JOURNAL OF HETREROCYCLIC CHEMISTRY Vol. 46 - 2009

SPIS TREŚCI

No. 1

REVIEWS 1 Benzoylpyruvates in heterocyclic chemistry / Jens M. J. Nolsöe and Dirk

Weigelt 10 Synthetic strategies of nonpeptidic β-secretase (BACE1) inhibitors /

Giuseppe La Regina, Francesco Piscitelli, and Romano Silvestri ARTICLES 18 2H-Pyran-2-one-3-carbothioamide derivatives: Synthesis and reaction with

hydrazine hydrate / Malika Makhloufi-Chebli, Maamar Hamdi, Artur M. S. Silva, Olivier Duval, and Jean-Jacques Helesbeux

23 A new route to allyl thiols and allyl thiocarbamates from Baylis-Hillman adducts / Young-Gi Kim, Hee Nam Lim, and Kee-Jung Lee

28 Reactivity of 3-cyano-N-ethoxycarbonyl-iminocoumarin with hydrazides as N-nucleophiles / Myriam Kammoun, Hamida Turki, Rachid El Gharbi, and Suzanne Fery-Forgues

33 Syntheses of new quinoline-containing heterocyclic scaffolds using inter- and intramolecular Pd-catalyzed amination / Borbála Bogányi and Judit Kámán

39 Synthesis of substituted 4-(5-alkyl-thiazol-2-ylmethyl)-3,4-dihydro-2H-1,4-benzoxazines and 5-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-4-methyl-1-phenyl-1H-pyrazol-3-ylamine / Pushpak Mizar and Bekington Myrboh

44 New imidazole derivatives of 2(3H)-benzazolones as potential antifungal agents / Ognyan Petrov, Mariana Gerova, Katya Petrova, and Yordanka Ivanova

49 Microwave-assisted, solvent-free synthesis of 3'-(aryl/heteroaryl)-1-morpholinomethyl/piperidinomethylspiro[3H- indole-3,2'-thiazolidine]-2,4' (1H)-diones via 3-isatinimines / Manju Pandey, Dushyant Singh Raghuvanshi, and Krishna Nand Singh

54 A simple three-component condensation: Highly efficient microwave-assisted one-pot synthesis of polyfunctional pyridine derivatives / Shujiang Tu, Dianxiang Zhou, Longji Cao, Chunmei Li, and Qingqing Shao

58 Synthesis of new 1-(2-, 3-, or 4-methanesulfonylphenyl)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: A search for novel cyclooxygenase and lipoxygenase inhibitors / Morshed A. Chowdhury, Hua Chen, Khaled R. A. Abdellatif, Ying Dong, Kenneth C. Petruk, and Edward E. Knaus

62 Regioselective unusual formation of spirocyclic 4-{3'-benzo(2',3'-dihydro)furo}-9-methyl-2,3,9-trihydrothiopyrano [2,3-b]indole by acid-catalyzed reaction of enol ethers / K. C. Majumdar, S. Alam, and B. Chattopadhyay

69 DBU-catalyzed three-component one-pot synthesis of highly functionalized pyridines in aqueous ethanol / Ritu Mamgain, Ram Singh, and Diwan S. Rawat

74 Solvent-free chemoselective synthesis of some novel substituted 2-arylbenzimidazoles using amino acid-based prolinium nitrate ionic liquid as catalyst / Shahnaz Rostamizadeh, Reza Aryan, Hamid Reza Ghaieni, and Ali Mohammad Amani

79 Synthetic strategy toward 1,9-functionalized pyrido[2,3-d:6,5-d']dipyrimidine-2,4,6,8-tetrones / Gabor Borzsonyi, Rachel L. Beingessner, and Hicham Fenniri

84 Functionalization of benzo[c,d]indole system for the synthesis of visible and near-infrared dyes / Maged Henary, Mariusz Mojzych, Martial Say, and Lucjan Strekowski

NOTES 88 New heterocycles from tetrazines and oxadiazoles / David E. Chavez and

Damon A. Parrish 91 Water-promoted Dowex 50W catalyzed highly efficient green protocol for

2-arylbenzothiazole formation / Chhanda Mukhopadhyay and Arup Datta

96 The reaction of (chlorocarbonyl)phenyl ketene with enaminones: A novel synthesis of some 5-acyl-4-hydroxy-2-(1H)-pyridinones and 7-hydroxy-5-oxo-1,4-diazepin derivative / Mehdi Abaszadeh, Hassan Sheibani, and Kazem Saidi

100 Polystyrene-supported palladium(II) ethylenediamine complex: A highly active and recyclable catalyst for the synthesis of 2-benzylimidazo[2,1-b]pyridines through heteroannulation of acetylenic compounds / Mohammad Bakherad, Bahram Bahramian, Hossein Nasr-Isfahani, Ali Keivanloo, and Nesa Doostmohammadi

105 Synthesis of 7,8-dihydroxy-3-(3,4-dihydroxyphenyl)-2H-chromen-2-one derivatives of crown ethers / Cihan Gündüz and Mustafa Bulut

108 Efficient and convenient method for the synthesis of isoxazoles in ionic liquid / Hassan Valizadeh, Mohammad Amiri, and Hamid Gholipur

111 Mild oxidative cyclization of sydnone-benzoylhydrazone with lead oxide to 2,5-disubstituted-1,3,4-oxadiazole-sydnone hybrid derivatives / Kuo-Chen Chiang, Fung Fuh Wong, Chih-Hao Hung, Yu-Ying Huang, Po-Wei Chang, Liao Yang-Ming, and Lin Shao-Kai

