Investigation of Insulin Like Protein From Spirulina

98

7. References

Abed RMM, Dobretsov S, Sudesh K (2008) Applications of cyanobacteria in

biotechnology. J Appl Microbiol 106:1–12

Abeliovich A, Weisman D (1978) Role of heterotrophic nutrition in growth of the alga

Scenedesmus obliquus in high-rate oxidation ponds. Appl Environ Microbiol

35:32-37

Adams M J, Blundell T, Dodson E, Dodson G, Vijayan M, Baker E, Harding M,

Rimmer B, Sheat S (1969) "Structure of Rhombohedral 2-zinc Insulin Crystals."

Nature 224: 491

Ajit kar, Choudhary BK, Bandhopadhyay NG (1999) Preliminary studies on the

inorganic constituents of some indigenous hypoglycaemic herbs on oral glucose

tolerance test. J Ethnopharmacol 64:179-184

Aleksandra V, Drobac-Åik, Tamara I, Duliã, Dejan B, Stojanoviã, Zorica B, Sviråev

(2007) The importance of extremophile cyanobacteria in the production of

biologically active compounds Proc. Nat. Sci, Matica Srpska Novi Sad 112:57

66

Allen MM (1972) Mesosomes in blue-green algae. Arch Mikrobiol 84:199-206

Alhonen L, Uimari A, Pietil¨a M, Hyv¨onen MT, Pirinen E, Kein¨anen TA (2009)

Transgenic animals modelling polyamine metabolism-related diseases. Essays in

biochemistry 46:125–144

Investigation of Insulin Like Protein From Spirulina

99

American Diabetes Association (2001) Gestational diabetes mellitus. Diabetes Care

24:S77-S79

Anuradha V, Vidhya D (2001) Impact of administration of spirulina on the blood

glucose levels of selected diabetic patients. Indian J Nutr Diebet 38:40-44

Archer T, Kostrzewa RM (2010) Staging neurological disorders: expressions of

cognitive and motor disorder. Neurotoxicity Research 18(2):107–111

Atkinson MA, Maclaren NK (1994) The pathogenesis of insulin –dependent diabetes

mellitus. N Engl J Med 331:1428 -1436

Aydemir-Koksoy A, Bilginoglu A, Sariahmetoglu M, Schulz R, Turan B (2010)

Antioxidant treatment protects diabetic rats from cardiac dysfunction by

preserving contractile protein targets of oxidative stress. J Nutritional Biochem

21(9):827–833

Ayehunie S, Belay A, Baba A, Ruprecht RM (1998) Inhibition of HIV-1 replication by

an aqueous extract of Spirulina plantesis (Arthrospira platensis). J. Acquire

Immune Defic Syndr Hum Retro virol 18: 7-12

Azevedo CR, Maciel FM, Silva LB, Ferreira ATS, da Cunha M, Machado OLT,

Fernandes KVS, Oliveira AEA, Xavier-Filho J (2006) Isolation and intracellular

localization of insulin-like proteins from leaves of Bauhinia variegate. Brazilian

J Medical and biol Res 39:1435-1444

Babu M (1995) Evaluation of chemoprevention of oral cancer with Spirulina. Nutr

cancer 24(2):197-202

Bailey CJ, Day C (1989) Traditional plant medicines as treatment for diabetes. Diabetes

Care 12: 553 -564

Investigation of Insulin Like Protein From Spirulina

100

Bannon P (1982) Effect of pH on the elimination of the labile fraction of glycosylated

hemoglobin. Clinical Chem 28: 2183

Banting F G, Best C H, Collip J B, Campbell W R, Fletcher A (1922) A Pancreatic

extracts in the treatment of diabetes mellitus. Preliminary report. Can Med

Assoc J 12: 141–146

Bazhan NM, Makarova EN (2009) The effect of the “yellow” mutation at the mouse

agouti locus on the hormonal profile of pregnancy and lactation. Rossiiskii

Fiziologicheskii Zhurnal Imeni I M Sechenova 95(11):1254–1257

Bearse MA Jr, Han T, Schneck ME (2004) Local multifocal oscillatory potential

abnormalities in diabetes and early diabetic retinopathy. Invest Ophthal Vis Sci

45:3259-3265

Becker E, Jakober B, Luft D, Suhmiilling RM (1986) Clinical and biochemical

evaluation of the alga spirulina with regard to its application in the treatment

obesity. A double blind crossover study. Nutr Rep Internal 33: 565-574

Belay A, Ota Y, Miyakawa K, Shimamatsu H (1993) Current knowledge on potential

health benefits of Spirulina. J Appl Phycol 5:235–241

Belkin S, Boussiba S (1971) Resistance of Spirulina platensis (Cyanophyta) to high pH

values. Plant cell Physiol 32:953-9589

Berelowitz M., LeRoith D, von Schenk H, Newgard C, Szabo M, Frohman L A,

Shiloach J, Roth J (1982) Somatostatin-like immunoactivity and biological

activity is present in Tetrahymena pyriformis, a ciliated protozoan.

