MEDICINE Pre-MD MCQ Practice Series
MCQ
Topic: Clinical Pharmacology
umh - 21 September 2015
Teacher: Chatterjee
UMMECLCH-20150921-2
Name:
Student id:
Class:
Question
1
(1)
(alpha)
blockers induce all of the following physiological effects except-
A cardiac outputB reflex bradycardiaC bronchodilatationD reflex tachycardia
Question
2
(1)
Which of the following oils are used as a carminative: for explusion of gas from the stomach?
A oil of eucalyptusB oil of wintergreenC castor oilD peppermint oilE asafoetida oil
Question
3
(1)
Which of the following is not a selective PDE3
phosphodiesterase inhibitor?
A cilostazolB milrinoneC vinpocetineD pimobendane
Question
4
(1)
Vitamin synthesized by the human body from choline-
A BiotinB Vitamin B8C Vitamin B16D dimethylglycine (DMG)E Vitamin B4
Question
5
(1)
All of the following drugs can damage esophageal mucosa except-
sidhartaTypewriterPractice Series in Medicine: Basic & Clinical Sciences
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sidhartaTypewriterTotal Questions: 100
sidhartaTypewriterMarks: 200
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sidhartaTypewriterObjective type practice series designed for students appearing for Medicine PGI Entrance examinations. This practice series contains questions from basic medical and clinical sciences; subjects include: Anatomy, Physiology, Biochemistry, and Microbiology. There is a Negative marking of -2 for each incorrect response. Figures in the margin indicate marks for each question.
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sidhartaTypewriterAfter taking the test, you may check with the answers given at the end.
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sidhartaTypewriterTotal Questions: 100
sidhartaTypewriterMarks: 200
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A potassium chlorideB iron saltsC erythromycinD doxycycline
Question
6
(1)
An example of Cataplerotic enzyme-
A pyruvate carboxylaseB aspartate transaminaseC adenylosuccinate lyaseD glutamate dehydrogenase
Question
7
(1)
What is not true regarding the law of mass action which governs interaction of drugs with their receptors?
A relationship between receptor occupany and drug response is linearB depends on concentration of both receptors and ligandC relationship between receptor occupany and drug response is nonlinear
Question
8
(1)
Which of the following is not a characteristic of essential oils?
A used as carminatives and antisepticsB formed by oxidation or polymerization of resinsC essential oils do not have any caloric valueD may contain hydrocarbon terpene
Question
9
(1)
Glycoside that yields glucose on acid hydrolysis:
A SalicinB strophanthinC laevomandelonitrileD amygdalinE Urushiol
Question
10
(1)
Which of the following agents is nephrotoxic?
A capreomycinB carbamazapineC methyldopaD carmustine
Question
11
(1)
Which of the following is a selective 5-HT1B agonist?
A buspironeB psilocinC lorcaserin
D rizatriptanE DMT
Question
12
(1)
Placebo may include all of the following except-
A naloxoneB Vitamin B1C lactoseD distilled water injections
Question
13
(1)
Drug whose intramuscular absorption is slower when compared to its oral absorption-
A buspironeB amitriptylineC diazepamD nortriptyline
Question
14
(1)
Amount of fluid administered during evacuant enema
A 600 mlB 300 mlC 450 mlD 150 ml
Question
15
(1)
An example of negative acute phase protein:
A Creactive proteinB albuminC 1acid glycoproteinD 2macroglobulin
Question
16
(1)
Vaccine which is administered intradermally:
A Hepatitis A vaccineB Rabies vaccineC BCG vaccineD Influenza vaccine
Question
17
(1)
Strength of electrostatic interaction in drug-receptor bonding-
A 57 kcal/molB 510 kcal/molC 58 kcal/molD 0.51 kcal/mol
Question The innermost layer of the epidermis is-
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18
(1)
A stratum basaleB stratum corneumC stratum lucidumD stratum spinosumE stratum granulosum
Question
19
(1)
Which of the following drug can be used by retrobulbar injection?
