HEME SYNTHESIS

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Succinyl CoA Glycine δ- Aminolevulinate 2 δ- Aminolevulinate Porphobilinogen 4-Porphobilinogen Uroporphyrinogen III Coproporphyrinogen III Protoporphyrinogen III Protoporphyrin IX Heme δ- Aminolevulinate Synthase δ- Aminolevulinate dehydratase Uroporphyrinogen I Synthase & uroporphyrinogen III cosynthase Uroporphyrinogen decarboxylase Coprophyrinogen oxidase Protophyrinogen oxidase Ferrochelatase Fe 2+ 4H + 4CO 2 4CO 2 4NH 3 4H 2 O CoASH Synthesis of heme

Transcript of HEME SYNTHESIS

Page 1: HEME SYNTHESIS

Succinyl CoA Glycine

δ- Aminolevulinate

2 δ- Aminolevulinate

Porphobilinogen

4-Porphobilinogen

Uroporphyrinogen III

Coproporphyrinogen III

Protoporphyrinogen III

Protoporphyrin IX

Heme

δ- AminolevulinateSynthase

δ- Aminolevulinatedehydratase

Uroporphyrinogen I Synthase &

uroporphyrinogenIII cosynthase

Uroporphyrinogendecarboxylase

Coprophyrinogenoxidase

Protophyrinogenoxidase

FerrochelataseFe2+

4H+

4CO2

4CO2

4NH3

4H2O

CoASH

Synthesis of heme

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Alkynes Nomenclature Physical Properties Synthesis Reactions.

Alkynes Nomenclature Physical Properties Synthesis Reactions.

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cDNA SYNTHESIS

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2 – Friedlander's synthesis

2 – Friedlander's synthesis

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SYNTHESIS OF α-FORMYLKETENE DITHIOACETAL MEDIATED …SYNTHESIS OF α-FORMYLKETENE DITHIOACETAL MEDIATED NOVEL PYRAMIDINE DERIVATIVES In chemistry, organic synthesis is the purposeful

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Iminium Salt in Organic Synthesis

Oxygen-sensitive mitochondrial accumulation of ... · accumulation of heme oxygenase-1, another heme protein, was also regulated by oxygen level and Lon protease in the same mechanism

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7. Heme pp

7. Heme pp

1 Citric acid cycle Synthesis of heme. Hemoproteins © Department of Biochemistry (J.D.) 2013.

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Myoglobin & Hemoglobin. Heme proteins Supply of oxygen – Oxidative metabolism Myoglobin – Monomeric – protein of red muscle – Stores oxygen.

Myoglobin & Hemoglobin. Heme proteins Supply of oxygen – Oxidative metabolism Myoglobin – Monomeric – protein of red muscle – Stores oxygen.

Microwave-assisted synthesis of cycloalkanespirohydantoins ...

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Synthesis via Sampling-Based Abstractions€¦ · Tabuada Reactive synthesis (Rice) Moshe Vardi 6/6. Title: Synthesis via Sampling-Based Abstractions - Some Problems and Initial Ideas

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