Endocrinology 110: 939-1944

Investigation of Insulin Like Protein From Spirulina

101

Berson S A, RS Yallow (1961) "Immunochemical distinction between insulins with

identical amino-acid sequences." Nauchni Tr Vissh Med Inst Sofiia 191:1392

1393

Best C, Scott MA (1923) Possible sources of insulin. J Metab Res 3:177-179

Best CH (1924) Recent work on insulin. Endocrinology 1: 617-629

Best MA, (1923) Scott Possible sources of insulin. J Metab Res 3: 177-179

Bethel MA, Feinglos MN (2002) Insulin analogues: new therapies for type2 diabetes

mellitus (review). Curr Diab Rep 2:403-408

Betterle C, Zannette F, Pedini B (1983) Clinical and subclinical organ-specific

autoimmune manifestations in type 1 (insulin -dependent) diabetic patients

and their first-degree relatives. Diabetologia 26:431-436

Binder C, Lauritzen T, Faber O, Pramming S (1984) Insulin pharmacokinetics. Diabetes

Care 7:188-199

Bliss M (2000) The Discovery of Insulin. Chicago: University of Chicago Press.

Bloomgarden ZT (1996) American Diabetes Association annual meeting 1996:

the etiology of type II diabetes, obesity, and the treatment of type II

diabetes. [Congresses] Diabetes Care 19: 1311-1315

Broderick TL, Wong P (2009) Influence of the estrous cycle on hypoxic failure in the

female rat heart. Gender Medicine 6(4):596–603

Bolli GB (1998) Hypoglycaemia unawareness. Diabetes Metab; 23 (suppl 3): 29-35

Bolli GB (1999) How to ameliorate the problem of hypoglycaemia in intensive as well

as non-Intensive treatment of type 1 diabetes mellitus. Diabetes Care 22 (suppl

2):B43-B52

Investigation of Insulin Like Protein From Spirulina

102

Bolotin E, Liao H, Ta TC, Yang C, Wendy H-V, Evans JR, Jiang T, Sladek FM (2010)

Integrated approach for the identification of human hepatocyte nuclear factor 4α

target genes using protein binding microarrays. Hepatology 51(2): 642–653

Bott S, Bott U, Berger M, Mühlhauser I (1997) Intensified insulin therapy and the risk of

hypoglycaemia. Diabetologia 40:926-932

Bourelly P (1970) Les algues d eau douce. III-N Boubee et cie., Paris, 512.

Consiglio Nazionale delle Ricerche, Rome. In R. Materassi (ed.) 145-153

Chamorro G, Salazar M, Favila L, Bourges H (1996) Pharmacology and toxicology

Spirulina alga. Rev Invest Clin. 48: 389-399

Chen YB, Li J, Qi Y, Miao X, Zhou Y, Ren D, Gou GZ (2010) The effects of

electromagnetic pulses (EMP) on the bioactivity of insulin and a preliminary

study of mechanism. International J Radiation Biol 86(1):22–26

Chithra P, Sajithlal GB, Chandrakasan G (1998) Influence of Aloe vera on the healing

of dermal wounds in diabetic rats. J Ethnopharmacol 59: 195–201

Ciofeta M, Lalli C, Del Sindaco P (1999) Contribution of postprandial versus

interprandial blood glucose to HbA1c in type I diabetes on physiologic intensive

therapy with lispro insulin at mealtime. Diabetes Care 22:795-800

Collier E, Watkinson A, Cleland CF, Roth J (1987) Partial purification and

characterization of an insulin-like material from spinach and Lemna gibba G3. J

Biol Chem. 262: 6238-47

Collip JB (1923) Glucokinin: A new hormone present in plant tissue. Preliminary paper

J Biol Chem 56:513-543

Investigation of Insulin Like Protein From Spirulina

103

Cohn F (1875) Untersuchungen uber Bakterien. II. Beitrage zur Biologie der Pflanzen. 1

(Heft 3):141-208

Coimbra TC, Danni FF, Blotta RM, da Periara CA, Guedes MD, Graf RG (1992) Plants

employed in the treatment of diabetes mellitus; results of an

ethnopharmacological survey in Porto Alegre, Brazil. Fitoterapia 63(4):320-322

D'Souza D, Lecossois M, Heasman J, Diemar C, Jackson, Pendrey R (2000) Evaluation

of centrifuged microalgae concentrates as diets for Penaeus monodon Fabricius

larvae. Aquac Res 31:661–670

Desikachary TV (1959) Cyanophyta. Indian Council Agricultural Research, New Delhi,

686.

DeFronzo RA, Bonadonna RC, Ferrannini E (1997) Pathogenesis of NIDDM. In

Albert KGMM, Zimmet P, DeFronzo RA (eds) International Textbook of

Diabetes Mellitus, 2nd edn. Chichester: Wiley 635-712

Endo H, Sanasawa H, Nakazima K (1977) Studies on Chlorella regularis, heterotrophic

fast growing strain. Mixotrophic growth in relation light intensity and acetate

condition. Plant Cell Physiol. 18:199–205.

Eriksson J, Saloranta C, Widen E (1991) Non-esterified fatty acids do not contribute

to insulin resistance in persons at increased risk of developing type 2 (non-

insulin -dependent) diabetes mellitus. Diabetologia 34:192 -197

Estrada JEP, Bescós PB, Fresno AMV (2001) Antioxidant activity of different fractions

of Spirulina platensis protean extract. Farmaco 56:497-500

Faintuch BL, Sato S, Aquarone E (1991) Influence of the nutritional sources on the

growth rate of cyanobacteria. Archiv Biol Technol 34:13–30

Investigation of Insulin Like Protein From Spirulina

104

Falasca M, Chiozzotto D, Godage HY, Mazoletti M, Riley AM, Previdi S, Potter BV,

Broggini M, Maffucci T (2010) A novel inhibitor of the PI3K/Akt pathway

based on the structure of inositol 1,3,4,5,6-pentakisphosphate. British Journal of

Cancer 102(1):104–114

Fay, P. and Van Baalen, C. [Eds] (1987) The Cyanobacteria. Elsevier, Amsterdam 534

pp.