116 The synthesis and application of 2-acetyl-6-(1-naphthyl)-pyridine oxime as a new ligand for palladium precatalyst in Suzuki coupling reaction / Yongchang Zhou, Tatsuro Kijima, and Taeko Izumi

119 An efficient Biginelli one-pot synthesis of new benzoxazole-substituted dihydropyrimidinones and thiones catalysed by alumina-supported trifluoromethane sulfonic acid under solvent free conditions / M. Arjun, D. Sridhar, M. Adharvana Chari, and M. Sarangapani

124 Efficient synthesis of 1,2,4-triazolo[4,3-a][1,8]naphthyridines under microwave irradiation / K. Mogilaiah, T. Kumara Swamy, and K. Shiva Kumar

127 PhI(OAc)2-Al2O3 mediated synthesis of 1,8-naphthyridinyl-1,3,4-oxadiazoles under microwave irradiation / K. Mogilaiah, E. Anitha, H. Sharath Babu, and T. Kumara Swamy

131 One-pot microwave-assisted solvent free synthesis of simple alkyl 1,2,3-triazole-4-carboxylates by using trimethylsilyl azide / Avat Arman Taherpour and Khojasteh Kheradmand

134 A simple method for the synthesis of 5-isoxazolyl-4-thioxo-1,3,5-benzoxadiazocines / E. Rajanarendar, E. Kalyan Rao, and A. Siva Rami Reddy

No. 2

ARTICLES 139 The first example of a regioselective Biginelli-like reaction based on

3-alkylthio-5-amino-1,2,4-triazole / Qiong Chen, Li-Li Jiang, Chao-Nan Chen, and Guang-Fu Yang

149 Microwave-assisted reactions: Three component process for the synthesis of 2-amino-2-chromenes under microwave heating / Ramadan A. Mekheimer, Kamal U. Sadek

152 An efficient and facile synthesis of pyrimidine and quinazoline derivatives via one-pot three-component reaction under solvent-free conditions / Liangce Rong, Hongxia Han, Haiying Wang, Hong Jiang, Shuajiang Tu, and Daqing Shi

158 2-Trifluoroacetyl-1-methoxycycloalkenes: A convenient precursor for the synthesis of geminated polymethylene trifluoromethyl substituted heterocycles / Helio Gauze Bonacorso, Michelle Budke Costa, Cleber André Cechinel, Ronan Carlo Sehnem, Marcos Antonio Pinto Martins, and Nilo Zanatta

164 Mesoionic carbenes: Reactions of 1,3-diphenyltetrazol-5-ylidene with electron-deficient alkenes, and synthesis and catalytic activities of the (tetrazol-5-ylidene)rhodium(I) complexes / Shuki Araki, Keisaku Yokoi, Ryosuke Sato, Tsunehisa Hirashita, and Jun-Ichiro Setsune

172 1,2,3,9-Tetrahydro-4H-carbazol-4-one and 8,9-dihydropyrido-[1,2-a]indol-6(7H)-one from 1H-indole-2-butanoic acid / Richard A. Bunce and Baskar Nammalwar

178 A novel microwave-assisted green synthesis of condensed 2-substituted-pyrimidin-4(3H)-ones under solvent-free conditions / Kishor S. Jain, Jitender B. Bariwal, Manisha S. Phoujdar, Madhuri A. Nagras, Rakesh D. Amrutkar, Manoj K. Munde, Riyaj S. Tamboli, Samrat A. Khedkar, Rahul H. Khiste, Nikhil C. Vidyasagar, Vinit V. Dabholkar, and M. K. Kathiravan

186 New functionalized N-heterocyclic carbene ligands for arylation of benzaldehydes / Öznur Dogbrevean, Nevin Gürbüz, Idotsmail Özdemir, and Bekir Çetinkaya

191 Synthesis of the hypotensive agent 8-amino-7-[2-hydroxy-3-morpholinopropyl]theophylline (P23) and analogs / Marek T. Cegla, Joanna Potaczek, Marek Zylewski, and Lucjan Strekowski

195 Synthesis and antimicrobial activity of novel analogs of trifenagrel / Lingaiah Nagarapu, Aneesa, Apuri Satyender, G. Chandana, and Rajaskaker Bantu

201 Synthesis, characterization, and reactions of selected multichalcone derivatives / Mousa Al-Smadi and Suhaib Mohammad

207 A new synthetic route to 2H-benzo[g]chromene-5,10-diones involving ring closing metathesis / Young Seok Song and Kee-Jung Lee

213 Synthesis and spectroscopic properties of some di- and trideuterated methylpyridines / James W. Pavlik, Tharinee Vongnakorn, and Supawan Tantayanon

217 Synthesis and bioactivity evaluation of 3-hydroxy-3-(phenylethynyl)indol-2-one analogues / Gang Chen, Ye Wang, Suo Gao, Hong-Ping He, Shun-Lin Li, Jian-Xin Zhang, Jian Ding, and Xiao-Jiang Hao

221 Synthesis and application of novel styryl dyes derived from 1,4-diethyl-1,2,3,4-tetrahydro-6-methoxyquinoxaline / Vijay Satam, Rajkumar

Rajule, Samir Bendre, Purushotthaman Bineesh, and Vinod Kanetkar

226 Investigation on the reactions of o-hydroxybenzyl alcohols with vinyl ethers under acidic and/or thermal conditions / Volkan Kumbaraci, Duygu Ergunes, Melike Midilli, Seckin Begen, and Naciye Talinli

