DNA Polymerase γ B Processivity Factor

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DNA PolymeraseγB Processi vity Factor Molecular Cell, Volume 7, Issue 1 , 1 January 2001, Pages 43- 54 PDB ID:1G5H

description

DNA Polymerase γ B Processivity Factor. Molecular Cell, Volume 7, Issue 1 , 1 January 2001, Pages 43-54 PDB ID:1G5H. Superpositioning with GRS. Dimerization domain. Four helix-bundle. DNA binding domain. Mutation of DNA bind domain. Modeling structure. PCNA. - PowerPoint PPT Presentation

Transcript of DNA Polymerase γ B Processivity Factor

Page 1: DNA Polymerase γ B Processivity Factor

DNA PolymeraseγB Processivity Factor

Molecular Cell, Volume 7, Issue 1 ,1 January 2001, Pages 43-54

PDB ID:1G5H

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Superpositioning with GRS

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Dimerization domain

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Four helix-bundle

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DNA binding domain

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Mutation of DNA bind domain

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Modeling structure

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PCNA

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What kinds of DNA will bind to it?

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BLASTP 2.2.10

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Multiple sequences alignment

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Phylogenetic tree

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ConclusionPolγB & Glycyl-tRNA synthetase diverged from early gene duplicationSuggest that eukaryotic Glycyl-tRNA synthetase is from Archaea, PolγB is from Bacterial Glycyl-tRNA synthetase.

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