Fritsch C (1945) The structure and reproduction of algae,vol II.Cambridge Univ. Press,

Cambridge.

Gademan K, Portman C (2008) Secondary metabolites from cyanobacteria: complex

structures and powerful bioactivities. Curr Org Chem 12:326–341

Gagliani N, Jofra T, Stabilini A, Valle A, Atkinson M, Roncarlo MG, Battaglia M

(2010) Antigen-specific dependence of Tr1-cell therapy in preclinical models of

islet transplant. Diabetes 59(2):433–439

Gaohua L, Kimura H (2009) A mathematical model of brain glucose homeostasis.

Theoretical Biology and Medical Modelling 6(1): article 26

Gebara VCB, Petricevich VL, Raw I, Da Silva WD (1995) Effect of Saponin from

Quillaja saponaria (Molina) on antibody, tumour necrosis factor and interferon

production. Biotechnology and Applied Biochemistry 22:31-37

Gerwick W, Reyes S, Alvarado B (1987) Two malyngamides from the Caribbean

cyanobacterium Lyngbya majuscula. Phytochem 26:1701-1704

Golubic S (1967) Algal vegetation der Felse, Eine őkologische Algenstudie im

dinarischen Karstgebiet – Vegetation of algae on rocks (Study of algal ecology in

Croatia). – 164 E. Schweizerbart’sche Verlagsbuchhandlung, Stuttgart.

Investigation of Insulin Like Protein From Spirulina

105

Gomont M (1895) Note sur le Scytonema ambiguum Klitz. J. Bot. Paris 9:49

Gross W, Schnarrenberger C (1995) Heterotrophic growth of 2 strains of the acido

thermophilic red alga Galdieria sulphuraria. Plant Cell Physiol 36:633–638

Grover JK, Vats V, Rathi SS (2000) Anti-hyperglycemic effect of Eugenia jambolana

and Tinospora cordifolia in experimental diabetes and their effects on key

metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol

73(3):461-470

Grover JK, Vats V (2001) Shifting Paradigm ‘‘from conventional to alternate

medicine.’’An introduction on traditional Indian medicine. Asia Pacific

Biotechnology News 5(1):28-32

Gutierrez P, Martha R, Rosario V, Flores M, Maria J, Garrido H, Sergio (2008)

Hypoglycaemic activity of aqueous extracts of Oscillatoria limnetica,

Blennothrix ganeshii, Hydrodictyon reticulatum and Microcoleous lacustris in

Normal and Alloxan Induced Diabetic mice. J Compl Intg Med 5:1553-3840

Halter B, Gonzalez de Aguilar JL, Rene F, Petri S, Fricker B, Echaniz-Laguna

A, Dupuis L, Larmet Y, Loeffler JP (2010) Oxidative stress in skeletal muscle

stimulates early expression of Rad in a mouse model of amyotrophic lateral

sclerosis. Free Radical Biology and Medicine 48(7):915–923

Han J, Liu YQ (2010) Reduction of islet pyruvate carboxylase activity might be related

to the development of type 2 diabetesmellitus in Agouti-Kmice. Journal of

Endocrinology 204(2):143–152

Harfenist EJ, Craig LC (1952) The molecular weight of insulin. J American Chemical

Society 74: 3087-3089

Investigation of Insulin Like Protein From Spirulina

106

Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR,

Wiedmeyer HM, Byrd -Holt DD (1998) Prevalence of diabetes, impaired

fasting glucose, and impaired glucose tolerance in U.S. adults: the third

National Health and Nutritional Examination Survey,1988-1994. Diabetes

Care 21:518 -524

Hayashi K (1996) Calcium-Spirulan, an inhibitor of enveloped virus replication, from

blue-green alga Spirulina. J Nat Prod 59: 83-87

Hayashi O, Hirahashi T, Katoh T, Miyajima H, Hirano T, Okuwaki Y (1998) Class

specific influence of dietary Spirulina platensis on antibody production in mice.

J Nutr Sci Vitaminol 44:841-851

He CN, Wang CL, Guo SX (2005) Study on chemical constituents in herbs of

Anoectochilus roxburghii II. J Chin Materia Medica 30:761–776

Hedenskog G, Hofsten AV (1970) The ultrastructure of Spirulina platensis-a new source

of microbial protein. Physiol Plant 23:209-216

Henry RR, Gumbiner BN, Ditzler T (1993) Intensive conventional insulin therapy for

type II Diabetes. Metabolic effects during 6-month outpatient trial. Diabetes Care

16:21-31

Higuchi A, Ohashi K, Shibata R, Sono-Romanelli, Walsh K, Ouchi N (2010)

Thiazolidinediones reduce pathological neovascularization in ischemic retina via

an adiponectindependent mechanism. Arteriosclerosis, Thrombosis, and

Vascular Biology 30(1):46–53

Hiroi M, Morishita Y, Hayashi M, Ozaki N, Sugimura Y, Nagasaki H, Shiota A, Oiso Y,

Arima H (2010) Activation of vasopressin neurons leads to phenotype

Investigation of Insulin Like Protein From Spirulina

107

progression in a mouse model for familial neurohypophysial diabetes insipidus.

