Interferon-α-2a/ribavirin
1
Reactions 1310 - 17 Jul 2010 S Interferon-α-2a/ribavirin Vogt-Koyanagi-Harada disease: case report A 35-year-old man had been receiving treatment for hepatitis C with interferon-α-2a and ribavirin [dosages and routes not stated] for 3 months when he presented with a 3-day history of sudden bilateral visual acuity reduction and meningeal irritation. Biomicroscopic and fundal examination demonstrated bilateral granulomatous panuveitis and retinal detachments. Vogt-Koyanagi-Harada disease was diagnosed after further investigations. Interferon-α-2a and ribavirin were stopped; systemic, followed by oral and topical corticosteroids were administered, and a favourable outcome was noted after 2 weeks. Corticosteroids were continued for 8 months after resolution of his symptoms, and his condition remained stable 10 months after withdrawal of corticosteroid therapy. Author comment: Autoimmunity plays a role in the pathogenesis of Vogt-Koyanagi-Harada disease. Chebil A, et al. [Vogt-Koyanagi-Harada disease associated with interferon-alpha and ribavirin therapy for chronic hepatitis C infection]. Journal Francais d’Ophtalmologie 33: 185-8, No. 3, Mar 2010 [French; summarised from a translation] - Tunisia 803026543 1 Reactions 17 Jul 2010 No. 1310 0114-9954/10/1310-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Interferon-α-2a/ribavirin
Reactions 1310 - 17 Jul 2010
SInterferon-α-2a/ribavirin
Vogt-Koyanagi-Harada disease: case reportA 35-year-old man had been receiving treatment for
hepatitis C with interferon-α-2a and ribavirin [dosages androutes not stated] for 3 months when he presented with a3-day history of sudden bilateral visual acuity reduction andmeningeal irritation. Biomicroscopic and fundalexamination demonstrated bilateral granulomatouspanuveitis and retinal detachments. Vogt-Koyanagi-Haradadisease was diagnosed after further investigations.Interferon-α-2a and ribavirin were stopped; systemic,followed by oral and topical corticosteroids wereadministered, and a favourable outcome was noted after2 weeks. Corticosteroids were continued for 8 months afterresolution of his symptoms, and his condition remainedstable 10 months after withdrawal of corticosteroidtherapy.
Author comment: Autoimmunity plays a role in thepathogenesis of Vogt-Koyanagi-Harada disease.Chebil A, et al. [Vogt-Koyanagi-Harada disease associated with interferon-alphaand ribavirin therapy for chronic hepatitis C infection]. Journal Francaisd’Ophtalmologie 33: 185-8, No. 3, Mar 2010 [French; summarised from atranslation] - Tunisia 803026543
1
Reactions 17 Jul 2010 No. 13100114-9954/10/1310-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