231 Preparation of 2H-spiro[benzo[d]isothiazole-3,3'-pyrazole]-1, 1-dioxide-2' (4'H)-carboxylates from dilithiated C(α),N-carboalkoxyhydrazones and methyl 2-(aminosulfonyl)benzoate / Anna C. Dawsey, Chandra Potter, John D. Knight, Zachary C. Kennedy, Ellyn A. Smith, Amanda M. Acevedo-Jake, Andrew J. Puciaty, Clyde R. Metz, Charles F. Beam, William T. Pennington, and Donald G. VanDerveer

237 An efficient synthesis of pyrimido[4,5-b]quinoline derivatives via three-component reaction in aqueous media / Da-Qing Shi, Li-Hui Niu, Hao Yao, and Hong Jiang

243 Symmetrical diamides based on 2,6-bis(methoxycarbonyl)pyridine: Syntheses and metal ion binding studies / Mery Napitupulu, Brendan L. Griggs, Shi-Xia Luo, Peter Turner, Marcel Maeder, and Geoffrey A. Lawrance

251 Microwave-assisted synthesis, metallation, and duff formylation of porphyrins / Muhammad Yaseen, Mukhtar Ali, Muhammad NajeebUllah, Munawar Ali Munawar, and Irshad Khokhar

256 Regioselective synthesis and bioactivity of new 5-amino-6-arylamino-pyrazolo[3,4-d]-pyrimidin-4(5H)-one derivatives / Hong-Qing Wang, Wei-Ping Zhou, Yu-Yuan Wang, Can-Rong Lin, and Zhao-Jie Liu

261 Synthesis and in vitro study of novel bis-[3-(2-arylmethylidenimino-1,3-thiazol-4-yl)-4-hydroxy-2H-chromen-2-one-6-yl]methane and bis-[3-(2-arylidenhydrazo-1,3-thiazol-4-yl)-4-hydroxy-2H-chromen-2-one-6-yl]methane as potential antimicrobial agents / M. Raghu, A. Nagaraj, and Ch. Sanjeeva Reddy

268 Synthesis of pyrone carbaldehydes, pyrone sulfonium ylides and related epoxides / Aziz Shahrisa and Mahnaz Saraei

273 Synthesis of 2,6-bis(1H-indole-6-yl)-4H-pyran-4-ones via Leimgruber-Batcho indole synthesis / Aziz Shahrisa, Zarrin Ghasemi, and Mahnaz Saraei

278 Microwave-assisted, solvent-free, parallel syntheses and elucidation of reaction mechanism for the formation of some novel tetraaryl imidazoles of biological interest / B. R. Prashantha Kumar, Gyanendra Kumar Sharma, S. Srinath, Mohamed Noor, B. Suresh, and B. R. Srinivasa

285 New dihydro-1,2,4-triazolo[1,5-a]pyrimidines based on arylidene derivatives of 5-acetylbarbituric and dehydroacetic acids / Roman V. Rudenko, Sergey A. Komykhov, Vladimir I. Musatov, and Sergey M. Desenko

NOTES 289 Sulfamic acid catalyzed one-pot synthesis of 2,5-diaryl-1,3,4-oxadiazoles

under microwave irradiation and conventional heating / J. Venu Madhav, Y. Thirupathi Reddy, P. Narsimha Reddy, Peter. A. Crooks, V. Naveen Kumar, and B. Rajitha

294 Synthesis and laser activity of halo-acridinedione derivatives / Muharrem Kaya, Yinodotlmaz Yinodotldinodotrinodotr, and Lemi Türker

298 Synthesis of new 1,3-thiazepine derivatives / Marta Struga, Jerzy Kossakowski, Barbara. Miroslaw, Anna E. Koziol, and Andrzej Zimniak

303 Ultrasound-accelerated synthesis of some bis-compounds and their biological evaluation / Vijay V. Dabholkar and Faisal Y. Ansari

309 Synthesis of substituted N-[4(5-methyl/phenyl-1,3,4-oxadiazol-2-yl)-3,6-dihydropyridin-1(2H)-yl]benzamide/benzene sulfonamides as anti-inflammatory and anti-cancer agents / Madhavi Gangapuram and Kinfe K. Redda

317 Synthesis of 2,3-dichloroquinoxalines via Vilsmeier reagent chlorination / Duane R. Romer

320 Synthesis and bioactivity of novel benzisothiazolone derivatives as potential microbiocides / Fengling Xu, Qiang Lin, and Baorong Hou

324 A palladium catalyzed new synthesis of N,N-dimethyl[1,8]-naphthyridine-2-amines: Facile incorporation of N,N-dimethylamino group from DMF in aqueous medium / Shyamaprosad Goswami and Nirmal Kumar Das

327 Vilsmeier-Haack formylation of acetonitrile revisited: Synthesis of novel pyrazolo[1,5-a]pyrimidines and triazolo[1,5-a]pyrimidine / Maruti G. Ghagare, Dilip R. Birari, Deepak P. Shelar, Raghunath B. Toche, and Madhukar N. Jachak

332 Reaction of 2-[(2-Oxo-2-arylethyl)anilino]-1-aryl-1-ethanones with o-phenylenediamine: Formation of quinoxalines / Gurusamy Ravindran, Shanmugam Muthusubramanian, and Subbu Perumal

336 Facile, microwave-assisted parallel syntheses of N-substituted 1,4-dihydropyridines of biological interest / B. R. Prashantha Kumar, Pankaj Masih, Chris Raju Lukose, Nimmy Abraham, D. Priya, Rinu Mary Xavier, Kesiya Saji, and Laxmi Adhikary

340 Bis(enaminones): Key intermediates for novel α,ω -bis(pyrazolylphenoxy), bis(pyranylphenoxy), and bis(benzo[b]furanylphenoxy) alkanes / Ashraf A. Abbas

