DoctorOs 01 2016

牙医1-2016

Management of impacted dilacerated maxillary incisor with

strategic positioning of a straightwire appliance

阻生弯曲上切牙正畸中的直丝弓矫治器定位技巧

Post-extraction application of beta-tricalcium phosphate in

alveolar socketβ-磷酸三钙在拔牙后牙槽窝

中的应用

Immediate implants in extraction sockets with periapical lesions:

an illustrated review牙窝根尖周变病的即刻种植:

一篇有插图说明的述评

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终于，第一套关于种植体的全面丛书到了。

Last call for companies: get your free entry in the companies’ list.Write to [email protected]

The Chapters:Dental implants, Osteointegration & biomaterials, 3D printers,

Rotary instruments, Equipment & supplies for implants, Radiology, Piezosurgery, Software, Micromotors.

Implantbook is a trademark of Infodent Srl

“Implantbook is the fastest way to discover the international implantology market.”

Baldo PipitoneInfodent International CEO

Book now your free copy on implant-book.com!

Implantbook Full Page.indd 1 27/05/16 14:56

Technology that innovatesSkema 6 combines the best of Castellini technology with the practicality and effectiveness of multiple integrated systems. Ample scope for personalisation ensures the achievement of outstanding clinical and specialist performance via a precise, interactive control panel, available as a Full Touch version with a 5.7” glass display. Cutting-edge configuration is completed via the availability of highly advanced dynamic instruments, an innovative multimedia system, all the main certified hygiene devices and the latest exclusive functions from Castellini.

SINODENTAL 9 - 12 June 2016 - Booth D77 - D80China National Convention Centre (CNCC) Beijing

CA_DoctorOs by Infodent_SK6_05_2016.indd 1 11/05/16 14:25

2

EDITORIAL Reinventing Marketing - 重塑营销

DoctorOs by Infodent 牙医 •1/2016

Communication is at the mo-ment facing a period of mar-ked uncertainties making it difficult to focus on the cur-

rent situation and to correctly foresee future perspectives. We are daily confronted with a stressing environment which gives us no time to reflect and to think about our tomorrow in a positive mood. On the other hand, times of crisis often open up new opportunities and motivate us further to look for newer and more concrete approa-ches. The structure and size of the market is being reshaped: in the future, there are likely to be less actors on the scene but better quali-fied and organized to face the new-business on an international scale. The main task of a marketing professional is to be sincere and to go beyond the schemes that communication itself has created: dreams, unfulfilled promises etc. As such a sincere dialogue with the reference target becomes essential. The crisis brings with it new opportunities of growth and improvement to those companies ready for it. Info-dent International operates as counselling and business partner for Italian and international companies. Our “global” attitude that brin-gs us in the international medical and dental markets, attending all the main events in these sectors, gives us a deep understanding of what is going on in the different markets and helps us discern direct and diverse feedbacks: trade/consumers. We strive to create new opportunities for companies also in terms of services and type of communication offered: strategic insight, creativity mixed with tech-nology, social networking and search engine marketing and, most of all, the interaction among all these ingredients. Infodent International has a marked attitude towards identifying new ways to communica-te even with less resources and in a consumer environment that is changing rapidly and radically. We focus on the creation of models and strategies, mono- or multi-medial, with greater ability than in the past to captivate and have an impact on the consumer. This implies a new structure of communication, more complete, sophisticated, en-veloping and engaging towards the reference target. Of course, these strategies are made possible by our high level of interaction and mar-ket penetration, mainly, but not only, in the medical and dental trade sectors, that we have achieved through many years of participation at countless international exhibitions and events. Against this background, we are capable of measuring results befo-re and after we implement custom-made communication strategies, constantly improving the understanding of what means work better for which products. The necessary requirements for our company to achieve this result is a good organization coupled with flexibility, aimed at finding always more effective approaches. We need to keep up to date with an international scenery of rapid and continuous market transformation, where factors such as innovation, quality and availabili-ty play a key role. Nevertheless, even in the hardest times, there aren’t necessarily “saturated markets”; we prefer to think of them as “tired”

Reinventing Marketing重塑营销

or “opportunist” markets, but it is always possible to stimulate them and companies can benefit from knowing that they can create great value through information and right interpretative counselling. Not all companies can support and coordinate such issues all by themselves. Therefore, here is our core mission, to always increase our ability and passion to team up with our customers in getting to their goal.

沟通是一段面临明显的不确定性而使得不能专注于现状和正确预见未来的时刻。我们每天都在面临一个压力环境，让我们没有积极的情绪去思考明天。另一方面，危机时刻往往开辟了新的机会并激励我们进一步寻找更多新的机会。市场的结构和规模正在重塑：在未来，出现的行动者会减少，但变得更有能力更有组织来面对国际化的新挑战。专业市场营销者的主要任务是要真诚，且要超越沟通本身创造的价值，如梦想，无法兑现的承诺等。因此与目标的真诚对话就显得至关重要了。危机会给已经做有准备的公司带来新的成长和进步的机会。Infodent是意大利及其他国际企业的咨询顾问和合作伙伴。我们 “全球性“的态度使我们在国际医疗和牙科市场参与该行业的主要事件，让我们深刻了解在不同市场的发生的一切，并帮助我们辨别来自各种贸易者和消费者的反馈。我们也在努力为提供服务和沟通类型的公司创造新的机遇：战略研究，基于技术的创造力，社交网络和搜索引擎混合营销，最重要的是，是所有这些资源之间的相互作用。 Infodent对不断变化且资源甚少的消费环境都有寻找新途径实现沟通的强烈态度。我们专注于创造模式和策略，单一或是多样途径，用比过去更大的能力来征服消费者，对消费者产生影响。这就意味着一种新的沟通结构，更加完整，更加精良，覆盖面更广，目的性更明确。当然，我们之所以能思考出这些策略，主要原因可能是因为我们的高交互性和市场渗透力，而且在医疗和牙科贸易领域，我们已经参加过无数的国际展览和活动。在此背景下，我们会对比测试实施定制沟通策略（针对不同产品为提高工作效率而不断改善工作方式）前后的效果。我们的自我要求是为达到目标建立起一支灵活变通的组织，旨在寻找更有效的方法。我们需要站在世界舞台跟随不断快速持续更新的市场改革，创新、质感和可实施性，这些因素都是我们做出反应的重要依据。然而，即使在最困难的时候，也未必是“饱和市场”；我们更愿意把它当作“疲软”的市场或是“等待机会”的市场，但也可能刺激某些公司，使他们了解到准确的行业信息和咨询辅导从而创造巨大的价值。不是所有的公司都能自我扶持并协调解决所有的问题。因此，这就是我们的核心任务：不断提高我们的能力和热情，并与我们的客户同在实现他们的目标。

Baldo PipitoneCEO Infodent S.r..l.

baldo.pipitone@infodent,com

4

CONTENTS In this Issue


Contents目录

• Editorial 2 Reinventing Marketing by Baldo Pipitone 重塑营销

• Highlights10-11 Touch the future with Castellini; Eighty years of experience, innovation and clinical expertise concentrated into a high-class unit: Skema 6.

12 Crosstex Secure Fit® Technology Face Masks – 3X MORE PROTECTION;Crosstex Secure Fit 科技口罩提供3倍多的保护

12 Polystom: The Russian leader in development and production of materials for bone tissue regeneration;Polystom: 俄罗斯骨组织再生界的先驱

14 - 15 DenTag - Evolution of Species;Dentag（登泰格） – 一个物种的进化

• Scientific Updates18-22 Management of impacted dilacerated maxillary incisor with strategic positioning of a straightwire appliance.23-27 阻生弯曲上切牙正畸中的直丝弓矫治器定位技巧

28-30 Mineral trioxide aggregate in treatment of perma-nent teeth with open apex and endo-perio lesions. A case report32-34 三氧化矿物骨料在治疗根尖开口并伴有牙周内切病变

恒牙中的应用: 一个病例报告

36-41 Post-extraction application of beta-tricalcium pho-sphate in alveolar socket42-47 ß-磷酸三钙在拔牙后牙槽窝中的应用

48-53 Immediate implants in extraction sockets with peria-pical lesions: an illustrated review54-59 牙窝根尖周变病的即刻种植: 一篇有插图说明的述评

60-62 Evaluation of 4 mm implants in mandibular edentu-lous patients with reduced bone height. Surgical preliminary results.64-66 长4毫米的种植体在下颚无齿且垂直骨量受限患者中的运用评估。手术初步结果

• Industry News67-69 B&B Dental: guided implantology;B&B Dental: 导引植牙术

70-71 Silfradent: CGF Concentrated Growth Factors: Pro-tocol and characterization72-73 Silfradent: CGF浓缩生长因子：学术方案和性质特征

74-76 Interview with G.COMM77-80 采访G COMM

82-85 Asa Dental 种植术前准备

• Infodent International 86 Infodent.com: since 1994 the fastest way to experience the dental industry.Infodent.com: 体验牙科行业的最快方法自

1994年以来

• Dentech Exhibition

90-92 Infodent International for Dentech China: the living magazine project Infodent International 为DenTech China开展互动杂志项目

94 The conferences program - 会议的内容

• What’s Next

96

5DoctorOs by Infodent 牙医 •1/2016

CoverMy Ray (Cefla Group)Via Bicocca, 14/CI-40026 Imola (BO) - ItalyContactsemail: [email protected]. +39 0542 653441

AEEDC exhibition................................................................................................87

AIO congress.........................................................................................................93

Asa Dental.............................................................................................................85

B&B Dental............................................................................................................63

Castellini...................................................................................................................1

Dentag..............................................................................................................13,16

DenTech exhibition...........................................................................................89

FDI World dental congress.............................................................................81

Gcomm..................................................................................................................31

Greater New York dental exhibition...........................................................35

Implantbook.................................................................................II and III cover

Infodent International......................................................................................88

Maco.......................................................................................................................95

New Tom...............................................................................................Back cover

Van Max...................................................................................................................3

18-22 Management of impacted dilacerated maxillary incisor with strategic positioning of a straightwire appliance 阻生弯曲上切牙正畸中的直丝弓矫治器定位技巧 Andreasen等学者在[1971]年给弯曲牙下了一个定义：弯曲牙就是牙齿的牙冠长轴与牙根比例有严重偏差，这是由于已经形成的硬体组织相对于发育中的软组织有一个创伤性非轴向移位而造成的...

36-41 Post-extraction application of beta-tricalcium phosphate in alveolar socketβ-磷酸三钙在拔牙后牙槽窝中的应用在正常情况下，健康的骨在不断地重塑而且具备有效的自我修复能力。在动态过程中，骨重建保持骨形成和骨吸收的连续平衡性来适应局部所受的应力（1）。但是，如果高于临界限度的话，骨不...

48-53 Immediate implants in extraction sockets with periapical lesions: an illustrated review牙窝根尖周变病的即刻种植:一篇有插图说明的述评从发表第一篇关于骨结合这一技术与其第一个临床试验 (1、2 ) 至今，人们对对骨结合式种植修复的兴趣已经增长了好多倍...

60-62 Evaluation of 4 mm implants in mandibular edentulous patients with reduced bone height. Surgical preliminary results长4毫米的种植体在下颚无齿且垂直骨量受限患者中的运用评估。手术初步结果在全无齿患者的口腔修复中，运用传统的可移动假牙可能会由于以下原因使患者不满意，不稳定性、不适.....

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6

DOCTOROS BY INFODENT


Everything a top dentist

needs. 每一位成功牙医

所需要的。

DoctorOs by Infodent is the first magazine created and written for Chinese dental specialists.

‘牙医杂志by Infodent’是第一本专门为中国的牙科专家创建的专业杂志。

This magazine comes from the experience of two big worldwide healthcare publishing houses: Infodent international and Ariesdue.

这本杂志源自两家世界知名的医疗刊物出版社多年的成功经验: Infodent International 和 Tecniche Nuove (天诺)。

If you’re reading this, you’re taking care about your future.如果您在读这篇文章的话，您就照顾您的将来。

Be careful: the reading of DoctorOs by Infodent can truly increase revenues and profitability.

阅读‘牙医杂志by Infodent’有助于开拓商业机会，增长您的收入和利润。

Ask your free subscription:In every issue you will discover

scientific articles and a selection of the best dental products

worldwide.

心动不如行动: 立刻免费订阅。在每一个发行，您会发现科学文章及

世界各地最好的牙科产品。

Write an email to [email protected], in Chinese or English,

or visit our stand at Sino Dental Beijing (booth U23 – U 24)

and Dentech China Shanghai (booth Hall 1 F 70 – 71 – 96 – 97).

联系邮箱：[email protected] (中英文均可!)或者请参观我们在中国国际口腔设备材料展览会暨技术交流会 (Sinodental)

的展位 (U23 – U 24), 上海口腔展 (Dentech) 的展位 (Hall 1 F 70 – 71 – 96 – 97)。

8

DOCTOROS BY INFODENT


General Info • DoctorOs by Infodent’s mission is to promote the scientific discourse within the entire domain of education and professional development in dentistry.

The magazine aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international scale. • The articles will be classified according to the following types: cli-nical research (observational and epidemiological studies), literature reviews, clinical cases, professional training.

Requirements• The manuscripts can’t be offer simultaneously to others publishing houses or published in other journals. • Authors whose manuscripts include illustrations or texts already pu-blished for another journal have to provide the permission from the copyright holder. This permission must be received in writing along with the manuscript. In the absence of it, all the material received will be considered property of the author of the work.• The publisher will provide free of charge to the publishing of the articles (scientific and professionals), for the drafting of the manuscript is excluded any sort of reward for the author. • The final drafting of the manuscript must be sent in a digital format to DoctorOs by Infodent headquarter, subsequent amendments will not be accepted.

Author information must include: • full name of all authors • complete address, telephone number and mailing address for each author• degrees (e.g. DDS, DMD, PhD)• affiliation (e.g. School of Dentistry, University of London…)

• the permission for texts already published or images depicting pe-ople• Send the work (text and iconography) to [email protected]• Illustrations must be sent in a digital form, numbered consecutively and accompanied by their captions with specific reference in the text.• Illustrations, graphs and figures must be provided as TIFF or JPEG files with the following parameters:• line art (and tables that are submitted as a graphic) must be sized at approximately 5” x 7” and have a resolution of 1200 dpi.• gray scale/black & white figures must have a minimum size of 3.5” x 5”, and a maximum size of 5” x 7” and a minimum resolution of 300 dpi and a maximum of 400 dpi. • color figures must have a minimum size of 2.5” x 3.5”, and a ma-ximum size of 3.5” x 5” and a minimum resolution of 300 dpi and a maximum of 400 dpi. • color photographs must be sized at approximately 3.5” x 5” and have a resolution of 300 dpi.• To offer a significant contribution to the individual authors, the ma-ximum number of authors accepted for bibliographical works or pre-sentation of clinical cases is 4, for clinical research and epidemiological studies the maximum is 6.• The texts must be written in English and Chinese and structured into:- Scientific title in English and Chinese - Author(s) name(s) and last name(s) and concerning professional qualifications- Structured summaries in English and Chinese including subtitles, scope of work, materials and methods, results and conclusions.- Keywords in English and Chinese, using terms listing in Index Me-dicus.

DoctorOs by Infodent: information for authors“牙医 by Infodent”杂志: 投稿信息

Borders are for people,development is for humankind.封疆为人民，发展为人类。We want to publish your articles and share your discoveries with the best dental audience ever: read DoctorOs by Infodent editorial policies and send your work to [email protected]

我们想把您的文章发布,把您的发现分享跟最好的牙科观众。请看看“牙医 by Infodent”杂志的编辑政策,就给 [email protected] 发您的文章。


- Introduction with the scope of the article. - Materials and methods, described in sufficient detail to allow others to reproduce the results. The study must be done in accordance with the Declaration of Hel-sinki and subsequent amendments.- Results- Discussion and conclusions- Bibliography. Entries and bibliographical references must be listed in order of appearance in the text and identified by Arabic numerals in parentheses (1), square brackets [1], superscript ¹, or a combination.- Tables, graphics, illustrations and captions.

• Approval for publication is given, within the deadline set, by the Science Board Committee, who can make changes to texts if deemed necessary. The proofs must be returned correct uniquely by any mi-sprints, without any changes or modifications.• The literary property of all texts, scientific and updated articles, is up to the editor. The author(s) requiring publication in DoctorOs by Info-dent implicitly accepts the possibility of being published by the maga-zine, fully or partially, in other online and print publications. To transfer the ownership of the manuscript the authors must ask to the staff and fill the copyright statement. The publisher declines any liability related to manuscripts not expressly requested by the publishing house.The opinions expressed are the opinions of the authors and do not necessarily reflect the views of DoctorOs by Infodent.The publishing house assumes no responsibility for any errors in the article published. •The original text is not returned. 基本信息“牙医 by Infodent”杂志的使命是促进科学论述在牙科学之内。这本杂志旨在影响临床医生，研修员和决策人的牙科做法在国际范围内。文章将根据以下类型分类: 临床研究（观察及流行病学研究)，文献综述，临床病例，专业培训。

必须条件• 手稿不能同时提供给其他出版社, 刊物都。

• 如果文章中包括其他受版权保护的作品，作者必须取得著作权人的书面许可。此许可必须与稿件一起收到。如果没有的话，收到的所有材料都将被认为是作品的作者的财产。

• 出版商将免费发表文章 (科学及专业人士的文章)，为稿件的写作没有回报。

• 手稿的最后起草必须以数字格式给“牙医 by Infodent”杂志的

总部发送，随后所有的修改都将不会接受。

• 手稿的最后起草必须以数字格式给“牙医 by Infodent”杂志的总部发送，随后所有的修改都将不会接受。

作者信息要包括:• 所有作者都的全名

• 每一位作者都的地址,电话号码,电邮地址。

• 学位 (比如说, 硕士学位, 博士学位等等)

• 人事关系 (比如说, 伦敦大学, 牙科学校等等)

• 已经发表的文章或描绘人的图像的许可

• 请把所有的材料都寄去 [email protected]• 插图必须以数字形式发送，连续编号和伴随着它们与文字

说明中引用的标题。

• 请把插图，图表和附图都提供为TIFF或JPEG文件用下列标准:

• 线艺术 (Line Art) 及 Tables (表格) 的必须尺寸约为5” x 7”，并有1200 dpi的分辨率。

• 灰度/黑白形象必须具有3.5” x 5”的最小尺寸，5” x 7”的最大尺寸。再说要300 dpi的最小分辨率, 400 dpi 的最大分辨率。

• 颜色的形象必须具有2.5” x 3.5”的最小尺寸， 3.5” x 5”的最大尺寸。另外需要300 dpi的最小分辨率, 400 dpi的最小分辨率。

• 彩色照片必须尺寸在大约3.5” x 5”，再说有300 dpi的分辨率。

• 以提供给各个作者的一个显著的贡献, 书目文章及临床病例文章最多的作者是4人, 临床研究及流行病学研究最多的作者是6个人。- 所有文章都要中英双语写。另外需要:- 科学标题要用中英双语写的。- 每一位作者的姓, 名字, 学位, 工作都。- 中英双语的摘要, 包括副标题, 工作的目的, 材料及方法, 结果, 结论。- 中英双语的关键字。- 简介与文章的目的。- 材料及方法。研究都必须遵循“赫尔辛基宣言” (Declaration of Helsinki) 。- 结果- 讨论及结论- 参考书目必须按出场顺序排列，另外要用阿拉伯数字在括号（ 1 ），方括号[ 1] ，上标 ¹ 。

• 发布的核准由科学委员会委员 (Science Board Committe)，如有必要可以把文章更改了。证明必须由印刷错误返回正确的唯一，没有任何变动或修改。

• 所有文章都的著作权随编者。作者们需要通过“牙医byInfodent” 杂志出版隐含接受由杂志正在出版的可能性，完全或部分，在其他在线和印刷出版物。表达的观点是作者的观点，不一定体现“牙医byInfodent”杂志的意见。对于因本期刊中任何错误或遗漏而引起的损害，编辑与出版社不承担任何责任。

• 原文不会返回。

10

Touch the future with Castellini

HIGHLIGHTS Our Advertiser’s Products


Eighty years of experience, innovation and clinical expertise con-centrated into a high-class unit: Skema 6.

Skema 6 by Castellini, with its high-tech instruments, touchscreen controls and integrated systems, offers dental professionals the ideal tool for high-performance treatment including conservative dentistry, endodontics and implantology. The advanced hygiene devices, fully certified by leading Italian universities, together with a design which ensures functionally ergonomic solutions, enables the dentist to work comfortably, enjoying total peace of mind.

High-performance instrumentsSkema 6 is equipped with Implantor LED, an extremely lightweight induction micromotor with electronic torque control up to 5.3 Ncm and fully autoclavable. When equipped with a peristaltic pump inte-grated on the dentist’s module and a cutting-edge control panel, Ske-ma 6 is ideal for surgical applications.

Further handpieces can be fitted including Silent Power turbines, ul-trasound handpieces (also for surgical applications) and an exclusive electronic apex locator offering maximum efficiency and clinical sa-fety in endodontic treatments. The file position inside the root canal is shown on the touchscreen display fitted to the dentist’s module. When the apex distance threshold programmed by the operator is reached, the LAEC will emit a warning tone. Innovative touchscreen controlsEquipped with one of two possible touchscreen control panels, Ske-ma 6 provides dentists with the ultimate technologies to monitor and manage unit system parameters or instrument settings, allowing for multiple personalisation when more than one dental surgeon is able to work on the unit. Smart Touch, which combines a touch-sensitive screen with traditional keypad for control of patient chair movement, is provided as standard; Full Touch, available as an optional, features a tempered glass display and 5.7” touchscreen interface.

Whatever the treatment being carried out, from conservative denti-stry to oral surgery, both touchscreen control panels allow the wor-king parameters of each individual instrument to be set and saved at the touch of a finger. Everything, from spray mode to turbine spe-ed and micromotor torque, can be controlled via the touch-screen, as can the duration of disinfection cycles and selection of certified contra-angles, the parameters of which are immediately recognised by the dental unit. Dentists can also save the most frequently used settings. Full Touch also features a USB port, which can be used by dentists to load X-ray images and view them in full-screen mode. Another advantage of the USB port is that it lets dentists store their personalised settings on a memory stick.