American J Physiol 298(2):R486– R493

Holmgren P R, Hostetter HP, Scholes VE (1971) Ultrastructural observation of

crosswalls in the blue-green alga Spirulina major. J Phycol 7:309-311

Hotta H, Miura T, Miki T, Togashi N, Maeda T, Kim SJ, Tanno M, Yano T, Kuno A,

Itoh T, Satoh T, Terashima Y, Ishikawa S, Shimamoto K (2010) Short

communication: angiotensin II type 1 receptor-mediated upregulation of

calcineurin activity underlies impairment of cardioprotective signaling in

diabetic hearts. Circulation Research 106(1):129–132

Huang C, Kim Y, Caramori ML (2002) Cellular basis of diabetic nephropathy: II. The

transforming growth factor-beta system and diabetic nephropathy lesions in type

1 diabetes. Diabetes 51:3577-3581

Hussain A, Mahmood H, EL-Hasani S (2009) Can Rouxen- Y gastric bypass provide a

lifelong solution for diabetes mellitus? Canadian Journal of Surgery 52(6): E269

-E275

Hyun E, Ramachandran R, Cenac N, Houle S, Rousset P, Saxena A, Liblau RS,

Hollenberg MD, Vergnolle N (2010) Insulin modulates protease-activated

receptor 2 signaling: implications for the innate immune response. Journal of

Immunology 184(5): 2702–2709

Iyer U, Deshmukh S (1998) Glycemic index of Spirulina supplemented meals. MS

thesis. Department of Foods and Nutrition, Faculty of Home Science, M.S.

University of Baroda, Baroda.

Investigation of Insulin Like Protein From Spirulina

108

Ji HF, Li XJ,Zhang HY (2009) Natural products and drug discovery. EMBO Rep 10 (3):

194–200

Johnson WC Jr (1988) Secondary structure of proteins through circular dichroism

spectroscopy. Annu Rev Biophys Biophys Chem 17:145-166

Jung M, Park M, Chul H L, Yoon-Ho Kang, Eun Seok Kang, Sang Ki Kim (2006)

Antidiabetic Agents from Medicinal Plants. Current Medicinal Chemistry

13:1203-1218

Kapoor R, Mehta U (1993) Effect of supplementation of blue green algae on outcome of

pregnancy of rats. Plants Food Hum Nutr 43:131-148

Katsoyannis PG, Tometsko A, Zalut C (1966) Insulin peptides XII. Human insulin

generation by Combination of synthetic A and B chains. J Am Chem Soc

88:186

Kawamura M, Sakakibara M, Watanabe T, Kita K, Hiraoka N, Abayashi A (1986) A

new restriction endonuclease from Spirulina platensis. Nucleic Acids Res 14:

1985-1990

Keen H, Glynne A, Pickup JC (1980) Human insulin produced by recombinant

DNA technology: safety and hypoglycaemic potency in healthy men. Lancet 398

-401

Khamseh ME, Safarnejad B, Baradaran HR (2009) The effect of captopril on

progression of retinopathy in type 2 diabetes. Diabetes Technology and

Therapeutics 11(11):711–715

Khanna P, Jain SC, Panagariya A, Dixit VP (1981) Hypoglycemic activity of

polypeptide-p from a plant source. J Nat Prod 44: 648-655

Investigation of Insulin Like Protein From Spirulina

109

Khanna P, Nag TN, Chandrajaia S, Mohan SV (1976) Process for isolation of insulin

from plant source. Patent No US 3: 945-988

Khanna P, Nag TN, Jain SC, Mohan S (1974) Extraction of insulin from a plant

source. 3rd International Congress on Plant Tissue & Cell Cultures. 21-26th July,

Leicester,UK

Khuwaja AK, Fatmi Z, Soomro WB, Khuwaja NK (2003) Risk factors for

cardiovascular disease in school children- -a pilot study. J Pak Med Assoc

53:396-40

Khuwaja AK, Rafique G, White F, Azam SI (2004) Macrovascular complications and

their associated factors among persons with type 2 diabetes in Karachi, Pakistan-

a multi center study. J Pak Med Assoc 54:60-66

King H, Aubert R, Herman W (1998) Global burden of diabetes, 1995-2025. Prevalence,

numerical estimates and projections. Diabetes Care 21:1414-1431

Kleiner (1919) Pancreatic extracts in the treatment of diabetes mellitus.Preliminary

report. Can Med Assoc J 12:141–146

Koening RJ, Peterson CM, Jones RL, Saudek C, Lehrman M, Cerami A (1976)

Correlation of glucose regulation and hemoglogbin A1 C in diabetes mellitus.

New Eng J Med 295:417-420

Kumar NP, Annamalai AR, Thakur RS (2009) Antinociceptive property of emblica

officinalis gaertn (Amla) in high fat dietfed/low dose streptozotocin induced

diabetic neuropathy in rats. Indian J Experimental Biol 47(9):737 742

Kumar PJ, Clark M (2002) Textbook of Clinical Medicine. Pub: Saunders (London)