A epinephrineB HyaluronidaseC lidocaineD hydrocortisone acetateE all of the above
Question
20
(1)
The type of chemical bonding that alters enzyme chemically following its binding with irreversible inhibitior-
A ionic bondingB hydrogen bondingC covalent bondingD van der Waals forces
Question
21
(1)
Which of the following is a short acting NSAID anti-inflammatory agent?
A ibuprofenB naproxenC meloxicabD celecoxib
Question
22
(1)
Not true about the composition of Lactated Ringer's solution-
A 4 mmol/L potassiumB 109 mmol/L sodiumC 28 mmol/L lactateD 1.5 mmol/L Calcium
Question
23
(1)
An example of an enzyme catalyzing anaplerotic reaction in the mitochondrial matrix of the liver-
A Glutamate dehydrogenaseB -ketoglutarate dehydrogenaseC Pyruvate dehydrogenaseD Pyruvate carboxylase
Question
24
(1)
Which of the following statements is not true about fixed oils?
A they posses aromas and contain hydrocarbon terpeneB they do not have any food (caloric) valueC include oleoresins that are mixtures of fixed oils and resinsD they are glycerides of oleic and palmitic acidsE include castor oil and coconut oil
Question
25
(1)
Drugs which are extensively bound (>90%) to plasma proteins-
A furosemideB fluconazoleC lisinoprilD metoprolol
Question
26
(1)
All of the following are positive acute phase proteins except:
A HaptoglobinB Alpha 1-antitrypsinC transferrinD Ceruloplasmin
Question
27
(1)
Following agents are not an alpha 1
selective blockers-
A terazosinB betaxololC prazosinD phentolamine
Question
28
(1)
The effects of placebo may be modified by all of the following factors except-
A personality of the physicianB form of administrationC potency of the preparationD personality of the patient
Question
29
(1)
Regarding bioavailability, what is not true?
A achlorhydria may affect drug bioavailabilityB AUC is the most reliable measure of a drug's bioavailabilityC highly ionized and polar drugs have high bioavailabilityD highly ionized and polar drugs have low bioavailability
Question
30
(1)
Not true regarding placebo-
A generally used in phase 2 and phase 3 clinical studiesB generally used in phase 1 and phase 2 clinical studies
C consists of inactive, inert preparationsD used as a control device in clinical drug trialsE may induce release of endorphins
Question
31
(1)
Which of the following is not a mitochondrial enzyme?
A SialyltransferasesB Monoamine oxidasesC Carnitine acetyltransferaseD Choline dehydrogenase
Question
32
(1)
Tendency of a drug binding to the receptors is governed by-
A its concentrationB its potencyC its efficacyD its affinityE its specificity
Question
33
(1)
Contraindications to digoxin therapy includes all of the following except-
A acute myocarditisB congestive heart failureC hypokalemiaD ventricular tachycardia
Question
34
(1)
The first pharmacology institute was created by
A Rudolf VirchowB Friedrich SertrnerC Sir Bernard KatzD Rudolf Buchheim
Question
35
(1)
Which of the following condition is a contraindication for beta blockeradministration?
A hypertensionB tachycardiaC cardiac arrhythmiasD bradycardia
Question
36
(1)
Calcium dependent clotting factors includes all of the following except-
A Factor IVB Factor VIIC Factor XII
D Factor IXE Factor X
Question
37
(1)
The first pass metabolism of which of the following agents is less in the liver?
A propanololB codeineC sD verapamil
Question
38
(1)
Severe bradycardia may occur when propanolol is concurrently taken with all of the following except
A digitalisB calcium channel blockersC indomethacinD adrenaline
Question
39
(1)
Which of the following agent is highly ototoxic capable of causing hearingimpairment/loss?