Certified hygiene systems for maximum protectionSkema 6 can be completed with a selection of the most advanced de-vices on the market. In particular the fully automatic Autosteril system using Peroxy Ag+ or hydrogen peroxide, provides automatic high-le-

vel disinfection of the spray water circuits, ensuring a mycobactericide, bactericide and anti-Legionella action, certified by the Sapienza Uni-versity of Rome.

Perfect for end-of-day hygienisation, dentists can also program the device for shorter cycles between patients ensuring excellent hygiene standards at all times. Other optional devices include the continuous disinfection system coupled to an air gap separation from mains water device (M.W.B.); independent water supply via a 1.8 litre tank (S.S.S.); an anti-retraction system as a standard feature preventing contami-nant suction during the instrument stopping phase and minimising cross-contamination risks (A.C.A.); suction system hygienisation pro-cedure using a special liquid from a dedicated tank (S.H.D.) and for surgical applications, as well as the peristaltic pump, a pneumatic sup-ply protection device with an autoclavabile filter element (H.P.A.).

Skema 6 brings dentistry a step closer to the future, with a host of innovative solutions enabling excellent hygiene, total control and en-viable comfort, both for patients and medical staff.

www.castellini.com

Skema 6是一款整合了八十年经验的新型临床专业高端设备。

Castellini的Skema 6是一款高科技工具，是牙科专业人员在保守牙科、根管治疗和种植牙领域内进行高效能治疗的理想工具。此先进设备得到了意大利领先大学的高度认可，其设计在功能上符合人体工程学方案，这使得牙医能够舒适愉快的工作。

高性能仪器Skema 6配置有离子注入机LED屏幕，和极轻量级感应微电机，电子扭矩控制可以高达5.3 Ncm，且可高温高压消毒。配备有按牙医模块设计的蠕动泵和先进的控制面板，适合在外科手术中应用。可以外接静音动力涡轮机，手持式超声波（同样适合手术应用)，和一个独立的根尖电子定位仪，在牙髓手术操作中保证最大效率和手术安全。触控屏会会按牙科模块显示根管位置，当达到由手术者设定的根尖距离临界值时，LAEC会发出警告音。

创新型触摸屏控制器由于配备了两个可用触屏控制面板之一，Skema 6给牙医提供了无限的技术来监视和管理设备中的系统参数，或当有多个牙医可以在本机上工作时允许对仪器进行多个个性化的设置。智能触控通过把一个触摸敏感屏幕结合在传统面板上，来监控病人座椅的动向，本功能作为标准配置提供;全触控，可作为可选，配有钢化玻璃显示屏和5.7“触摸屏界面。从传统牙科到口腔外科，无论实施了何种治疗，两个屏幕

与Castellini一起触摸未来


触摸控制面板都可以通过一根手指的触摸来进行设置和保存。从喷雾模式到涡轮机速度和微电机扭矩，一切都可以通过触摸屏来控制，也可以制定消毒周期的持续时间和认证反角的选择，这些参数会立即被该牙科仪器识别出来。牙医也可以进行保存最常使用的设置。全触摸还设有一个USB端口，可以让牙医加载X射线图像并在全屏模式下观看。 USB端口的另一个优点是，它可以让牙医把自己的个性化设置存储在一根存储棒上。

已通过认证的提供最大保护限度的卫生体系可以通过选择市场上最先进的设备来完善SKEMA6。尤其是全自动Autosteril系统，它通过使用过氧银离子或过氧化氢来提供一个自动高水平消毒的喷水回路，来起到杀细菌剂，杀菌剂和抗军团菌的作用，此系统由罗马Sapienza大学认证。这对一天结束时的卫生工作是个完美的选择，牙医

也可以在不同的患者之间给设备设定更短的周期，以此来确保在任何时候都有出色的卫生标准。其他可选设备包括可持续消毒的连接了一个空气间隙来分离自来水的设备 (M.W.B.), 该设备用一个1.8升的罐体来实现独立供水 (S.S.S.); 反收放系统作为标准配置，在仪器停用期间防止污染物抽吸，并尽量减少交叉污染的风险 (A.C.A.); 抽吸系统的消毒程序运用一种来自一个专用罐体的特殊液体 (S.H.D.), 这种液体还用于外科手术，以及蠕动泵，具有一个可高温高压消毒的过滤元件的充气供给保护装置(H.P.A.)。SKEMA6使牙科离未来更近了一步，它用新颖的解决方案，给病人和医务人员都提供了优秀的卫生质量和可以完全被控制和令人羡慕的舒适性。

我们的网址：www.castellini.com

12

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这种设计大大减少了面罩周围和底部与面部形成的缝隙。

Secure Fit 口罩提供了3个等级的保护性能(这些保护等级是根据抗液体喷溅性、细菌过滤效率和材料性能来制定的)，它们包括：Ultra系列，该系列口罩的质量测试通过了EN14683评级中的IIR级标准；Procedural系列，该系列在质量测试中超过了EN14683评级中的IIR级标准；还有Isofluid系列，该系列的性能超过了EN14683评级中的II级标准。

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这些口罩很明显地比呼吸面罩更便宜，并能提供更好的透气性，而且可以随时通过分部全球的分销商购买。 www.Crosstex.com/SecureFit // [email protected]

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这些产品在价格和质量方面均名列前茅。至今，通过使用这些产品取得成功的手术案例已经超过200万个，这些案例分布在医药界广泛的各种分支和机构中，包括外科、口腔科、颌面外科、耳鼻喉科、骨伤科以及创伤科。

POLYSTOM的产品几乎可以用于牙科界的所有领域，如牙科手术、牙科治疗、和牙种植等，该产品所用的材料还用于神经科，所有的产品都具有良好的生物相容性、生物可降解性、无毒性，而且不会引起过敏反应。

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在POLYSTOM团队的赞助下，研究磷酸钙材料在医疗和保健中的运用的学者们，于2003年获得的了俄罗斯国家级科学技术研究奖。

www.polystom.com // [email protected]

DenTag s.r.l.

Via Maniago, 9933085 Maniago (Pn) Italy tel. + 39 0427 71561fax + 39 0427 [email protected]

www.dentag.com

Visit us!

9 • 12June 2016 • Beijing

Floor 1 stand L73-L77

14

DenTag - Evolution of Species Dentag（登泰格） – 一个物种的进化

INDUSTRY NEWS Dentag


As you know, DenTag always produces surgical and dental instru-ments ... using stainless steel.

Over the years, we have produced, for us and others, innumerable variations of instruments. We have also started the production of to-ols in aluminum, titanium and with inserts in hard metals but always working in the field of metals. We believe, in our little experience, to have built a recognized standard of quality and reliability.However, we always pay attention to changes and trends in the mar-ket that evolves rapidly and sometimes suddenly.

Cyclically we receive requests for instruments lighter but at the same time as reliable as those made of stainless steel. Not being able to change the material used for the tips, to lighten the devices, we can only works on the handles. That is why we started to manufacture an entirely new line of plastic material handles.

Clearly this solution is already used by others before us so that, in the design, we started to study the state of art, trying to take advanta-ge and, if possible, improve the positivity, correcting any errors if we found. The result of this search is an handle which has, we think for the first time, several positivity together.

We are not the first to bring to market devices with plastic handle, but we tried to do it in the best way.

As always we are respecting our quality standards and, we are proud of, 101% Italian quality.

众所周知，DenTag一直专注生制作外科和牙科器械……原材料选择不锈钢。

多年来，我们为我们自己和其他人，制作了无数的各种各样的器械。我们也开始生产其他材质的器械，例如铝、钛以及硬金属的内嵌件，但是一直还是在金属领域。我们相信，在我们有限的经验下，去建立了一个公认的质量和可靠性的标准。即便如此，我们总是关注市场里因发展迅速或是突然发生的变化和趋势。

我们经常收到订单要求仪器轻的同时，还要求原材料为可靠的不锈钢。无法改变材料使用部份的材料，为了减轻重量，我们只能在手柄上想办法。这就是为什么我们开始制造一个全新的制作塑料材料手柄的新产品线。

显然这个解决方案已经被别人在我们之前想到了，所以在设计时，我们开始研究工艺水平，尝试利用现有的优势，如果可能，提高产品性能，纠正我们发现任何错误。

研究探求的结果就是我们在第一次开始研究时就考虑过的手柄，它包含我们要求的性能。我们不是第一个将塑料工具手柄引入在市场的公司，但我们尽自己最大的努力使用最好的方法。

一直尊重并遵守我们的质量标准，我们感到非常自豪，追求101%意大利品质。

It is known that simple dental instruments such as curettes or double probes may injure the operator’s hand or lacerate the glove (with the opposite working points). The possibility of injury is during use, han-dling or passing the instrument between Assistant-Dentist-Assistant while performing the procedures on the patient.

Directive 2010/32/EU - prevention from sharp injuries in the hospital and healthcare sector, also it states that it’s necessary to prevent wor-kers’ injuries caused by all medical sharps and pointed devices.Instruments with a handle 100, 105 mm are too short and the tips, even if they are turned contrary than working one, very often touch on the back of his hand.

Instead, what it can do as an additional preventive action is to choose, when buying or replacing, one instrument with a long handle.The longer instruments can be wrapped exactly like the other and, in the event that the dentist use cassettes or trays for sterilization of small size, it will be sufficient to put the instruments in the direction of the longer side.

That’s another reasons to choose new DenTag “EVO” family of in-struments.

众所周知简单的牙科器械,例如刮勺或双探针可能伤害操作者的手或割裂手套(与之相反的工作要点)。在使用过程中是有受伤的可能性的, 虽然助理和牙医在对待病人或和使用器械时候履行着操作程序。

欧盟2010/3/2 /下令——预防在医院和医疗保健领域发生的尖锐器械伤害事故,也同时指出有必要防止来自所有医学专用尖锐器械或锐利的设备对医务工作者造成伤害。

器械操作手柄100、105毫米太短和需要留意,即使他们工作时一个转向与经常接触他的手相反。

然而,它能做什么额外的预防措施作为选择和提醒,当器械或设备购买或更换时需用一个长柄器械。

长的手术器械可以包装的和另一个都一样精巧,如果牙医使用类似长方磁带盒子或消毒托盘的体积较小,就足可以将器械的长边朝着长的方向摆放。

那也是另一个选择新的DenTag “EVO”家族系列器械的原因。

DoctorOs by Infodent 牙医 •1/2016 15

Material: Lightweight (11 g) and resistant to stress. Use turns out to be easy, for sure grip and non-fatiguing. Tested and used in the food field, then completely non-toxic and free of potentially harmful substances. Auto-clavable without change of shape and color.Form: 10.5 mm Diameter of the handle and the center of 9.0 mm to minimize the pro-blems to carpal tunnel data from prolonged use in time. Longitudinal notches to increase the grip and the sensibility. Construction: We have inserted during molding of the handle, two stainless steel bushes suitably shaped, in which the tips are then introduced. With this procedure will eliminate the presence of an internal longi-tudinal metal bar with obvious reduction in weight. The tips are not glued to the plastic and so there is no risk of potentially harmful substances are released.Aesthetics: Profile simple, easy to wash and clean. Without deep grooves or notches that may cause accumulation of germs and bacteria. Since plastic is possible to color in various shades aesthetically pleasing and with advantages for the immediate recognition of the instrument.

材质：重量轻（11 g）和抗压力。结果证明使用容易，抓握牢固以及无金属疲劳。经食品领域测试和使用，完全无毒，无有害物质。经受高温高压后无形状和颜色的变化。形状：工具手柄抓握处直径10.5毫米和中心处9毫米，以减少由于长时间使用而引起腕管综合症的风险。纵向的刻痕用来增加抓握力与手的敏感性。结构：在工具手柄的成型阶段，我们插入两个相配成形的不锈钢衬套，这个衬套用于随后将工具头植入。这个过程去除了纵向内部金属核的存在，减少相当大的重量。工具头不是粘结在塑料上，因此没有释放潜在的有害物质的风险。美学：简单的轮廓，容易清洗，无可能导致细菌和细菌的积累的深沟槽或刻痕。作为塑性材质，其色彩可以是不同的色度，美观和并拥有可以立即辨识器械的优势。

DenTag s.r.l.

Via Maniago, 99 • 33085 Maniago (Pn) • Italytel. + 39 0427 71561fax + 39 0427 [email protected]

www.dentag.com

The EvohandleIt is known that simple dental instruments such as curettes or double pro-bes may injure the operator’s hand or lacerate the glove (with the oppo-site working points). The possibility of injury is during use, handling or passing the instrument between Assistant-Dentist-Assistant while performing the procedures on the patient.

Directive 2010/32/EU - prevention from sharp injuries in the hospital and healthcare sector, also it states that it’s ne-cessary to prevent workers’ injuries caused by all medical sharps and pointed devices.

Instruments with a handle 100, 105 mm are too short and the tips, even if they are turned contrary than working one, very often touch on the back of his hand.

Instead, what it can do as an additional preventive action is to choose, when buying or replacing, one instrument with a long handle.

The longer instruments can be wrapped exactly like the other and, in the event that the dentist use cassettes or trays for sterilization of small size, it will be sufficient to put the instruments in the direction of the longer side

That’sanother reason to choose

new Evofamilyof instruments!


Scientific Update

学术文章

18

SCIENTIFIC UPDATE Management of impacted dilacerated maxillary incisor with strategic positioning of a straightwire appliance


INTRODUCTIONAndreasen et al. [1971] defined dilaceration as the abrupt deviation of the long axis of the crown or root portion of the tooth, which is due to a traumatic non-axial displacement of already formed hard tis-sue in relation to the developing soft tissue [Andreasen et al., 1971]. The knowledge regarding how, where and when the traumatic injury has occurred is very important in order to make a precise diagnosis during the emergency visit, and to adopt the correct and most effi-cient clinical procedure [Ribeiro and Campos, 2009].The aetiology of dilaceration is not fully understood. There are two main explanations of its causes: an acute mechanical injury to the pri-mary predecessor tooth, which causes dilaceration of the underlying developing succedaneous permanent tooth; idiopathic developmen-tal disturbances as the cause of dilacerations, mainly in cases where there is no clear sign or history of traumatic injury [Topouzelis et al., 2010; Smith and Winter, 1981; Jafarzadeb and Abbott, 2007; Stewart, 1978]. The treatment of a dilacerated anterior tooth includes surgical exposure followed by orthodontic traction; endodontic treatment or apicectomy may be associated [Lin, 1999]. Alternatively, treatment often involves surgical removal followed by orthodontic therapy to either close the space or keep it open until the patient reaches an age when implants or prosthetic treatment can be performed.This article presents a patient with a dilacerated maxillary right cen-tral incisor managed with a multidisciplinary approach. The dilacera-ted tooth was disimpacted and aligned using a simple and effective method by strategic positioning of a straightwire appliance.

CASE REPORTDiagnosis and treatment planA 9-year-old Caucasian girl was referred by her general dentist to our examination. The chief concern was the non-eruption of the ma-xillary right central incisor. His parents mentioned a traumatic injury affecting the frontal oral region when the child was 5 years old.Clinical examination revealed that the patient had a symmetric face and brachyfacial type.Intraoral examination showed an early mixed dentition and an Angle Class I molar and canine relationship. The impaction of the maxillary right central incisor had resulted in drifting of the adjacent teeth with

a resultant midline deviation (Fig. 1). A metal chain showed through the gingival tissues of tooth 1.1 area because her general dentist had performed a surgical exposure and applied a traction chain. We per-formed an occlusal radiograph that showed a bracket bonded to the palatal surface of the impacted tooth (Fig. 2).Palpation of the vestibular mucosa indicated a bulge in the upper anterior area where the dilacerated incisor was probably located. Cephalometric, panoramic and occlusal radiographs revealed that the permanent maxillary right central incisor was impacted and di-splayed root dilaceration. Its apical foramen appeared as a circular radiopaque area with a dark radiolucent spot in the center, known as the ‘Bull’s eye’. The tooth’s morphology and position were clearly visible in the lateral cephalometric radiograph showing a horizontally displaced tooth, with its crown rotated more than 100° from normal, and its incisal tip just below the floor of the nose (Fig. 3).The palatal surface of the crown was facing forward “like the hand of a traffic policeman” and the root was shortened. It was not possible to exactly define the root apex on the conventional radiographs. The analysis of the lateral cephalometric radiograph disclosed a ske-letal Class II occlusion with a balanced facial pattern (Table 1).The aim of the treatment was to guide the impacted incisor into proper alignment with the adjacent incisor teeth and to re-create a complete anterior dentition. The treatment aimed at obtaining pro-per crown and root alignment without furtherroot damage while maintaining the vitality and integrity of the root of the dilacerated tooth. The purpose of the treatment was, also, to extrude the tooth with all its supporting tissues (alveolar bone and attached gingiva) and to evaluate the long-term gingival and perio-dontal conditions. The approach was multidisciplinary involving a combined surgical/orthodontic treatment.

Treatment progressA STEP (Leone®, Florence, Italy) straightwire appliance was placed on the maxillary permanent teeth to create space for the impacted central incisor (Fig. 4). Prefabricated Ni-Ti, round section, 0.014 and 0.016-inch arch wires were used to align and to level the maxillary anterior teeth. Then an open-coil spring was positioned on 0.018

Management of impacted dilacerated maxillary incisor with strategic positioning of a straightwire appliance

ABSTRACT Aim:To describe the orthodontic management of root dilaceration of an impacted maxillary tooth following trauma to its deciduous predecessors, to show the clinical management of root dilaceration of a maxillary central incisor and describe how the dilacerated tooth was successfully moved into alignment in a young patient with a proper multidisciplinary approach, using the simple and effective straightwire technique. Case report: After surgical exposure and orthodontic traction, the impacted dilacerated tooth was brought to alignment in the arch. The patient’s chewing and speech function, and aesthetics were restored. The radio-graph shows that the root is finally straight and relatively well developed. This approach avoids extraction and prosthetic rehabilitation of the dilacerated tooth.

Author D. Celli.A. L. Grego, S. Sferra, R. Deli Catholic University ofSacred Heart, RomeItaly

e-mail: [email protected]

KEY WORDS dilacerated teeth; straightwire appliance;impacted maxillary central incisor.

TO CITE IN THIS ARTICLE: Celli D, Greco AL, Sferra S, Deli R. Management of impacted dilacerated maxillary incisor with strategic positioning of a straightwire appliance. Eur J Paediatr Dent 2015; 16(3): 191-196.


Fig.2a

Fig.3a

Australian archwire between teeth 2.1 and 1.2 to open up space in the arch to full availability for the dilacera-ted tooth.After adequate space was obtained and the tooth be-gan to erupt, the surgery was planned. Surgical expo-sure of the permanent maxillary right central incisor ensued with apical repositioning flap, so that a button could be bonded onto the labial tooth surface. The placement of a button on the labial surface allows for better palatal movement of the crown (Fig. 5). Ortho-dontic traction of the permanent maxillary right cen-tral incisor was accomplished by attaching the traction chain to archwires.Alignment and leveling was then continued using a 0.020 Australian archwire with a vertical occlusal step

with an eyelet on extrusion axis. Traction was activated changing the elastic cotton thread every 2 weeks un-til the crown of the permanent maxillary right central incisor appeared properly oriented in the oral cavity. The traction force was about 40 g. This treatment stage lasted 6 months (Fig. 6).Next, the button was removed from the labial surface of the permanent maxillary right central incisor and a bracket was bonded. Prefabricated round section Ni–Ti archwires with 0.014 and 0.016 inches were used again, in sequence, on the upper teeth.In the same time a straightwire appliance was placed on the mandibular permanent teeth. After that, Australian 0.018 and 0.020 inch archwire were used for the total alignment of the permanent

Pre-treatment Post-treatmentSNA 81 82SNB 76,5 78ANB 5,5 4Wits appraisal 2 0SN/Go-Gn 34 37FMA 26 28SN/ANS-PNS 8 14ANS-PNS / Go-Gn 22 23+1 / ANS-PNS 112 118IMPA 102 96-1 / A-Pg 2 2+1 / A-Pg 8 4OVJ 5 2OVB 4 2

Fig.2bFig.2a

Fig.3a Fig.3b

Fig.1a

Fig.1f

Fig.1b

Fig.1g

Fig.1c

Fig.1h

Fig.1d

Fig.1e

Fig.1i

Fig. 1(a-i) Pre-treatment ex-traoral and intraoral photographs. Fig. 2(a-b) Pre-treatment pano-ramic and maxillary occlusal radiographs.

Fig. 3aPre-treatment cepha-logram showing the dilacerated maxillary incisor ; Fig. 3b Celophametric tracing

Table 1Cephalometric data.

20



Fig.4a Fig.4b Fig.4c

Fig.4d Fig.4e Fig.4f

maxillary right central incisor. The right central incisor was brought closer to align-ment, so an orthodontic bracket was bonded upside down on the labial surface to initiate labial root torque using a 0.019 x 0.025 Ni-Ti archwire. The strategic po-sitioning of the bracket allowed a better position of the tooth root and harmonic gingival margin of the two central incisors (Fig. 7).Treatment continued with a 0.019 x 0.025-inch SS wire with tie-back. After about 3 months the bracket on the 1.1 was repositioned normally. The finishing stage was performed by 0.018 Australian archwire.

Treatment resultsAfter 26 months of treatment the brackets were re-moved and permanent retention was bonded to the lingual surface of the lower anterior teeth. At the end of the treatment, the free and attached gingiva of the

dilacerated tooth appeared acceptable (Fig. 8). The dilacerated impacted teeth was properly aligned in the dental arch restoring the masticatory, phonatory functions and patient’s aesthetics. The root appears ra-diographically aligned and not severely compromised (Fig. 9-11). The patient was referred to the conserva-tive dentist for restoration of the incisal margin. The one-year follow-up showed a good maintenance of the result. Aesthetic periodontal surgery and a prosthetic treatment might be recommended in adulthood (Fig. 12).

DISCUSSIONMost studies of dilaceration have concerned the ma-xillary central incisors, as was the case in the present study. McNamara et al. [1998] successfully aligned di-lacerated maxillary central incisors planning a therapy that encompassed endodontic treatment and apico-

Fig.5a

Fig.5b

Fig.6a


Fig.6b Fig.6c

Fig. 4(a-f) Intraoral view before surgery. Fig. 5(a-b) Surgical exposure of the impacted tooth.

