S.A HAMMA. INTRODUCTION 1 CH 3 COCH 2 COOH Acétoacétate CH 3 CHOHCH 2 COOH β -Hyroxybutyrate CH 3...

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METABOLISME DES CORPS CÉTONIQUES S.A HAMMA

Transcript of S.A HAMMA. INTRODUCTION 1 CH 3 COCH 2 COOH Acétoacétate CH 3 CHOHCH 2 COOH β -Hyroxybutyrate CH 3...

Page 1: S.A HAMMA. INTRODUCTION 1 CH 3 COCH 2 COOH Acétoacétate CH 3 CHOHCH 2 COOH β -Hyroxybutyrate CH 3 COCH 3 Acétone.

METABOLISME DES CORPS CÉTONIQUES

S.A HAMMA

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INTRODUCTION 1

CH3—CO—CH2—COOH Acétoacétate

CH3—CHOH—CH2—COOH β-Hyroxybutyrate

CH3—CO—CH3 Acétone

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INTRODUCTION 2

Besoins énergétiques

Glucose Acides gras

Corps cétoniques

ORIGINE LIPIDIQUE

FACILITÉ D’EMPLOI ÉNERGÉTIQUE DU GLUCOSE 

Petites molécules hydrosolubles Diffusion facile

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MÈTABOLISME DES CORPS CÈTONIQUES

CÈTOGENÈSE CÈTOLYSE

Acétyl-CoA

Acides grasAcides aminés cétoformateurs

Mitochondrie

Corps cétoniques Corps cétoniques

Acétyl-CoA

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CÈTOGENÈSE 1

ß-cétoacétylthiolase

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CÈTOGENÈSE 2

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CÈTOGENÈSE 3

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CÈTOGENÈSE 4

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CÈTOLYSE 1

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CÈTOLYSE 2

CoA

ATP

AMP+ 2Pi

Thiokinase acétoacétiqueAcétoacétyl-CoA synthase

ß-Cétoacyl-CoA transférase

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CÈTOLYSE 3

ß-Cétothiolase

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RÉGULATION DE LA CÉTOGENÈSE

OAAAcétyl-CoA

--

Insuline-


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ALCANI Legami presenti in un alcano: e )-H C( 3)-C( 3...3 ΔH = +33.CH 3 + I2 CH3I + I. ... Br Cl CH 3 H C CH 3 H C Br H CH 3 Cl (2S,3S) 2 3 Il C chirale preesistente resta invariato,

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