MEDICINE Pre-MD MCQ Practice Series

MCQ

Topic: Clinical Pharmacology

umh - 21 September 2015

Teacher: Chatterjee

UMMECLCH-20150921-2

Name:

Student id:

Class:

Question

1

(1)

(alpha)

blockers induce all of the following physiological effects except-

A cardiac outputB reflex bradycardiaC bronchodilatationD reflex tachycardia

Question

2

(1)

Which of the following oils are used as a carminative: for explusion of gas from the stomach?

A oil of eucalyptusB oil of wintergreenC castor oilD peppermint oilE asafoetida oil

Question

3

(1)

Which of the following is not a selective PDE3

phosphodiesterase inhibitor?

A cilostazolB milrinoneC vinpocetineD pimobendane

Question

4

(1)

Vitamin synthesized by the human body from choline-

A BiotinB Vitamin B8C Vitamin B16D dimethylglycine (DMG)E Vitamin B4

Question

5

(1)

All of the following drugs can damage esophageal mucosa except-

sidhartaTypewriterPractice Series in Medicine: Basic & Clinical Sciences

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sidhartaTypewriterTotal Questions: 100

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sidhartaTypewriterObjective type practice series designed for students appearing for Medicine PGI Entrance examinations. This practice series contains questions from basic medical and clinical sciences; subjects include: Anatomy, Physiology, Biochemistry, and Microbiology. There is a Negative marking of -2 for each incorrect response. Figures in the margin indicate marks for each question.

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sidhartaTypewriterAfter taking the test, you may check with the answers given at the end.

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sidhartaTypewriterTotal Questions: 100

sidhartaTypewriterMarks: 200

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A potassium chlorideB iron saltsC erythromycinD doxycycline

Question

6

(1)

An example of Cataplerotic enzyme-

A pyruvate carboxylaseB aspartate transaminaseC adenylosuccinate lyaseD glutamate dehydrogenase

Question

7

(1)

What is not true regarding the law of mass action which governs interaction of drugs with their receptors?

A relationship between receptor occupany and drug response is linearB depends on concentration of both receptors and ligandC relationship between receptor occupany and drug response is nonlinear

Question

8

(1)

Which of the following is not a characteristic of essential oils?

A used as carminatives and antisepticsB formed by oxidation or polymerization of resinsC essential oils do not have any caloric valueD may contain hydrocarbon terpene

Question

9

(1)

Glycoside that yields glucose on acid hydrolysis:

A SalicinB strophanthinC laevomandelonitrileD amygdalinE Urushiol

Question

10

(1)

Which of the following agents is nephrotoxic?

A capreomycinB carbamazapineC methyldopaD carmustine

Question

11

(1)

Which of the following is a selective 5-HT1B agonist?

A buspironeB psilocinC lorcaserin

D rizatriptanE DMT

Question

12

(1)

Placebo may include all of the following except-

A naloxoneB Vitamin B1C lactoseD distilled water injections

Question

13

(1)

Drug whose intramuscular absorption is slower when compared to its oral absorption-

A buspironeB amitriptylineC diazepamD nortriptyline

Question

14

(1)

Amount of fluid administered during evacuant enema

A 600 mlB 300 mlC 450 mlD 150 ml

Question

15

(1)

An example of negative acute phase protein:

A Creactive proteinB albuminC 1acid glycoproteinD 2macroglobulin

Question

16

(1)

Vaccine which is administered intradermally:

A Hepatitis A vaccineB Rabies vaccineC BCG vaccineD Influenza vaccine

Question

17

(1)

Strength of electrostatic interaction in drug-receptor bonding-

A 57 kcal/molB 510 kcal/molC 58 kcal/molD 0.51 kcal/mol

Question The innermost layer of the epidermis is-

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18

(1)

A stratum basaleB stratum corneumC stratum lucidumD stratum spinosumE stratum granulosum

Question

19

(1)

Which of the following drug can be used by retrobulbar injection?