Fig. 6(a-f)Progress of the ortho-dontic traction.


Fig.8m

ectomy. Dilacerated impacted teeth can be properly aligned in the dental arch by appropriate treatment, which frequently requires cooperation among ortho-dontists, periodontists, paedodontists, endodontists, and/or prosthodontists. In the present study, no endo-dontic treatment or apicoectomy was needed during or after treatment, as has sometimes been required in similar cases.A dilacerated tooth is said to be more resistant to ex-trusion than a tooth with a normal root, making the apical area more prone to resorption. However, in our patient, no severe root resorption could be detected, suggesting that, in the case of dilaceration, root resorp-tion can hardly be predicted. Radiographic checkups during orthodontic traction are advisable [Cozza et al., 2005].

The success rate of an impacted dilacerated tooth ali-gnment mainly depends on the following factors:- position and direction of the impacted tooth;- degree of root formation;- degree of dilaceration;- availability of space for the impacted tooth. Machtei et al. [1990] also include the condition of the periodontium. McNamara et al. [1998] under-line the decisive significance of the post-trauma-tic condition of the Hertwig’s epithelial root she-ath for a successful therapeutic outcome, since normal root development depends on its integrity. A dilacerated tooth with an obtuse inclination angle, a lower position in relation to the alveolar crest com-bined with an incomplete root formation has a better prognosis for orthodontic traction.

Fig.7a Fig.7c

Fig.7b Fig.7d

Fig.8a Fig.8b Fig.8c Fig.8d

Fig.8e Fig.8f Fig.8gFig.8h

Fig.8i Fig.8l

Fig. 7(a-d) Strategic positioning of the bracket bonded upside down. Fig. 8(a-o) Records after debonding.

Fig.8n

Fig.8o

22



CONCLUSIONThe factors that determined a positive outcome are the following.- The strategic placement of the straightwire appliance allows correct positioning of the tooth root and har-monic gingival margin of the two central incisors.- The placement of buttons on the labial surface allows the palatal movement of the crown.- The use of light and constant orthodontic forces (40 g) exerted by means of traction chain and elastic cot-ton thread before and NiTi superelastic wires.

REFERENCES › Andreasen JO, Sndström B, Ravn JJ. The effect of traumatic injuries to primary teeth on their permanent successors. A clinical and histologic study of 117 injured permanent teeth. Scand J Dent Res 1971 ; 79:219–83.› Cozza P, Marino A, Condo, R. Orthodontic treatment of an impacted dilacerated maxillary incisor : a case report. J Clin Pediatr Dent Winter 2005 ; 30(2):93-7, .› Jafarzadeb H, Abbott P. Dilaceration: review of an endo-dontic challenge. J Endod 2007 ; 33:1025–30.

› Lin YTJ. Treatment of an impacted dilacerated maxillary central incisor. Am J Orthod Dentofacial Orthop 1999 ; 115:406–9.› Machtei EE, Zyskind K, Ben-Yehouda A. Periodontal con-siderations in the treatment of dilacerated maxillary inci-sors. Quintessence Int 1990; May 21(5):357-60.› McNamara T, Woolfe SN, McNamara CM. Orthodontic management of a dilacerated maxillary central incisor with an unusual sequel. J Clin Orthod 1998; 32:293–7.› Ribeiro D, Campos V. Prevalence of sequelae in the per-manent anterior teeth after trauma in their predecessors: a longitudinal study of 8 years. Dental Traumatology 2009 ; 25:300–304.› Stewart DJ. Dilacerate unerupted maxillary central inci-sors. Br Dent J 1978 145: 229–33.› Smith DMH, Winter GB. Root dilaceration of maxillary incisors. Br Dent J 1981; 150:125–7.› Topouzelis N, Tsaousoglou P, Pisoka V, Zouloumis L. Di-laceration of maxillary central incisor : a literature review. Dental Traumatology 2010; 26:427–433.› White SC, Pharoah MJ, Oral radiology: principles and in-terpretation. 4th ed., St Louis: Mosby; 2000.

Fig.9


Fig.12e Fig.12f Fig.12g Fig.12h

Fig.12i Fig.12l

Fig.12d

Fig.10a Fig.10b Fig.11

Fig. 9 Post-treatment pa-noramic radiograph showing no signs of root resorption of the aligned left central incisor.

Fig. 10a A Post-treatment cephalogram proving that penetration of the cortical bone from the dilacerated root apex was avoided; b cephalometric tracing.

Fig. 11 Superimpositions of the lateral cephalo-grams showing the dental and skeletal changes during or-thodontic treatment: superimposition on the anterior cranial base (S-N).

Fig. 12 (A-L) One year post-treatment.

Article courtesy of: European Journal OfPaediatric Dentistry; Vol 16/3 - 2015 © Ariesdue



摘要目的：描述由于前乳牙创伤而引起的上颌切牙阻生弯曲的正畸操作方案，展示上中切牙牙根弯曲的临床操作，叙述如何通过合适的多学科方法用一个最简单而有效的直丝弓技术把一个年幼患者的弯曲牙成功地移到对齐于牙列的位置。

病例报告通过手术暴露和正畸牵引后，阻生弯曲牙移到于牙列排齐。患者的咀嚼功能、说话功能和美观度均得到恢复，X光片显示，牙根最后变直并相对得到发育。这个方法避免了弯曲牙的拔除和假体修复。

Author D. Celli.A. L. Grego, S. Sferra, R. Deli 意大利罗马圣心天主教大学

e-mail: [email protected]

关键词：弯曲牙；直丝弓矫治器；阻生上中切牙。

引言 Andreasen等学者在[1971]年给弯曲牙下了一个定义：弯曲牙就是牙齿的牙冠长轴与牙根比例有严重偏差，这是由于已经形成的硬体组织相对于发育中的软组织有一个创伤性非轴向移位而造成的。在急诊中，知道在何时、何地、如何造成创伤对于做出一个精确的诊断是非常重要，如此才可以采用正确的最有效的临床步骤。[Ribeiro 和 Campos在 2009年提出]。目前还尚未完全理解弯曲牙的病因，现在有两种主流的解释;由于乳牙受到急性机械性创伤而导致下层正在发育的恒压变弯曲；特发性发育障碍引起的牙弯曲，这种情况，一般均在没有明显的创伤痕迹和创伤史的病例中[Topouze-lis 等在2010年报道; Smith 和Winter在 1981年报道; Jafarzadeb 和Abbott也在2007年报道; Stewart在1978年报道]。弯曲牙的治疗程序包括手术暴露和之后的正畸牵引，还可能有配合性的根管治疗和根尖切除术 [Lin,在1999年提出]。其他的治疗方案经常包括外科手术摘除，之后进行正畸治疗来闭合空间，或者保留空间一直等到患者可以接受种植或假体治疗的年龄。本文介绍了如何把一个多学科方法的操作流程用在一个有弯曲上中切牙的患者上。通过运用一个简单而有效的直丝弓矫治器定位技巧，在实验的结果，弯曲牙已被去除阻力，并最终被排齐。

病例报告诊断和治疗方案一个9岁的白人女孩被她的牙医推荐给我们的试验，患者主要症状是上右中切牙阻生，她的父母提到，孩子在5岁的时候有过一次跌打性损伤擦伤了她的前额口腔区域。

文章来源: Celli D, Greco AL, Sferra S, Deli R. Management of impacted dilacerated maxillary incisor with strategic positioning of a straightwire appliance. Eur J Paediatr Dent 2015; 16(3): 191-196.

临床检查显示患者有对称的颅面部。口腔检查显示有早期的牙列混合不齐，犬牙和磨牙之间形成一个I类角。右上中切牙的阻生导致其远离了邻近牙，最终出现中线偏差（图1）。1.1牙区的牙龈组织上有根金属链，因为她的牙医已经给她进行了手术暴露并放置了一根牵引链。我们给患者做了X咬合线片，结果显示有一个支架和阻生牙的颚面粘合在一起（图2）。前庭黏膜的触诊显示，在上前方有个隆起的部位，很有可能就是阻生牙所在位置。根据X头影、全景X光片和咬合面结果发现，上颌右侧中切恒牙阻生并显示牙根弯曲。根尖孔显示有一个圆形区域，在该圆形区域的中心还有一个可透射暗斑，该暗斑被称为“靶心”。外侧牙齿的位置和形态清晰可见，头部测量的X线片显示了一颗平躺的牙齿，牙冠从正常牙冠的位置旋转了100°，牙尖就在鼻腔基下方(图3)。牙冠的颚面朝向前方，就像交通指挥警察的手一样，牙根缩短；因此不可能精确地在X成像上确定根尖。 X头影的侧面分析显示一副II型闭塞骨架和均衡的面型（表1）。治疗的目标是引导阻生牙到正确地于邻近的牙对齐，并重新打造一个完整的前牙。治疗的目的是在维持阻生牙牙根的活力和完整性的前提下避免牙根进一步受损，并实现对牙冠和牙根的正确定位。治疗的目标还有，挤压其所有的周围组织（牙槽骨和附着龈），并评估牙龈和牙周的长期状况。这是一个综合了多个学科的治疗方法，是个外科手术和正畸治疗的结合。

治疗过程为了给阻生中切牙疼出空间，我们在上颌恒牙上固定了一个STEP（由意大利佛罗伦萨的

24

SCIENTIFIC UPDATE 阻生弯曲上切牙正畸中的直丝弓矫治器定位技巧


Leone公司生产）直丝弓矫治器(图4). 用预制的Ni-Ti 0.014 和 0.016英寸的弓丝来调整和整平上颌前牙。然后，一个开放式的螺旋弹簧被固定在2.1号牙和 1.2号牙之间的0.018英寸澳大利亚弓丝上，以便于在弓内给弯曲牙打开足够的空间。获得足够的空间后，阻生牙亦开始长出，手术计划已经完成。上颌中切恒牙手术暴露后接着进行顶端折翼重新定位，如此，在唇齿面上可以粘贴一个按钮。唇面上的按钮可以使牙冠颚更好的运动（图5）。通过连接牵引链和弓丝完成了右上中切恒牙的正畸牵引。之后，用0.020英寸的澳大利亚弓丝与挤压轴上的小孔来垂直咬合并继续进行排齐和整平；

通过每2周更换一次弹力棉线，牵引被激活，直到上颌中切恒牙牙冠在口腔的正确位置上为止。牵引力大约40克，这个治疗阶段持续了6个月（图6）。接下来，从上颌右中切恒牙的唇面移除了按钮，并粘合了一个支架。预制的Ni–Ti 0.014 和0.016英寸的圆弓丝被用在上牙上。与此同时，在下颌恒牙上放置了一个直丝弓矫治器。之后的整个上颌右中切牙排齐过程都用 0.018 和0.020 英寸的澳大利亚弓丝。右中切牙被调整到里中切线更近的地方，一个正畸支架被倒置在弯曲牙的唇面上，用一根Ni-Ti 0.019 x 0.025的弓丝来启动唇根扭矩。这种战略性的支架定位可以保证两颗中切牙更好

Pre-treatment Post-treatmentSNA 81 82SNB 76,5 78ANB 5,5 4Wits appraisal 2 0SN/Go-Gn 34 37FMA 26 28SN/ANS-PNS 8 14ANS-PNS / Go-Gn 22 23+1 / ANS-PNS 112 118IMPA 102 96-1 / A-Pg 2 2+1 / A-Pg 8 4OVJ 5 2OVB 4 2

Fig.1a

Fig.1f

Fig.1b

Fig.1g

Fig.1c

Fig.1h

Fig.1d

Fig.1e

Fig.1i

图 1(a-i) 治疗前口内和口外照片。图 2(a-b) 治疗前的全景和上颌咬合X线片。

图 3a治疗前的X线投影显示弯曲的上切牙。图 3b Celophametric tracing

Table 1Cephalometric data.

Fig.2a Fig.2b

Fig.3a Fig.3b



Fig.4dFig.4e Fig.4f

的牙根位置和协调的龈缘（图7）。用一根带有一个系带的 0.019 x 0.025英寸的不锈钢丝继续治疗，约3个月后，1.1齿上的支架被放正。最后一步用的是 0.018英寸的澳大利亚弓丝。

治疗结果治疗26个月后，支架被摘除，恒牙被粘合在下前牙的靠舌面上。在治疗结束时，独立的已连接的弯曲牙牙龈似乎到了可以接受的程度(图8)。阻生弯曲牙已经被适当地排齐在牙列中，恢复了患者的咀嚼、发音和审美功能。从X光线角度来讲，牙根最终被排齐并且没有受到严重的损害（图9至11）。患者后来被转至原来的牙医处进行切缘恢复。为期一年的

随访发现维持了良好的手术结果。在成年后，患者有可能需要接受牙周审美手术和修复治疗 (图12)。

讨论如这项研究一样，很多关于弯曲牙的研究中提到了上颌中切牙。 McNamara 等用一个综合了根管治疗和根尖切除术的治疗方法，在 [1998]年成功地排齐了弯曲的上颌中切牙。通过一个适当的治疗方案，阻生弯曲牙可以被排齐在牙列中，这往往需要正畸医生、牙周医生、牙髓医生和假牙医生之间的合作。不同于一些其他类似的案例，在本次实验中没有必要进行牙髓治疗和根尖切除术。

Fig.5a

Fig.5b



图 4(a-f) 术前口内视图。图 5(a-b) 阻生牙的手术暴露。

图 6(a-f)正畸牵引的进度。

Fig.4d

26

SCIENTIFIC UPDATE 阻生弯曲上切牙正畸中的直丝弓矫治器定位技巧


弯曲牙被认为比正常牙根的牙更耐挤压，使得心尖区更容易再吸收。但总的来说并没有发现明显的严重的牙根再吸收，需要强调一点，在弯曲牙中，牙根再吸收现象很难被预测。正畸牵引期间最好进行X光线检查 [Cozza 等在 2005年提出]。影响一个阻生弯曲牙的排齐成功率的因素有如下几种;- 阻生牙的位置和朝向- 牙根的形成程度；- 弯曲程度；- 阻生牙的可用空间。 Machtei 等 [1990年的报告中]则认为应该还包括牙周组织的条件，McNamara 等[在1998年的报告中]却强调了牙根外部Hertwig外皮细胞的

伤后条件对一个成功的治疗结果有关键性的作用，因为正常牙根的发育取决于它的完整性。在正畸牵引中，一个钝角倾斜而且位置低于牙槽嵴却有完整成形牙根的弯曲牙会有一个更好的预知结果。

结论决定能否取得一个良好结果的因素如下;- 战略性定位直丝弓矫治器可以正确定位牙根，并且使两颗中切牙的龈缘有较好的协调性。- 按钮放置在唇面上可以使牙冠颚运动不被限制。- 通过牵引链、弹力棉线和超弹性NiTi丝发挥的作用而施加柔和恒定的矫治力(40克)。

Fig.7a Fig.7c

Fig.7b Fig.7d

Fig.8a Fig.8b Fig.8c Fig.8d

Fig.8e Fig.8f Fig.8gFig.8h

Fig.8i Fig.8lFig.8m

Fig.8o

图 7(a-d) 支架倒装固定战略定位。图 8(a-o) 剥离后的记录。

Fig.8n


参考文献› Andreasen JO, Sndström B, Ravn JJ. The effect of traumatic injuries to primary teeth on their permanent successors. A clinical and histologic study of 117 injured permanent teeth. Scand J Dent Res 1971 ; 79:219–83.› Cozza P, Marino A, Condo, R. Orthodontic treatment of an impacted dilacerated maxillary incisor : a case report. J Clin Pediatr Dent Winter 2005 ; 30(2):93-7, .› Jafarzadeb H, Abbott P. Dilaceration: review of an endo-dontic challenge. J Endod 2007 ; 33:1025–30.› Lin YTJ. Treatment of an impacted dilacerated maxillary central incisor. Am J Orthod Dentofacial Orthop 1999 ; 115:406–9.› Machtei EE, Zyskind K, Ben-Yehouda A. Periodontal con-siderations in the treatment of dilacerated maxillary inci-sors. Quintessence Int 1990; May 21(5):357-60.› McNamara T, Woolfe SN, McNamara CM. Orthodontic management of a dilacerated maxillary central incisor

with an unusual sequel. J Clin Orthod 1998; 32:293–7.› Ribeiro D, Campos V. Prevalence of sequelae in the per-manent anterior teeth after trauma in their predecessors: a longitudinal study of 8 years. Dental Traumatology 2009 ; 25:300–304.› Stewart DJ. Dilacerate unerupted maxillary central inci-sors. Br Dent J 1978 145: 229–33.› Smith DMH, Winter GB. Root dilaceration of maxillary incisors. Br Dent J 1981; 150:125–7.› Topouzelis N, Tsaousoglou P, Pisoka V, Zouloumis L. Di-laceration of maxillary central incisor : a literature review. Dental Traumatology 2010; 26:427–433.› White SC, Pharoah MJ, Oral radiology: principles and in-terpretation. 4th ed., St Louis: Mosby; 2000.


Fig.12e Fig.12f Fig.12g Fig.12h

Fig.12i Fig.12l

Fig.12d

Fig.9 Fig.10a Fig.10b Fig.11


图 9 治疗后的全景X线片显示被排齐的上中切牙根没有再吸收现象。

图 10a 治疗后的X头影证明避免了根尖的皮骨质渗透； b 头影测量跟踪。

图 11 横向X线头影测量表明正畸治疗过程中的牙齿和骨骼的变化：前颅底部的上面。

图 12 (A-L) 治疗一年后。

28

SCIENTIFIC UPDATE Mineral trioxide aggregate in treatment of permanent teeth with open apex and endo-perio lesions. A case report


Mineral trioxide aggregate in treatment of permanent teeth with open apex and endo-perio lesions. A case report

ABSTRACTBackground Mineral trioxide aggregate (MTA), one of the latest materials applied in dentistry, has a variety of potential uses. Numerous studies emphasise its biocompatibility with periodontal and hard tissues, as well as excellent sealing and regeneration abilities. Case report This article describes the successful therapy of immature mandibular premolars with large open apex, resorption, and endo-perio lesions. In the presented case, the canal was filled with the MTA material. At present, the treated tooth is asymptomatic, and a three-year follow-up radiographic examination demonstra-ted the dramatic regeneration of periradicular tissues and the new hard tissue formation in the area of the affected teeth.

Author K. OLCZAKH. PAWLICKA Department of Endodontics, Medical University of Lodz, Poland

e-mail: [email protected] KEY WORDS Endo-perio diseases; Mineral trioxide ag-gregate; Open apex.

INTRODUCTION

Endodontic treatment of permanent teeth with incom-plete root apex development, apical periodontitis and bone loss poses a challenge to the dentist [Andreasen et al., 2002; Felippe et al., 2005]. For many years, mul-ti-appointment therapy has been performed using cal-cium hydroxide dressings. Such a treatment is however long-term and associated with the risk of root weake-ning and tooth fracture. Additionally, there is a fear that the patient will not see the dentist regularly to change temporary dressings [Andreasen et al., 2002]. In this situation, the application of mineral trioxide aggregate (MTA) seems to be a better treatment [Parirokh and Torabinejad, 2010]. MTA was developed in the early 90ties at the Loma Linda University in the USA, and in 1998 was introduced in the dental market as ProRoot MTA® (Dentsply Tulsa Dental Specialties, Tulsa, USA) [Torabinejad et al., 1994; Torabinejad et al., 1995]. Since that time, it has been successfully used in different clini-cal cases such as apexification of teeth with incomplete root development, direct pulp capping, pulpotomy and pulpectomy, repair of perforations of root and pulp chamber floor, treatment of tooth resorption, and re-trograde canal filling during root resection [Roberts et al., 2008]. Numerous reports emphasise that MTA may improve the outcome of not only endodontic treat-ment but periodontal as well [Katsamakis et al., 2013; Srinivasan et al., 2009].

REPORT

A 12-year-old female patient was referred to the En-dodontic Clinic of the Medical University of Lodz (Po-land) to continue root canal treatment that had been started two years earlier at a private dental office. A

medical history revealed that the girl suffered from asthma and received inhaled corticosteroids. On the basis of earlier treatment records it was found that after trephination of tooth #35, the calcium hydroxide dressing was inserted into the canal. Since then (1.5 year), no endodontic procedures were performed. On admission to the Endodontic Clinic, an extensive cavity within the tooth crown filled with a temporary dres-sing and a deep pathological pocket were visible. The dental radiograph showed the incompletely developed root apex with a very wide apical foramen, thin root wall, a bony pocket and chronic periradicular periodon-titis around tooth #35 indicating an endo-perio lesion (Fig. 1). Due to a very bad condition of the tooth and a concomitant malocclusion, the patient was referred to the orthodontist for consultation whether tooth #35 should be treated or extracted for orthodontic reasons. The specialist diagnosed severe retrognathia and tooth abnormalities (crowding of upper teeth), and advised the endodontist to treat and retain tooth #35 as long as possible. The involved tooth was trea-ted at the Endodontic Clinic using a dental operating microscope and a rubber dam for tooth isolation. After the removal of the dressing, a hemorrhagic exudate from the canal was observed. Approximate working

TO CITE IN THIS ARTICLE: Olczak K, Pawlicka H. Mineral trioxide aggregate in treatment of permanent teeth with open apex and endo-perio lesions. A case report. Eur J Paediatr Dent 2015; 16(4): 287-289.

Fig. 1Preoperative radio-graphic examination showing radiolucency at the apical and mesial area of tooth #35. The apex is clearly open.Fig.1


Fig. 2 Postoperative radiograph showing the root canal filled with MTA.

Fig. 3 Follow-up after 1 year after therapy completion.

