Steven P. Brown Solid-State NMR Research

Collaborations with AstraZeneca, Daiichi Sankyo, GlaxoSmithKline,Pfizer and Syngenta to characterise solid-state forms

CH2,CH3

δ DQ (1 H

) / p

pm

δSQ (1H) / ppm

H3

H2H15

H10

14 12 10 8 6 4 2 0δSQ (1H) / ppm

14 12 10 8 6 4 2 0

30

25

20

15

10

5

0

30

25

20

15

10

5

0

amount of cimetidinefree form in mixture

with salt

level of detectionis 1% w/w

0%

100%

10%5%1%

0.5%

N SNH

N

NH

CH3

NN

H

H

(NH+)

CH3

12

3 4

5

6

7

8

9 1011

1213

14

1516

24 20 16 12 8 4 0δSQ (1H) / ppm