347 A simple and novel eco-friendly process for the synthesis of cyclic dithiocarbonates from epoxides and carbon disulfide in water / Azim Ziyaei Halimehjani, Forogh Ebrahimi, Najmedin Azizi, and Mohammad R. Saidi

351 A novel method for the synthesis of 1(2H)-phthalazinones using silica-supported perchloric acid / Majid M. Heravi, Bita Baghernejad, and Hossein A. Oskooie

No. 3

REVIEW 355 Synthesis and properties of diaza-, triaza-, and tetraazaphenothiazines /

Krystian Pluta, Beata Morak-Młodawska, Małgorzata Jeleń ARTICLES 392 Facile synthesis of 4-alkoxycarbonylisoquinoline-1,3-diones and 5-

alkoxycarbonyl-2-benzazepine-1,3-diones via a mild alkaline cyclization / Muriel Billamboz, Fabrice Bailly, and Philippe Cotelle

399 Synthesis and reactivity of spiro[1,3,4-thiadiazoline-2,4' -thioflavans] and analogues / László Somogyi

410 Reaction of 4,5-dichloro-2-chloromethylpyridazin-3(2H)-one with phenols / Seung-Beom Kang, Song-Eun Park, Hyung-Geun Lee, Bo Ram Kim, Kwang-Ju Jung, Ju-Eun Won, Min-Jung Kim, and Yong-Jin Yoon

415 Syntheses and fluorescent properties of 2-amino substituted 6,7-dimethoxy-4-(trifluoromethyl)quinolines / Wolfgang Stadlbauer, Appasaheb B. Avhale, Naresh S. Badgujar, Georg Uray

421 From DMF to isatine: A novel and general one-pot synthesis of isatine and its N-unsubstituted derivatives via nucleophilic substitution reactions on 1,2-bis(dimethylamino)-1,2-dichloro-ethene / Stefan M. Huber, André Hennig, Frank G. Pühlhofer, and Robert Weiss

428 The synthesis of 4-(3,3-dimethyl-3H-pyrrolo[2,3-f]quinolin-2-yl)pyrazoles and 4-(3,3-dimethyl-3H-pyrrolo[3,2-h]quinolin-2-yl)pyrazoles / A. Rashidi, A. Afghan, Mehdi M. Baradarani, and John A. Joule

432 the alkylation of isatin-derived oximes: spectroscopic and x-ray crystallographic structural characterization of oxime and nitrone products / Ny Sin, Brian L. Venables, Xiaohong Liu, Stella Huang, Qi Gao, Alicia Ng, Richard Dalterio, Ramkumar Rajamani, and Nicholas A. Meanwell

443 A facile electrochemical method for the synthesis of 5-phenyl-1,3,4-oxadiazol-2-ylthio-benzene-1,2-diol derivatives / Ali Reza Fakhari, Saied Saeed Hosseiny Davarani, Hamid Ahmar, Kobra Hasheminasab, and Hamid Reza Khavasi

447 Suzuki-Miyaura arylations of tetramic acid sulfonates: Evaluation of lactam protection, sulfonate esters, and sterics / Sarah J. P. Yoon-Miller, Kathryn M. Dorward, Kimberly P. White, and Erin T. Pelkey

455 Synthesis and antimicrobial studies of novel bis(diamino)thiazoles / Sreedharan L. Manju, Satyabhama K. C. Devi, and Kallikat N. Rajasekharan

459 Unexpected C-O bond formation in Suzuki coupling of 4-chlorothieno [2,3-d]pyrimidines / Enrico Perspicace, Stéphanie Hesse, Gilbert Kirsch, Mehdi Yemloul, and Claude Lecomte

465 An efficient synthesis of indeno[1,2-b]pyridine and benzo[h]quinoline derivatives under solvent-free conditions / Liangce Rong, Hongxia Han, Hong Jiang, and Shujiang Tu

469 A facile synthesis of furo[3,4-e]pyrazolo[3,4-b]pyridine-5(7H)-one derivatives via three-component reaction in ionic liquid without any catalyst / Da-Qing Shi, Fang Yang, and Sai-Nan Ni

477 Synthesis, structure, and some chemical properties of diferrocenyl-1,2,3-triazines / Elena I. Klimova, Tatiana Klimova, Marcos Flores Álamo, Daniel Méndez Iturbide, and Marcos Martínez García

484 Insertion and fragmentation of 2-ferrocenylmethylidene-1, 3-diketones upon their reactions with N-methylhydrazine / Elena I. Klimova, Eduardo A. Vázquez López, Juan M. Martínez Mendoza, Lena Ruíz Ramírez, Marcos Flores Alamo, and Leon V. Backinowsky

492 Regioselective synthesis of bioactive spiro heterocyclic compounds containing both indoline and quinolone moieties by aryl radical cyclization / K. C. Majumdar, and N. Kundu

497 Synthesis and in vitro study of a new class of methylene-bis-4,6-diarylbenzo[d]isoxazoles as potential antifungal agents / A. Srinivas, A. Nagaraj, Ch. Sanjeeva Reddy

503 In situ vinylpyrrole synthesis. Diels-Alder reactions with maleimides to give tetrahydroindoles / Wayland E. Noland, Nicholas P. Lanzatella, Elena P. Sizova, Lakshmanan Venkatraman, and Oleg V. Afanasyev

NOTES 535 A new catalytic method for ecofriendly synthesis of bis- and

trisindolylmethanes by zirconyldodecylsulfate under mild conditions / Maasoumeh Jafarpour, Abdolreza Rezaeifard, and Tayebeh Golshani