Fig. 4 Follow-up after 3 years after therapy completion.

length was established with an electronic apical locator and radiographs. The root canal was cleaned with 2.5% NaOCl and NaCl. Next, the canal was delicately dried with paper points and the calcium hydroxide dressing (Calxyl®, OCO Präparate) was placed for two weeks. At the first appointment, instructions on oral hygiene were given to the patient and rinsing of the oral cavity was recommended after each application of inhaled corticosteroids. The patient had in fact many teeth with fillings and carious lesions.After two weeks, the calcium hydroxide dressing was removed by instrumentation and irrigation with 2.5% NaOCl and 17% EDTA. Additionally, ultrasonic activa-tion of a #25 K-file passively placed in the canal was carried out to improve canal debridement and Calxyl®. The canal was finally filled. At first, the periapical region of the canal was filled with small pieces of resorbable collagen sponge (Biokol®, Stalmed). Next, small por-tions of the MTA material were inserted into the canal and condensed vertically using pluggers. In this way, the entire canal was filled with MTA. In the region of the pericoronal canal orifice, a sterile cotton pellet satura-ted with physiological saline was placed on MTA (Fig. 2). A tight dressing (GC Fujii Triage®) was inserted into the crown. After two days, the cotton pellet was remo-ved and the permanent filling (Tetric Evo Ceram® Ivo-clar Vivadent®) was placed. Root canal retreatment of tooth #36 was also carried out. The patient visited the endodontist again after the following one and three years, despite the recommended earlier follow-ups. Clinical examination did not present any pathological changes in the tooth and the periodontal ligament. On the basis of the radiograph, bone regeneration and he-aling of apical periodontitis were observed (Fig. 3, 4).

DISCUSSION

Modern endodontics offers different treatment pos-sibilities, even in very complicated endo-perio lesions of immature teeth [Felippe et al., 2006; Kottoor and Velmurugan, 2013; Parirokh and Torabinejad, 2010]. In the presented case report, the incompletely developed root apex with a large open apical foramen, external root resorption, endo-perio lesions, extensive apical periodontitis involving the mesial side of the alveolar process along with the bony pocket were diagnosed. Additionally, a long time that had passed from the tre-phination to the final root canal filling was considered a

poor prognostic factor. After preparing an access cavity to the tooth at the private dental office, a calcium hy-droxide dressing was inserted into the canal and was left in the tooth for a period of 1.5 year. Long-term calcium hydroxide dressings weaken the root structu-re, possibly by naturalizing, denaturing, or dissolving the acidic components of dentine [Andreasen et al., 2002]. Moreover, the inadequate dressing within the tooth root and the crown undoubtedly contributed to ongoing bacterial infection. Despite such an unfa-vourable situation, the treatment was successful. Both, the root canal and periodontal treatment as well as canal filling with the MTA material were the factors which determined the success of therapy. Numerous studies emphasise very good biocompatibility, and anti-bacterial and antifungal activity of this material [Ferk et al., 2011; Al-Kahtani et al., 2005; Srinivasan et al., 2009]. MTA also possesses excellent sealing properties and the ability to harden in the presence of fluids including blood [Tang et al., 2002; Torabinajed et al., 1994]. MTA has low solubility in tissue fluids (less than 3%), the-refore it does not undergo resorption [DaSilva et al., 2010]. MTA induces proper growth and development of the new root, bone and periodontal cells including periodontal ligament [Guven et al., 2007; Katsamakis et al., 2013]. MTA has stimulated the expression of oste-ocalcin, alkaline phosphatase, collagen type 1, and bone sialoprotein in cementoblast cell cultures [Hakki et al., 2009; Hakki et al., 2012]. The research also indicated that after MTA application, the human periodontal fi-broblasts presented attachment, normal growth, and functions [Hakki et al., 2009; Lin et al., 2004]. A gre-at advantage of this material is its strong alkaline pH and pH-related beneficial therapeutic activity. While hardening, the pH of MTA equals 10.2 and increases up to 12.5 during the first hours [Torabinejad et al., 1994; Torabinejad et al., 1995]. Calcium hydroxide also possesses alkaline pH, however it should not remain in the canal longer than two weeks as this time is op-timal for its antibacterial activity and drying of exuda-te. In the presented case, a short-term placement of calcium hydroxide was justified by the presence of a large amount of exudate and concomitant infection of the root canal and periodontal tissues. MTA filling is a quicker and more effective method than using calcium hydroxide. In the case of canals with an excessively widened apical foramen, it is recommended to create a barrier in the apical region with a resorbable col-

Fig.3Fig.3 Fig.4


30

SCIENTIFIC UPDATE Mineral trioxide aggregate in treatment of permanent teeth with open apex and endo-perio lesions. A case report


lagen sponge and then to condensate small portions of MTA. This procedure prevents excessive extrusion of MTA outside the root to the periapical tissues and enables the material to be condensed [D’Arcangelo et al., 2007]. The root canal with incomplete development of the root and/or its external resorption can be filled with MTA entirely or in two stages, in which MTA is in-serted into the periapical part, and the remaining canal is filled with gutta-percha and sealer (most frequently thermoplastic gutta-percha is used) [D’Arcangelo et al., 2007]. In our patient, the entire canal was filled with MTA because the root (and the canal) was very short and the root walls were thin. Due to the unfavourable ratio of the crown length to the root length, future prosthodontic reconstruction (post and core crown) was excluded. The cavity within the crown and the co-ronal part of the root were restored with light-cured composite, which strengthens the tooth tissues. After filling the entire or part of the canal with MTA, radiological examination and follow-ups are recom-mended. MTA due to 20% bizmuth oxide content is radiopaque [Song et al., 2006].

CONCLUSION

To sum up, the application of MTA in the treatment of nonvital teeth with the incompletely developed root and/or its external resorption and apical periodontitis involving endo-perio lesions is an efficient method of treatment, resulting in a good state of the tooth re-tained in the oral cavity and healing of inflammatory lesions in the bone and periodontium. Short-term tre-atment is an additional advantage of the MTA material.

REFERENCES

› Al-Kahtani A, Shostad S, Schifferle R, Bhambhani S. In vitro evaluation of microleakage of an orthograde apical plug of mineral trioxide aggregate in permanent teeth with simu-lated immature apices. J Endod 2005; 31:117-119.› Andreasen JO, Farik B, Munksgaard EC. Long-term calciu-mhydroxide as a root canal dressing may increase risk of root fracture. Dent Traumatol 2002; 18: 134-137.› D’Arcangelo C, D’Amario M, L’Aquila Ch. Use of MTA for orthograde obturation of nonvital teeth with open apices: raport of two cases. Oral Surg Oral Med Oral Pathol 2007; 104: e98-e101.› Dominguez M, Munoz L, Aznar MT. Study of calcium hydroxide apexification in 26 young permanent incisors. Dent Traumatol 2005; 21:141-145.› Felippe MC, Felippe WT, Marques MM, Antoniazzi JH. The effect of renewal of calcium hydroxide paste on the a exification and periapical healing of teeth with incomplete root formation. Int Endod J 2005; 38: 436-442.› Ferk S, Simeon P, Matijevi J, Prpi M, Ani I, Juki K. Antibacte-rial Effect of Mineral Trioxide Aggregate and Amalgam. Acta Stomatol Croat 2011; 45: 8-12. › Guven G, Cehreli ZC, Ural A, Serdar MA, Basak F. Effect of mineral trioxide aggregate cements on transforming

growth factor beta1 and bone morphogenetic protein pro-duction by human fibroblasts in vitro. J Endod 2007; 33: 447–50.› Hakki SS, Bozkurt SB, Hakki EE, Belli S. Effects of mineral trioxide aggregate on cell survival, gene expression asso-ciated with mineralized tissues, and biomineralization of cementoblasts. J Endod 2009; 35:513-519.› Hakki SS, Bozkurt SB, Ozcopur B, Purali N, Belli S. Perio-dontal ligament fibroblast response to root perforations restored with different materials: a laboratory study. Int Endod J 2012; 45: 240-248.› Hayashi M, Shimizu A, Ebisu S. MTA for Obturation of Mandibular Central Incisors with Open Apices: Case Re-port. J Endod 2004; 30: 120-122.› Katsamakis S, Slot DE, Van der Sluis LWM, Van der Wei-jden F. Histological response of the periodontium to MTA: a systematic review. J Clin Periodontol 2013; 40: 334-344.› Kottoor J, Velmurugan N. Revascularization for a necrotic immature permanent lateral incisor : a case report and literature review. Int J Paediatr Dent 2013; 23: 310–316.› Lin CP, Chen YJ, Lee YL, Wang JS, Chang MC, Lan WH, Chang HH, Chao WM, Tai TF, Lee MY, Lin BR, Jeng JH. Ef-fects of root-end filling materials and eugenol on mito-chondrial dehydrogenase activity and cytotoxicity to hu-man periodontal ligament fibroblasts. J Biomed Mater Res B Appl Biomater 2004;71:429–440.› Parirokh M, Torabinejad M. Mineral Trioxide Aggregate: A Comprehensive Literature Review—Part III: Clinical Ap-plications, Drawbacks, and Mechanism of Action. J Endod 2010; 36: 400-413.› Roberts HW, Toth JM, Berzins DW, Charlton DG. Mineral trioxide aggregate material use in endodontic treatment: a review of the literature. Dent Mater 2008; 24: 149–64. › da Silva WJ, Souza PH, Ribeiro EA. Mineral trioxide ag-gregate as root canal filing material: comparative study of physical properties. Rev Odonto Ciênc 2010, 25: 386-390.› Simon S, Rilliard F, Berdal A, Machtou P. The use of mine-raltrioxide aggregate in one-visit apexification treatment: a prospective study. Int Endod J 2007; 40: 186-97.› Song JS, Mante FK, Romanow WJ, Synnkcung K. Chemical analysis of powder and set forms of Portland cement, gray ProRoot MTA, white ProRoot MTA, and grey MTA-Angelus. Oral Surg Oral Med Oral Pathol 2006; 102: 809-815. › Srinivasan V, Waterhouse P, Whitworth J. Mineral Trioxide Aggregate in paediatric dentistry. J Clin Pediatr Dent 2009; 19: 34–47› Tang HM, Torabinajed M, Kettering JD. Leakage evalua-tion of root end filling materials using endotoxin. J Endod 2002; 28: 5-7.› Torabinejad M, Hong CU, McDonald F, Pitt Ford TR. Physi-cal and chemical properties of a new root-end filling ma-terial. J Endod 1995; 21: 349–353. › Torabinejad M, Rastegar AF, Kettering JD, Pitt Ford TR. Dye leakage of four root end filling materials: effects of blood contamination. J Endod 1994; 20: 159-163.

32

SCIENTIFIC UPDATE 三氧化矿物骨料在治疗根尖开口并伴有牙周内切病变恒牙中的应用一个病例报告


引言

对牙医来说，根尖发育不完整、根尖周炎和骨量流失的情况在治疗恒牙牙髓的过程中是个很大的挑战 [Andreasen 等在2002年报告；Felippe 等也在 2005年提出]。多年来，多种预约治疗一直把氢氧化钙作为敷料来使用，但是这种治疗方法周期长，而且会带来牙根弱化和齿断裂的风险。再者，还有一种风险就是，患者有可能会不定期去看牙医进行更换临时敷料 [Andreasen 等在 2002年提出]。在这种情况下，运用三氧化矿物骨料似乎是一个更好的治疗方法 [Parirokh 和Torabinejad在2010年提出]。三氧化矿物骨料在90年代早期由美国的罗马琳达大学研发出来，并在1998年以ProRo-ot MTA为名被引进牙科市场（由美国塔尔萨市的“Dentsply Tulsa Dental Specialties”公司生产）[Torabinejad 等在 1994年报道; Torabinejad 等在1995年报道]。从那以后，它被成功地应用在多个临床病例中，如根系发育不完整牙的根尖诱导成形术、直接盖髓术、活隋切断术和牙髓摘除术，牙根穿孔和根髓室底板的修复，再吸收牙的治疗和牙根切除术后的逆行根管填充[Roberts 等在 2008年报道]。大量的报告指出，MTA不仅能够提高牙髓疾病的治疗结果，还能改善牙周疾病的治疗结果 [Katsamakis 等在2013报告; Srinivasan 等在 2009年报道]。

病例报告一个12岁的女性患者被转诊至波兰罗茨医科大学的牙髓诊所继续根管治疗，两年前，她在一个私人牙科诊所开始接受治疗。病例显示，女童患有哮喘，并接受过吸入性激素治疗。之前的治疗记录表明，患者的35号牙齿通过环钻后，在根管中填充了氢氧化钙敷料。从那以后（1年半），没有再进行过根管治疗。入住到牙髓诊所时，可见一个宽阔的牙洞中填充了临时敷料，还有一个很深的病变口袋。牙科X光片显示，牙根先尖发育不完整且有一个宽的根尖孔，薄牙根壁，骨骼突出的牙周袋和35号牙

三氧化矿物骨料在治疗根尖开口并伴有牙周内切病变恒牙中的应用一个病例报告

摘要背景：三氧化矿物骨料（简称MTA），它是口腔医学中最新被应用的材料之一，具有多种潜在用途。大量的研究均强调了它与牙周组织和硬组织的生物相容性、良好的密封性和再生能力。病例报告：本文介绍一个有先尖开口大、再吸收、内切牙周病变的未成熟下前磨牙的成功治疗案例，在这个案例中，病变牙根管中填充了MTA材料。目前，被治疗的牙显示出无症状，并且通过三年的随访放射检查证明了在受影响牙的区域中产生了显著的根尖周组织再生和硬组织新生迹象。

K. Olczak, H. Pawlicka

波兰罗茨大学医学院牙体牙髓科

电子邮箱: [email protected]

关键词 : 内切牙周疾病；三氧化矿物骨料；根尖开口

图 1术前X线片检查显示35号牙的根尖和内侧区域透亮，说明根尖是开口的。

周围的慢性根尖周炎和牙周炎表明有牙周内切病变（图1）。鉴于很糟糕的牙齿状况，外加咬合不良的情况，患者被推荐到正畸医生处，咨询是否继续治疗35号牙或出于正畸原因而进行拔除。专家诊断后，确诊出患者有严重下颌后缩和牙齿异常（上牙拥挤），并建议牙髓病科医师对35号牙进行治疗并保留尽可能长的时间。在牙髓诊所，用牙科手术显微镜和橡皮障对所涉及牙进行了隔离。去除敷料后，在根管中发现了血性渗出物。用电子根尖定位仪和X光片测定了大致工作长度。用2.5%的次氯酸钠和氯化钠溶液冲洗了根管。接下来，用纸尖轻轻地干燥根管，并填入氢氧化钙敷料(Calxyl OCO Präparate)2周。第一次会诊后，医师给患者提供了关于口腔卫生的指导，并要求每次使用吸入性激素后都进行口腔的清洗。事实上患者的牙齿也确实有很多的填充物和龋损伤。

两周后，利用牙科仪器，再用2.5%次氯酸钠和17%的EDTA溶液冲洗，清除了氢氧化钙敷料。此外，为了改善根管的清创效果并更好地清除氢氧化钙敷料，进行超声激活了一个无源性放置于根管中的25号K-锉。最后，根管被重新填充；首先，在根尖区域填充了吸收性胶原海绵(Biokol®, Stalmed)；接下来，少部分的MTA材料被填入根管中并用填充器垂直压紧。用这种方式，MTA材料填充了整个根管。在冠周管口区域，把一个饱和了生理盐水的无菌

文章来源: Olczak K, Pawlicka H. Mineral trioxide aggregate in treatment of permanent teeth with open apex and endo-perio lesions. A case report. Eur J Paediatr Dent 2015; 16(4): 287-289.

Fig.1


Fig.3Fig.3 Fig.4

棉球放置在MTA材料上(图2)。一种密封敷料(GC Fujii Triage®)被填入牙冠内。两天后，棉球被摘除，并放置了永久性填充物(Tetric Evo Ceram由® Ivoclar Vivadent公司生产 )。同时也对36号牙齿的根管进行了治疗。患者在治疗结束后一年和三年时随访了牙髓医师，虽然医生早前建议的随访时间比这个要短，临床检查中没有出现任何关于牙齿和牙周韧带的病理改变。在X光片上，观察到了骨再生和根尖牙周炎愈合的迹象(图3和4)。

讨论现代的根管治疗术给我们提供了不同治疗方法的可能性，即使是在不成熟牙有非常复杂的内切牙周病变的情况下[Felippe 等在 2006报道; Kottoor 和 Velmurugan在2013年报道; Parirokh 和Torabinejad在 2010年报道]，在本病例报告中，发育不完整的根尖有一个很宽的根尖孔，牙根外部再吸收，内切牙周病变和大范围的根尖周炎一直到牙槽骨的内侧。再者，本病例中的患者牙齿的环钻和填充之间的间隔时期很长，这样长的间隔时间被认为是个不良预后因素。在私人牙科诊所中，患者的牙齿被开孔后在根管中填充了三氧化钙敷料，在之后1年半的时间里，三氧化钙敷料一直被留在根管中。而长期把三氧化钙敷料留在牙齿内会使牙根结构变弱，这很有可能是牙质的酸性成分被同化、溶解或被改变性质而造成（由Andereasen等在2002年提出）。此外，在根管和牙冠中没有填充足够的敷料，毫无疑问，这也引发了持续的细菌感染。尽管情况如此不利，但我们的治疗取得了成功；进行根管和牙周治疗并用MTA材料填充根管，这是两个促进治疗成功的重要因素。大量研究表明，此材料有非常好的生物相容性、抗菌性和抗真菌活性[Ferk 等在 2011年提出; Al-Kahtani 等在2005年报道过; Srinivasan 等

在2009年报道过]。MTA还有很好的密封性，并且在有包括血液的液体存在下也有很好的固化能力[Tang 等在2002年报道; Torabinajed 等在1994年报道]。MTA在在组织性溶液中有低溶解性(小于3%)，因此它不耐吸收[DaSilva 等在 2010年报道]。MTA能诱导新根、骨、牙骨细胞包括牙周韧带的正常生长和发育[Guven 等在 2007年报道; Katsamakis 等在2013年报道]。MTA促进了骨钙蛋白、碱性磷酸酶、骨胶原1型和骨粘稠蛋白在骨质细胞培养液中的表现[Hakki 等在 2009年报道; Hakki 等在2012年报道]。该研究还表明，在应用MTA材料后，人的牙周成纤维细胞呈现出连接状态，并恢复了正常功能和正常的发育[Hakki 等在2009年报道; Lin 等在 2004年报道]。这种材料一个很大的优点是其具有强碱性PH值和于PH值相关的有益治疗活性，在硬化过程中，MTA的PH值在最初的几个小时中从10.2增加至10.5[Torabinejad 等分别在1994年和1995年报道]。

氢氧化钙也具有碱性PH值，但它留在根管中的时间不应该超过两周，因为氢氧化钙具有最佳抗菌活性和干燥渗出物的时间为两周。在本病例中，我们使用了短期的氢氧化钙敷料，因为患者牙内有大量的渗出物和根管与牙周组织的伴发性感染。比起使用氢氧化钙，使用MTA材料是个更快更有效的方法，在根尖孔被过度扩大的情况下，建议先用吸收性胶原海绵创建一个屏障，再用少部分的MTA材料聚合。这种方法可以防止MTA材料过度挤压根尖周组织，并使材料易于凝结[D’Arcangelo 等在2007年报道]。牙根根管发育不完整或根外吸收的情况下，可以全部用MTA材料填充，也可分两步填充，就是在根尖部填充MTA材料，剩下的部分用牙胶和密封材料（目前应用得最多的是热塑性牙胶） [D’Arcangelo 等在2007年报道]。在我们的患者牙齿中，整个根管中都填充了MTA材料，因为该患者的牙根(和根管)非常短，并且牙根壁也很薄。由于牙冠和牙根比例的不利性，后来的口腔修复（桩核冠）被排

图 2 术后X光片显示根管中填充了MTA材料。

图 3 治疗结束后1年时的随访。

图 4 治疗结束后3年时的随访。

34

SCIENTIFIC UPDATE 三氧化矿物骨料在治疗根尖开口并伴有牙周内切病变恒牙中的应用一个病例报告


除。通过用光固化复合法来增强牙齿组织的方法修复了冠内的空洞和牙根顶部。

在根管的一部分或整个根管被填充MTA材料后，要求进行影像检查并跟进后期随访。由于MTA材料中有20%的含量为氧化铋，所以具有不投射性[Song 等在 2006年报道]。

结论综上所述，在牙根发育不完整并且根外部有再吸收现象还伴有根尖周炎和牙周病变的非活髓牙中运用MTA材料是个有效的治疗方法，从而使牙齿以一个良好的状态保留在口腔内，并且愈合了骨及牙周组织中的炎症病变。可以实现短期治疗也是MTA材料的一个附加优点。

参考文献› Al-Kahtani A, Shostad S, Schifferle R, Bhambhani S. In vitro evaluation of microleakage of an orthograde apical plug of mineral trioxide aggregate in permanent teeth with simu-lated immature apices. J Endod 2005; 31:117-119.

› Andreasen JO, Farik B, Munksgaard EC. Long-term calciu-mhydroxide as a root canal dressing may increase risk of root fracture. Dent Traumatol 2002; 18: 134-137.

› D’Arcangelo C, D’Amario M, L’Aquila Ch. Use of MTA for orthograde obturation of nonvital teeth with open apices: raport of two cases. Oral Surg Oral Med Oral Pathol 2007; 104: e98-e101.

› Dominguez M, Munoz L, Aznar MT. Study of calcium hydroxide apexification in 26 young permanent incisors. Dent Traumatol 2005; 21:141-145.

› Felippe MC, Felippe WT, Marques MM, Antoniazzi JH. The effect of renewal of calcium hydroxide paste on the a exification and periapical healing of teeth with incomplete root formation. Int Endod J 2005; 38: 436-442.› Ferk S, Simeon P, Matijevi J, Prpi M, Ani I, Juki K. Antibacte-rial Effect of Mineral Trioxide Aggregate and Amalgam. Acta Stomatol Croat 2011; 45: 8-12.

› Guven G, Cehreli ZC, Ural A, Serdar MA, Basak F. Effect of mineral trioxide aggregate cements on transforming growth factor beta1 and bone morphogenetic protein pro-duction by human fibroblasts in vitro. J Endod 2007; 33: 447–50.

› Hakki SS, Bozkurt SB, Hakki EE, Belli S. Effects of mineral trioxide aggregate on cell survival, gene expression asso-ciated with mineralized tissues, and biomineralization of cementoblasts. J Endod 2009; 35:513-519.

