Concentrations of Zt/g4-DM1 (μg/ml)

Ce

ll v

iab

ilit

y (

% o

f c

on

tro

l)

Feng et al. Supplementary Fig 2:

IC50 for DLD1 (μg/ml) CmIgG-DM1: not calculated Zt/g4-DM1: 20.36 Zt/c1-DM1: 21.14

IC50 for LoVo (μg/ml) CmIgG-DM1: not reached Zt/g4-DM1: not reached Zt/c1-DM1: not reached

Caption: Effect of anti-RON ADCs in vitro on reduction of viability of CRC cells expressing no or low levels of RON.