Just accepted for publication

Renga Barbara, Bucci Maria-Rosaria, Cipriani Sabrina, D’Amore Claudio, Monti Maria Chiara, Angela Zampella, Gargiulo

Antonella , d’Emmanuele di Villa Bianca Roberta, Eleonora Distrutti, and Stefano Fiorucci

Cystationine γ-liase, a H2S generating enzyme, is a GPBAR1 regulated gene

and contribute to vasodilation caused by secondary bile acids",

American Journal of Physiology - Heart and Circulatory Physiology

Ca

GP-BAR1

LCA

cAMP CREB

CRE1 CRE2

CSE

Transcription

H2S

Endothelial cells

PAG

CDCA

BKCa

Smooth muscle cells

Iberitoxin eNOS

NO

CDCA

FXR

IR1

LCA CDCA

LCA

Muscarinic receptors

K+

L-NIO