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ASU Drug Research Group Dismantled
Transcript of ASU Drug Research Group Dismantled
NEWS OF THE WEEK
"I read this paper and thought, Why didn't I think of that?'" J i l l ian M. Bur iak , Univers i t y of A l b e r t a , Edmonton
N A N O T E C H N O L O G Y
WRITE, READ, ERASE, AGAIN AND AGAIN Lithography method forms nanosized metal structures reversibly and repeatedly
Ν AN ADVANCE REMINISCENT OF the children's toy Etch A Sketch, researchers have developed a li
thography method for preparing erasable nanomete r - s i zed patterns. Similar to the plaything with which kids sketch with aluminum powder then wipe the slate clean and start over again, the new technique provides a way to p repa re nanoscale metal patterns that can be erased and redrawn repeatedly
N u m e r o u s p r o c e d u r e s have been demonstrated in recent years for preparing nanoscale metal dots, wires, tubes, and other structures that may function as components of miniature electronic and op-tical devices. T h e processes are as varied as the structures themselves and rely on electrodeposition, elect r o n - b e a m m e t h o d s , scann ing
probe manipulat ions, and other distinct procedures.
Despite the unique qualities of the fabrication methods, they tend
IN T H E GROOVE Using a probe tip to shave away surface molecules, Temple University researchers expose 25 -nm-wide patches (dark line at left) , which serve as templates for reversible electrochemical formation of silver nanowires (right).
to share an undesirable distinction: By and large, they're irreversible-meaning that the nanostructures cannot be created, removed, and re-
C A M P U S C O N F L I C T
ASU Drug Research Group Dismantled
M ore than two-dozen members of a cancer drug research group at Arizona State University (ASU) have lost their jobs in
what observers say is an escalating battle between a prominent chemistry professor and the university's administration.
An ASU spokesman says the Tempe-based group headed by George R. Pettit was dissolved because it wasn't able to renew its federal funding. Pettit's supporters say personal clashes have fueled the university's real desire: to supplant Pettit's original Cancer Research Institute (CRI) with ASU's much larger, new facility, the Biode-sign Institute.
On Jan. 27,31 of Pettit's group members, whose salaries are paid by grant money, were told they would be given 30 days' severance pay.
They were locked out of their labs immediately, and their e-mail accounts were canceled, they say. Nine members of the group remain at ASU, and a handful of his students and staff wi l l be incorporated into other university labs, ASU officials say. Pettit remains at ASU as a tenured professor.
Research professor Thomas H. Smith, one of those ousted, says the group was aware of brewing trouble, "but it was a shock that it happened as suddenly as it did."
Pettit has directed CRI since 1975. His group has several anticancer drugs in clinical trials. Recently, Pettit locked horns with ASU's new president, Michael M. Crow, and other officials. Last year, CRI was incorporated into the Biodesign Institute and renamed the Center for Cancer Research.— ELIZABETH WILSON
created efficiently in a "single pot." Now, chemists at Temple Uni
versity, in Philadelphia, have developed a straightforward method based on electrodeposi t ion and atomic force microscopy that can be used to prepare closely spaced 25-nm-wide metal wires in an insulating medium. By controlling the electrochemical conditions, the researchers can form the patterns reversibly and repeatedly from a single aqueous reagent solution (Langmuir, published online Jan . 19, dx.doi.org/10.1021/la0524891).
S t a r t i ng w i t h a self-ass e m b l e d m o n o l a y e r of 1-hexadecanethiol on a gold surface submerged in a solution of silver ions, associate professor Eric Borguet and postdoc Kyoungja Seo use t h e mic roscope t ip t o shave away thiol molecules selectively, thereby exposing nanomete r - s i zed ba re patches of controllable size. T h e n by applying a suitable voltage to the gold surface (a few tenths of avoir), the team induces electrodeposition of silver in the bare patches.
After forming the wires (writing) and imaging the surface (reading), the group adjusts the voltage slightly, thereby causing the silver wires to dissolve back into solut ion (erasing). T h e n they image the surface again and repeat the entire process. According to the researchers, the thiol monolayer remains stable throughout multiple write-erase-rewrite cycles.
Borguet 's group has taken an extremely well-established system, thiols on gold, and shown that it can be used in a fascinating, constructive, and almost simple manner, says Jillian M . Buriak, a chemistry professor at the University of Alberta, Edmonton, and a specialist in surface patterning. "I read this paper and thought, ' W h y didn' t I t h i n k of that? ' " Bur iak adds tha t the m e t h o d broadens the capabilities of nanolithogra-phy and may be used to fabricate increasingly complex metal nanostructures.—MITCH JACOBY
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