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Acetylcholine Receptor Binding Toxins
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Acetylcholine Receptor Binding Toxins Naja naja: α-cobra toxin source Bungarus multicinctus : κ-bungarotoxin toxin source ACh Receptor Results: *Overlay: α-cobra toxin a (Y), κ- bungarotoxin (B), Cobratoxin (G), Erabutoxin (O) Hypothesis: Similar functioning proteins that bind the ACh receptors will have similar amino acid sequences. *Phylogenetic Tree: Conclusion: Four (4) toxins that affect ACh receptors were found to be closely related evolutionarily resulting in proteins that have structural areas of similarity in their amino acid sequences. *Associated Amino Acid Residue Sequences: α- bungarotoxin κ- bungarotoxin Cobratoxin Erabutoxin Link to BioQUEST Lesson
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Bungarus multicinctus : κ -bungarotoxin toxin source. Link to BioQUEST Lesson. Hypothesis: Similar functioning proteins that bind the ACh receptors will have similar amino acid sequences. Naja naja : α -cobra toxin source. Results: - PowerPoint PPT Presentation
Transcript of Acetylcholine Receptor Binding Toxins
Acetylcholine Receptor Binding Toxins
Naja naja: α-cobra toxin source
Bungarus multicinctus: κ-bungarotoxin toxin source
ACh Receptor
Results:*Overlay: α-cobra toxin a (Y), κ-bungarotoxin
(B), Cobratoxin (G), Erabutoxin (O)
Hypothesis: Similar functioning proteins that bind the
ACh receptors will have similar amino acid sequences.
*Phylogenetic Tree:Conclusion:
Four (4) toxins that affect ACh receptors were found to be closely related evolutionarily resulting in proteins that have structural areas of similarity in their amino acid sequences.*Associated Amino Acid Residue
Sequences:α-bungarotoxinκ-bungarotoxin
CobratoxinErabutoxin
Link to BioQUEST Lesson
