( , , )

13 ) : . (,

, , ) : ,

,

-

. ,

. , 4.5-5 . . :

. 6-9 :TDF Testicular Determining

Factor & SRY: Sex determining Region of the Y chromosome. A & & .

- : 1. (

: & ).

2. ( )

& .

. :) :

, ) ) . 6m :

, , .

: 1. Sertoli

/

2. .

:

1. Leydig - ()

, , ,250 . : - . -: 1-4 & ( Leydig).

- 50-70cm/.0,12-0,30mm. - 20-30

6 .

& Sertoli.

.

MIS/AMH (Mullerian Inhibiting Substance- Muller Wolff: , , .

Sertoli . & : , , . .

. . & : - & FSH - , & FSH (Androgen Binding Protein) & .

H ( LEYDIG)

(, , , , ) Leydig .

, , , , , , Golgi. .

.

4

. 10-12 .

() ( ) , ( ) ( -)

3 -75 . 1.

. & . .

2.

(). ( 46=44++).

1 -: ()

2 : ( 23=22+/)

3. .

Sertoli & . & FSH.

.

:

.

.

.

:

. . 26 , 40 ,

74 .

: 2-3C , .(2-5 +/)

& & .

250R(Roentgen) . 500-600R

Vasectomy- -reversal.

- -

- . WHO

. 1.5ml 95%

. p 7.2 15-250x106/ml. :

100x106/ml. (5% . ) 40% 50% 4%

pH

: , 15 x 106 /ml 39 x 106 . : ( 1 ), 40% , 32%

: ( Kruger) 4 %. : , .

& & .

-

: ,

& ::

. : 40-50 &

. ( ), ( ), & .

.

(Catsper proteins).

. Leydig

LH. : DHEA,

&

DHT, , .

17- ( & ) & . .

98%

. 1. TeBG - (Testosterone Binding Globulin)

65%. 2. 33% 3. . . 25-30

.

Leydig

(, { }, -DHEA{ } & -DHT) ( & )

Sertoli , ABP.

& & .

.

, , .

: ( Kallman

Syndrome/ ) (/ .)

1. . 2. . 3. . 4. . 5. . 6. . 7. .

. : 1. Wolff

& . 2. Muller. 3.

4. &

. : 1. ,

, , , & .

.

.

( , , )

&

& .

& .

1. . 2. . 3. .

. , , & .

& .

& .

.

&

& .

.

.

.

, (Libido).

DHT 5- /

. , .

DHT.

= DHT. .

5- ( ) DHT .

= Wolff & LH.

DHT

DHTA & & .

5- - . (46, +, ,, + + .

- LH, T .

ANA- -

Sertoli & - .

& FSH & GnRH .

.

& -- .

Luteinising Hormone (LH) & Follicle Stimulating Hormone (FSH)

LH & FSH.

LH & FSH & .

LH & FSH. LH Leydig

. FSH Sertoli ABP,

, . Leydig

Sertoli.

LH. FSH.

/ Sertoli/Leydig (,,) , / , , , , .

Slide Number 3 - - Slide Number 8 & . , , ,250 . : - .-: 1-4 & ( Leydig). Slide Number 12 MIS/AMH (Mullerian Inhibiting Substance- Muller Wolff: , , . . . & :- & FSH- , & FSH (Androgen Binding Protein) & .H ( LEYDIG)Slide Number 21 . : .: Slide Number 26Slide Number 27Slide Number 28Slide Number 29 Slide Number 36 . & DHT DHTANA- - Slide Number 56