A vancomycinB ethambutolC gentamicinD dantroleneE neomycin
Question
40
(1)
Clinical pharmacology includes the study of all of the following except-
A determination of ideal dosage regimensB cost-benefit and risk-benefit ratio analysisC qualitative and quantitative evaluation of drug activitiesD therapeutic evaluation of a drug in human subjects
Question
41
(1)
Not correct regarding the composition of Ringer's Lactate-
A sodium 130 mmol/LB chloride 109 mmol/LC glucose 185 mmol/LD sodium 154 mmol/L
Question
42
(1)
Regarding transdermal therapeutic system (TTS), which of the following statements is not true?
A drug is subjected to first pass metabolismB percutaneous absorption into circulationC constant and predictable rate of drug deliveryD absorbed via the stratum corneum
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Question
43
(1)
All of the following drugs can cause abscess following intramuscular
injection except-
A diclofenacB procaine penicillinC quinineD moclobemide
Question
44
(1)
Vitamin produced in the human body from glucose-
A nicotinic acidB Vitamin B8C thiamineD riboflavinE niacin
Question
45
(1)
Which of the following statements regarding dose-response curve is nottrue?
A used to measure the affinity of agonist drugs for their receptorsB used to estimate the maximal response of a drug (Emax)C estimation of concentration needed to produce a 50% maximal response
(EC50)D used for comparing the potencies of different drugs
Question
46
(1)
Following is not a characteristic of agonists-
A have affinity and maximal intrinsic activityB have affinity but negative intrinsic activityC potency of agonist is inversely related to its EC50 valueD have affinity but no intrinsic activityE potency of agonist is inversely related to its ED50 value
Question
47
(1)
Why binding curves with agonists are difficult to interpret?
A due to apparent heterogeneity among receptorsB due to apparent homogeneity among receptorsC due to secondary event of G-protein couplingD due to lack of secondary event of G-protein coupling
Question
48
(1)
Leptin mediates the activation of all of the following except-
A protein kinase BB phosphodiesterase 3BC cAMPD phosphatidylinositol 3-kinase (PI3K)
Question Pharmacokinetics concerns with all of the following except-
49
(1)
A what the body does to the drugB what the drug does to the bodyC binding and distributionD biotransformation
Question
50
(1)
Nonabsorbable drug given orally which is extremely nephrotoxic-
A kaolinB aluminium hydroxideC neomycinD kanamycinE Chlorpromazine
Question
51
(1)
Which of the following do not belong to G-protein coupled receptor family?
A insulin receptorB integrinC adrenergic 1D histamine H2E angiotensin AT1
Question
52
(1)
Plasma protein binding of nortriptyline is-
A 96%B 9296%C 93%D 9395%
Question
53
(1)
Denervation in skeletal muscles results in-
A a decrease in the number of receptors in the target cellB an increase in the number of receptors in the target cellC a phenomenon called denervation insensitivityD all of the above
Question
54
(1)
Pick out the incorrect statements regarding the composition of normal saline-
A glucose 185 mmol/LB chloride 154 mmol/LC sodium 130 mmol/LD sodium 154 mmol/L
Question
55
(1)
Collagens employ ========= as an intermediate in extracellular signal transduction mechanism.
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A Gprotein coupled receptorB tyrosine kinaseC JAKSTAT pathwayD integrins
Question
56
(1)
Plasma protein binding of digoxin is-
A 70%B 20%C 35%D 25%
Question
57
(1)
The rates of absorption following intramuscular injection-
A thigh>arm>buttocksB thigh>buttocks>armC arm>thigh>buttocksD arm>buttocks>thigh
Question
58
(1)
Which of the following agents is not categorized as an Orphan drug?
A ketokonazole HRAB vigabatrinC pulmozymeD defifrobateE vidarabine
Question
59
(1)
Following are not responses mediated by leptin-
A minimizes use of endogenous reserves of energyB leptin minimizes energy expenditureC maximizes use of endogenous reserves of energyD leptin maximizes energy expenditureE triggers decrease production of thyroid hormones
Question
60
(1)
Regarding essential drug concept laid down by the WHO, not true is-
A should be of fixed ratio combinationB choice depends on relative efficacy, priceC safety from clinical studiesD depend upon pattern of prevalent diseases
Question
61
(1)
Drugs that increase gastric emptying includes all of the following except-
A acetylcholine
B cisaprideC MetoclopramideD erythromycinE mitemcinal
Question
62
(1)
What is not true about tannins?