A epinephrineB HyaluronidaseC lidocaineD hydrocortisone acetateE all of the above

Question

20

(1)

The type of chemical bonding that alters enzyme chemically following its binding with irreversible inhibitior-

A ionic bondingB hydrogen bondingC covalent bondingD van der Waals forces

Question

21

(1)

Which of the following is a short acting NSAID anti-inflammatory agent?

A ibuprofenB naproxenC meloxicabD celecoxib

Question

22

(1)

Not true about the composition of Lactated Ringer's solution-

A 4 mmol/L potassiumB 109 mmol/L sodiumC 28 mmol/L lactateD 1.5 mmol/L Calcium

Question

23

(1)

An example of an enzyme catalyzing anaplerotic reaction in the mitochondrial matrix of the liver-

A Glutamate dehydrogenaseB -ketoglutarate dehydrogenaseC Pyruvate dehydrogenaseD Pyruvate carboxylase

Question

24

(1)

Which of the following statements is not true about fixed oils?

A they posses aromas and contain hydrocarbon terpeneB they do not have any food (caloric) valueC include oleoresins that are mixtures of fixed oils and resinsD they are glycerides of oleic and palmitic acidsE include castor oil and coconut oil

Question

25

(1)

Drugs which are extensively bound (>90%) to plasma proteins-

A furosemideB fluconazoleC lisinoprilD metoprolol

Question

26

(1)

All of the following are positive acute phase proteins except:

A HaptoglobinB Alpha 1-antitrypsinC transferrinD Ceruloplasmin

Question

27

(1)

Following agents are not an alpha 1

selective blockers-

A terazosinB betaxololC prazosinD phentolamine

Question

28

(1)

The effects of placebo may be modified by all of the following factors except-

A personality of the physicianB form of administrationC potency of the preparationD personality of the patient

Question

29

(1)

Regarding bioavailability, what is not true?

A achlorhydria may affect drug bioavailabilityB AUC is the most reliable measure of a drug's bioavailabilityC highly ionized and polar drugs have high bioavailabilityD highly ionized and polar drugs have low bioavailability

Question

30

(1)

Not true regarding placebo-

A generally used in phase 2 and phase 3 clinical studiesB generally used in phase 1 and phase 2 clinical studies

C consists of inactive, inert preparationsD used as a control device in clinical drug trialsE may induce release of endorphins

Question

31

(1)

Which of the following is not a mitochondrial enzyme?

A SialyltransferasesB Monoamine oxidasesC Carnitine acetyltransferaseD Choline dehydrogenase

Question

32

(1)

Tendency of a drug binding to the receptors is governed by-

A its concentrationB its potencyC its efficacyD its affinityE its specificity

Question

33

(1)

Contraindications to digoxin therapy includes all of the following except-

A acute myocarditisB congestive heart failureC hypokalemiaD ventricular tachycardia

Question

34

(1)

The first pharmacology institute was created by

A Rudolf VirchowB Friedrich SertrnerC Sir Bernard KatzD Rudolf Buchheim

Question

35

(1)

Which of the following condition is a contraindication for beta blockeradministration?

A hypertensionB tachycardiaC cardiac arrhythmiasD bradycardia

Question

36

(1)

Calcium dependent clotting factors includes all of the following except-

A Factor IVB Factor VIIC Factor XII

D Factor IXE Factor X

Question

37

(1)

The first pass metabolism of which of the following agents is less in the liver?

A propanololB codeineC sD verapamil

Question

38

(1)

Severe bradycardia may occur when propanolol is concurrently taken with all of the following except

A digitalisB calcium channel blockersC indomethacinD adrenaline

Question

39

(1)

Which of the following agent is highly ototoxic capable of causing hearingimpairment/loss?