540 A simple preparation of ethyl 2,5-dimethylfuran-3-carboxylate and 2,5-dimethylfuran-3,4-dicarboxylic acid from diethyl 2,3-diacetylsuccinate / Gang-Qiang Wang, Zhi Guan, Rong-Chang Tang, Zeljko Ostojic, T. Nicholas Jones, Ting-Ting Wu, and Yan-Hong He

544 Synthesis and herbicidal activity of 3-aryl-1-[2-(aryloxy)propanoyl] imidazolidine-2,4-diones / Ke Li, and De-Qing Shi

548 Synthesis and antitumor activity of novel pyrazolylenaminone and bis(pyrazolyl)ketones via hydrazonoyl halides / Ahmad S. Shawali, Sherif M. Sherif, Mahmoud M. El-Merzabani, and Manal A. A. Darwish

552 Ring-expansion of 5-methylene-thiazolidine-2-thione with hydrazine / Saifidin Safarov, Elmurod Pulatov, Muhamacho Amadovich Kukaniev, Heinz Kolshorn, and Herbert Meier

555 Stereoselective synthesis and biological activities of diethyl (E)-{[4-cyano-5-[[(disubstitutedamino)methylene]amino]-3-(methylthio)- 1H-pyrazol- 1-yl]substituited phenylmethyl}phosphonates / Lin-Xia Xiao, and De-Qing Shi

560 Improved preparation of 3-(1,1-dimethylallyl)decursinol / Xiangrui Jiang, Jianfeng Li, Rongxia Zhang, Hongli Guo, Shaolei Huang, and Jingshan Shen

563 A facile and efficient synthesis of novel pyrimido[5,4-b][4,7]phenanthroline-9,11(7H,8H,10H,12H)-dione derivatives via microwave-assisted multicomponent reactions / Feng Shi, Shu Yan, Dianxiang Zhou, Shujiang Tu, Xiang Zou, Wenjuan Hao, Xiaohong Zhang, Zhengguo Han, Shanshan Wu, and Xudong Cao

567 Synthesis and spectral characterization of a novel series of methylcinnamate derivatives of 15-crown-5 / Cihan Gündüz, Ümit Salan, and Mustafa Bulut

571 Solvent-free microwave-assisted synthesis of 1H-indole-2, 3-dione derivatives / Ashish Kumar Singh, Sudhish Kumar Shukla, Ishtiaque Ahamad, and M. A. Quraishi

COMMUNICATION TO THE EDITOR 575 Synthesis and biological evaluation of novel conjugated coumarin-thiazole

systems / Franco Chimenti, Simone Carradori, Daniela Secci, Adriana Bolasco, Paola Chimenti, Arianna Granese, and Bruna Bizzarri

No. 4 ARTICLES 579 Synthesis and biological activity of 4-methylene-pyrido[4,3-d]pyrimidines /

Wenyan Mo, Yongyan Yao, Yunli Shen, Hongwu He, and Yucheng Gu

584 A new method for the synthesis and herbicidal activity of 3-phenoxy-6-(1H-(substituted)pyrazol-1-yl) pyridazines / Fang-Zhong Hu, Gui-Feng Zhang, Bin Liu, Xiao-Mao Zou, You-Quan Zhu, and Hua-Zheng Yang

591 Influence of differently ionized species on fragmentation pathways and energetics of a potential adenosine receptor antagonist using a triple quadrupole and a multistage LTQ-OrbitrapTM FTMS instrument / Wendy Zhong, Patrick A. Irish, and Gary E. Martin

599 Preparation of 5-nitro-2-amino[b]thiophenes and 1-(2-amino-5-nitrophenyl)ethanones via microwave irradiation / Afsha Rais, Haribabu Ankati, and Ed Biehl

603 Regiospecific synthesis of 3H-pyrido[2,3-b][1,4]diazepin-4(5H)-ones via haloform reaction with the isolation of N3-[3-oxo-4,4,4-trichloroalk-1-en-1-yl]-2,3-diaminopyridine inte / Helio G. Bonacorso, Rogério V. Lourega, Liliane M. F. Porte, Everton D. Deon, Nilo Zanatta, Alex F. C. Flores, and Marcos A. P. Martins

610 Molecular interaction between free base meso-tetraarylporphyrins and o-chloranil / Hossein Dehghani, and Mahmood Farshchian

616 Dicyanomethylene compounds and heterocyclization of substituted carbohydrazides / Alaa A. Hassan, Yusria R. Ibrahim, and Ahmed M. Shawky

623 1-Alkyl-2,3-dihydro-4(1H)-quinolinones by a tandem Michael-SNAr annulation reaction / Richard A. Bunce, and Takahiro Nago

629 (±)-1,2-Dialkyl-5-nitro-2,3-dihydro-1H-indoles by a tandem reductive amination-SNAr reaction / Richard A. Bunce, Takahiro Nago, and Brian White

635 Efficient synthesis of 5-(2-hydroxyethyl)-2-phenylimino- 1,3-thiazolidin-4-ones and 5-(2-hydroxyethyl)-2-phenylamino-4,5-dihydro-1,3-thiazol-4-ones / Jiří Váňa, Jiří Hanusek, Aleš Růžička, and Miloš Sedlák

640 Synthesis of novel pyrazole-linked norcantharidin derivatives of substituted aromatic amines with efficient 1,3-dipolar cycloaddition / Liping Deng, Weifeng Tao, Jianguo Lv, and Wei Wang