A non-nitrogenous plant constituentsB nitrogenous plant constituentsC is an astringent, plant polyphenolic compoundD precipitate proteins from cells of the mucous membranes
Question
63
(1)
Which of the following is an Uncoupling protein (UCP)?
A leptinB thermogeninC adiponectinD ubiquitin
Question
64
(1)
All of the following agents are nonselective NSAIDs that inhibit both COX-1 and COX-2 except:
A ibuprofenB naproxenC indometacinD celecoxib
Question
65
(1)
Continuous infusion pumps consists of-
A high infusion rate used to administer antibioticB method of choice for patient-controlled analgesia (PCA)C small pulses for repeated small doses of opioid analgesicsD small pulses to administer medications
Question
66
(1)
Which of the following is not a lipid soluble drug?
A clonidineB fentanylC scopolamineD terazosin
Question
67
(1)
- blockers include all of the following except-
A PhenoxybenzamineB butaxamineC sotalol
D metoprololQuestion
68
(1)
Which of the following alkaloid is a pyridine derivative?
A anabasineB emetineC ibotenic acidD quinidine
Question
69
(1)
Regarding intravenous colloids, true is-
A increase intravascular volumeB increase intracellular volumeC cheaper than crystalloidsD increase interstitial volume
Question
70
(1)
Which of the following agents is toxic to osteoclasts?
A estrogenB methotrexateC parathyroid hormone (PTH)D bisphosphonates
Question
71
(1)
Regarding Ringers Lactate/Lactated Ringers solution, all of the following statements are true except-
A has a pH of 7.45B contain potassiumC conrain crystalloidsD contain colloidsE contain lactateF contain NaCl
Question
72
(1)
Antihypertensive that is primarily used in patients who develop bradycardia with propanolol-
A labetalolB atenololC pindololD metoprolol
Question
73
(1)
A prototype of cardioselective blocker-
A metoprololB propanololC labetalolD pindolol
Question
74
(1)
Which of the following is not an action mediated by leptin?
A activates AMP-dependent protein kinase (AMPK)B leptin inhibits insulin releaseC leptin acts on hypothalamic receptors to stimulate appetiteD leptin acts on hypothalamic receptors to curtail appetiteE leptin stimulates insulin release
Question
75
(1)
Which of the following drugs have the lowest therapeutic index?
A remifentanylB diazepamC morphineD dimercaprol
Question
76
(1)
-adrenergic agent with least oral bioavailability-
A pindololB labetololC sotalolD timolol
Question
77
(1)
Drug-receptor system that can display the phenomenon of "hormesis"-
A prostaglandinsB serotonergic agonistsC serotonergic antagonistsD all of the following
Question
78
(1)
Drugs having flow-dependent clearence thus high hepatic extraction ratios-
A alfentanylB profofolC methadoneD Both A & C
Question
79
(1)
Which of the following mechanism is not involved in drug absorption?
A facilitated osmosisB filtrationC active transportD passive diffusionE osmosis
Question
80
Arsenical compounds for treating syphilis was discovered by-
(1)
A Ulf von EulerB Jack StromingerC John Newport LangleyD Paul EhrlichE Gerhard Domagk
Question
81
(1)
All of the following drugs are capable of causing esophageal damage/ulcerexcept-
A doxycyclineB alendronateC Vitamin CD clopidogrel
Question
82
(1)
Bioequivalence:
A contain the same active compound in the same amountB result in more adverse effect but less efficacyC have the same therapeutic and adverse effectsD result in equivalent concentrations of drug in plasma and tissues
Question
83
(1)
Which of the following adrenergic blocking agents have the highest oralbioavailibility?