1099-1121

Investigation of Insulin Like Protein From Spirulina

110

Labieniec O, Ulicna O, Vancova J, Kucharska T, Gabryelak, Watala C (2010) Effect of

poly(amido)amine (PAMAM) G4 dendrimer on heart and liver mitochondria in

an animal model of diabetes. Cell Biol International 34(1):89–97

Lacaz R, Nascimento E (1990) Produçáo de biomassa de Spirulina máxima para

alimentaçáo humana e animal. Rev Microbiol 21:85-97

Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of

bacteriophage T4. Nature 227:680-685

Lalibertè G, de la Noüe J (1993) Auto, hetero and mixotrophic growth of

Chlamydomonas humicola (Chlorophyceae) on acetate. J Phycol 29:612–620

Lan Z, Zassoko R, Liu W, Garcia B, Sun H, Wang R, Wang H (2010) Development of

techniques for gastrojejunal bypass surgery in obesemice. Microsurgery

30(4):289–295

Layam A, Reddy C L K (2007) Antidiabetic property of Spirulina. Diabeto Croa 35:29

-33

Lee YM, Gweon OC, Y. J. Seo Y-J, Im J, Kang M-J, Kim M-J, Kim J-I (2009)

Antioxidant effect of garlic and aged black garlic in animal model of type 2

diabetes mellitus. Nutrition Research and Practice 3(2):156–161

Legros F, Uytdenhoef P, Dumont I, Hanson B, Jeanmart J, Massant B, Conard V (1975)

Specific binding of insulin to the unicellular alga Acetabularia mediterranea.

Protoplasma 86:119-134

Li CJ, Zhang QM, Li MZ, Zhang JY, Yu PU, Yu DM (2009) Attenuation of myocardial

apoptosis by alpha-lipoic acid through suppression of mitochondrial oxidative

Investigation of Insulin Like Protein From Spirulina

111

stress to reduce diabetic cardiomyopathy. ChineseMedical Journal 122(21):2580

-2586

Liang C, DeCourcy K, Prater MR (2010) High-saturated-fat diet induces gestational

diabetes and placental vasculopathy in C57BL/6 mice. Metabolism 59(7):943

-950

Lindberg G, Lindblad U, Melander A (2004) Sulfonylureas for treating type 2 diabetes

mellitus. Cochrane Database Systemic Reviews 3

Lin HV, Plum L, Ono H, Gutierrez-Juarez, Shanabrough M, Borok E, Horovath TL,

Rossetti L, Accili D (2010) Divergent regulation of energy expenditure and

hepatic glucose production by insulin receptor in agouti-related protein and

POMC neurons. Diabetes 59(2):337–346

Lin CY, Wang JY, Ko JY, Huang YT, Kuo YH, Wang FS (2010) Dickkopf-1 promotes

hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction.

J American Society of Nephrol 21(1):124– 135

Liu J, Tang H, Niu L, Xu Y (2009) Upregulation of Tanis mRNA expression in the liver

is associated with insulin resistance in rats. Tohoku Journal of Experimental

Medicine 219(4): 307–310

Luzardo Y, Mathews CE (2010) Attacking the source: Anti- PDX-1 responses in type 1

diabetes. Laboratory Investigation 90(1):6–8

Investigation of Insulin Like Protein From Spirulina

112

Lynda JG Annette W. Coleman (1988) The use of plastid dna restriction endonuclease

patterns in delineating red algal species and populations. J Phycol 24 (3):357–

368

Malecki MT, Jhala US, Anatonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH,

Montminy M, Krolewski AS (1999) Mutations in NEUROD1 are associated with

the development of type 2 diabetes mellitus. Nature Genet 23:323-328

Mani S, Iyer U, Subramanian S (1998) Studies on the effect of Spirulina

supplementation in control of diabetes mellitus. Cyanobacterial Biotechnology

USA: Science Publishers Inc 301-304

Mani UV, Desai S, Iyer UM (2000). Studies on the long-term effect of spirulina

supplementation on serum lipid profile and glycated proteins in NIDDM

patients. J Nutraceuticals Functional and Med Foods 2:25-32.

Mani UV, Iyer UM, Nayak US (2002) Hypocholesterolemic effect of Spirulina in

patients with hyperlipidemic nephrotic syndrome. J Med Food 5:91-96

M¨arker T, Kriebel J, Wohlrab U, Habich C (2010) Heat shock protein 60 and

adipocytes: characterization of a ligandreceptor interaction. Biochemical and

Biophysical Research Communications 391(4):1634–1640

Marquez FJ, Sasaki K, Kakizono T, Nishio N, Nagai S (1993) Growth characteristics of

Spirulina platensis in mixotrophic and heterotrophic conditions. J Ferment

Bioeng 76:408–410

Marty F, Busson F (1970) Donnees cytologique, etsystematiques sur Spirulina platensis

(Gom.) Geitler et Spirulina Geitleri J de Toni (Cyanophyceae-Oscillatoriaceae).

C R Acad Sci Ser D 270:786-789

Investigation of Insulin Like Protein From Spirulina

113

Matsumoto T, Ozawa Y, Taguchi K, Kobayashi T, Kamata K (2009) Chronic treatment

with losartan (angiotensin II type 1 receptor antagonist) normalizes enhanced

acetylcholine induced coronary vasoconstriction in isolated perfused hearts of

type 2 diabetic OLETF rats. J Smooth Muscle Research 45(5):197–208

Meienhofer J, Schnabel E, Bremer H (1963) Synthese der Insulinketten und ihre

Kombination zu insulactiven Präparaten. Z Naturforsch. 18:1120

Microbiological Reviews Dec (1983) American Society for Microbiology Spirulina, the

