DRUG TARGET & DELIVERY SYSTEM

DRUG TARGET & DELIVERY SYSTEMVivek Singh M.Sc. BiotechnologyUniversity of Allahabad

An example of targeted nanoparticle internalization in tumor cells: 9L glioma brain tumor cells stained with 4 g/ml anti-CD44 FITC-polystyrene nanoparticles (200 nm) (green) at37C (left) and counterstained with phalloidin-Texas red to reveal the cell shape (right).INTRODUCTIONFirst Ehrlich in 1906 postulated the magic bullet.The durability of magic bullet continues as challenge for clinical usage.The challenge have three fronts-Finding the proper target for particular disease state;Finding a drug that effectively treat particular disease;Finding a means of carrying drug in stable form to specific site while avoiding immunogenic & non specific interaction.Nanoparticles are potentially useful as carriers of active drugs and, when coupled with targeting ligands, may fulfill many attributes of a magic bullet.

ContNanoparticle encompases a variety of submicron(