A terazosinB prazosinC bisoprololD nadolol
Question
84
(1)
Pick the incorrect statements regarding drug absoption:
A ionized form of drug is usually water solubleB unionized form of drug is usually lipid solubleC ionized form of drug penetrate cell membrane easilyD unionized form of drug penetrate cell membrane easilyE water soluble drugs have low electrical resistance
Question
85
(1)
Orphan drugs includes all of the following except-
A baclofenB acetylcysteineC desmopressinD acetyl salicylic acid
Question
86
(1)
Which of the following agents is hepatotoxic?
A
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cisplatinB vancomycinC demeclocyclineD naltrexone
Question
87
(1)
1-selective agonist agents include-
A propanololB labetololC nadololD atenololE timilol
Question
88
(1)
Pick among the following oils that have no food value:
A oil of wintergreenB castor oilC sweet almond oilD mustard oil
Question
89
(1)
An estimation of non-specific binding can be measured by-
A measuring the binding of the radioactive drug to the receptorsB measuring the radioactivity taken up in presence of a non-radioactive ligandC measuring the radioactivity taken up in absence of a non-radioactive ligandD measuring the radioactivity of the unbound drug to its receptors
Question
90
(1)
Which of the following are competitive antagonists?
A isoproterenolB propanololC pentazocineD morphine
Question
91
(1)
Which of the following statements is not true regarding drug-receptorinteractions?
A interaction with ligandactivated ion channelB interaction with intracellular nuclear receptorC receptoractivated tyrosine kinaseD interaction with cAMPcoupled receptorE interaction with Gprotein coupled receptor
Question
92
(1)
All of the following agents are Selective serotonin reuptake inhibitor (SSRIs)
except-
A linezolid
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B sertralineC fluvoxamineD selegilineE paroxetine
Question
93
(1)
Which of the following drugs is not included in WHO essential drug conceptclassification?
A ketoconazoleB neomycinC amidopyrineD carbamazepineE procarbazine
Question
94
(1)
Which of the following statements is not true about natural resins?
A natural resins contain tanninsB insoluble in alcohol but soluble in waterC soluble in alcohol but insoluble in waterD shellacE natural resins contain terpenes
Question
95
(1)
Which of the following agents is a nonselective 1 and
1 blocker?
A metoprololB atenololC metoprololD timolol
Question
96
(1)
Therapeutic index of diazepam is about
A 15 : 1B 100 : 1C 1000 : 1D 10 : 1
Question
97
(1)
What is true about therapeutic index in human?
A TD50/ED50B LD50/ED50C LD50/EC50D TD50/EC50
Question
98
(1)
Which of the following statements regarding action of digoxin is not true?
A positive chronotropic effect
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B positive inotropic effectC reduces AV conductionD negative chronotropic effect
Question
99
(1)
Antihypertensive agent with intrinsic sympathomimetic activities-
A bisoprololB pindololC atenololD propanolol
Question
100
(1)
Examples of alkaloids are-
A strophanthinB oleoresinsC atrophineD digoxin
sidhartaTypewriterEvery attempt has been made to validate each and every answer. Please consult standard textbooks given in the reference section for any discrepancy. Any remaining error is regreted.
Please Note: Usual disclaimer applies to this series and all other accompanying / previous test banks designed by the author. Students should note that the questions included in the practice sets are not selected from any previous exams / PGI tests, but meticulously designed by the author to enhance the skills of students and recap quick essential facts.