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SCIENTIFIC UPDATE Post-extraction application of beta-tricalcium phosphate in alveolar socket


Post-extraction application of beta-tricalcium phosphate in alveolar socket

ABSTRACT Aim The objective of this study was to assess the capacity of beta-tricalcium phosphate to facilitate bone formation in the socket and prevent post-extraction alveolar resorption.Materials and methods After premolar extraction in 16 patients, the sockets were filled with beta-tricalcium phosphate. Six months later, during the implant placement surgery, a trephine was used to harvest the bone samples which were processed for histological and histomorphometrical analyses. Data were gathered on pa-tient, clinical, histological and histomorphometric variables at the extraction and implant placement sessions, using data collection forms and pathological reports. Results Clinical outcomes were satisfactory, the biomaterial was radio-opaque on X-ray. Histological study showed: partial filling with alveolar bone of appropriate maturation and mineralization for the healing time, osteoblastic activity and bone lacunae containing osteocytes. The biomaterial was not completely resorbed at six months.Conclusion Beta-tricalcium phosphate is a material capable of achieving preservation of the alveolar bone when it is positioned in the immediate post-extraction socket followed by suture; it also helps the formation of new bone in the socket. Further studies are needed comparing this technique with other available bioma-terials, with growth factors and with sites where no alveolar preservation techniques are performed.

Author M. Muñoz-Corcuera A.Bascones-Martínez 1 J. Ripollés-de Ramón Department of Oral Medicine and Surgery, School of Dentistry, Madrid Complutense University, Madrid, Spain 1 Professor at dental school KEY WORDS Bone graft; Calcium phosphate; Dental implant; Post-extraction alveolar socket.

INTRODUCTIONIn normal conditions, healthy bone is under continuo-us remodelling and has an effective self-repair capacity. Bone remodelling maintains a continuous balance of bone formation and resorption in a dynamic process that adapts the bone to local forces (1). Above a critical defect size, however, bone cannot be repaired by its own osteogenic activity, and some type of bone grafts must be used (2).Jaw bone defects can be caused by surgical resection, traumatic loss, ossification impairment (in the elderly), periodontal and peri-implant diseases and congenital disorders. These defects may complicate the surgical phase of implant supported rehabilitation treatment due to insufficient bone volume for an adequate im-plantation (3, 4). Jaw bone loss is frequently caused by post-extraction alveolar resorption, a physiological phenomenon which leads to a reduction of the original height and width of the alveolar ridge to a degree that varies among localizations and patients (5). Alveolar ridge preservation techniques have been developed to address the ensuing clinical problem, especially in aesthetic areas (5). They are conducted during or after extraction and are designed to minimize external rid-ge resorption and maximize bone formation inside the socket (5). Measures include autologous bone grafts, allografts, bone of animal origin (xenografts) and syn-thetic bone substitutes (alloplastic grafts), as well as the application of growth factors and gene therapies (3, 4, 6).Beta-tricalcium phosphate (beta-TCP) is widely used as a biocompatible, resorbable and osteoconductive ceramic substitute to repair bone defects. Thanks to its

physicochemical characteristics, it has been successfully used to fill spaces in multiple settings, including biology, veterinary medicine, human medicine and dentistry (7-12). It has also been proposed as a vehicle for growth factors that stimulate bone formation (12, 13). Various authors have reported on its capacity as a biomaterial for bone regeneration in animals and humans (4, 14-21). The study is aimed at evaluating granular beta-TCP in post-extraction sockets in order to measure its bone regenerative potential and its capacity to preserve the original height and width of the alveolar bone for sub-sequent implant placement. Specifically, the study objectives were the following.1. To analyze the clinical and radiological results obtai-ned after placement of the biomaterial in the post-ex-traction socket and at the subsequent insertion of den-tal implants.2. To assess the effectiveness of beta-TCP as bone fil-ling material in the post-extraction socket.3. To perform histological analysis of the amount and quality of bone formed in the dental socket six months after the placement of the biomaterial.4. To determine the percentage of biomaterial parti-cles in contact with patient bone.

MATERIALS AND METHODS

Study design This prospective longitudinal observational clinical stu-dy complied with the principles of the Helsinki Decl0a-ration and was approved by the clinical research ethics committee of the San Carlos Clinical Hospital, Madrid (Spain). All patients in the study were aged over 18 years and scheduled for ≥ 1 premolar extraction due

TO CITE IN THIS ARTICLE: Muñoz-Corcuera M, Bascones-Martínez A, Ripollés-de Ramón J. Post-extraction application of beta tricalcium phosphate in alveolar socket. J Osseointegr 2015;7(1):8-14.


to periodontal disease, caries or fractures and for sub-sequent replacement with dental implant(s) up to a maximum of four premolar extractions (one per qua-drant) per patient. Exclusion criteria were: failure to sign informed consent or commit to compliance with the study appointment schedule; the presence of en-docrine-metabolic disease or chronic, general or local disease; the presence of disease that may be affected by the surgery or by the intraoperative or postopera-tive medication; alveolar socket wall defects; smoking habit of ≥10 cigarettes/day, due to its relationship with implant failure; and treatment with bisphosphonates or antibiotics during the previous month. Patients were recruited from the School of Dentistry clinic (Complu-tense University of Madrid, Spain) and private clinics. A non-probabilistic sampling of consecutive cases was conducted and only patients who met the above cri-teria were included. Sixteen patients were enrolled in the study between March 2008 and July 2010, with a mean age of 44.3 years (standard deviation: 10.74); se-ven were male (44%) with mean age of 39.7 years and nine were female (56%) with mean age of 48 years. No participant (0%) was a daily drinker of alcohol, and two (12%) were daily smokers (of 1-9 cigarettes). A total of 19 upper and 2 lower teeth were extracted (lower teeth were excluded from the analysis because of this small number). After a baseline clinical assessment, all patients received basic periodontal therapy before the surgery and were instructed to maintain good oral hy-giene throughout the study.

Surgical procedureAfter applying local anaesthesia and performing full- thickness buccal and lingual flap elevation, the premo-lar was extracted; a full-thickness flap was elevated to enable a subsequent suture to keep the granules of the material in place. Any granulation tissue present in the socket was removed by surgical curettage, and the socket was filled with 0.5 g beta-TCP KeraOs®

(Keramat, La Coruña, Spain) mixed with physiological saline solution or blood from the same patient (Fig. 1). The socket was then closed by suture using a coronal-ly repositioned flap (Fig. 2). Patients were instructed to rinse daily for two weeks with 0.12% chlorhexidi-ne digluconate. Sutures were removed at 7-10 days post-extraction. During the implant placement surgery (about 6 months after biomaterial placement), a bone biopsy was harvested using a trephine (inner diameter of 2.2 mm, outer diameter of 3 mm), placed in a 10% buffered formalin and sent to the Ceramic Institute of Galicia (Santiago de Compostela, Spain) laboratory for processing.

Histological processingThe specimens were processed to obtain thin unde-calcified sections following Donath’s method and using the EXACT system.Briefly, specimens were fixed in buffered 10% formalin, progressively dehydrated in alcohol and then embed-ded in photopolymerizable methacrylate resin (Tech-novit 7200®, VLC-Heraus Kulzer GMBH, Werheim, Germany). After polymerization, the specimens were cut with a diamond saw and then ground with silicon carbide papers to a width of about 70 microns. After thinning, samples were stained with Levai Laczko stain and chromotrope 2R/Harris haematoxylin. A motori-zed Olympus BX51 microscope with Olympus DP71 camera was used to image the specimens, with Olym-pus D-cell capture software and Photoshop CS3 ima-ge processing software, employing a Wacom Intuos 4 pen tablet and applying the Olympus MicroImage 4.0 program to obtain histomorphometric measurements.Data were gathered on the following.1. Patient variables, sex, age, and consumption of al-cohol and cigarettes (smoker = 1-9, non-smoker = 0 cigarettes/day, to test whether a light tobacco habit af-fects socket healing).2. Clinical variables, biomaterial stability within socket

FEMALES MALES MEAN STANDARD DEVIATION

Age (yrs) 48 39.7 44.3 10.47

Number 9 (56.25%) 7 (43.75%)

Smokers (1-9 cigs/day) 2 (12%) 0 (0%)

Drinkers 0 (0%) 0 (0%)

Fig.1 Fig.2

Fig. 1 Socket filled with a mixture of beta-TCP and patient blood. Fig. 2 Socket closed by su-ture using a coronally repositioned flap.

Table 1 Results. Variables related to the indivi-dual. Mean age 44.3 yrs (standard devia-tion: 10.74); 7 males (44%) with mean age 39.7 yrs and 9 females (56%) with mean age 48 yrs. No participant (0%) was a daily drinker of alcohol, and two (12%) were daily smokers of 1-9 cigarettes.

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and primary implant stability.3. Radiological findings.4. Histological variables at 6 months, degree of bone neoformation in socket, amount and quality of newly formed bone, degree of contact between patient bone and beta-TCP and degree of beta-TCP resorption, all assessed by direct microscopic observation. 5. histomorphometric variables, areas of newly formed bone, immature bone, old bone, biomaterial and lamel-lar bone, bone-biomaterial contact index (perimeter of material in contact with bone / perimeter of whole material), remnant volume (surface of material present / [surface of material present + total bone surface]) and immature:mature bone ratio (mature bone surface / total bone surface).Specifically designed forms were used to collect data at the following time points: tooth extraction, gathe-ring patient variables; suture withdrawal (7-10 days post-extraction), recording radiological findings; and implant placement (around 6 months post-extraction), gathering radiological findings and data on material retention in the socket and primary implant stability. Histological data were obtained from the pathology report on samples taken at implant placement.Microsoft Excel and SPSS were used for the statistical analyses, which included: descriptive analysis of patient, clinical and histomorphometric variables; frequency histograms for histomorphometric variables; Shapi-ro-Wilks normality tests for histomorphometric va-riables, age and healing time; 95% confidence intervals for histomorphometric variables; use of the Pearson correlation coefficient to analyse associations of diffe-rent histomorphometric variables with each other and with healing time and age; analysis of variance (ANO-VA) to determine the effect of healing time on newly formed bone area, biomaterial area and bone-bioma-terial contact index; and the Student’s t test to com-pare newly formed bone area, biomaterial area and bone-biomaterial contact index between shorter and longer healing times (5-6 months versus 7-8 months, respectively).

VARIABLE (%) MINIMUM VALUE

MAXIMUM VALUE MEAN MEDIAN STANDARD

DEVIATION

Newly formed bone area 0.30 45.33 20.15 13.64 15.42

Immature bone area 8.34 31.80 20.07 20.07 16.58

Old bone area 0.43 21.03 11.98 11.87 7.65

Biomaterial area 0.33 26.25 11.40 7.99 8.88

Lamellar bone area 2.02 6.11 4.06 4.06 2.89

Bone-implant contact index 0 69.70 32.31 19.82 24.94

Remnant volume 0 98.85 31.98 35.60 25.68

Immature bone-mature bone relationshop

0 96.07 42.62 36.13 36.48

Fig.3

Fig.4

Fig.5

Fig. 3 Newly formed bone around the biomaterial, (white arrows) with faint signs of resorp-tion in the central area of the biopsy (red arrow). Most of the bone is newly formed, with traces of old bone at the periphery. Levai-Laczko stain. 100X.

Fig. 4 Material integrated in the bone tissue; there is a predominance of lax connective tissue (red arrow), although with areas of denser connective tissue. The biomaterial is integra-ted in bone trabeculae (white arrows). Le-vai-Laczko stain. 100X. Fig. 5Biomaterial surroun-ded by immature bone. Chromotrope 2R/Harris haema-toxylin staining.100X. Table 2 Results. Descriptive statistics of histomor-phometric variables. Table shows the minumim and maxi-mum values for each variable; the mean and the median are also showed for each variable.


RESULTSPatient variables One male patient abandoned the study before im-plant placement. Among the 15 remaining patients, 21 biopsies were obtained after a mean healing time of 6.2 months (standard deviation: ±1.05). Out of the 21 biopsies, 3 were impaired during grinding and could not be processed, and 2 were incorrectly sampled and excluded from the analyses. Hence histological and hi-stomorphometric analyses were conducted in a final sample of 16 biopsies (Table 1).

Clinical resultsNone of the patients evidenced biomaterial loss at implant placement; in some cases, the most superficial area showed residual graft particles that had no effect on the surgical procedure or primary stability, which was obtained in all cases. X-ray images revealed no complications, and in all the films, high radiopacity and consequent prompt identification of the material was detected.

Histological and histomorphometric resultsNo biomaterial fragments or necrotic bone splinters were detected in any of the 16 biopsies analyzed. In three cases, the biomaterial was integrated in the bone and surrounded by fibrous tissue with rim of osteo-blasts and osteoid matrix; in one case, the biomaterial was surrounded by lax conjunctive tissue; in five cases, it was surrounded by mature bone trabeculae with scant osteoid and osteoblastic rimming; in seven cases, modest to highly abundant immature bone trabecu-lae growth was observed with osteoid and osteoblasts rim. Ten of the biopsies showed the presence of me-dullary fibrosis, at a low level in most cases.Evidence of vital bone growth was found in the sockets, with bone neoformation in close contact with graft particles. All samples showed residual particles of the material, with various degrees of material remodelling and resorption (Fig. 3, 4, 5). The histological study at 6 months revealed that the

degree of bone neoformation in the socket was ge-nerally moderate, that the newly formed bone was immature (consistent with the healing time) and sur-rounded by and in direct contact with biomaterial frag-ments and that the beta-TCP material showed initial signs of resorption.Table 2 exhibits the results of the histomorphometric variables, which were found to follow a normal distri-bution (Shapiro-Wilk test). The frequency histograms showed that the mean contact between bone and bio-material was <20% in 8 out of 15 biopsies and that the newly formed bone area was >20% in most of them; the biomaterial area was <20% in most of the biop-sies. Calculation of 95% confidence intervals showed significance for all variables, except for the immatu-re bone area and lamellar bone area, for which there were measurements in only two cases (Table 3). These two variables were excluded from analysis, using Pe-arson’s correlation coefficient, of the relationships of histomorphometric variables with each other and with healing time and age; a positive correlation was found between remnant volume and biomaterial area (p= 0.0056) and between old bone area and the immature bone:mature bone ratio (p= 0.015).Although the healing period was established as 6 mon-ths for this study, this time was sometimes influenced by specific patient circumstances and ranged from 5 to 8 months. The results for newly formed bone area, biomaterial area and bone-biomaterial contact index were analyzed in function of healing time, finding no significant differences. Then, newly formed bone area, biomaterial area and bone-biomaterial contact index were compared between healing times of 5-6 mon-ths and 7-8 months, finding no significant differences, altough borderline significance (p=0.08) was obtained for newly formed bone area.

DISCUSSIONIn this study, post-extraction placement of beta-TCP in the socket did not cause any complications and achie-ved good clinical outcomes. There was histological evi-

VARIABLE Upper Interval limit

Lower interval limit

Statistical significance

Newly formed bone area 29.95 10.35 Significant

Immature bone area 169.11 -128.97 Not Significant

Old bone area 19.06 4.91 Significant

Biomaterial area 18.23 4.58 Significant

Lamellar bone area 30.04 -21.92 Not Significant

Bone-implant contact index 46.12 18.49 Significant

Remnant volume 46.20 17.76 Significant

Immature bone: mature bone ratio 63.69 21.56 Significant

Table 3 Results. 95% confiden-ce intervals. Calculation of 95% confidence intervals showed signi-ficance for all variables, with the exception of immature bone area and lamellar bone area, for which there were measurements in only two cases.

40



dence of bone neoformation at implant placement, with the presence of osteocytes and immature bone. The mean percentage of neofor-med bone was 20.15%, in line with previous reports (22-25). The biomaterial area was less than 20% in most of the biopsies, confir-ming the resorbability of the biomaterial. The biomaterial was readily identifiable on X-ray, being much denser than the adjacent bone, as previously reported by Von Doernberg et al. (26). This characteristic is useful for the radiographic follow-up of healing, because the radio-pacity changes as the material is resorbed and replaced by new bone.Clinical studies on humans generally require the use of non-invasive techniques, e.g. radiology; but a biopsy study is the currently optimal method to assess the regeneration, quantity and quality of bone. A two-phase approach, inserting the graft in the first phase and the im-plant in the second, allows a histological sample to be obtained (20). This technique was applied in the present study.We mixed beta-TCP with saline solution or blood from the patient, as in the study by Horowitz et al. (24), given the difficulty of managing this porous material in granular form (27).Six months as bone healing time was selected, because most of the ceramic is resorbed, and the grafted tissue can be considered suffi-ciently stable for functional implant loading (19, 24). A study in pigs (28) found beta-TCP degradation to be slow, with 80% of the mate-rial resorbed at 28 weeks and 97% at 86 weeks; therefore, the authors recommended an interval of 5-6 months before implant placement in grafted areas, concluding that the cell response to their simultane-ous placement could damage implant osseointegration. Some authors suggested lengthening this healing time in order to increase implant stability (4), and it was found that the presence of residual particles at 9 months does not compromise implant placement (23). In contrast, as reported above, Ormianer et al. achieved a 97% success rate after the immediate placement of implants in augmented areas and their immediate implant loading (22). With regard to the mechanism of beta-TCP degradation before its substitution by bone, it was attributed by Wiltfang et al. (28) to che-mical hydrolysis (halisteresis) and the activity of phagocytic cells (mul-tinucleated giant cells). Two degradation pathways have since been described: osteoclast-mediated resorption and dissolution in inter-stitial fluid (23). A study in 2005 detected no osteoclastic activity in biopsies from sinuses augmented with this biomaterial, but this finding does not rule out the participation of osteoclasts although it sugge-sted that it is limited (29). Besides these two mechanisms, it has been postulated that beta-TCP resorption may also be mediated by cells other than osteoclasts (20). However, Martinez et al. (30) suggested that osteoclasts or macrophage cells may not play an important role in beta-TCP resorption, as they found in the bone-beta-TCP inter-face cells of the reticuloendothelial system. Some data are available on the use of beta-TCP for alveolar preservation (22-25). Ormianer studied the use of beta-TCP alone in 338 patients, although alveolar preservation was not investigated in all of these, and the number of patients undergoing the different procedures was not specified; the mean follow-up was 19.2 months and the global implant survival rate was 97.6%. In 2008, Brkovic reported on the use of beta-TCP with collagen alone in one patient, followed up for 9 months, reporting good clinical outcomes with bone formation activity. In 2012, Horowitz used beta-TCP with a membrane in 30 patients, followed up for a mean of 6 months, also observing good outcomes with preservation of 91% of the socket width. Finally, in the same year, Brkovic studied 20 patients in two groups, one receiving be-ta-TCP with membrane and apically repositioned flap and the other beta-TCP alone, with a mean follow-up of 9 months, concluding that socket preservation was lower in the group without membrane. Our

results are comparable to the findings of these four studies, because the implant survival was 100%, the clinical outcomes were good, bone neoformation was observed in the biopsies, and there was only a small volume of residual bone (11.98%) (Table 2).There have also been reports on socket preservation with the use of other materials. Thus, Liasella et al. employed allografts with good results (31), while De Coster et al. (32) used biphasic ceramics but obtained poor outcomes that delayed implant placement.

After experiencing some problems in harvesting the specimens from the trephine, the protocol was modified and the samples were pro-cessed with the trephine as a block. Zerbo (33) also found it difficult to remove beta-TCP biopsies in a single piece from the trephine, and Suba (20) reported that biomaterial particles frequently broke during sample preparation. In the present study three biopsies were lost in the polishing process, due to the complexity of sample processing, and one biopsy was taken from the incorrect area, a problem that some authors have resolved by using surgical guides (25).In the study by Horowitz 2010 (34), two cases are discussed. In the first one an identical procedure to the one here described was fol-lowed, except for the use of a resorbable membrane after the place-ment of the biomaterial. The clinical outcome was excellent, allowing the placement of a dental implant 6 months after extraction. The bio-material was replaced by new vital bone, just as in our work. Their second case is that of a smoker patient; the biomaterial was placed in the socket followed by a membrane. Healing time in this case was 10 months, after which an implant was placed. The clinical, radiological and histological results are comparable to those of our study, they ob-served the formation of osteon and Haversian systems in the biopsy due to increased healing time.With the limitations of this study, especially regarding the small sample size, the histological and clinical results are in agreement with reports by various authors, evidencing problem-free healing, primary stability of implants placed in the augmented area, and an adequate substitu-tion of beta-TCP particles by newly formed bone at 6 months.

CONCLUSIONThe clinical and radiographic outcomes of this procedure are sati-sfactory, with no associated complications. Beta-tricalcium phosphate seems to be a biomaterial capable of achieving preservation of the alveolar bone when it is positioned immediately in post-extraction socket followed by suture; also facilitating the formation of new bone in the socket in the first six months. This resorbable material allows predictable and reproducible bone regeneration. As advantages, it can be noted its unlimited availability, its easy handling and its great radiopacity, allowing radiographic follow-up of the area. Multiple pu-blications have shown the suitability of this material for use in bone augmentation techniques. Further clinical studies and randomized cli-nical trials are needed, comparing this technique with other available biomaterials, with growth factors and with alveoli in which no alveolar preservation techniques are performed.

ACKNOWLEDGEMENTS This study was supported by an FPU training grant for university pro-fessors from the Spanish Ministry of Education (nº AP2008-00011) and by a project of Universidad-Empresa Foundation (47/2009) si-gned with Keramat.