A vancomycinB ethambutolC gentamicinD dantroleneE neomycin

Question

40

(1)

Clinical pharmacology includes the study of all of the following except-

A determination of ideal dosage regimensB cost-benefit and risk-benefit ratio analysisC qualitative and quantitative evaluation of drug activitiesD therapeutic evaluation of a drug in human subjects

Question

41

(1)

Not correct regarding the composition of Ringer's Lactate-

A sodium 130 mmol/LB chloride 109 mmol/LC glucose 185 mmol/LD sodium 154 mmol/L

Question

42

(1)

Regarding transdermal therapeutic system (TTS), which of the following statements is not true?

A drug is subjected to first pass metabolismB percutaneous absorption into circulationC constant and predictable rate of drug deliveryD absorbed via the stratum corneum

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Question

43

(1)

All of the following drugs can cause abscess following intramuscular

injection except-

A diclofenacB procaine penicillinC quinineD moclobemide

Question

44

(1)

Vitamin produced in the human body from glucose-

A nicotinic acidB Vitamin B8C thiamineD riboflavinE niacin

Question

45

(1)

Which of the following statements regarding dose-response curve is nottrue?

A used to measure the affinity of agonist drugs for their receptorsB used to estimate the maximal response of a drug (Emax)C estimation of concentration needed to produce a 50% maximal response

(EC50)D used for comparing the potencies of different drugs

Question

46

(1)

Following is not a characteristic of agonists-

A have affinity and maximal intrinsic activityB have affinity but negative intrinsic activityC potency of agonist is inversely related to its EC50 valueD have affinity but no intrinsic activityE potency of agonist is inversely related to its ED50 value

Question

47

(1)

Why binding curves with agonists are difficult to interpret?

A due to apparent heterogeneity among receptorsB due to apparent homogeneity among receptorsC due to secondary event of G-protein couplingD due to lack of secondary event of G-protein coupling

Question

48

(1)

Leptin mediates the activation of all of the following except-

A protein kinase BB phosphodiesterase 3BC cAMPD phosphatidylinositol 3-kinase (PI3K)

Question Pharmacokinetics concerns with all of the following except-

49

(1)

A what the body does to the drugB what the drug does to the bodyC binding and distributionD biotransformation

Question

50

(1)

Nonabsorbable drug given orally which is extremely nephrotoxic-

A kaolinB aluminium hydroxideC neomycinD kanamycinE Chlorpromazine

Question

51

(1)

Which of the following do not belong to G-protein coupled receptor family?

A insulin receptorB integrinC adrenergic 1D histamine H2E angiotensin AT1

Question

52

(1)

Plasma protein binding of nortriptyline is-

A 96%B 9296%C 93%D 9395%

Question

53

(1)

Denervation in skeletal muscles results in-

A a decrease in the number of receptors in the target cellB an increase in the number of receptors in the target cellC a phenomenon called denervation insensitivityD all of the above

Question

54

(1)

Pick out the incorrect statements regarding the composition of normal saline-

A glucose 185 mmol/LB chloride 154 mmol/LC sodium 130 mmol/LD sodium 154 mmol/L

Question

55

(1)

Collagens employ ========= as an intermediate in extracellular signal transduction mechanism.

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A Gprotein coupled receptorB tyrosine kinaseC JAKSTAT pathwayD integrins

Question

56

(1)

Plasma protein binding of digoxin is-

A 70%B 20%C 35%D 25%

Question

57

(1)

The rates of absorption following intramuscular injection-

A thigh>arm>buttocksB thigh>buttocks>armC arm>thigh>buttocksD arm>buttocks>thigh

Question

58

(1)

Which of the following agents is not categorized as an Orphan drug?

A ketokonazole HRAB vigabatrinC pulmozymeD defifrobateE vidarabine

Question

59

(1)

Following are not responses mediated by leptin-

A minimizes use of endogenous reserves of energyB leptin minimizes energy expenditureC maximizes use of endogenous reserves of energyD leptin maximizes energy expenditureE triggers decrease production of thyroid hormones

Question

60

(1)

Regarding essential drug concept laid down by the WHO, not true is-

A should be of fixed ratio combinationB choice depends on relative efficacy, priceC safety from clinical studiesD depend upon pattern of prevalent diseases

Question

61

(1)

Drugs that increase gastric emptying includes all of the following except-

A acetylcholine

B cisaprideC MetoclopramideD erythromycinE mitemcinal

Question

62

(1)

What is not true about tannins?

