology. Before and during

the incubation, the unique WASPLab® vision system acquires high-quality digital images on which a technologist can

perform the reading phase.

Enhance reading performance, allowing lab technicians

to make the most accurate workup-decisions

Modular and scalable, adapts to every workflow

Standardizes optimal incubation conditions for better

and faster results5

Improves lab productivity and quality through the

automated specimen organization and easier

recognition of bacteria

Advantages

Digital microbiology

WASPLab®

Digital microbiology

Acquires 48 Megapixel plates images at

designated incubation times

Telecentric camera

Multiple combinations of light conditions to

maximize the image quality of di�erent media

plates

Lightning system

Arrange upside down plates in individual spots for

homogeneous incubation conditions and constant

traceability

Robotic plate handlers

Improves manual plate management, screening,

reading, and picking

WorkstationDesigned to be the main access-point to

WASPLab®, ensuring an easy and user-friendly

interaction

WebApp

Wide range of controlled atmosphere settings for

optimal bacterial growth

O2 and CO2 atmosphere

Incubate plates fitting the needs of laboratories of

all sizes

Single and double incubators

Tech-based quality

Image acquisition system [b] Modularity and scalability examples A sophisticated lighting and camera system acquires

the image of each plate clearly and accurately.

Radian® is the WASPLab® module dedicated to the full automation and interpretation of Disk Di�usion Antibiotic

Susceptibility Testing. It is composed of two modules:

Radian®

Automated AST

Applies EUCAST standard and rapid rules from

direct blood cultures[d] automatically

Enables early antibiotic therapy for the final benefit

of patients

Expresses the full potential of disk di�usion

susceptibility testing

Connecting Colibrì™, WASP®, WASPLab® , and Radian®:

a new workflow perfectly integrated

Advantages

Automated AST

Radian® In-Line Carousel is the new WASPLab®'s module that takes care of disk dispensation, ensuring optimal

integration and throughput.

Radian® Expert System leverages WASPLab®'s superior Digital Imaging and EUCAST rules to deliver an exceptional-

ly accurate SIR interpretation.

Rapid system advantages6

A fast time to result is crucial in the treatment of critical patients. We conceived a rapid direct AST (4h)

compliant with the new EUCAST protocols and available on Radian® for blood cultures[d]. The simultaneous

application of Rapid Rules to multiple types of samples will be available soon.

Radian® expert system

Radian® in-Line Carousel

Boosts the integration of AST tasks into your daily routine

Parallel redirection line

Ensures maximum exibility in the antibiotic choice

50 cartridge carousel

Before the disk deposition, a dedicated vision system assures

the ATB disk removal from the cartridge and the congruency

between the disk and the selected protocol.

Quality check

An extra safety layer protecting from dangerous samples

Dual hepa filtering system

Keep everything in sight while

working directly on the plate

Expert system hints

With direct communication

to the rules database

Halo-reading interface

Adapt or write from scratch

your own interpretation rules

Rule editor

Located on the conveyor between WASP® and WASPLab® first incubator, Radian® In-Line Carousel receives plates

dedicated to AST disk dispensing on a parallel conveyor without compromising the throughput of WASPLab®.

Radian® In-Line Carousel allows high disk dispensing flexibility thanks to its 50 positions ATB wheel and its 1 to 8 disk

deposit protocols, assuring high quality and standards by cartridge ATB disk removal check and ATB acronyms control.

A flexible, customizable, and user-friendly platform to interpret sensitive, intermediate, or resistant results.

Being connected with the WASPLab® WebApp Halo Recognition image analysis algorithm and communicating with

the lab LIS, Radian® Expert system is our fully integrated solution for AST automated interpretation in your lab.

PhenoMATRIX® uses artificial intelligence combined with clinical information from the LIS system to

automatically read, interpret, and segregate bacterial cultures with the click of a button. Adding PhenoMATRIX®

suite of algorithms to WASPLab® automation system eases the interpretation of patient results and gives microbiology

labs the ability to shorten their time to results7,8.

Custom expert rules for a tailored solution on your

laboratory standards

Sorts your plates images according to your rules and

LIS data

Breaks down the plate's key features thanks to its

advanced digital image analysis algorithms

Accelerates your interpretation through a clear plate

visualization

Advantages

PhenoMATRIX®

Microbiology brain

Microbiologybrain

All the results sorted using the custom filters are

sent to LIS with a single click

One- click result release [c]

Groups plates in a folder-style interface, based on

the laboratory rules

Custom filters

Summarizes all the plate results: negativity, isolate,

colony count, and workup

Results workup

Tech-based quality

PhenoMATRIX® directly sorts all images

based on the lab custom rules, combining

patient demographic data, clinical results, and

the output of image analysis algorithms.