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21. Szabó G, Huys L, Coulthard P, Maiorana C, Garagiola U, Barabas J et al. A prospective multicenter randomized clinical trial of autogenous bone versus beta-tricalcium phosphate graft alone for bilateral sinus elevation: histologic and histomorphometric evaluation. Int J Oral Maxillofac Implan-ts 2005;20:371-81.22. Ormianer Z, Palti A, Shifman A. Survival of immediately loaded dental implants in deficient alveolar bone sites augmented with beta-tricalcium phosphate. Implant Dent 2006;15:395-403.23. Brkovic BM, Prasad HS, Konandreas G, Milan R, Antunovic D, Sánd-or GK et al. Simple preservation of a maxillary extraction socket using beta-tricalcium phosphate with type I collagen: preliminary clinical and histomorphometric observations. J Can Dent Assoc 2008;74:523-8.24. Horowitz RA, Mazor Z, Miller RJ, Krauser J, Prasad HS, Rohrer MD. Clinical evaluation of alveolar ridge preservation with a beta-tricalcium phosphate socket graft. Compend Contin Educ Dent 2009;30:588-90, 592, 594 passim; quiz 604, 60625. Brkovic BM, Prasad HS, Rohrer MD, Konandreas G, Agrogiannis G, Antunovic D, Sándor GK. Beta-tricalcium phosphate/type I collagen cones with or without a barrier membrane in human extraction socket healing: clinical, histologic, histomorphometric, and immunohistochemical evalua-tion. Clin Oral Investig 2012;16:581-90.26. von Doernberg MC, von Rechenberg B, Bohner M, Grünenfelder S, van Lenthe GH, Müller R et al. In vivo behavior of calcium phosphate scaffolds with four different pore sizes. Biomaterials 2006;27:5186-98. 27. Walsh WR, Vizesi F, Michael D, Auld J, Langdown A, Oliver R et al. Beta-TCP bone graft substitutes in a bilateral rabbit tibial defect model. Biomaterials 2008;29:266-71.28. Wiltfang J, Merten HA, Schlegel KA, Schultze-Mosgau S, Kloss FR, Rupprecht S et al. Degradation characteristics of alpha and beta tri-cal-cium-phosphate (TCP) in minipigs. J Biomed Mater Res 2002;63:115-21.29. Zerbo IR, Bronckers AL, de Lange G, Burger EH. Localisation of osteogenic and osteoclastic cells in porous beta-tricalcium phosphate particles used for human maxillary sinus floor elevation. Biomaterials 2005;26:1445-51.30. Martinez A, Franco J, Saiz E, Guitian F. Maxillary sinus floor augmen-tation on humans: Packing simulations and 8 months histomorphome-tric comparative study of anorganic bone matrix and ß-tricalcium pho-sphate particles as grafting materials. Mater Sci Eng C Mater Biol Appl 201015;30:763-9.31. Iasella JM, Greenwell H, Miller RL, Hill M, Drisko C, Bohra AA et al. Rid-ge preservation with freeze-dried bone allograft and a collagen membra-ne compared to extraction alone for implant site development: a clinical and histologic study in humans. J Periodontol 2003;74:990-9.32. De Coster P, Browaeys H, De Bruyn H. Healing of extraction sockets filled with BoneCeramic® prior to implant placement: preliminary histolo-gical findings. Clin Implant Dent Relat Res 2011;13:34-45.33. Zerbo IR, Zijderveld SA, de Boer A, Bronckers AL, de Lange G, ten Bruggenkate CM et al. Histomorphometry of human sinus floor augmen-tation using a porous beta-tricalcium phosphate: a prospective study. Clin Oral Implants Res 2004;15:724-32.34. Horowitz RA, Mazor Z, Foitzik C, Prasad H, Rohrer M, Palti A. b-tri-calcium phosphate as bone substitute material: properties and clinical applications. J Osseointegr 2010;2(2):61-68.

42

SCIENTIFIC UPDATE β-磷酸三钙在拔牙后牙槽窝中的应用


Fig.12i Fig.12l

β-磷酸三钙在拔牙后牙槽窝中的应用

摘要

目的：本次试验的目的是评估β-磷酸三钙对促进牙槽骨的形成和防止拔牙后牙槽骨再吸收的能力。材料和方法：在给16位患者提取前磨牙后，牙槽窝内填充了β-磷酸三钙。6个月后，在载入种植体的手术过程中，用环锯提取了骨样本，并进行了组织学和形态学分析。在提取和植入种植体期间，利用数据收集表格和病理报告的方式，收集了有关患者、临床、病理以及组织形态学上的变量数据。结果：临床结果是令人满意的，该生物材料在X影像上显示出不透射性。组织学研究结果显示：在愈合过程中得到适当矿化和成熟的牙槽骨部分地整合在生物材料中，还有成骨活性细胞和含有骨细胞的骨馅窝。第6个月的时候，生物材料没有完全被吸收。结论: 提取后，如果即刻把β-磷酸三钙填充在牙槽窝中并加以缝合，它是一种可以促进牙槽骨保存的材料；它还能促进牙周内新骨形成。这种技术与其他可用的生物材料、生长因子和没有得到保存的牙槽骨上的操作技术相比，还需要进行进一步研究。

Author M. Muñoz-Corcuera A.Bascones-Martínez 1 J. Ripollés-de Ramón 西班牙马德里孔普鲁顿大学牙科学院口腔内科和外科系 1牙科学院教授l 关键词: 骨移植；磷酸钙；牙的种植；拔牙后的牙槽窝

引言在正常情况下，健康的骨在不断地重塑而且具备有效的自我修复能力。在动态过程中，骨重建保持骨形成和骨吸收的连续平衡性来适应局部所受的应力（1）。但是，如果高于临界限度的话，骨不能单靠自己的成骨活性被修复，这时候必须使用某种类型的骨移植（2）。

颚骨缺损可以由手术切除、外伤性损失、骨化损害（一般多发于中老年人群）、牙周病、种植体周围疾病和先天性疾病造成。由于没有正常种植时所需的足够骨量，这些缺陷可能会使由种植体支撑的修复治疗手术过程变得更加复杂(3，4)。颚骨损失经常是由于拔牙后牙槽再吸收导致的，这是一种可以导致减少牙槽脊的高度和宽度的生理现象，其减损程度会根据部位和患者的差异而有所不同(5)。为了解决其带来的临床问题，特别是针对有审美需求的部位，牙槽脊的保存技术已经被研发出来（5）。骨移植方法包括自体骨移植、异体移植、动物骨来源（异种骨移植）和合成骨替代物（异质移植物），以及生长因子和基因疗法的应用(3，4，6)。

作为一种具有生物相容性和可再吸收性的材料，β-磷酸三钙是一种被广泛地作为替代陶瓷的传导骨来修复骨缺损的生物材料。由于其化学和物理的性质，它被成功地运用于各种行业中的空隙填充，包括生物、兽药、人类

医学、口腔医学等各种邻域中（7-12）。它还被建议作为生长因子快速通道来刺激骨的形成 (12，13)。作为一种生物材料，已经有不同的学者报告了它在动物和人骨再生过程中的作用(4，14-21)。

本实验的目的是评估拔牙后在牙槽窝中填充颗粒β-磷酸三钙的情况，并测量β-磷酸三钙对促进新骨形成的潜在能力和对保留原始牙槽骨重量和厚度的作用；对后续的种植手术来说，牙槽骨的保留和修复情况是至关重要的。

具体而言，研究目标有如下4个：1.分析从拔牙后在牙周槽中填充β-磷酸三钙到后期的种植体的载入期间所获得的临床和组织学结果。2.评估β-磷酸三钙作为拔牙后的骨填充材料的有效性。3.在牙周槽内放置生物材料6个月后，对所形成新骨的数量和质量进行组织学分析。4.测定生物材料颗粒与患者骨接触的比例。

材料和方法

研究设计这项具有前瞻性的临床研究符合赫尔辛基宣言的原则，并由西班牙马德里圣卡洛斯临床医院的临床研究伦理委员会批准。

所有参与研究的患者年龄在18岁以上，根据计划，每位患者将拔除一至四颗的前磨牙并在后期种植新牙，拔除四颗磨牙的患者占所有受

文章来源 Muñoz-Corcuera M, Bascones-Martínez A, Ripollés-de Ramón J. Post-extraction application of beta tricalcium pho-sphate in alveolar socket. J Osseointegr 2015;7(1):8-14.


试者的四分之一，拔牙原因有牙周疾病、龋齿和骨折等。受试者排除标准为:没有签署知情同意书者，不愿意遵守预定研究日程者，带有由外科手术、术中或术后药物影响而导致的疾病者，牙槽窝壁缺损者，每日吸烟10支或10支以上者，因为吸烟的习惯可以导致种植的失败，在研究开始前一个月内有过双膦酸盐或抗生素治疗者。患者均从临床口腔学院（西班牙孔普卢顿大学）和私人牙科诊所中招募。患者的选择是通过非概率连续抽样法进行，并且只选择符合上述标准的个体。

有16名患者在2008年三月到2010年七月间被纳入研究对象，这16名患者平均年龄为44.3 岁（标准偏差年龄为：10.74）；男性7个（占44%），平均年龄为39.7岁；女性9个(占56%)，平均年龄为48岁。没有一个受试者(0%)是每日饮酒者，2个(占12%)患者是每日吸烟者（每天1至9支）。一共有19颗上磨牙和2颗下磨牙被拔除（由于下磨牙的数量太少，最后并没有纳入研究数据分析中）。在一个基准临床评估后，所有患者均接受了基本的术前牙周治疗，并被告之在整个研究过程中都要保持良好的口腔卫生。

手术步骤

通过局部麻醉后，整片颊舌瓣被翻起，拔掉磨牙；一整片颊舌瓣被抬起，以便于通过缝合来固定颗粒状的填充材料。用手术刮匙清除牙槽中的所有肉芽组织，并在牙槽中填充由生理盐水或患者血液混合了0.5克 KeraOs β-磷酸三钙（由西班牙拉科鲁尼亚的Keramat公司生产）的填充物（图1）。然后，通过重新定位牙周冠瓣后进行了牙槽缝合(图2)。指导患者每天用0.12%的葡萄糖酸氯己定冲洗口腔两周。

在拔牙后的7到10天时拆除了缝合线。

在种植手术期间，用环锯（环锯内径为2.2 mm，外径3 mm）切下了一片样品骨，并放置在福尔马林缓冲液中送到加利西亚陶瓷研究所（在西班牙的Santiago de Compostela）实验室进行研究。

组织的处理

按照多纳特方法，利用精确的系统对样品骨进行了加工，使其变成未脱钙的薄片。

简单来说，就是将样品固定在10%福尔马林缓冲液中，并用酒精使其逐渐脱水，再将其镶入光聚合性的丙烯酸甲酯树脂中。经过聚合后，用金刚石锯将样品切割，然后用金刚砂纸研磨至约70微米的宽度。变薄后，把样品放在Levai Laczko 染色剂和2R/Harris苏木精中进行染色。为了获得组织形态学的测量数据，使用了以下设备：一个带有奥林巴斯DP71摄影机的电动奥林巴斯BX51显微镜使样品成像，用奥林巴斯D-cell细胞捕获软件、Photoshop CS3 图像处理软件、采用Wacom Intuos4数位板和奥林巴斯显微图像4.0程序。所收集数据如下：

1. 患者变量，根据性别、年龄、酒精和烟的消费情况来分类（吸烟者每日1至9支，不吸烟者每日0支，以便于测试轻量吸烟是否会影响到牙槽的康复）。2.临床变量分生物材料在牙槽中的稳定性和种植体的初期稳定性

3.放射学发现4.6个月时候的组织学变量，牙槽中新骨形成的程度，所形成新骨的总量和质量，患者骨和

FEMALES MALES MEAN STANDARD DEVIATION

Age (yrs) 48 39.7 44.3 10.47

Number 9 (56.25%) 7 (43.75%)

Smokers (1-9 cigs/day) 2 (12%) 0 (0%)

Drinkers 0 (0%) 0 (0%)

图 1 牙槽窝中填充了β-磷酸三钙和患者血液的混合物图 2 用冠瓣顶部重新定位后牙槽窝被缝合。

表 1 结果，单个个体的变量。平均年龄44.3岁 (标准偏差：10.74);7个男性（占44%）平均年龄为39.7岁， 9个女性（占56%）平均年龄为48岁。没有患者（0%）是每日饮酒者，有2个患者（12%）每天抽烟1-9根。

44



β-磷酸三钙结合的程度，β-磷酸三钙的吸收程度，这些均直接通过显微镜观察评估。5.组织形态学变量：新骨形成区域、不成熟骨、原骨、生物材料和层状骨、骨与生物材料接触指数（与骨接触的材料周长 /整块材料的周长）、残留体积（当前材料表面 /[所剩材料表面积+ 总骨表面积]）、不成熟骨:成熟骨的比值（成熟骨表面 / 总骨表面）。

我们用专门设计的表格处理了在以下时间点收集的数据:拔牙、采集患者变量、缝合线的拆除（在拔牙后7至10天）记录反射学发现、种植手术（大约在拔牙6个月后），采集影像学研究结果和材料保留在牙槽中的数据、种植体初期的稳定性。组织学数据是从种植时采样的病理报告中获得的。

Microsoft Excel和SPSS软件被用于统计分析，其中包括：对患者、临床和组织形态学变量的描述性分析；为描述组织形态变量用了频率直方图；为组织形态学而运用的Shapiro-Wilks正态性检验，患者年龄和恢复时间，形态学变量的可信区间为95%，用Pearson相关系数，来分析形态学变量与每个不同的恢复时间和患者年龄之间的差异，通过方差分析来确定愈合时间对新骨形成区、生物材料区以及骨与生物材料接触指数的影响。而由学生进行的T检验法却把新骨形成区和骨与生物材料接触指数与愈合时间的长短进行了比较（5至6个月的愈合时间相比于7至8个月的愈合时间）。

结果

患者变数一个男性患者在进行种植手术之前放弃了研究，在剩下的15个患者中采集到了21个样品，这些患者的平均愈合时间为6.2个月（标准差为±1.05）。在21个样品中，有3个样品在研磨过程中受损而无法进行评估，还有2个由于不

VARIABLE (%) MINIMUM VALUE

MAXIMUM VALUE MEAN MEDIAN STANDARD

DEVIATION

Newly formed bone area 0.30 45.33 20.15 13.64 15.42

Immature bone area 8.34 31.80 20.07 20.07 16.58

Old bone area 0.43 21.03 11.98 11.87 7.65

Biomaterial area 0.33 26.25 11.40 7.99 8.88

Lamellar bone area 2.02 6.11 4.06 4.06 2.89

Bone-implant contact index 0 69.70 32.31 19.82 24.94

Remnant volume 0 98.85 31.98 35.60 25.68

Immature bone-mature bone relationshop

0 96.07 42.62 36.13 36.48

图 3 新形成骨在生物材料的周围, (白色箭头所指之处)，在活组织样品的中心区有微弱的再吸收迹象(红色箭头处)。大部分的骨是新形成骨，周围有旧骨痕迹。 Levai-Laczko 染色，100倍。

图 4 生物材料整合在骨组织中；松懈结缔组织占优势（红色箭头处），虽然也有一部分在密致结缔组织区域内，生物材料整合在骨小梁中 (白色箭头所指之处)。Levai-Laczko 染色，100倍。图 5生物材料被不成熟骨包围，变色2R/哈里斯染色.100倍。表 2 结果，形态学变量的描述性统计；表格显示了每个变量的最大值和最小值；也显示了每个变量的中值和均值。


正确取样而被排除在参与分析的可能之外。因此，我们最终对16个样品进行了组织学和形态学分析。

临床结果在种植过程中，没有患者被发现有明显的生物材料流失，在一些病例中，从最表面来看，移植的残留颗粒对外科手术和种植的初步稳定性没有影响，而所有的病例都获得了成功的手术过程和初步的稳定性。X射线图像显示没有并发症，在所有的黏膜中后来被确定检测到了高不透射线的材料。

组织学和形态学结果在被分析的16个样品中，没有检测到生物材料的碎片和坏死骨碎片，在三个病例中，生物材料已经融合在骨中，并被具有骨纤维和骨基质边缘的纤维组织包围；在一个病例中，生物材料被松弛的结膜组织包围；在5个病例中，生物材料被成熟的骨小梁、少量类骨质和成骨细胞包围；在7个病例中，从少量到高度丰富的带有类骨质和成骨细胞边缘的不成熟骨小梁的生长迹象。活组织样品中的10个显示出有纤维化骨髓的存在，但其中大部分样品中的存在比例较低。在牙槽中发现了很明显的活骨生长现象，且新形成骨与移植颗粒紧密结合。所有样品中都发现了材料的残留颗粒，那些残留颗粒都有不同程度的重塑和再吸收迹象（图3、4和5）。

6个月时的组织学研究显示，牙槽中新形成骨为一般中等程度，刚形成的新骨还未成熟（这和愈合时间的长短有一定的关系）并被生物材料碎片包围或与其直接接触，而β-磷酸三钙材料显示出再吸收的初步现象。

表2展示了组织形态学变量结果，呈现出正态分布状体（用Shapiro-Wilk检测法)。15个活组织样品中8个样品的频率直方图显示骨和生

物材料接触面积为<20%，而其中大部分样品的刚形成新骨面积为>20%；大部分活组织样品中的生物材料面积为<20%。除了由于只在2个样品中获得了测量数据的未成熟骨和层状骨变量外，计算显示其他所有变量均显示出非常不错的95%的可信区间(表3)。这两个变量被排除在分析之外，用Pearson相关系数，找出各个组织形态学变量之间和愈合时间于年龄之间的相关性，在残留体积和生物材料面积之间的相关系数为正相关（p= 0.0056），旧骨面积和不成熟骨面积与成熟骨比值的相关性为(p= 0.015)。虽然本次研究的预期恢复时间为6个月，但这个期限有时被患者的具体情况受到影响而变成了5至8个月。我们分析了恢复时间对新形成骨的面积、生物材料面积以及骨与生物材料接触指数结果的影响，并没有发现显著异常。之后又把新形成骨面积、生物材料面积以及骨与生物材料接触指数的结果分别与5到6个月的愈合时间的病例与7到8个月愈合时间的病例做了比较，也没有发现很大的差异，尽管新骨形成的面积获得了较高的临界意义(p=0.08)。

讨论

在本次研究中，在牙槽中放置β-磷酸三钙没有引发任何并发症，并且获得了良好的临床结果。在植入种植体时有存在骨形成的组织学证据，还有骨细胞和不成熟骨的存在。新形成骨的平均百分比为20.15%，与之前的报告一致（22-25）。在大部分的活组织样品中，生物材料的面积为小于20%，证实了生物材料的再吸收能力。生物材料在X射线影像中可以被很容易的识别出来，并且比相邻骨要密致得多，就如Von Doernberg等学者在之前报道的一样（26）。生物材料的这个特征对后期愈合中的X射线很有用，因为不透射线会随着材料被吸收和被新骨取代而改变。

VARIABLE Upper Interval limit

Lower interval limit

Statistical significance

Newly formed bone area 29.95 10.35 Significant

Immature bone area 169.11 -128.97 Not Significant

Old bone area 19.06 4.91 Significant

Biomaterial area 18.23 4.58 Significant

Lamellar bone area 30.04 -21.92 Not Significant

Bone-implant contact index 46.12 18.49 Significant

Remnant volume 46.20 17.76 Significant

Immature bone: mature bone ratio 63.69 21.56 Significant

表 3 结果，形态学变量的描述性统计；表格显示了每个变量的最大值和最小值；也显示了每个变量的中值和均值。

46



对人类的临床研究一般要求用非侵入技术，如X射线；但在评估骨再生、骨体积和骨质量时，用一个活组织样品进行研究是目前最好的方法。分两个阶段的研究方法可以使我们获得组织学样品（20），第一步放置移植物，第二步进行种植，本次研究用的便是这种方法。

由于这种颗粒状多孔材料的不易操作性(27)，我们把β-磷酸三钙混合在生理盐水或患者自身血液中使用，根据Ho-rowitz等学者提出的方案（24)。

我们决定了愈合时间为6个月，因为大部分的陶瓷已经被吸收，并且认为被移植的组织有足够的稳定性来负载种植体（19，24）。一项对猪的研究发现，β-磷酸三钙的降解性趋于缓慢，在28周时只有80%的材料被吸收，到86周时有97%的材料被吸收；因此，作者建议在移植区域移植和种植的间隔时间应该为5到6个月，结论认为，细胞对同步移植的反应有可能损害种植体的骨整合。一些学者建议通过延长愈合时间来提高种植的初步稳定性（4），且发现在9个月的时候有残留颗粒的存在已经不影响种植手术(23)。于此相反，如上报告，Ormianer等学者在被扩充部位进行了即刻填充和种植体载入，他们他们获得了97%的成功率（22）。

至于β-磷酸三钙在被骨取代前的降解机制，Wiltfang等学者认为（28）是通过化合水解和巨噬细胞的活性（多核巨噬细胞）达成的。至今有两种降解途径被描述出来：破骨细胞介导的吸收和组织液中溶解（23）。2005年的一项研究表明，他们在上颌窦底部填充β-磷酸三钙6个月后所获得的一个组织样品中并没有检测到活性破骨细胞，但这个结论并不能排除有活性破骨细胞的参与，即便认为它的存在是有限的（29）。除了这两种机制外，据推测，β-磷酸三钙还可能被破骨细胞以外的其他细胞介导（20)。然而，Mart-inez等学者（30）却提出破骨细胞或巨噬细胞在β-磷酸三钙的再吸收中可能并没有起到很重要的作用，因为他们在骨与β-磷酸三钙的接口细胞中发现了网状内皮系统。

可以找到一些关于用β-磷酸三钙来保存牙槽骨的资料（22-25）。Ormianer在338个患者上单独使用了β-磷酸三钙，虽然没有对所有患者的牙槽骨保留状态进行调查，而且接受不同治疗方法的患者数目也未被指明；平均随访时间为19.2个月，整体的种植存活率为97.6%.。在2008年，Brkovic报告了他在一个患者身上使用了β-磷酸三钙和胶原蛋白的混合物，愈合时间为9个月，他的报告得出了具有骨形成迹象的良好临床结果。

在2012年，Horowitz在30个患者的牙槽窝中填充了β-磷酸三钙和薄膜，平均愈合时间为6个月，他也得到了良好的临床结果，保留了牙槽骨91%的宽度。最后，在同年，Brko-vic进行了对20个患者的研究，他把患者分成两组，其中一组患者的牙槽窝中填充了β-磷酸三钙和薄膜的混合物并用龈翼重新定位顶部，而另外一组则只用β-磷酸三钙填充，两组的平均愈合时间为9个月，得出的结论是，没有添加薄膜的患者组的牙槽骨保存程度更低。我们的结果跟这四个研究的结果是有可比性的，因为本次研究的种植体存活率为100%，临床结果是良好的，在活组织样品中观察到了骨形成，并且只有少量的残留骨，为11.98%（表2）。

还有一些用其他材料来保存牙槽骨的报告，比如，Liasella

等学者运用了同种异体移植方法也得到了良好的结果（31），而De Coster等学者则运用了双向性陶瓷材料，但他们得到的结果并不好，也因此推迟了种植手术（32）。由于在从环锯上提取样品时碰到了一些困难，我们改变了提取方法，我们把样品放置在一起再用环锯加工。Zerbo也发现单片的β-磷酸三钙活组织样品很难从环锯上移除（33) 。Suba 也报道过，他经常在样品加工过程中损坏生物材料颗粒。由于样品处理的复杂性，本次研究中，在抛光过程中损失了三个样品，还有一个样品在不正确的部位被提取，而一些学者则用外科手术指南解决了这个问题（25）。 Horowitz在2010（34）年的一项研究中讨论了两个病例，第一个病例的方法与本次研究描述的方法几乎完全一致，不同的是，在放置生物材料后他还使用了可吸收性薄膜。他得出的临床结果非常好，在拔牙6个月后可以进行种植。生物材料被新的活骨取代，就如我们试验中的结果一样。第二个病例是一个吸烟患者，在牙槽中填充生物材料后也运用了薄膜，在这个例子中，愈合时间为10个月，完成种植后的临床、放射和组织学结果与我们本次研究的的结果有可比性。由于增加了愈合时间，他们在活组织样品中观察到了骨单元和哈弗僧系统的形成。这项研究有一些局限性，尤其是小尺寸的样品。组织学结果和临床结果与一些学者在之前报告的结果是一致的，在6个月的时候，不受限制的愈合时间、在扩充部位中种植的初期稳定性，还有β-磷酸三钙颗粒充足地被新形成骨取代。

结论此次研究的临床和影像学结果是另人满意的，没有引起相关的并发症。在拔牙后，如果把β-磷酸三钙即刻放入牙槽窝中并缝合的话，β-磷酸三钙似乎是一个能够保存牙槽骨的生物材料；在头6个月中它还能促进牙槽窝中的新骨形成。这种具有再吸收性的材料使可预见和可重复的骨再生变成了可能，由此我们可以看到它无限的可能性，容易处理和巨大的不透射性，对后期愈合中的放射过程很有帮助。已经有各种出版物表明了这种材料在骨增长技术运用中的稳定性。与其他可用的生物材料、生长因子和没有经过保存的牙槽脊运用技术相比，这项技术还需要进一步的临床研究和随机临床试验。鸣谢

这项研究由西班牙教育部给大学教授的FPU培训基金(nº AP2008-00011)，和Universidad-Empresa基金与Keramat所签署项目(47/2009)共同资助。

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SCIENTIFIC UPDATE Immediate implants in extraction sockets with periapical lesions: an illustrated review


Immediate implants in extraction sockets with periapical lesions: an illustrated review

ABSTRACT Aim: Immediate implantation has gained great attention since first proposed. Immediate implants in repla-cement of teeth with periapical lesion is, to date, an issue of discussion. The aim of this study is to perform an illustrated literature review of immediate implants in sockets exhibiting previous periapical lesions.Materials and methods: A search on medline/eMBAse database was done for the literature review which is presented together with two case reports illustrating the state of the art of immediate implants on sockets with periapical lesions. Both cases are presented in areas with great aesthetic demands and a periapical lesion of considerable size. The two cases were conducted following strict granulation tissue removal and careful rinsing and pre-operative antibiotics, followed by good primary stability of the dental implant. Results and conclusion: Both cases represented successes in aesthetics and function, describing a successful protocol for immediate implant installation in areas exhibiting periapical lesions.