A non-nitrogenous plant constituentsB nitrogenous plant constituentsC is an astringent, plant polyphenolic compoundD precipitate proteins from cells of the mucous membranes

Question

63

(1)

Which of the following is an Uncoupling protein (UCP)?

A leptinB thermogeninC adiponectinD ubiquitin

Question

64

(1)

All of the following agents are nonselective NSAIDs that inhibit both COX-1 and COX-2 except:

A ibuprofenB naproxenC indometacinD celecoxib

Question

65

(1)

Continuous infusion pumps consists of-

A high infusion rate used to administer antibioticB method of choice for patient-controlled analgesia (PCA)C small pulses for repeated small doses of opioid analgesicsD small pulses to administer medications

Question

66

(1)

Which of the following is not a lipid soluble drug?

A clonidineB fentanylC scopolamineD terazosin

Question

67

(1)

- blockers include all of the following except-

A PhenoxybenzamineB butaxamineC sotalol

D metoprololQuestion

68

(1)

Which of the following alkaloid is a pyridine derivative?

A anabasineB emetineC ibotenic acidD quinidine

Question

69

(1)

Regarding intravenous colloids, true is-

A increase intravascular volumeB increase intracellular volumeC cheaper than crystalloidsD increase interstitial volume

Question

70

(1)

Which of the following agents is toxic to osteoclasts?

A estrogenB methotrexateC parathyroid hormone (PTH)D bisphosphonates

Question

71

(1)

Regarding Ringers Lactate/Lactated Ringers solution, all of the following statements are true except-

A has a pH of 7.45B contain potassiumC conrain crystalloidsD contain colloidsE contain lactateF contain NaCl

Question

72

(1)

Antihypertensive that is primarily used in patients who develop bradycardia with propanolol-

A labetalolB atenololC pindololD metoprolol

Question

73

(1)

A prototype of cardioselective blocker-

A metoprololB propanololC labetalolD pindolol

Question

74

(1)

Which of the following is not an action mediated by leptin?

A activates AMP-dependent protein kinase (AMPK)B leptin inhibits insulin releaseC leptin acts on hypothalamic receptors to stimulate appetiteD leptin acts on hypothalamic receptors to curtail appetiteE leptin stimulates insulin release

Question

75

(1)

Which of the following drugs have the lowest therapeutic index?

A remifentanylB diazepamC morphineD dimercaprol

Question

76

(1)

-adrenergic agent with least oral bioavailability-

A pindololB labetololC sotalolD timolol

Question

77

(1)

Drug-receptor system that can display the phenomenon of "hormesis"-

A prostaglandinsB serotonergic agonistsC serotonergic antagonistsD all of the following

Question

78

(1)

Drugs having flow-dependent clearence thus high hepatic extraction ratios-

A alfentanylB profofolC methadoneD Both A & C

Question

79

(1)

Which of the following mechanism is not involved in drug absorption?

A facilitated osmosisB filtrationC active transportD passive diffusionE osmosis

Question

80

Arsenical compounds for treating syphilis was discovered by-

(1)

A Ulf von EulerB Jack StromingerC John Newport LangleyD Paul EhrlichE Gerhard Domagk

Question

81

(1)

All of the following drugs are capable of causing esophageal damage/ulcerexcept-

A doxycyclineB alendronateC Vitamin CD clopidogrel

Question

82

(1)

Bioequivalence:

A contain the same active compound in the same amountB result in more adverse effect but less efficacyC have the same therapeutic and adverse effectsD result in equivalent concentrations of drug in plasma and tissues

Question

83

(1)

Which of the following adrenergic blocking agents have the highest oralbioavailibility?