The sorted images are subjected to the

technologist for final validation.

Complete set results

PhenoMATRIX™ TAG

Understanding the colonies' coordinates and morphology, PhenoMATRIX® TAG assigns the

proper workup for each colony, according to your rules[e]. PhenoMATRIX® TAG consequently

communicates to Colibrí™ to pick the most appropriate ones for each specific task.

PhenoMATRIX® PLUS will automatically

send all negative results to the LIS,

discarding media plates without

microbiologist validation.

This will drastically decrease the hands-on time

for negatives and speed up the time-to-result

for patients.

Autorelease concept [d]PhenoMATRIX®WASPLab®

Negative

PositiveAutorelease

Colibrí™ is a microbiology system that automatically picks

colonies previously selected by PhenoMATRIX® TAG or

by an operator on the WASPLab® reading station.

The instrument spots targets for microbial identification

through MALDI-TOF technology and prepares microbial

suspensions for Antibiotic Susceptibility Testing (AST).

Integrates data with IVD analyzers for seamless

traceability [a]

Maximizes the focus on higher-profile tasks

Ensures picking accuracy thanks to synchronized

vision systems

Advantages

Colibrí™

Precision microbiology

colony picking

colony picking

isolate data

AST tube preparation

Formic acid matrix deposition

turbidity check

target spotting

McFarlandsuspension tube

ID AST

Precision microbiology

Handles both colony picking and liquids transfer

with extreme precision [a]

Robotic pipettor

Holds up to sixteen target McFarland suspension

tubes and AST tubes for the preparation of the

microbial suspension [a]

Containers table

Checks the turbidity of the microbial suspension to

guarantee maximum precision and standardization

Nephelometer

Loads and unloads plates through seven

configurable stackers

Loading and unloading carousel

Controls the tip alignment and retrieves the colony

coordinates from WASPLab®, matching them for

accurate picking

Vision system

Automatically labels tubes and purity plates for

traceability and label reconciliation

Printer and barcode system

Tech-based quality

Accurate pipetting

Synchronization of nephelometer and pipettor

to maximize standardization and ensure the

highest precision.

Direct communication with WASPLab®

and PhenoMATRIX® TAG

WASPLab® WebApp highlights the isolated colonies

and the aggregated ones with di�erent colors.

PhenoMATRIX® TAG defines the optimal colonies to

be picked, communicating the coordinates with

Colibrí™ for a reliable picking.

Radian® compatible

Automated colony picking by Colibrì™ is

compatible with McFarland suspension tube

preparation prior to Automated Susceptibility

testing performed by Radian™.

WASP-FLO™ is the module we developed for microbiology

laboratories with multiple WASP® or WASPLab® lines, to

streamline sample loading and unloading. WASP-FLO™

automatically sorts samples[a], drives them to the appropriate

WASP®, and batches the tubes in output racks after processing.

Boosts your lab's productivity to

high-throughput levels

Thanks to the complete data management

system, it keeps under control the full path of

each sample.

Optimizes sample management through random

access and evaluation of the workload in real time

Sorts and route in and out samples to increase the

lab's e�ciency

Advantages

Wasp-flo™

Moving microbiology

Moving microbiology

Backup loading system for special containers

Graphical user interface

The Pick-and-Place robots sort tubes in RFID-driven pallets

and unload completed samples onto dedicated racks

Dual SCARA robots

Contains up to 600 samples per batch and sorts them

individually

Hopper module

Hosts 792 samples divided into eight output racks

Completed specimen output

Includes four columns composed of eleven RFID pallets

Manual specimen loading

Manages overall system data

RFID pallet stacker

Tech-based quality

Workflow example

Sorted outputsamples

Random incomingsamples

Sorted inputsamples

WASP® WASPLab® incubators

WASP-FLO™

Connecting WASPLab® to LIS and other instruments, MicroHub® represents the next step into a new way of managing

lab data.[d] Think of it as middleware, handling patient data, test orders, results, and the entire lab workload in

real-time. MicroHub® is the perfect tool to centralize the final validation step and keep lab's productivity under control.

