DNA PolymeraseγB Processivity Factor

Molecular Cell, Volume 7, Issue 1 ,1 January 2001, Pages 43-54

PDB ID:1G5H

Superpositioning with GRS

Dimerization domain

Four helix-bundle

DNA binding domain

Mutation of DNA bind domain

Modeling structure

PCNA

What kinds of DNA will bind to it?

BLASTP 2.2.10

Multiple sequences alignment

Phylogenetic tree

ConclusionPolγB & Glycyl-tRNA synthetase diverged from early gene duplicationSuggest that eukaryotic Glycyl-tRNA synthetase is from Archaea, PolγB is from Bacterial Glycyl-tRNA synthetase.

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