S y n t h e s i s of a r o m a t i c a l d e h y d e s . N-Methyl-N-phenylcarbamoyl Chloride (EASTMAN 10912) Under Friedel-Crafts conditions, N-methyl-N-phenylcarbamoyl chloride reacts with an aromatic compound to form an amide. Lithium aluminum hydride reduction of the amide yields the corre­sponding aldehyde. [Fieser and Fieser, Reagents for Organic Synthesis, John Wiley δε Sons, Inc., New York, 1967, p. 494.]

M o d i f i c a t i o n of a - c h y m o t r y p s i n . Methyl p-Nitrobenzenesulfonate (EASTMAN 10958) The modification of α-chymotrypsin through spe­cific methylation of histidine-57 is accomplished with methyl p-nitrobenzenesulfonate in 0.1 M sodium phosphate buffer at pH about 7.9. Radio­isotope studies confirm an almost stoichiometric reaction with α-chymotrypsin. Amino acid analy­sis pinpointed the modified active site of the en­zyme as histidine-57. [/.ACS., 91, 1566 (1969).]

P o i s o n i n g R o s e n m u n d -r e d u c t i o n c a t a l y s t : . Quinoline-Sulfur Reagent (EASTMAN 10979) The Rosenmund reaction for reducing acid chlo­rides to their corresponding aldehydes requires a supported Pd catalyst. The quinoline-sulfur poi­son inhibits further hydrogénation under the nor­mal reaction conditions. [Ber., 54, 425 (1921).]

P r o t e i n m o d i f i c a t i o n . l-Nitroguanyl-3,5-dimethylpyrazole (EASTMAN 10910) Free amino groups of bovine serum albumen are modified by nitroguanidation with 1-nitroguanyl-3,5-dimethylpyrazole. Such modification is desir­able, since it replaces a positively charged ammo­nium group with the non-basic nitroguanidino group. The modified proteins allow a study of the effect of changes in the net charge on physico-

Dept. 412L Eastman Organic Chemicals Eastman Kodak Company, Rochester, N.Y. 14650

Π Send JJ-1, "EASTMAN Organic Chemicals" catalog Π Send JJ-29, "Phthalocyanine-Type Compounds"

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NEW PHTHALOCYANINE COMPOUNDS Six new metallo-phthalocyanines are now avail­able. These bring the number offered by Eastman Organic Chemicals to 21, not including metal-free phthalocyanine. The new additions are :

• Aluminum Phthalocyanine Chloride (EASTMAN 11004)

• Cadmium Phthalocyanine (EASTMAN 10859)

• Chlorogallium Phthalocyanine (EASTMAN 10962)

• Copper Phthalocyanine (EASTMAN 5590) • Manganous Phthalocyanine

(EASTMAN 10885) • Tin Phthalocyanine Dichloride

(EASTMAN 10885)

The complete list is available in Kodak Publica­tion JJ-29, Phthalocyanine-Type Compounds. Check the coupon below.

Every one of the reagents listed here is new. T o o new, in fact, to be listed in the current E A S T M A N Organic Chemicals catalog. Recently synthesized at the Eastman Organic Chemicals Laboratories, one or more of them just could be the reagent you've been looking for to complete an assignment or spark a new undertaking. These newly listed reagents are available from the dealer nearest you. For a copy of E A S T M A N Organic Chemicals List 45—a catalog of more than 6000 available reagents, and to receive automatically periodic supplements to it—simply return coupon. W e look forward to filling your request.

B&A N O R T H - S T R O N G C U R T I N P R E I S E R F I S H E R SARGENT-WELCH H O W E & F R E N C H WILL

C&EN 7

Fill yourself in on reagents for: chemical properties, as well as on their biological activity. Tyrosine, tryptophan, and histidine resi­dues are unaffected by the reagent. [Biochim. Biophys. Acta., 93, 533 (1964).]

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