Enhances the validation

process boosting data

accessibility and integrating

mass-operation features

Apply custom laboratory rules

for the automatic result

validation

Includes communication

drivers for all laboratory

platforms

Advantages

MicroHub®

Microbiology string

Microbiologystring

Patient demographics

Ongoing, completed, and historical process

Validation hub

Patient-related filters

Test-related filters

Filtered worklist

Customizable dashboard

Data categorization

Status and workload

Tech-based quality

Focus on your needs

MicroHub® is your patient-centric interface.

In the Validation Page, you can access all the patient

data to validate results, keep track of ongoing processes,

and avoid expensive repetitions.

The Advanced Search page is the ideal representation of

MicroHub®’s flexibility. Depending on your goal and

access rights, you land to the data you are interested in

just a few clicks.

The Activities Management page lets you track the

laboratory's real-time performance and workload,

highlighting data you choose as indicators of your

priorities.

Administration

Turnaround times

Lab automation workload

Test order statistics

Reimbursement data

Microbiologist

Worklist

Real time results

Patient historical results

Check in and test order validation

Lab manager

Turnaround times

Workflow statistics

Lab automation workload

Notes

To grant the reliability of results and allow the instruments safe and correct functioning, spare parts and technical support must be provided by Copan (or its

authorized distributors). Any third party's containers, culture plates and consumables to be used on the instruments must be approved in writing by Copan.

Limitations may apply: Please refer to Copan's o�cial technical documentation.

The WASPLab® imaging system is patented (AU2014259028B2, JP6460421B2, IT1417398) and patent pending (EP2989470A1, US2016083686A1).

Subject to final reporting performed by qualified personnel.

Product not yet commercially available.

Plate compatibility and strain compatibility are in continuous development. Please contact Copan for the latest updates.

to which the systems described in this brochure contribute

[a].

[b].

[c].

[d].

[e].

Please consult Copan for the availability of these products in your Country

Scientific references

All the independent studies we cited in this product focus are listed here.

1. Zaninotto M, Plebani M. The "hospital central laboratory": automation, integration and clinical usefulness. Clinical Chemistry and Laboratory

Medicine, 2010.

2. Hoi-Ying Elsie Yu, Harold Lanzoni, Tracy Ste�en, et al. Improving Laboratory Processes with Total Laboratory Automation. Laboratory Medicine, 2019.

3. Jonathan R Genzen, Carey-Ann D Burnham, Robin A Felder, et al. Challenges and Opportunities in Implementing Total Laboratory Automation.

Clinical Chemistry, 2018.

4. Karissa Culbreath, Heather Piwonka, John Korver, et al. Benefits Derived from Full Laboratory Automation in Microbiology: a Tale of Four

Laboratories. Journal of Clinical Microbiology, 2021.

5. A. Cherkaoui, G. Renzi, N. Vuilleumier, et al. Copan WASPLab automation significantly reduces incubation times and allows earlier culture readings

Clinical Microbiology and Infection, 2019.

6. Stefano Mancini, Kim Röthlin, Elias Bodendoerfer, et al. Tentative breakpoints and areas of technical uncertainty for early reading automated disc

di�usion for Enterobacterales. Journal of Antimicrobial Chemotherapy, 2020.

7. Justin Baker, Karen Timm, Matthew Faron, et al. Digital image analysis for the detection of Group B Streptococcus from ChromID StreptoB Media

using a PhenoMatrix Artificial Intelligence Software Algorithm. Journal of Clinical Microbiology, 2020.

8. Tam T. Van, Kenneth Mata, Jennifer Dien Bard. Automated Detection of Streptococcus pyogenes Pharyngitis by Use of Colorex Strep A CHROMagar

and WASPLab Artificial Intelligence Chromogenic Detection Module Software. Journal of Clinical Microbiology, 2019

This document may contain product information otherwise not accessible or valid in your country. Please be aware that Copan Wasp s.r.l. does take any responsibility for accessing such information which may not comply with any valid legal process, regulation, registration or usage in the country of your origin. Product clearance and availability restrictions may apply in some Countries. Please refer to Copan website (www.copangroup.com) to view and/or download the most recent version of the brochure. This document is mainly intended for marketing purposes, always consult product insert for complete information.The use of these products in association with diagnostic kits or instrumentation should be previously validated by the user. ©2021 Copan Italia. All rights reserved. The trademarks mentioned herein are property of Copan Italia S.p.A.Code: MMWB-GEN04 Rev.00 Date 2021.06

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