Edible Microorganism ORIO CIFERRI Department of Genetics and

Microbiology, University of Pavia, 27100 Pav'ia, Italy. 47:551-578

Moore R, Mynderse J, Kashiwagi M, Norton T (1977) Antileukemia activity in the

oscillatoriaceae: isolation of debromoaplysiatoxin from Lyngbya. Science

196:538-539

Moore R, Barchi J, Patterson G (1984) Acutiphicin and 20,21-didehydroacutiphicin,

new antineoplasic agents from the cyanophyta Oscillatoria acutissima. J Am

Chem Soc 106:8193-8197

Motta AB (2010) Dehydroepiandrosterone to induce murine models for the study of

polycystic ovary syndrome. Journal of Steroid Biochemistry and Molecular

Biology 119(3–5):105–111

Mukherjee K, Ghosh NC, Datta T (1972) Coccinia indica Linn. As potential

hypoglycemic agent. Indian Journal of Experimental Biology 10(5): 347-349

Murlin (1913) Jour Biol Chem XV:365. In Banting FG, Best CH, Collip JB, Campbell

WR, Fletcher A (1922) A Pancreatic extracts in the treatment of diabetes

mellitus. Preliminary report. Can Med Assoc J 12: 141–146

Investigation of Insulin Like Protein From Spirulina

114

Ndisang JF, Lane N, Syed N, Jadhav A (2010) Up-regulating the heme oxygenase

system with hemin improves insulin sensitivity and glucose metabolism in adult

spontaneously hypertensive rats. Endocrinol 151(2):549– 560

Nagasawa H, Kataoka H, Isogai A, Tamura S, Suzuki A, Mizoguchi A, Yuko F, Suzuki

AS, Takahashi Y, Ishizaki H (1986) Amino acid sequence of a

prothoracicotropic hormone of the silkeworm Bombyx mori. Proc Natl Acad Sci

USA 83:5840–5843

Nakaya N, Homma Y, Goto Y (1988) Cholesterol lowering effect of Spirulina Nutr Rep

Int 37:1329-1337

National Institutes of Health. Diabetes in America, 2nd edn. Bethesda, MD: National

Institutes of Health, 1995. (NIH Publication no. 95-1468.)

Ng TB, Wong CM, Li WW, Yeung HW (1986) Insulin-like molecules in

Momordica charantia seeds. J Ethnopharmacol 15:107-117

Oftedal L, Selheim F, Wahlsten M, Sivonen K, Døskeland SO, Herfindal L (2010)

Marine benthic cyanobacteria contain apoptosis-inducing activity synergizing

with daunorubicin to kill leukemia cells, but not cardiomyocytes. Mar Drugs

8:2659-2672

Oliveira AEA, Machado OLT, Gomes VM, Xavier-Neto J, Pereira AC, Vieira JGH,

Fernandes KVS, Xavier-Filho J (1999) Jack bean seed coat contains a protein

with complete sequence homology to bovine insulin. Protein Pept Lett 6:15-21

Ördög V, Stirk WA, Lenobel R, Bancírová M, Strnad M, van Staden J, Szigeti J,

Németh L (2004) Screening microalgae for some potentially useful agricultural

and pharmaceutical secondary metabolites. J Appl Phycol 16:309–314

Investigation of Insulin Like Protein From Spirulina

115

Owens DR, Zinman B, Bolli GB (2001) Insulins today and beyond. Lancet 358:739-746

Pampanelli S, Porcellati F, Fanelli C (2002) Glycaemic control, awareness of and

counter-regulation to hypoglycaemia, in the second decade of intensive treatment

of TIDM (abstract). Diabetes 51 (Suppl 2): A492

Pfluger-PJIugers Arch (1907) 118: 265-321. In Banting F G, Best C H, Collip J B,

Campbell W R, Fletcher A (1922) A Pancreatic extracts in the treatment of

diabetes mellitus. Preliminary report. Can Med Assoc J 12:141–146

Pandey JP, Tiwari A (2010) Optimization of Biomass Production of Spirulina maxima. J

Algal Biomass Utilization 1(2):20-32

Pandit Mk, Burke J, Gustafson AB (1993) Drug-induced disorders of glucose tolerance.

Ann Intern Med 118:529-539

Paniagua MJ, SAZÓN A (1995) Moléculas de microalgas de importancia

económica. In: Alveal K, Ferraio M, Oliveila E, Sar E, Eds. Manual de métodos

ficológicos. Universidad de Concepción, Chile. pp. 297-310

Patterson GML, Larsen LK, Moore RE (1994) Bioactive natural products from blue

green algae. J Appl Phycol 6:151-157

Patumraj S, Tewit S, Amatyakul S, Maneesri S, Kasantikul V, Shepro D (2000)

Comaritive effects of garlic and aspirinon diabetic cardiovascular complications.

Drug Deliv 7:91-96

Paulesco (1921) Comp. rend. de Soc. de biol. In Banting F G, Best C H, Collip J B,

Campbell W R, Fletcher A (1922) A Pancreatic extracts in the treatment of

diabetes mellitus. Preliminary report Can Med Assoc J 12:141–146

Investigation of Insulin Like Protein From Spirulina

116

Purves WK, Sadava D, Orians GH, Heller HC (2001) Life: the Science of Biology, sixth

edition. Sunderland, Massachusetts: Sinauer Associates, 724(905):283-284

Raffel LJ, Scheuner MT, Rotter JI (1993) Genetics diabetes. In: Porte D Jr,

Sherwin RS, eds. Ellenberg & Rifkin’s Diabetes Mellitus, 5th ed.

Stamford, CT, Appleton & Lange 401-454.