645 One-pot synthesis of quinazoline-2,4(1H,3H)-diones and 2-thioxoquinazolinones with the aid of low-valent titanium reagent / Guo-Lan Dou, Man-Man Wang, Zhi-Bin Huang, and Da-Qing Shi

650 Synthesis and characterization of some 3-acyl-4-amino-1-aryl-1H-pyrazoles / Petr Šimůnek, Markéta Svobodová, and Vladimír Macháček

656 Synthesis of novel amide-crownophanes and Schiff base-crownophanes based on p-phenylene, 2,6-naphthalene, and 9,10-anthracene / Hussni A. Muathen, Nour A. M. Aloweiny, and Ahmed H. M. Elwahy

664 Poly(ethyleneglycol): A versatile and recyclable reaction medium in gaining access to benzo[4,5]imidazo[1,2-a]pyrimidines under microwave heating / Shu-Liang Wang, Wen-Juan Hao, Shu-Jiang Tu, Xiao-Hong Zhang, Xu-Dong Cao, Shu Yan, Shan-Shan Wu, Zheng-Guo Han, and Feng Shi

669 Formation of an unusual product in the reaction of a 1,2,5-thiadiazolidine 1,1-dioxide-derived thioether with sulfuryl chloride / Dengfeng Dou, Erach R. Talaty, Curtis E. Moore, John C. Bullinger, David M. Eichhorn, and William C. Groutas

674 Synthesis and characterization of new phthalhydrazothiazole derivatives: A preliminary investigation on their activity against hepatocellular carcinoma / Maria Cristina Cardia, Simona Distinto, Elias Maccioni, Antonio Plumitallo, Laura Sanna, Maria Luisa Sanna, and Sara Vigo

680 Convenient synthesis of some new pyrazolo[1,5-a]pyrimidine, pyridine, thieno[2,3-b]pyridine, and isoxazolo[3,4-d]pyridazine derivatives containing benzofuran moiety /Abdou O. Abdelhamid

687 Synthesis of [1,2,4]triazolo[3,4-b][1,3]thiazine-5-carboxylates via one-pot reaction of N-substituted-hydrazino-carbothioamides with diethyl maleate / Ashraf A. Aly, Alaa A. Hassan, Yusria R. Ibrahim, and Mohamed Abdel-Aziz

691 Substituent-dependence of photophysical properties of trans-2-styrylpyridazin-3(2H)-ones / Bo Ram Kim, Su-Dong Cho, Hyung-Geun Lee, Heung-Seop Yim, Min-Jung Kim, Jaeyoung Hwang, Song-Eun Park, Jeum-Jong Kim, Kwang-Ju Jung, and Yong-Jin Yoon

702 Synthesis of 2,4,5-triaryl-5H-chromeno[4,3-b]pyridines under microwave radiation / Hui Wu, Yu Wan, Xiu-Mei Chen, Cai-Fa Chen, Lei-Lei Lu, Hai-Qiang Xin, Hua-Hong Xu, Li-Ling Pang, Rui Ma, and Cai-Hui Yue

708 New one-step synthesis of pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives via multicomponent reactions / Bhausaheb K. Ghotekar, Madhukar N. Jachak, and Raghunath B. Toche

714 Self termination of ring opening reaction of p-substituted phenol-based benzoxazines: An obstructive effect via intramolecular hydrogen bond / Suwabun Chirachanchai, Apirat Laobuthee, and Suttinun Phongtamrug

722 Synthesis, characterization, and anti-inflammatory evaluation of 1,2,4-oxadiazoles combined with thiosemicarbazide and 1,3,4-oxadiazole moieties / José M. dos Santos Filho, José G. de Lima, and Lúcia F. C. C. Leite

728 TMSCl-mediated one-pot, three-component synthesis of 2H-indazolo [2,1-b]phthalazine-triones / Lingaiah Nagarapu, Rajashaker Bantu, and Hari Babu Mereyala

732 Synthesis and biological screening of some fluorinated dibenzofuran containing 3-chlorochromones and benzothiazepines / Pratibha Randhavane, and Bhausaheb Karale

737 Utilization of 2-benzo[b]furan carboxylic acid hydrazide in the synthesis of 1,3,4-oxadiazole derivatives / Yu-Xia Da, Zhi Yang, Zheng-Jun Quan, Zhang Zhang, and Xi-Cun Wang

742 Microwave-assisted multicomponent reaction for the synthesis of new and significative bisfunctional compounds containing two furo[3,4-b]quinoline and acridinedione skeletons / Xing-Han Wang, Wen-Juan Hao, Shu-Jiang Tu, Xiao-Hong Zhang, Xu-Dong Cao, Shu Yan, Shan-Shan Wu, Zheng-Guo Han, and Feng Shi

748 Friedel-Crafts heteroarylation of (hetero)arenes: A facile entry to 4-(hetero)aryl quinazolines and quinolines / Shailesh Kumar, Devi Prasad Sahu

756 An efficient two-step synthesis of novel thiazolo[2,3-b]pyrazolo[3,4-f][1,3,5]triazepines / Braulio Insuasty, Alexis Tigreros, Henry

Martínez, Jairo Quiroga, Rodrigo Abonia, Alexander Gutierrez, and Manuel Nogueras, Justo Cobo

762 Unusual retention of isoxazole ring under the influence of 3-(substituted nitrophenyl)-2-isoxazoline during catalytic hydrogenation of isoxazoline-substituted isoxazole systems / Vijay Singh, Samiran Hutait, Gaya P. Yadav, Prakas R. Maulik, and Sanjay Batra

NOTES 770 A convenient approach to the canthin-4-one ring system: Total synthesis

of the alkaloids tuboflavine and norisotuboflavine / Andreas Puzik, and Franz Bracher

