WATER SOLUBLE VITAMINS
Dr Vijay Marakala MBBS.,MD
Assistant ProfessorBIOCHEMISTRY
SIMS & RC
FOLIC ACID
Folic acid consist of pteridine nucleus, p-aminobenzoic acid and glutamate .
•CHEMISTRYFOLIC ACID
FOLIC ACID SOURCES
Green leafy vegetables
PulsesEggsLiver
Daily Requirement (RDA)
200μg/day
FOLIC ACID RDA
ABSORPTION AND TRANSPORT
Polyglutamate form converted to monoglutamate form
After cellular uptake converted to THF
FOLIC ACID
ACTIVE FORM Tetrahydrofolate [THF]
FOLIC ACID
•FOLIC ACID -FUNCTIONS
One carbon metabolism
THF is required for cell division.
↓Plasma Homocysteine
One carbon compounds
CH3
CH2
CHCHO
CO2
One carbon groups can be transferred from one compound to another
One carbon metabolism
FOLIC ACID
DHF
THF
N5-Methyl-THF
N5,N10-Methylene THF N5Formyl-THF
Homocysteine
Methionine FIGLU
HISTIDINE
GLUTAMATE
Serine Glycine dUMP
TMP
DNA
Methyl VitB12
Purine
DNARNA
FOLIC ACID-Deficiency Megaloblastic anaemia
Neural tube defects in fetus
Hyperhomocysteinemia
Accumulation and excretion of FIGLU in urine
Normal marrow Megaloblastic marrow
FOLATE TRAP THEORY
•FOLIC ACID ANTAGONISTS
Sulfonamides
Methotrexate
Pyrimethamine
Top Related