Rania MA, Hala MT (2008) Antibacterial and antifungal acivity of cyanobacteria and

green microalgae. Evaluation of medium components by Plankett-Burman

design for antimicrobial activity of Spirulina platensis. Global J Biotech & Biochem

3(1):22-31

Raffel LJ, Scheuner MT, Rotter JI (1997) Genetics diabetes. In: Porte D Jr,

Sherwin RS, eds. Ellenberg & Rifkin’s Diabetes Mellitus, 5th ed.

Stamford, CT, Appleton & Lange 401-454.

Rastogi RP, Sinha RP (2009) Biotechnological and industrial significance of

cyanobacterial secondary metabolites. Biotechnol Adv 27:521–539

Raven PH, Evert RF, Eichhorn SE (1992) Biology of Plants. Worth Publishers,

NewYork, 791pp Rhodes Ch J, Shoelson S, Halban P A (2005) Insulin

biosynthesis, processing, and chemistry.In: Joslin’s Diabetes mellitus..In:

Joslin’s Diabetes mellitus. Eds.: Kahn, C. Lippincott Williams&Wilkins,

Philadelphia. 66-82

Richard R, Rubin Paul Ciechanowski MPH, Leonard E Egede, Elizabeth HB Lin,

MPH Patrick J (2004) Lustman.Recognizing and Treating Depression in

Patients with Diabetes 4:119–125

Investigation of Insulin Like Protein From Spirulina

117

Richmond A (1992) Mass culture of cyanobacteria. In: Mann N, Carr N, Eds.

Photosynthetic prokaryotes. 2nd ed. Plenum Press New York and London 181

-210

Richmond A, Becker EW (1984) Technological aspects of mass cultivation–a general

outline: In: Richmond A, Ed. Handbook of microalgal mass culture. CRC

Press, Inc, Boca Ratón pp. 245-263

Richmond A, Grobbelaar JU (1986) Factors affecting the output rate of Spirulina

platensis with reference to mass cultivation. Biomass 10:253-264

Richmond A (2000) Microalgal biotechnology at the turn of the millennium: A personal

view. J Appl Phycol 12:441-451

Rodriguez-Hernandez A, Ble-Castillo JL, Juarez-Oropeza MA, Diaz-Zagoya JC (2001)

Spirulina maxima prevents fatty liver formation in CD-1 male and female mice

with experimental diabetes. Life Sci 69(9):1029-37

Rychlik W (1934) Elimination of iodine in human colostrums and milk after child birth.

Compt Rend Soc Biol 116:1135

Saely CH, Aczel S, Marte T (2004) Cardiovascular complications in type 2 diabetes

mellitus depend on the coronary angiographic state rather than on the diabetes

state. Diabetologia 47:145-146

Sandmeyer W (1895) Z Biol 31: 12-8. In Banting FG, Best CH, Collip JB, Campbell

WR, Fletcher A (1922) A Pancreatic extracts in the treatment of diabetes

mellitus. Preliminary report. Can Med Assoc J 12: 141–146

Investigation of Insulin Like Protein From Spirulina

118

Sanger F (1988) "Sequences, sequences, and sequences." Annu Rev Biochem 57: 1-28

Schafer EA (1916) An introduction to the study of internal secretion. In: The Endocrine

Organs. London: Longmans,Green

Schopf JW (2000) The fossil records: tracing the roots of the cyanobacterial lineage. In:

Whitton BA, Potts M (eds) The ecology of cyanobacteria. Kluwer, Dordrecht, pp

13–35.

Schwartz J, Shklar G (1988) Prevention of experimental oral cancer by extracts of

Spirulina –Duraliella algae. Nutr Cancer 11:127-134

Seki M, Tanaka T, Nawa H (2004) Involvement of brain-derived neurotrophic factor in

early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic

potential of brain-derived neurotrophic factors for dopaminergic amacrine cells.

Diabetes 53: 2412-2419.

Sethubathi GVB, Prabu VA (2010) Antibacterial Activity of Cyanobacterial Species

from Adirampattinam Coast, Southeast Coast of Palk Bay. Current Research J

Biol Sci 2(1):24-26

Sheng Q Yao, H Xu, Ling H, He X T (2004) Isolation of plant insulin from Momordica

charantia seeds by gel filtration and RP-HPLC. Zhong Yao Cai 27: 414-416

Shukla N Angelini GD Jeremy JY (2003) Homocysteine as a risk factor for nephropathy

and retinopathy in type 2 diabetes. Diabetologia 46:766-772

Sies H, Stahl W (1995) Vitamins E and C, β-carotene and other carotenoids as

antioxidants. Am J Clin Nutr 62(suppl):1315S-21S

Investigation of Insulin Like Protein From Spirulina

119

Silva LB, Santos SS, Azevedo CR, Cruz MA, Venancio TM, Cavalcante CP (2002) The

leaves of green plants as well as a cyanobacterium, a red alga, and fungi contain

insulin- like antigens. Braz J Med Biol Res 35: 297-303

Smith C (2002) The neomuran origin of archaebacteria, the negibacterial root of the

universal tree and bacterial mega classification. Int J Syst Evol Microbiol 52:77

-76

Steiner DF, James DE (1992)"Cellular and molecular biology of the beta cell."