774 Junjappa-Ila annulation: α -Oxoketene dithioacetal mediated synthesis of substituted benzotriazoles / Nitinkumar S. Shetty, Ravi S. Lamani, Shridhar I. Panchamukhi, and Imtiyaz Ahmed M. Khazi

778 Facile and selective solvent-free synthesis of 2-isoxazolines under microwave irradiation / Arash Mouradzadegun, and Shima Dianat

782 Ring transformation of spirocyclopropanepyrazoles into pyrano[2,3-c]pyrazoles / Hiroshi Maruoka, Eiichi Masumoto, Takafumi Eishima, Fumi Okabe, Sho Nishida, Yuki Yoshimura, Toshihiro Fujioka, and Kenji Yamagata

788 Synthesis and characteristic of 5,6-dinitro and 5,6-diaminobenzimidazolone-2 / Zehui Yang, Jiarong Wang, Linglan Li, Chuping Ye, and Hui Liu

COMMUNICATIONS TO THE EDITOR 791 Ionic liquid catalyzed expeditious synthesis of 2-aryl-2,3-dihydroquinolin-

4(1H)-ones and 2-aryl-2,3-dihydro-4H-chromen-4-ones under microwave irradiation / Dalip Kumar, Gautam Patel, Anil Kumar, and Ram K. Roy

796 Hafnium (IV) bis(perfluorooctanesulfonyl)amide-catalyzed one-pot synthesis of substituted quinolines in fluorous media / Ming-Gui Shen, Chun Cai, and Wen-Bin Yi

No. 5 REVIEW 801 Dimethylformamide dimethyl acetal as a building block in heterocyclic

synthesis / Fathi A. Abu-Shanab, Sherif M. Sherif, and Sayed A. S. Mousa

ARTICLES 828 An efficient method for synthesis of pyrano[3,2-c]pyridine derivatives

under microwave irradiation / Shu-Liang Wang, Zheng-Guo Han, Shu-Jiang Tu, Xiao-Hong Zhang, Shu Yan, Wen-Juan Hao, Feng Shi, Xu-Dong Cao, and Shan-Shan Wu

832 A facile route to the synthesis of 1,4-pyranonaphthoquinone derivatives under microwave irradiation without catalyst / Xing-Han Wang, Xiao-Hong Zhang, Shu-Jiang Tu, Feng Shi, Xiang Zou, Shu Yan, Zheng-Guo Han, Wen-Juan Hao, Xu-Dong Cao, and Shan-Shan Wu

837 Utility of p-phenylenediformamidine in the synthesis of bisazoles and phenanthroline / Saleh M. Al-Mousawi, and Abdel-Zaher A. Elassar

843 Diastereoselective synthesis of gamma-dispiroiminolactone bearing naphthalene or bipyridine pendant groups / Malek T. Maghsoodlou, Nourollah Hazeri, Sayyed M. Habibi-Khorassani, Morteza Ziyaadini, Ghasem Marandi, Khatereh Khandan-Barani, Pouneh Ebrahimi, Faramarz Rostami Charati, Alexandre Sobolev, and Mohamed Makha

849 An efficient and stereoselective synthesis of pyrazolo[4,3-c]pyridine derivatives under microwave heating / Ju-Hua Peng, Wen-Juan Hao, and Shu-Jiang Tu

854 Divergent reactivity in tandem reduction-Michael ring closures of five- and six-membered cyclic enones / Richard A. Bunce, Baskar Nammalwar, and LeGrande M. Slaughter

861 New access to the one-pot solvent-free synthesis of 4,5-dihydro-pyrido[2,3-b][1,4]diazepines and 2,3-dihydro-benzo[b][1,4]diazepines by microwave irradiation / Shyamaprosad Goswami, Anita Hazra, and Subrata Jana

866 Unsymmetrically substituted furoxans. Part 19. Methyl and phenylfuroxansulfonic acids and related sulfonamides / Konstantin Chegaev, Barbara Rolando, Stefano Guglielmo, Roberta Fruttero, and Alberto Gasco

873 Synthesis and antifungal evaluation of hydroxy-3-phenyl-2H-1,3-benzoxazine-2,4(3H)-diones and their thioanalogs / Pavel Skála, Miloscaron Macháccaronek, Marcela Vejsová, Lenka Kubicová, Jircaroní Kunescaron, and Karel Waisser

881 Highly soluble perylene tetracarboxylic diimides (PDI)-tetrathiafulvalene (TTF) dyad and TTF-PDI-TTF triad / Chengyun Wang, Wei Tang, Hanbin Zhong, Xuechao Zhang, and Yongjia Shen

886 An efficient and direct synthesis of 2-thiopyridines via microwave-assisted three-component reaction / Xing-Han Wang, Xu-Dong Cao, Shu-Jiang Tu, Xiao-Hong Zhang, Wen-Juan Hao, Shu Yan, Shan-Shan Wu, Zheng-Guo Han, and Feng Shi

890 An efficient and convenient multicomponent reaction for the synthesis of 2-methyl-4,6-diarylpyrimidine under solvent-free conditions / Liangce

Rong, Hongxia Han, Hong Jiang, Yisi Dai, Mengjie Zhuang, Minxiang Cao, and Shujiang Tu

895 Ethyl {4-[2-(saccharin-2-yl)acetylsulfamoyl]phenylazo}cyanoacetate in the synthesis of polyfunctionally heteroaromatic derivatives / A. A. Aly