A terazosinB prazosinC bisoprololD nadolol

Question

84

(1)

Pick the incorrect statements regarding drug absoption:

A ionized form of drug is usually water solubleB unionized form of drug is usually lipid solubleC ionized form of drug penetrate cell membrane easilyD unionized form of drug penetrate cell membrane easilyE water soluble drugs have low electrical resistance

Question

85

(1)

Orphan drugs includes all of the following except-

A baclofenB acetylcysteineC desmopressinD acetyl salicylic acid

Question

86

(1)

Which of the following agents is hepatotoxic?

A

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cisplatinB vancomycinC demeclocyclineD naltrexone

Question

87

(1)

1-selective agonist agents include-

A propanololB labetololC nadololD atenololE timilol

Question

88

(1)

Pick among the following oils that have no food value:

A oil of wintergreenB castor oilC sweet almond oilD mustard oil

Question

89

(1)

An estimation of non-specific binding can be measured by-

A measuring the binding of the radioactive drug to the receptorsB measuring the radioactivity taken up in presence of a non-radioactive ligandC measuring the radioactivity taken up in absence of a non-radioactive ligandD measuring the radioactivity of the unbound drug to its receptors

Question

90

(1)

Which of the following are competitive antagonists?

A isoproterenolB propanololC pentazocineD morphine

Question

91

(1)

Which of the following statements is not true regarding drug-receptorinteractions?

A interaction with ligandactivated ion channelB interaction with intracellular nuclear receptorC receptoractivated tyrosine kinaseD interaction with cAMPcoupled receptorE interaction with Gprotein coupled receptor

Question

92

(1)

All of the following agents are Selective serotonin reuptake inhibitor (SSRIs)

except-

A linezolid

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B sertralineC fluvoxamineD selegilineE paroxetine

Question

93

(1)

Which of the following drugs is not included in WHO essential drug conceptclassification?

A ketoconazoleB neomycinC amidopyrineD carbamazepineE procarbazine

Question

94

(1)

Which of the following statements is not true about natural resins?

A natural resins contain tanninsB insoluble in alcohol but soluble in waterC soluble in alcohol but insoluble in waterD shellacE natural resins contain terpenes

Question

95

(1)

Which of the following agents is a nonselective 1 and

1 blocker?

A metoprololB atenololC metoprololD timolol

Question

96

(1)

Therapeutic index of diazepam is about

A 15 : 1B 100 : 1C 1000 : 1D 10 : 1

Question

97

(1)

What is true about therapeutic index in human?

A TD50/ED50B LD50/ED50C LD50/EC50D TD50/EC50

Question

98

(1)

Which of the following statements regarding action of digoxin is not true?

A positive chronotropic effect

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B positive inotropic effectC reduces AV conductionD negative chronotropic effect

Question

99

(1)

Antihypertensive agent with intrinsic sympathomimetic activities-

A bisoprololB pindololC atenololD propanolol

Question

100

(1)

Examples of alkaloids are-

A strophanthinB oleoresinsC atrophineD digoxin

sidhartaTypewriterEvery attempt has been made to validate each and every answer. Please consult standard textbooks given in the reference section for any discrepancy. Any remaining error is regreted.

Please Note: Usual disclaimer applies to this series and all other accompanying / previous test banks designed by the author. Students should note that the questions included in the practice sets are not selected from any previous exams / PGI tests, but meticulously designed by the author to enhance the skills of students and recap quick essential facts.

