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AlkaloidsU 0600 DOI: 10.1002/chin.201050194

Eudistomidin G, a New β-Carboline Alkaloid from the Okinawan Marine Tuni-cate Eudistoma glaucus and Structure Revision of Eudistomidin B. — Isolation and structure elucidation of eudistomidin G (Ia) is described. The structure of the iso-meric eudistomidin B is revised to (Ib) after total asymmetric synthesis (5 steps) of this substance. Both compounds show cytotoxicity against L1210 murine leukemia cells with IC50 = 4.8 and 4.7 μg/ml, resp. — (TAKAHASHI, Y.; ISHIYAMA, H.; KUBOTA, T.; KOBAYASHI*, J.; Bioorg. Med. Chem. Lett. 20 (2010) 14, 4100-4103, DOI:10.1016/j.bmcl.2010.05.071 ; Grad. Sch. Pharm. Sci., Hokkaido Univ., Sapporo 060, Japan; Eng.) — H. Haber

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ChemInform 2010, 41, issue 50 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim