WATER SOLUBLE VITAMINS

Dr Vijay Marakala MBBS.,MD

Assistant ProfessorBIOCHEMISTRY

SIMS & RC

FOLIC ACID

Folic acid consist of pteridine nucleus, p-aminobenzoic acid and glutamate .

•CHEMISTRYFOLIC ACID

FOLIC ACID SOURCES

Green leafy vegetables

PulsesEggsLiver

Daily Requirement (RDA)

200μg/day

FOLIC ACID RDA

ABSORPTION AND TRANSPORT

Polyglutamate form converted to monoglutamate form

After cellular uptake converted to THF

FOLIC ACID

ACTIVE FORM Tetrahydrofolate [THF]

FOLIC ACID

•FOLIC ACID -FUNCTIONS

One carbon metabolism

THF is required for cell division.

↓Plasma Homocysteine

One carbon compounds

CH3

CH2

CHCHO

CO2

One carbon groups can be transferred from one compound to another

One carbon metabolism

FOLIC ACID

DHF

THF

N5-Methyl-THF

N5,N10-Methylene THF N5Formyl-THF

Homocysteine

Methionine FIGLU

HISTIDINE

GLUTAMATE

Serine Glycine dUMP

TMP

DNA

Methyl VitB12

Purine

DNARNA

FOLIC ACID-Deficiency Megaloblastic anaemia

Neural tube defects in fetus

Hyperhomocysteinemia

Accumulation and excretion of FIGLU in urine

Normal marrow Megaloblastic marrow

FOLATE TRAP THEORY

•FOLIC ACID ANTAGONISTS

Sulfonamides

Methotrexate

Pyrimethamine

04/12/2023 10:05 AM

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