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Answers MEDICINE Pre-MD MCQ Practice Series

umh - 21 September 2015

Teacher: Chatterjee

UMMECLCH-20150921-2

Question Points Answer

1 1 reflex bradycardia; bronchodilatation2 1 oil of eucalyptus; asafoetida oil3 1 C - vinpocetine4 1 Vitamin B16; dimethylglycine (DMG)5 1 C - erythromycin6 1 D - glutamate dehydrogenase7 1 A - relationship between receptor occupany and drug response is linear8 1 B - formed by oxidation or polymerization of resins9 1 B - strophanthin10 1 A - capreomycin11 1 D - rizatriptan12 1 A - naloxone13 1 C - diazepam14 1 A - 600 ml15 1 B - albumin16 1 C - BCG vaccine17 1 B - 510 kcal/mol18 1 A - stratum basale19 1 E - all of the above20 1 C - covalent bonding21 1 B - naproxen22 1 B - 109 mmol/L sodium23 1 D - Pyruvate carboxylase24 1 they posses aromas and contain hydrocarbon terpene; they do not have

any food (caloric) value; include oleoresins that are mixtures of fixed oils and resins

25 1 A - furosemide26 1 C - transferrin27 1 betaxolol; phentolamine28 1 C - potency of the preparation29 1 C - highly ionized and polar drugs have high bioavailability30 1 B - generally used in phase 1 and phase 2 clinical studies31 1 A - Sialyltransferases32 1 D - its affinity33 1 B - congestive heart failure34 1 A - Rudolf Virchow35 1 D - bradycardia

36 1 C - Factor XII37 1 B - codeine38 1 C - indomethacin39 1 E - neomycin40 1 C - qualitative and quantitative evaluation of drug activities41 1 glucose 185 mmol/L; sodium 154 mmol/L42 1 A - drug is subjected to first pass metabolism43 1 D - moclobemide44 1 B - Vitamin B845 1 A - used to measure the affinity of agonist drugs for their receptors46 1 have affinity but negative intrinsic activity; have affinity but no intrinsic

activity; potency of agonist is inversely related to its ED50 value47 1 due to apparent heterogeneity among receptors; due to secondary event

of G-protein coupling48 1 C - cAMP49 1 B - what the drug does to the body50 1 C - neomycin51 1 insulin receptor; integrin52 1 D - 9395%53 1 B - an increase in the number of receptors in the target cell54 1 glucose 185 mmol/L; sodium 130 mmol/L55 1 D - integrins56 1 D - 25%57 1 C - arm>thigh>buttocks58 1 E - vidarabine59 1 minimizes use of endogenous reserves of energy; leptin maximizes

energy expenditure60 1 A - should be of fixed ratio combination61 1 C - Metoclopramide62 1 B - nitrogenous plant constituents63 1 B - thermogenin64 1 D - celecoxib65 1 D - small pulses to administer medications66 1 D - terazosin67 1 A - Phenoxybenzamine68 1 A - anabasine69 1 A - increase intravascular volume70 1 D - bisphosphonates71 1 has a pH of 7.45; contain colloids72 1 C - pindolol73 1 A - metoprolol

74 1 leptin acts on hypothalamic receptors to stimulate appetite; leptin stimulates insulin release

75 1 D - dimercaprol76 1 B - labetolol77 1 prostaglandins; serotonergic agonists78 1 B - profofol79 1 A - facilitated osmosis80 1 D - Paul Ehrlich81 1 D - clopidogrel82 1 D - result in equivalent concentrations of drug in plasma and tissues83 1 A - terazosin84 1 ionized form of drug penetrate cell membrane easily; water soluble

drugs have low electrical resistance85 1 D - acetyl salicylic acid86 1 D - naltrexone87 1 D - atenolol88 1 oil of wintergreen; castor oil89 1 B - measuring the radioactivity taken up in presence of a non-radioactive

ligand90 1 B - propanolol91 1 D - interaction with cAMPcoupled receptor92 1 A - linezolid93 1 C - amidopyrine94 1 natural resins contain tannins; insoluble in alcohol but soluble in water95 1 D - timolol96 1 B - 100 : 197 1 A - TD50/ED5098 1 A - positive chronotropic effect99 1 B - pindolol100 1 C - atrophine

sidhartaTypewriterReference Textbooks:1. Essentials of Medical Pharmacology, KD Tripathi, 7th Edition2. Basic and Clinical Pharmacology, Katzung 13E

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