Author Athur B. Novaes jr. 1, ValdIir A. MuglIa 3, Umberto d. Ramos 1, Danilo M. ReIno1, Lauro g. Ayub 2

1 department of Bucco-Maxillo-Facial surgery and Traumatology and Periodontology, school of dentistry of ribeirao Preto, University of sao Paulo, ribeirão Preto, SP, Brazil2 department of clinical dentistry, school of dentistry, Pontifical catholic University of rio Grande do sul, Porto Alegre, rs, Brazil Rio Grande3 department of Prosthetic dentistry, school of dentistry of ribeirao Preto, University of sao Paulo, ribeirão Preto, SP, Brazil KEY WORDS Bone grafting; dental implants; Immediate implant loading; Periapical disease.

INTRODUCTIONSince the publication of the first papers describing the phenomenon of osseointegration and the very first clinical trials (1, 2), the interest on osseointegrated im-plant rehabilitation has grown exponentially. At first, for the treatment of totally edentulous patients, poste-riorly for partially edentulous and single unit implants.The classic protocol for the treatment with osseointegrated implants recommended 6 to 8 month between tooth extraction and implantation. This long waiting period is associated with an unavoidable bone loss that occurs after tooth extraction, which may lead to difficulties such as insufficient bone at the time of implantation. The insufficient bone leads to the use of angulated implants or the need of bone grafting procedures, increasing the morbidity, the treatment chair time and costs. At first, the main concern was with bone quality, and with the length and width of the site of implantation. With the advances on guided bone regeneration and grafting procedures, most of the problems related to the amount of bone has been solved or mostly solved, now the focus is mainly on aesthetics and amount of soft tissue increase or stabili-ty (3, 4). Immediate implantation has gained attention

in order to avoid the problems related to the time lag between extraction and implant placement. The difference between crestal bone level and success rate has been evaluated by a number of authors (6,7). The success of immediate implants has been reported as similar to delayed implantation, as suggested by the original protocol (7, 8, 9), becoming an attractive treat-ment protocol to reduce treatment time and the lag between implantations and the prosthesis.Most of the reasons for tooth extraction include in-fected areas as a result of microbial and inflammatory diseases, such as periodontal disease, or periapical le-sions from endodontic infections. Thus, an increasing interest has been shown on how immediate implan-tation would perform in infected sites. This illustrated review has the objective of reviewing current litera-ture and to propose a predictable clinical protocol for immediate implantation on infected sites, presenting two clinical cases with 12 months of follow up.

Literature on immediate implant placement in AlveolI with periapical lesionsPeriapical lesions are known as areas of inflammatory reaction due to the presence of pathologic agents on

TO CITE IN THIS ARTICLE: Novaes Jr. AB, Muglia VA, ramos, Ud, reino dM, Ayub lG. Immediate implants in extractionsockets with periapical lesions: an illustrated review. J osseointegr 2013;5(3):45-52.

Fig.1 Fig.2


an infected root canal. On histologic examination it is possible to notice the presence of granulation tissue and inflammation with a dense neutrophil infiltrate near the apical foramen delimiting the bacteria on the apical part of the root canal. Thus, a number of authors consider the presence of periapical lesions a risk to the predictability of immediate implant success, contraindi-cating this treatment protocol (10-13). On the other hand, some authors showed, on histological studies, that immediate implantation in sockets with periapical lesions presented similar results to non-infected sites (14). The first report of success on immediate implan-tation in sockets with periapical lesions was described by Novaes Jr and Novaes in 1995 (15). The protocol suggested by the authors included careful extraction and debridation of the socket (removing a thin layer of bone from hte periapical lesion area with chisels and curettes to remove any infected bone and to induce bleeding, thus favoring cell population of the graft) followed by copious irrigation with saline solu-tion, by guided bone regeneration, primary closure and a systemic antibiotic regimen, starting 24 hours before implantation. A prospective randomized study compa-ring the placement of immediate implants in sites with previous periapical lesions with delayed implantation was published in 2006. The investigation included clini-cal and radiographic parameters, microbiological cul-ture from samples collected from periapical lesions and Resonance Frequency Analysis (RFA) measuring

implant stability. The authors reported a success rate of 92% for immediate implants and 100 % for delayed implant placement. Although there was a numerical dif-ference, there was no significant statistical difference (16). A study with 34 subjects compared the clinical results achieved by implant placement in periapical le-sion sites and healthy sites. One year after the implant placement, there was no difference between the tre-atment protocols. This study showed that immediate implant placement in periapically compromised teeth is not contraindicated (17).

A retrospective study with 922 implants (285 placed in periapical infected sites and 637 in healthy sites) compared the success rate on both treatment pro-tocols: success was defined as successful osseoin-tegration, restoration and absence of periimplantitis. Success rates were 97.5% for the test group (periapical infection group) and 98.7% for the control group (he-althy group). Therefore, the authors considered the placement of immediate implants in periapically in-fected sites a safe and a viable treatment protocol (18).

Another retrospective study comparing implant place-ment into infected sockets and on pristine sites with a mean time of function of 64 months reported a similar success rate (98.1% for infected sites and 98.2% for pristine sites) for both treatment protocols (19).

Fig. 1 Periapical rx showing extensive periapical lesion on the upper right central incisor. Fig. 2 A cT scan was used as a diagnostic tool to plan the immediate implant..

Fig. 3 cT can with the sagittal view showing the hypo-density (green arrow) and the bone height available for implant anchorage. Fig. 4 Three dimensional mo-del fabricated from the cT scan and the surgical and prosthetic planning

Fig.5 clinical aspect of the tooth before extraction.

Fig.6 The pre-existent metal-loceramic crown was re-moved before extraction. Frontal view.

Fig.7occlusal view of the to-oth without the prosthe-sis, before extraction.

Fig.8 Tooth extraction with the periotome, minimally invasive approach.

Fig.9Tooth extracted with the periapical lesion attached.

Fig.10occlusal aspect of the socket after tooth extraction. There was minimal surgical damage to adjacent soft tissue

Fig.3 Fig.4

Fig.5

Fig.6

Fig.7

Fig.8

Fig.9 Fig.10

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CASE REPORTCase 1The upper right central incisor was indicated forextraction due to an extensive periapical lesion diagnosed from periapical radiographs (Fig. 1). Due to favorable clinical characteristics, tooth replacement with an immediate implant-supported crown, flapless surgery and immediate provisionalization was planned. On the first visit all compromised sites were recorded and a scaling and root planning was performed. Oral hygiene instructions were given in order to perform excellent plaque control. The gingival marginal position and apico-coronal crown dimensions were established with a diagnostic waxing, considering gingival thickness and architecture. A Cone Beam CT scan was perfor-med in order to obtain a tridimensional model (Fig. 2, 3). Thus, it was possible to fabricate a surgical guide and a precise reverse treatment planning. A surgical simulation (Fig. 4) on the 3D model to choose and individualize the prosthetic component and the

confection of a provisional crown before the surgical phase was made. The surgical phase was performed with local anesthesia and the prescription of Amoxi-cillin 875 mg for 10 days, starting 24 hours before the surgical procedure.

Flapless tooth extraction, with the least amount of trauma as possible, was performed and the socket was carefully debrided as suggested by Novaes Jr and No-vaes (15) (Fig. 5-10).

After irrigation with saline solution the socket wal-ls were inspected and the vestibular wall and socket morphology were considered suitable for immedia-te implant insertion. The surgical guide was placed (Fig. 11, 12) and the protocol for socket preparation was performed, in accordance to the manufacturer’s instruction, for a 4.5 mm diameter and 15 mm length implant (XiVe S Plus, Dentsply Implants, Mannheim, Germany). The implant was placed 1 to 1.5 mm from

Fig. 11 occlusal view from the 3d model and the tridimensional position of the implant carefully planned. Fig. 12 occlusal view of the sur-gical guide showing theoptimal prosthetic posi-tion for the implant.

Fig. 13 occlusal view of the implant after insertion. Fig. 14 The full flap preserving corona The full flap pre-serving coronal attached gingiva, soft tissues and aesthetics. Thick buccal bone on the apical aspect required a graft to avoid fenestration.

Fig.15 Graft (bioactive glass) in position.

Fig.16 Primary closure achieved and provisional crown in position.

Fig.17Final aspect of the provisional crown after surgery.

Fig.18Periapical radiograph onthe immediate post-ope-rative period.

Fig.19Periapical radiograph taken 1 month after surgery.

Fig.20Periapical radiograph taken 3 months after surgery with the zirconia abutment.

Fig.11

Fig.16 Fig.17 Fig.18

Fig.19 Fig.20

Fig.21

Fig.22

Fig.23 Fig.24


Fig.15


the buccal bone wall and anchored on the nasal cavity floor to obtain primary stability (Fig. 13).Although the coronal alveolar wall was in good con-diditon, the apical portion was too thin, due to the periapical lesion, and a grafting material (Biogran, Biomet 3i, Palm Beach, FL- USA) was placed with an apical access (Fig. 14, 15). A provisional crown was pla-ced after the implant and grafting procedures.A zirconia abutment (Cercon, Dentsply Implants, Mannheim, Germany) was connected to the implant and a metal-free ceramic crown was cemented (Fig. 16-18). At 1 and 3 months post-operatively, a periapical radiograph was performed (Fig. 19, 20), and clinical photos were taken (Fig. 21, 22). During this period the left central incisor was lost due to trauma.After 6 and 12 months a CT scan was made to ensure treatment success and resolution of the periapical lesion (Fig. 23-25).

Case 2The upper right incisor was indicated for extractiondue to an endo-perio lesion diagnosed by periapical radiographs (Fig. 26). Based on defect configuration, analyzed by a CT scan examination (Fig. 27), an imme-diate implant with an immediate provisional crown was planned.

The tooth was extracted with a previous antibiotic prescription (Amoxicillin 875 mg-Potassium Clavu-lanate 125 mg combination, twice daily, for ten days, starting one day before the procedure). After tooth extraction a 5.5 mm diameter and 13 mm length im-plant (XiVe S Plus, Dentsply Friadent, Mannheim, Germany) was inserted 1 mm apically to palatal bone wall (Fig. 28-30). On the same day, a 4.5 mm diameter prosthetic component was installed and a provisional crown was placed, performing a platform switching strategy (Fig. 31). After 9 months, a metalloceramic

Fig. 21 Periapical rx showing clinical buccal aspect of the zirconia abutment. Fig. 22 clinical occlusal aspect of the zirconia abutment.

Fig. 23 Final aspect of the pro-sthetic crown 6 months after prosthesis installa-tion.

Fig. 24 cT scan 12 months after surgery.

Fig.25 Periapical radiograph 12 months after surgery.

Fig.26 Periapical radiograph showing extensive peria-pical lesion on the upper right incisor.

Fig.27cT scan showing buccal bone wall fenestration on apical aspect of the tooth.

Fig.28clinical aspect of the tooth before extraction.

Fig.29A full flap was reflected. Implant was positioned subcrestaly to the bone crest.

Fig.30clinical aspect of the surgical area after flap closure.

Fig.25

Fig.26


Fig.30 Fig.31

Fig.32 Fig.33

52



crown was placed (Fig. 32). At 12 months, a control periapical radiograph and CT scan was requested (Fig.33), confirming the treatment success.

DISCUSSION

In order to maintain aesthetic and functional condi-tions with implant therapy, it is important to preserve alveolar bone dimensions, gingival margin position, gingival thickness and keratinized gingival tissue. Thus, aiming to reduce alveolar process resorption and tre-atment time, immediate implant placement in fresh extraction sockets has been largely proposed (7, 8, 9,2 0). However, most of the reasons for tooth extraction include infected areas caused by tooth fracture, perio-dontitis or endodontic infection. It is still controversial and there is no scientific or clinical consensus about the immediate implant indication in areas of chronic periapical infected sites, in addition, few clinical data are available. Some clinical reports have suggested that history of endodontic or periodontal infections is a predictive risk marker for future implant infection and failure (21, 22, 23). This hypothesis may be justified by the possibility of soft and hard tissue contamination located near the implant surgical bed. This led most cli-nicians to avoid immediate placement of dental implan-ts at infected sites and to consider periapical infection a contraindication for immediate implantation (25).On the other hand, placement of immediate implant in chronically infected sites may have successful outcomes and is not a contraindication in all cases. A prospective controlled clinical study comparing immediate implan-ts in sites with or without periapical lesions failed to achieve differences between the two protocols. The failure index did not increase in the presence of periapical lesions when the implant achieved primary stability (14, 15, 17). More recent data of a retrospecti-ve study (418 implants placed in sockets with periapical lesions) with a minimum of 2 years follow up showed a survival rate (98.1%) similar to implants placed on pristine sites (98.2%) (27).A protocol option to achieve a successful outcome was proposed by Novaes Jr and Novaes in 1995 (15),consisting in the elimination of the etiological factors and to create favorable conditions for tissue healing. In the first step the patient must receive oral hygiene instructions and scaling and root planing in order to perform good plaque control. After one week, a re-duction of soft tissue inflammation can be noted and the surgery in association with the use of antibiotics (for 10 days, every 8 hours, starting 24 hours before surgical procedure) (15) can be performed. Atraumatic flapless tooth extraction is encouraged, and the socket must have 4 intact walls and in sequence should be carefully debrided (14, 15). The contaminated soft and hard tissues removal by meticulous debridement (15,25), combined with pre- and postoperative antibioti-cs will establish a favorable basis for bone healing and osseointegration (15). Some other factors must be considered: the extent of bone resorption and the angle of the implant for a satisfactory aesthetic re-

storation (15). The implant should be placed in the optimal aesthetic position, if not, the procedure should be delayed and a GBR should be considered in order to avoid future aesthetic complications. In case of compromised buccal bone walls, in order to preser-ve horizontal alveolar bone dimensions, association of Guided Bone Regeneration procedures can create adequate aesthetic conditions avoiding visualization of a gray band, from the implant, due to buccal wall fe-nestration. However, it is possible to perform a flapless approach in cases in wich the buccal bone fenestration is expected. Planning a GBR procedure with an api-cal approach, as shown in this paper, is only possible with a CT scan as a diagnostic tool before tooth ex-traction. The preservation of the coronal buccal wall crest will permit stability of the gingival position, avoiding black spaces and gingival recession or implant abutment exposure, giving an optimal aesthetic result. According to a recent systematic review, immediate implant placement into sockets with previous periapi-cal pathology is not contraindicated when a protocol of systematic debridement and cleaning is perfor-med. The same publication reported that the use of bone graft and the use of systemic antibiotics, although controversial, is encouraged to avoid possi-ble postoperative complications at the regenerated site (28). More recently, a controlled clinical trial with aesthetic and radiographical outcomes after 5 years was published (29). This study compared immediate implants placed in sockets exhibiting previous periapi-cal lesions (n=11) with sockets without this condition (n=15), both groups received GBR concomitant to implant installation and received 5 days of systemic an-tibiotics (Amoxicillin 750 mg) and were instructed to rinse with chlorhexidine 0.2% (period not informed). The implants were loaded 3 months after installation. The results achieved did not demonstrate differences between both groups on the parameters evaluated. None of the immediate implants installed in sites with previous periapical lesions exhibited retrograde peri-implantitis during the 5 years of follow up (29). This protocol cannot be used in cases where an acute in-fection persists even when the pre-surgical antibiotic is used, the immediate implant placement should be postponed, the tooth removed and the acute infection treated (25). It is indicated for experienced surge-ons since the correct debridement of the granulation tissue, avoiding violation of noble tissues, accurate guided bone regeneration procedures, correct 3D im-plant positioning and primary stability are important factors for treatment success.

CONCLUSIONThe proposed protocol used in the two cases re-ported, presented a successful outcome, achieving elimination of the infection and immediate dental im-plant placement with good functional and aesthe-tic outcomes. This is possible thanks to a meticu-lous execution of the proposed treatment protocol..

Fig. 31 Provisional crown in place. Fig. 32 Final clinical aspect after the metalloceramic crown was cemented.

Fig. 33 Periapical radiograph and cT scan of the area 1 year after prosthesization


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placed into infected sites: a clinical report. Int J oral Ma-xillofac Implants 1995;10:609-13.16. lindeboom JA, Tjiook y, Kroon Fh. Immediate pla-cement of implants in periapical infected sites: a pro-spective randomized study in 50 patients. oral surg oral Med oral Pathol oral radiol endod 2006;6:705-10.17. siegenthaler dw, Jung re, holderegger c, roos M, hämmerle chF. replacement of teeth exhibiting peri-apical pathology by immediate implants. A prospective controlled clinical trial. clin oral Impl res 2007;18:727-37.18. Bell cl, diehl d, Bell BM, Bell re. The immediate pla-cement of dental implant into extraction sites with periapical lesions: A retrospective chart review. J oral Maxillofac surg 2011;69:1623-7.19. Fugazzotto PA, A retrospective Analysis of Implants Immediately Placed in sites with and without Periapical Pathology in 64 Patients. J Periodontol 2011 [ahead of print].20. lazzara rJ. Immediate implant placement into ex-traction sites: surgical and restorative advantages. Int J Periodontics restorative dent 1989;9:332-43.21. Ayangco l, sheridan PJ. development and treat-ment of retrograde peri-implantitis involving a site with a history of failed endodontic and apicoectomy procedures: a series of reports. Int J oral Maxillofac Im-plants 2001;16:412-7.22. oh TJ, yoon J, wang hl. Management of the im-plant periapical lesion: a case report. Implant dent 2003;12:41-6.23. Karoussis IK, salvi Ge, heitz-Mayfield lJ, Brägger U, hämmerle ch, lang NP. long-term implant progno-sis in patients with and without a history of chronic periodontitis: a 10-year prospective cohort study of the ITI dental Implant system. clin oral Implants res 2003;14:329-39.24. Polizzi G, Grunder U, Goené r, hatano N, henry P, Jackson wJ, et al.. Immediate and delayed implant pla-cement into extraction sockets: a 5-year report. clin Implant dent relat res 2000;2:93- 9.25. casap N, Zeltser c, wexler A, Tarazi e, Zeltser r. Im-mediate placement of dental implants into debrided infected dentoalveolar sockets. J oral Maxillofac surg 2007;65:384-92.26. Fugazotto P. A retrospective analysis of Immedia-tely Placed Implants in 418 sites exhibiting periapical pathology: results and clinical considerations. Int J oral Maxillofacial Impl 2012; 27:194-202.27. lindeboom JA, Tjiook y, Kroon Fh. Immediate pla-cement of implants in periapical infected sites: a pro-spective randomized study in 50 patients. oral surg oral Med oral Pathol oral radiol endod. 2006;101:705-10.28. waasdorp JA, evian cI, Mandracchia M. Immediate Placement of Implants into Infected sites: A systematic review. J Periodontol 2010;81:801-8.