903 Efficient synthesis of benzothieno[3,2-d]-1,2,4-triazolo [1,5-a]pyrimidin-5(1H)-ones via a tandem aza-Wittig/heterocumulene-mediated annulation / Sheng-Zhen Xu, Min-Hui Cao, Chang-Shui Chen, and Ming-Wu Ding

909 The Boulton-Katritzky rearrangement of isocarboxazid / Susan D. Van Arnum and Henry J. Niemczyk

914 Synthesis of novel naphth[1,2-f][1,4]oxazepine-3,4-dione heterocycles / Mehdi Ghandi, Abolfazl Olyaei, and Saeed Raoufmoghaddam

919 Synthesis of functionalized 1,2,3-triazole derivatives of 2-indolones from Morita-Baylis-Hillman adducts of isatin via ldquoclick chemistryrdquo / Ponnusamy Shanmugam, Mumusamy Damodiran, Kodirajan Selvakumar, and Paramasivan T. Perumal

925 Near-infrared bis(indolium heptamethine cyanine) dyes with a spacer derived from oligo(ethylene glycol) / Ewa Wolinska, Maged Henary, Ekaterina Paliakov, and Lucjan Strekowski

931 A simple, efficient, one-pot three-component domino synthesis of Hantzsch pyridines under solvent-free condition / Masoud Nasr-Esfahani, Bahador Karami, and Masoume Behzadi

936 Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles / Hakan Göker, Mehmet Alp, Zeynep Atescedil-Alagöz, and Sulhiye Yinodotldinodotz

949 About the reaction of beta-dimethylamino-alpha,beta-enones with active methylene nitriles / Fathy M. Abdelrazek and Akram N. Elsayed

954 A basic ionic liquid catalyzed reaction of benzothiazole, aldehydes, and 5,5-dimethyl-1,3-cyclohexanedione: Efficient synthesis of tetrahydrobenzo[b]pyrans / Li-Rong Wen, Huai-Yuan Xie, and Ming Li

960 Palladium-catalyzed cross-coupling reaction of 2- and/or 5-substituted 4,6-dichloropyrimidines with arylboronic acids / S. Tumkevicius, J. Dodonova, I. Baskirova, and A. Voitechovicius

965 A facile and efficient synthesis of N-substituted furo[3,4-b]indeno[2,1-e]pyridine analogues of azapodophyllotoxin via microwave-assisted multicomponent reactions / Feng Shi, Ge Zhang, Yan Zhang, Ning Ma, Bo Jiang, and Shu-Jiang Tu

971 One-pot synthesis of imidazo[1,2-c]quinazoline derivatives from nitro-componds reduced by zinc / Da-Qing Shi, Shao-Feng Rong, Guo-Lan Dou, and Man-Man Wang

975 Synthesis, characterization, and antimicrobial evaluation of novel 4-pyrrol-1-yl-5,6,7,8-tetrahydro-pyrido[4prime,3prime:4,5] thieno[2,3-d]pyrimidine derivatives / Kokila Parmar, Bharat Suthar, Arun Suthar, and Abhay Maheta

980 Synthesis, characterization, and antimicrobial activities of clubbed [1,2,4]-oxadiazoles with fluorobenzimidazoles / Ganesh R. Jadhav, Mohammad U. Shaikh, Rajesh P. Kale, Anand R. Ghawalkar, and Charansingh H. Gill

NOTES 988 Reinvestigation of alternative method for the preparation of

dibenz[b,f][1,4]oxazepine / Hossein Fakhraian and Yaser Nafary

993 Concurrent formation of five and eight-membered heterocyclic methylphosphonates in cyclization reactions from diethyleneglycole / Abolghasem Moghimi, Javad Rafiei, Parvin Baghaie, Shokoofeh Aghabeygi, and S. Mojtaba Moosavi

997 Efficient synthesis of 14-substituted-14-H-dibenzo[a,j]xanthenes using silica supported sodium hydrogen sulfate or amberlyst-15 catalyst / Chebolu Naga Sesha Sai Pavan Kumar, Chiguru Srinivas, Partha Sarathi Sadhu, Vaidya Jayathirtha Rao, and Srinivasan Palaniappan

1000 A facile method for the synthesis of thiocoumestan derivatives / Davood Nematollahi, Javad Azizian, Mohsen Sargordan-Arani, Mahdi Hesari, and Behrooz Mirza

1003 One-pot three-component synthesis of dihydrobenzo- and naphtho[e]-1,3-oxazines in water / Bijoy P. Mathew and Mahendra Nath

1007 5,5-diaryl and 5-alkyl-3-phenyl-4-imidazolidones: A novel synthesis / Jitender M. Khurana, Arpita Agrawal, and Geeti Bansal

1011 Synthesis of [2,4-bis(arylamino)thiazol-5-yl](1-methyl-1H-benzimidazol-2-yl)methanones / T. F. Abbs Fen Reji and Kallikat N. Rajasekharan

1016 Synthesis of halogenoindirubins / Yasuhiro Tanoue, Yousuke Ikoma, Norihisa Kai, and Takeshi Nagai

1019 An efficient one-pot synthesis of naphthoxazinones by a three-component coupling of naphthol, aldehydes, and urea catalyzed by zinc triflate / Alakananda Hajra, Dhiman Kundu, and Adinath Majee

1023 One-pot synthesis of 2H-thiochromenes via TiCl4-promoted reaction of 2-tert-butylthiobenzaldehydes with activated alkenes / Chang Hoon Lee and Kee-Jung Lee

COMMUNICATION TO THE EDITOR 1028 Silica gel-supported sulfuric acid catalyzed synthesis of 1,5-benzodiazepine

derivatives / D. Shobha, M. Adharvana Chari, K. Mukkanti, K. H. Ahn