Diabetologia 35 Suppl 2: S41-8

Svensson M, Eriksson JW, Dahlquist G (2004) Early glycemic control, age at onset, and

development of microvascular complications in childhood-onset type 1 diabetes:

a population-based study in northern Sweden. Diabetes Care 27:955-962

Fujisawa T, Narikawa R, Okamoto S, Ehira S, Yoshimura H, Suzuki I, Masuda T,

Mochimaru M, Takaichi S, Awai K, Sekine M, Horikawa H, Yashiro I, Omata S,

Takarada H, Katano Y, Kosugi H, Tanikawa S, Ohmori K, Sato N, Ikeuchi M,

Fujita N, Ohmori M (2010) Genomic Structure of an Economically Important

Cyanobacterium, Arthrospira (Spirulina) platensis NIES-39). Oxford Journals

Life Sciences DNA Research 17(2):85-103

Teuscher A (1979) The biological effect of purely synthetic human insulin in patients

with diabetes mellitus. Schweiz Med Wochenschr 109:743–747

Thein M (1993) Production of Spirulina in Myanmar. In: Doumengue, F., Durand

Chastel H, Toulemont A, Eds. Spiruline algue de vie. Musée

Océanographique. Bulletin de l´Institut Océanographique Monaco. Numéro

spécial 12:175-178

Investigation of Insulin Like Protein From Spirulina

120

Thuret G (1875) Essai de classification des Nos tochint e s. Ann Sci Nat Bot vi(i): 372

Towbin H, Staehelin NT, Gordon J (1979) Electrophoretic transfer of proteins from

polyacrylamide gels to nitrocellulose sheets; procedures and some applications.

Proceedings of the National Academy of Sciences, USA, 176: 4350- 4354

UK Prospective Diabetes Study Group (1998) Tight blood pressure control and risk of

macrovascular and microvascular complications in type 2 diabetes: UKPDS 38.

BMJ 317: 703-713

Van Eykelenburg C (1979) The ultrastructure of Spirulina platensis in relation to

temperature and light intensity. Antonie van Leeuwenhoek J Microbiol Serol

45:369-390.

Van Eykelenburg C (1980) Rapid reversible macromorphological changes in Spirulina

platensis. Naturwissen-schaften 67:200-201

Van Eykelenburg C (1980) Some theoretical considerations on the in vitro shape of the

cross walls in Spirulina spp. J Theor Biol 82:271-282

Van Eykelenburg C (1980) Ecophysiological studies onSpirulina platensis. Effect of

temperature, light intensity and nitrate concentration on growth and ultrastructure

Antonie van Leeuwenhoek. J Microbiol Serol 46:113-127

Vats V, Grover JK, Rathi S (2002) Evaluation of antihyperglycemic and hypoglycaemic

effect of Trigonella foenumgraecum, Ocimum sanctum, and Pterocarpus

marsupium in normal and alloxanized diabetic rats. J Ethnopharmacol 79: 95-

100

Investigation of Insulin Like Protein From Spirulina

121

Venancio TM, Oliveira AE, Silva LB, Machado OL, Fernandes KV, Xavier-Filho J

(2003) A protein with amino acid sequence homology to bovine insulin is

present in the legume Vigna unguiculata (cowpea). Braz J Med Biol Res 36: 1167-1173

Venkataraman LV, Fatma T (1989) Microalgae as a source of food, bio-chemicals

bioenergy and bio fertilizers, Prospects in Asia, Proceedings of International

Biotechnology Symposium (A N B S), Bangkok

Verspohl EJ (2002) Recommended testing in diabetes research. Planta Med. 68:581–590

Vonshak A, Abeliovich S, Boussiba S, Arad, A Richmond (1982) Production of

Spirulina biomass: effects of environmental factors and population density.

Biomass 25:341–349

Vonshak A (1997) Spirulina platensis (Arthrospira) Physiology, Cellbiology and

Biotechnology. Taylor & Francis, London. ISBN 0-2035- 8670-0

Vonshak A, Cheung SM, Chen F (2000) Mixotrophic growth modifies the response of

Spirulina (Arthrospira) platensis (Cyanobacteria) cells to light. J Phycol 36:675

-679

Wallace C, Reiber GE, LeMaster J (2002) Incidence of falls, risk factors for falls, and

fall-related factures in individuals with diabetes and a prior foot ulcer. Diabetes

Care 25:1983-1986

World Health Organization Expert Committee on Diabetes Mellitus (1965) Second

WHO Technical Report, Series 310. Geneva: World Health Organization

Zarrouk C (1966) Contribution a` l’e´tude d’une cyanophyce´e. Influence de divers

facteurs physiques et chimiques sur la croissance et la photosynthe`se de

Spirulina maxima. Ph. D. Thesis, Paris

Investigation of Insulin Like Protein From Spirulina

122

Zhang XF, Tan BK (2000) Antihyperglycaemic and anti-oxidant properties of

Andrographis paniculata in normal and diabetic rats. Clinical and Experimental

Pharmacology and Physiology 27: 358–363

Zimmet P (1982) Type 2 (non-insulin -dependent) diabetes: an epidemiological

overview. Diabetologia 22:399 -411

Zimmet P, Dowse G, Finch C, Serjeantson S, King H (1990) The epidemiology

and natural history of NIDDM - lessons from the South Pacific. Diabetes

Metab Rev 6: 91-124

Zimmet P (2000) Globalization, coca-colonization and the chronic disease epidemic: can

the Doomsday scenario be averted? J Med 247:301-310

Zimmet P, Cowie C, Ekoe JM, Shaw JE (2004) Classification of diabetes mellitus

and other categories of glucose intolerance. In: International Textbook of

Diabetes Mellitus chapter 1, 3rd Ed. 3 -14