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Answers MEDICINE Pre-MD MCQ Practice Series
umh - 21 September 2015
Teacher: Chatterjee
UMMECLCH-20150921-2
Question Points Answer
1 1 reflex bradycardia; bronchodilatation2 1 oil of eucalyptus; asafoetida oil3 1 C - vinpocetine4 1 Vitamin B16; dimethylglycine (DMG)5 1 C - erythromycin6 1 D - glutamate dehydrogenase7 1 A - relationship between receptor occupany and drug response is linear8 1 B - formed by oxidation or polymerization of resins9 1 B - strophanthin10 1 A - capreomycin11 1 D - rizatriptan12 1 A - naloxone13 1 C - diazepam14 1 A - 600 ml15 1 B - albumin16 1 C - BCG vaccine17 1 B - 510 kcal/mol18 1 A - stratum basale19 1 E - all of the above20 1 C - covalent bonding21 1 B - naproxen22 1 B - 109 mmol/L sodium23 1 D - Pyruvate carboxylase24 1 they posses aromas and contain hydrocarbon terpene; they do not have
any food (caloric) value; include oleoresins that are mixtures of fixed oils and resins
25 1 A - furosemide26 1 C - transferrin27 1 betaxolol; phentolamine28 1 C - potency of the preparation29 1 C - highly ionized and polar drugs have high bioavailability30 1 B - generally used in phase 1 and phase 2 clinical studies31 1 A - Sialyltransferases32 1 D - its affinity33 1 B - congestive heart failure34 1 A - Rudolf Virchow35 1 D - bradycardia
36 1 C - Factor XII37 1 B - codeine38 1 C - indomethacin39 1 E - neomycin40 1 C - qualitative and quantitative evaluation of drug activities41 1 glucose 185 mmol/L; sodium 154 mmol/L42 1 A - drug is subjected to first pass metabolism43 1 D - moclobemide44 1 B - Vitamin B845 1 A - used to measure the affinity of agonist drugs for their receptors46 1 have affinity but negative intrinsic activity; have affinity but no intrinsic
activity; potency of agonist is inversely related to its ED50 value47 1 due to apparent heterogeneity among receptors; due to secondary event
of G-protein coupling48 1 C - cAMP49 1 B - what the drug does to the body50 1 C - neomycin51 1 insulin receptor; integrin52 1 D - 9395%53 1 B - an increase in the number of receptors in the target cell54 1 glucose 185 mmol/L; sodium 130 mmol/L55 1 D - integrins56 1 D - 25%57 1 C - arm>thigh>buttocks58 1 E - vidarabine59 1 minimizes use of endogenous reserves of energy; leptin maximizes
energy expenditure60 1 A - should be of fixed ratio combination61 1 C - Metoclopramide62 1 B - nitrogenous plant constituents63 1 B - thermogenin64 1 D - celecoxib65 1 D - small pulses to administer medications66 1 D - terazosin67 1 A - Phenoxybenzamine68 1 A - anabasine69 1 A - increase intravascular volume70 1 D - bisphosphonates71 1 has a pH of 7.45; contain colloids72 1 C - pindolol73 1 A - metoprolol
74 1 leptin acts on hypothalamic receptors to stimulate appetite; leptin stimulates insulin release
75 1 D - dimercaprol76 1 B - labetolol77 1 prostaglandins; serotonergic agonists78 1 B - profofol79 1 A - facilitated osmosis80 1 D - Paul Ehrlich81 1 D - clopidogrel82 1 D - result in equivalent concentrations of drug in plasma and tissues83 1 A - terazosin84 1 ionized form of drug penetrate cell membrane easily; water soluble
drugs have low electrical resistance85 1 D - acetyl salicylic acid86 1 D - naltrexone87 1 D - atenolol88 1 oil of wintergreen; castor oil89 1 B - measuring the radioactivity taken up in presence of a non-radioactive
ligand90 1 B - propanolol91 1 D - interaction with cAMPcoupled receptor92 1 A - linezolid93 1 C - amidopyrine94 1 natural resins contain tannins; insoluble in alcohol but soluble in water95 1 D - timolol96 1 B - 100 : 197 1 A - TD50/ED5098 1 A - positive chronotropic effect99 1 B - pindolol100 1 C - atrophine
sidhartaTypewriterReference Textbooks:1. Essentials of Medical Pharmacology, KD Tripathi, 7th Edition2. Basic and Clinical Pharmacology, Katzung 13E
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