Presentación de PowerPoint y personal...β-sitosterol colesterol Behrman, E. J.; Gopalan, V....
Transcript of Presentación de PowerPoint y personal...β-sitosterol colesterol Behrman, E. J.; Gopalan, V....
1.4 Esteroles
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1.5 Colesterol
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β-sitosterol colesterol
Behrman, E. J.; Gopalan, V. Journal of Chemical Education, 2005, 82, 1791-1793.
estigmasterol campesterol
C29-esterol
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Medicinal Natural Products. Paul M Dewick, 2002 John Wiley & Sons, Ltd. England. 4
5 Medicinal Natural Products. Paul M Dewick, 2002 John Wiley & Sons, Ltd. England.
6 Medicinal Natural Products. Paul M Dewick, 2002 John Wiley & Sons, Ltd. England.
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Formula Weight : 412.69Formula : C29H48O
estigmasterol
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HPLC
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Cañabate-Díaz, B.; Carretero, S. A.; Fernández-Gutiérrez, A.; Belmonte, V. A.; Garrido, F. A.; Martínez, V. J. L.;
Duran, M. J. Separation and determination of sterols in olive oil by HPLC-MS. Food Chemistry, 2007, 10, 593-598.
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Formula Weight : 386.65 g/molFormula : C27H46O Formula Weight : 412.69 g/mol
Formula : C29H48O
Formula Weight : 414.71g/molFormula : C29H50O
Formula Weight : 416.72 g/molFormula : C29H52O
Formula Weight : 412.69 g/molFormula : C29H48O
Formula Weight : 442.72 g/molFormula : C30H50O2
Formula Weight : 442.72 g/molFormula : C30H50O2
colesterolestigmasterol
-sitosterol
sitostanolfucosterol eritrodiol uvaol
lanosterol
C30-esterol
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5-avenasterol 16
ergosterol
C28-esterol
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D2 ergocalciferol D3 cholecalciferol
ergosterol
1.6 Grupo de la vitamina D
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19 Medicinal Natural Products. Paul M Dewick, 2002 John Wiley & Sons, Ltd. England.
D3 cholecalciferol
?
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Law, M. Plant sterol and stanol margarines and health. Brit. Med. J., 2000, 320, 861–864.
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1.7 Esteroides anabólicos
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Structural modifications to the A- and B-rings of testosterone which increase
anabolic activity; substitution at C-17 confers oral or depot activity (i.m. =
intramuscular)
Steroid Analysis. Edited by H.L.J. MAKIN, D.B. GOWER. Springer Dordrecht Heidelberg London New York.
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3: Diosgenin
4: Progesterone
5: Cortisone
6: 11α-hydroxyprogesterone
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1.8 Cardenolides
A B
C D1
2
3
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67
89
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1218
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Steroid Analysis. Makin H.L.J.; Gower, D.B. 2th Edition. Springer. 2010. UK.
R = H; digitoxin isolated from foxglove (Digitalis purpurea)
R = OH; digoxin from D. lanata; widely used treatment for heart failure
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Convallatoxin, from lily of the valley (Convallaria majalis)
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Medicinal Natural Products. Paul M. Dewick, 2002 John Wiley & Sons, Ltd. 32
Medicinal Natural Products. Paul M. Dewick, 2002 John Wiley & Sons, Ltd. 33
1.9 Sapogeninas
Diosgenina
iso 25R
They are found in many monocotyledon
families, especially the Dioscoreaceae (e.g.
Dioscorea), the Agavaceae (e.g. Agave,
Yucca) and the Liliaceae (e.g. Smilax,
Trillium).
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Medicinal Natural Products. Paul M. Dewick, 2002 John Wiley & Sons, Ltd.
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Agave sisalana
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1.10 Alcaloides esteroidales
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