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SCIENTIFIC UPDATE 牙窝根尖周变病的即刻种植:一篇有插图说明的述评


牙窝根尖周变病的即刻种植:一篇有插图说明的述评

摘要从第一次被提出至今，即刻种植已获得了极大的关注，即刻种植牙替换根尖病变的牙齿是到今天为止一直被讨论的话题。这次研究的目的是，提供一个配有插图说明的根尖病变牙窝即刻种植的述评。

材料和方法我们对MEDLINE/ EMBA的文摘数据库进行了搜索，和文献中介绍的两个配有拔牙窝根尖病变的即刻种植技术步骤插图的案例。两个案列中的手术部位都有极高的审美要求而且存在相当规模的牙窝根尖周病变现象。对这两个案例都实施了严格的肉芽组织切除、仔细冲洗拔牙窝和配合术前康生素的治疗。其次是保证种植牙良好的初期稳定性。

结果和结论这两个案列的结果都呈现了满意的功能与美学效果。为根尖周病变区进行即刻种植描述了一个成功的治疗方案。

Author Athur B. Novaes jr. 1, ValdIir A. MuglIa 3, Umberto d. Ramos 1, Danilo M. ReIno1, Lauro g. Ayub 2

1 巴西圣保罗大学里贝兰普雷图牙科学院，口腔与颜面外科学系、外伤学系和牙周病学系。 2 巴西RIO GRANDE天主教大学阿雷格里港牙科学院临床牙科学系。3 巴西圣保罗大学里贝朗普雷图牙科学院牙科修复学系l 关键词骨移植，牙的种植，即刻种植载入，尖周病。

前言从发表第一篇关于骨结合这一技术与其第一个临床试验 (1、2 ) 至今，人们对对骨结合式种植修复的兴趣已经增长了好多倍。从当初对完全无牙颌患者的治疗，到后来对部分无牙颌患者的治疗，再到对单颗牙齿的修复。传统的骨结合式种植，对拔牙和种植手术时间的间隔要求是6到8个月。在拔牙后这段长时间的等待中会发生不可避免的骨遗失，这样的话植入时就会有骨量不足的问题。骨量不足导致了需要使用角形植入物或骨移植的办法来解决。这就导致增加了发病率、疗程的延长和成本的增加。在种植过程中首先需着重考虑的是与骨质量和种植部位的深度和宽度，随着诱导骨再生和骨移植技术的进步，骨量不足所带来的大部分问题已经解决或大部分已得到解决。现在主要关注美学效果和软组织增加与稳定性 ( 3、4) 。因为可以避免拔牙和种植手术间隔时间长所带来的问题，即刻种植已经得到了人们的重视。这一技术最早在1976年被提出 (5) ，此后一直

成为业界科学讨论的主题。已经有很多的学者对牙槽嵴水平和成功率之间的差异做出了评估 ( 6、7) .关于即刻种植术的成功，人们像报道治疗方案本身时一样的报道它，并和其他传统方案一样被推荐 ( 7、8、9) ,由于缩短了治疗时间和植入物与假体之间滞后的问题，即刻种植成了一个很吸引人的治疗方案。大多数拔牙原因包括感染区的微生物和炎症引起的疾病，如牙周炎，或因牙髓感染的根尖病变。因此，一个越来越感兴趣的问题被提了出来，如何在一个受感染的区域内进行即刻种植。这篇配有插图的综述的目标是，查阅现有的文献资料，并给如何在受感染区域进行即刻种植提出一个可预测的临床方案，介绍两个经过12个月跟踪治疗的临床病例。

牙窝根尖周病变即刻种植的文献所谓的根尖周病变就是由于被感染根管上有病源菌而引起炎症反应的区域，在组织学检查中可以发现肉芽组织增生和有密集的嗜中性粒细胞的炎症渗入到根尖孔的周围，把细菌界定在

引用了本述评: Novaes Jr. AB, Muglia VA, ramos, Ud, reino dM, Ayub lG. Immediate implants in extractionsockets with periapical lesions: an illustrated review. J osseointegr 2013;5(3):45-52.

Fig.1 Fig.2


根管的根尖部。因此，一些学者认为根尖周病变对即刻种植的成功存在可预见性的风险，与这种治疗方案是相悖的 (10至13) 。另一方面，一些研究者在组织学研究中发现对根尖周病变牙槽进行即刻种植时呈现出类似非感染区域的症状 (14) 。首例牙槽根尖周病变即刻种植成功的报告于1995年发表在Novaes Jr and Novaes上 (15)。该方案作者提出的建议包括小心的提取和种植窝的准备(在根尖周病变区用骨凿和刮匙薄薄的去除所有被感染骨，并诱导出血从而有利于移植中细胞的增生)之后用丰富的生理盐水溶液冲洗，到引导骨再生和初次缝合，在离种植还有24小时时需要做系统性的抗生素治疗方案。

通过对比在根尖周病变区即刻种植法和延期种植法。一个前瞻性的随机对照研究报告在2006年发表了。该调查包括临床和影像指标对从根尖周病变中提取的样品进行微生物培养和谐振频率分析的办法来测量种植体的稳定性。作者的报告显示，即刻种植成功率为92%，延期种植为100%。两种方案，虽然有个数值差，但没

有显著的统计学差异 (16) 。通过对34个受试者由种植体植入根尖病变部位和健康部位所取得的临床效果进行对比。种植体植入1年后结果是，两种治疗方案的结果之间没有差异。这个研究表明即刻种植体与根尖周损害牙齿并不相悖 (17)。

一项对922列种植手术的回顾性研究( 285个种植在根尖周感染部位，和637个在健康部位，) 相比两种治疗方案的成功率，结果是成功的定义为：成功的骨结合修复，没有不被吸收的植入物。成功率分别为试验组(根尖周感染组)为97.5%，和对照组(健康组)为98.7%。所以作者认为在根尖周感染的部位即刻种植是一个安全可行的治疗方法 (18)。

另一个回顾性研究是对种植物植入感染部位和植入健康部位后64个月内进行功能测试。最后对两种治疗方案都报道了类似的成功率，(感染部位种植的成功率为98.1%,健康部位的种植成功率为98.2%)(19)。

图 1 尖周RX显示右上角中门牙有严重的根尖周病变图 2 图2用CT扫描作为诊断工具进行规划即刻种植

图 3 矢状的CT扫描图显示低密度绿箭头所指处和骨长度适合种植棒的固定。图 4 利用CT扫描制造了三维模型以用于手术规划和义齿的制造

图 5 拔牙前牙齿临床外观

图 6 图6之前的金属瓷冠在术前被摘除，正面观。

图 7拔牙前旧义齿被取下后的咬合视图

图 8用微创拔牙法拔掉患牙。

图 9有根尖病变的牙齿被提取出来。

图 10提取手术后拔牙窝的咬合视图，手术对临近软组织的伤害减到了最小化

Fig.3 Fig.4

Fig.5

Fig.6

Fig.7

Fig.8

Fig.9 Fig.10

56



病例报告

病例1上门牙右边中间的一颗被指出需要拔除，因为根据根尖X光片(图1)的显示确诊为严重的根尖周病变。根据临床特征的需要，我们决定用即刻种植体支撑种植牙来替代原牙、无翻瓣手术和即刻临时修复。初诊中所有受损部位都被记录了下来，并对受损部位进行了刮治和根面整平，为了得到良好的菌斑控制效果，对口腔进行了卫生处理。考虑到牙龈的厚度和结构，用诊断涂蜡法给龈缘位置和APICO冕冠建立了尺寸。为获得一个三维模型还做了一个锥束CT扫描(图2和3)。这时，制定一个手术指南和精确的反向治疗计

划已经有了可能。在制定手术步骤之前，我们通过对一个三维模型进行外科仿真(图4)来选择和个性化义体部件并制出一个合适的临时冠。手术是在局部麻醉状太下进行的，另外，开了10天用的875毫克阿莫西林处方，患者应该在手术前24小时开始服用。根据Novaes Jr and Novaes【15】的建议做了无翻瓣拔牙，拔牙时尽量把创伤减小到最低,拔出牙齿后仔细清理了拔牙窝创口(图5至10)。用生理盐水冲洗结束，检查拔牙窝壁，确定前庭壁合牙窝组织结构适合植入即刻种植棒时，手术指南就被列出来了(图11和12)。种植窝的准备已经完成，根据种植棒生产商给出的指示为一个4.5毫米直径，15毫米长标准的XiVe S Plus种植体准备了种植窝（XiVe S Plus种植棒由德国曼海姆Dentsply Implants公司生

图 11 取自三维模型的咬合视图和通过精心设置的种植棒三维位置图 12 手术指南视图显示最佳美学效果的种植棒位置

图13 植入种植棒后的视图图 14 保留完整的冠瓣附着牙龈和软组，这有助于得到满意的美学效果。为避免开窗，需要在厚颊骨顶端进行移植。

图 15 移植物生物活性玻璃已经放置

图 16 初步缝合已经完成，临时冠固定完毕

图 17术后临时冠最终效果图

图 18即时手术后的根尖X光片

图 19手术1个月后的根尖X光片

图 20氧化锆基台种植3个月后的根尖X光片

Fig.11


Fig.19 Fig.20

Fig.21

Fig.22

Fig.23 Fig.24


Fig.15


病例2 通过根尖X光片诊断，右侧上切牙由于牙周内侧病变而需要被拔除（图26）。CT扫描片（图27）的检查分析显示有结构缺陷的存在，基于此因，决定对其进行即刻种植和使用临时冠。在提前服用了一天的康生素后（阿莫西林875毫克，克拉维酸钾125毫克的组合，每日两次，连续服用10天，在手术开始前一天开始服用）拔除了牙齿，提取牙齿后一颗5.5毫米直径13毫米长的种植棒被固定在离颊骨壁1毫米处（图28至30）。在同一天，一个4.5毫米直径的义齿部件被安装好了，然后用旋转基台的办法放置了临时冠（图31）。9个月后用金属瓷冠替代了临时冠(图32），12个月后，为了确认治疗的成功，做了根尖X光片和CT扫描（图33）。

图 21 氧化锆基台的临床颊侧面图 22 氧化锆基临床咬合面

图 23 义齿安装6个月后义齿冠最终外观效果

图 24 手术12个月后的CT扫描图

图 25 手术12个月后的根尖X光片

图 26 根尖X光片显示，右上切牙有严重的根尖病变

图 27扫描显示颊骨壁位于牙根尖部位穿孔

图 28除之前的牙齿临床外观

图 29一片完整的冠瓣被反褶起，把种植棒定位在骨嵴顶端正中。

图 30瓣关闭后手术区临床外观

Fig.25

Fig.26


Fig.30 Fig.31

Fig.32 Fig.33

58



讨论

在种植疗法中，为了确保种植的美学和功能效果，保留牙槽骨的尺寸、牙龈缘位置、牙龈厚度和牙龈角化组织是非常重要的。因此，为了减少牙槽突的吸收和减短治疗时间，在新鲜的拔牙窝内即刻植入种植体被广泛推荐 (7、8、 9、20)。然而，大多数需要拔牙的原因，由牙齿折裂、牙周炎或牙髓感染引起的。对慢性根尖周炎感染的区域的即刻种植，并没有达成一个科学或临床上的共识，它仍然是个有争议的话题。此外，也没有很多的临床资料可用来参考。一些临床报告表明，牙髓或牙周发炎史是一个对导致种植后发炎和种植失败的预测性风险指标 (21、22、23) 。可以通过靠近种植手术床附近的软硬组织受到污染来证明这个假说。这导致了大多数临床医生避免在受感染区域即刻种植，并认为根尖周感染对即刻种植来说是一个禁忌 (25)。

另一方面，在慢性感染部位即刻植入种植体有可能获得成功的结果，而且并不是对所有情形的禁忌。一个乐观的临床对照研究，比较根尖病变即刻种植和无根尖病变即刻种植两种治疗方案的失败率，当手术取得初期稳定时，发现手术失败指数并没有因为有根尖病变的存在而增加 (14、15、17)。一个最新的回顾性研究数据显示，通过对481例根尖周病变的即刻种植，经过不少于2年的跟踪观察后，发现其存活率为98.1％，接近于无尖周病变即刻种植98.2％的存活率 (27)。

Novaes Jr 和 Novaes在1995年提出了一个可以获得满意结果的治疗方案 (15)，就是通过消除致病因素和创造有利于组织愈合的条件。为了得到一个良好的菌斑控制效果，首先，需要对病人实施口腔卫生措施和刮治与跟面平整。一个星期后，可以注意到软组织炎症已经减少，这时在使用抗生素的同时可以进行手术了。抗生素用法：从手术前24小时时服用第一次，之后每8个小时一次，连续服用10天 (15)。提倡用无创无翻瓣拔牙法，拔牙窝必需有4个完整的壁，接下来还要对其进行清创处理 (14、15)。要用细致的清创手术去除受污染的软、硬组织 (15、25)，结合术前与术后的抗生素服用将为骨愈合及骨结合创造一个有利的条件 (15)。

其他一些必需考虑的因素：骨吸收程度和令人满意的美学修复效果的种植体角度 (15)。重要的是，植入物应该放置在最佳审美位置，如果没有得到这个效果，为了避免将来的审美并发症，应该考虑诱导骨再生（GBR）。

如果遇到受损害的颊骨壁，为了保证牙槽骨尺寸的水平，使用诱导性骨再生程序可以建立足够的审美条件，因为这样可以在种植手术中避免由于颊壁穿孔而出现灰色区域。然而，在有可能出现颊骨开窗的情况下可以进行无翻瓣手

术。要设计一个像本篇所示的根尖诱导骨再生程序的话，拔牙前一定要用CT扫描来作为诊断工具。冠状颊侧壁嵴的保存，有利于牙龈位置的稳定，可避免出现黑色空间和牙龈萎缩或种植体基台的暴露；可以带来最佳的美学效果。根据一个最近的系统性述评，在治疗过程中进行清创和清洁处理的情况下，曾有根尖病变的拔牙槽对即刻种植来说并不是一个禁忌。同一个出版物也报道，虽然对骨移植和系统性的抗生素应用还有争议，但提倡避免骨再生部位有可能的术后并发症 (28)。

最近，发表了一个针对美学和影响学结果而进行了5年的临床对照试验报告 (29)。这项研究比较了有根尖病变牙窝和无根尖病变牙窝的即刻种植，两组均接受了诱导性骨再生方案（GBR）和接受5天的系统性服用康生素（阿莫西林750毫克）并嘱咐用0.2％的洗必泰冲洗（没有指出具体的期限）。种植体在安装3个月后载入。两组所取得的结果并没有评估参数上的差异。在5年的跟踪研究中，根尖病变牙窝患者的种植体周围并没有发现任何逆向情况(29)。

对有持续性急性感染部位是不可以用此治疗方案的，即时在手术前使用抗生素的情况下，这种情况下，应该推迟即刻种植计划，直到完成拔牙，急性感染被得到处理和控制 (25)。对一个有经验的外科医生而言的，除了对肉芽组织进行正确清创、避免伤到高贵组织、精确的诱导骨再生程序、正确的3D植入定位和初期的稳定性都是影响手术成功的重要因素。

结论

提供的两个病例中所用的治疗方案呈现了一个圆满的结果，既消除了感染又兼顾了即刻种植结果良好的功能和美学效果。这可能要归功于所提出的治疗方案得到了认真细致的执行。

图 31 临时冠入位图 32 胶固金属瓷冠后的最终临床效果图

图 33 义齿安装1年后根尖X光片和CT扫描图


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SCIENTIFIC UPDATE Evaluation of 4 mm implants in mandibular edentulous patients with reduced bone height. Surgical preliminary results


Evaluation of 4 mm implants in mandibular edentulous patients with reduced bone height. Surgical preliminary results

ABSTRACT Aim Growing evidence has suggested the utility of short dental implants for oral reconstructive procedures in clinical situations of limited vertical bone height. The aim of this short comunication was to evaluate the clinical use of implants < 10 mm in length and to determine short implant-supported prosthesis success in the atrophic jaw.Materials and methods Six women and three men were recruited for the treatment of edentulous mandi-bles. A total of 6 implants were inserted in each patient: two anterior implants of conventional lenght and four posterior 4 mm Titanium Zirconium (TiZr) implants. The insertion torque and bone density were evaluated.Results The mean insertion torque for the 4 mm implants was lower than for conventional ones, without any statistical difference. Moreover, most of the patients (88%) showed a D2 bone type.Conclusion The provision of short implant-supported prostheses in patients with atrophic alveolar ridges appears to be a successful treatment option in the short term; however, more scientific evidence is needed for the long term.

Author J.L. CALVO-GUIRADO1, M. MALLAUN2, M. DARD3, J.A. LÓPEZ TORRES4 1 University of Murcia, Murcia, Spain2 Institut Straumann, Basel, Switzerland3 New York University, New York, USA4 UNIVERSITY OF MURCIA, MURCIA, SPAIN KEY WORDS bone density, insertion torque, short implants, success rate.

INTRODUCTIONRehabilitation of totally edentulous patients with con-ventional removable dentures could be unsatisfactory for patients due to instability, discomfort, nerve pun-ching and affection of the ability to eat and speak. A complete screw-retained implant-supported prosthe-sis may be a viable alternative in such cases. However, the lack of sufficient bone volume and close proximity to the inferior alveolar nerve may represent a difficult clinical situation for the placement of endosseous im-plants (1). By using short implants to circumvent these difficulties, the primary stability may be compromised due to the reduced contact area for osseointegration. Moreover, successful placement of short implants in dense bone may furthermore depend on an accurate surgical technique to prevent a loose fit and overhea-ting of the bone site (2-3). Traditionally, clinicians have avoided the use of short-length implants in areas of compromised bone (e.g., posterior locations, low bone density, and thin ridges). With the introduction of new surfaces, the surgical and clinical performance of short-length implants may become very similar to that of standard length ones.The main purpose of this short communication was to evaluate and report the surgical performan-ce of novel short 4 mm implants made of Titanium Zirconium (TiZr) alloy with a hydrophilic surface. MATERIAL AND METHODSSix women and three men with a mean age of 64 (range 44–86) years were recruited for treatment of edentu-lous mandibles. Each individual was thoroughly informed of the overall requirements/procedures of the study after explaining the purposes of the study, the nature of the planned treatment and alternative procedures.

Potential risks, possible complications, and benefits of the proposed treatment were explained to the study subjects and they all signed an informed consent. The inclusion and exclusion criteria were selected as follows.

› Inclusion criteria: age >18 years; committed to participate up to 3 years follow-up; complete edentu-lism in the mandible to allow placement of 6 implan-ts (two in the canines zone of 10 mm in lenght and four 4 mm implants placed in the resorbed sites behind the mental nerve); full or partial dentition opposing the implants. The implant site had to be edentulous for >2 months and healed, with evidence of bone resorption and atrophy; the minimal residual bone height should be adequate in the canine zone, and at least 8 mm in the posterior zone.

› Exclusion criteria: presence of blood, metabolic, endocrine, renal, or neoplastic disease; human immu-nodeficiency virus infection; smoking >10 cigarettes per day; alcoholism; any conditions that may prevent study participation or interfere with analysis of results; mucosal diseases; history of irradiation therapy; pre-vious reconstruction, bone grafting, or failed GBR at the site of intended implant surgery; severe bruxism/clenching; inadequate oral hygiene or unmotivated for home care; lack of primary stability; insufficient bone or any abnormality that would contraindicate implant placement.

Pretreatment proceduresA clinical and radiological examination was carried out including panoramic x-rays (Fig. 1) (8000C Digi-tal Panoramic and Cephalometric System, Carestream, Rochester, NY, USA) and Cone beam scan (CS 9300

TO CITE IN THIS ARTICLE: Calvo-Guirado JL, Mallaun M, Dard M, López Torres JA. Evaluation of 4 mm implants in mandibular edentulous patients with reduced bone height. Surgical preliminary results. J Osseointegr 2014;6(2):43-45.


System, Carestream, Rochester, NY, USA). Bone and non-bone voxels were segmented using a heuristic segmentation algorithm that was developed specially for bone tissue with highly nonhomogeneous CT atte-nuation density distributions (4). Study designEach patient received 6 implants: two anterior implants of 10 mm length and four posterior implants of 4 mm lenght with a hydrophilic surface (Tissue Level Standard Plus, RN, Roxolid, SLActive, diameter 4.1 mm, Institut Straumann AG, Basel, Switzerland) for a screw-retained fixed complete denture.

Surgical procedureImplant placement was performed using single-stage surgery. Local anesthesia was achieved by inferior al-veolar nerve block and administration of an appro-priate dose of Articaine dental® 4% with epinefrine 1:100.000 (Inibsa, Barcelona, Spain). A midline incision was done at the alveolar crest from the distal surface

of the missing first molar. Full thickness mucoperiosteal flaps were raised and the path of the mental foramen identified with two realease incisions at the back (Fig. 2). The preparation of the implant sites was performed according to a precise sequence (Fig. 3). Immediately postoperatively, the initial implant stability was asses-sed by recording the insertion torque value of the 4 mm implants. Cover screws were placed on the im-plants and the flaps were repositioned and sutured (Fig. 4). Antibiotics were prescribed at the discretion of the surgeon. Analgesics were given as required for pain control. The patients were instructed to rinse with a 0.12% chlorhexidine solution (Dentaid, Barce-lona, Spain) twice a day for 1 or 2 weeks until suture removal. After suture removal, the patients were in-structed in proper mechanical brushing of the implants using 1% chlorhexidine gel until placement of the final restoration. A removable temporary prosthesis was in-stalled in the mandible by using provisional implants lo-aded with Structur (Voco Gmbh, Cuxhaven, Germany), in order to avoid stress/load on the definitive implants

Fig. 1 Preoperative panoramic radiograph. Fig. 2 Mucoperiosteal flap elevated before implant placement.

Fig. 3 Drilling sequence for 4mm Standard Plus Im-plants: Lance-shaped drill (pointed drill designed to break the cortical bone); 2,2mm drill (initial step for dental implant); Implant Depth Gauge; 2,8mm drill; Implant Depth Gauge: 3,5mm drill; Implant Depth Gauge. Fig. 4 Six implants placed in edentulous mandible, two long implants of 10mm lenght and 4mm implants behind mental nerve in both sides.

Fig.5 Preoperative radiograph after implantplacement

Fig.1 Fig.2

Fig.3 Fig.4

Fig.5

62

SCIENTIFIC UPDATE Evaluation of 4 mm implants in mandibular edentulous patients with reduced bone height. Surgical preliminary results


during the healing phase. Panoramic radiographs were obtained before and after surgery (Fig. 5). Statistical analysis The statistical software used was StatXact (Cytel, Cambridge, MA, USA) and descriptive statistics by means of Excel (Microsoft, Redman, WA, USA). The patient was used as the unit of analysis in all tests. For continuous data, a mean value was calculated per patient. The paired two-sample t-test was used and the level of significance was set at 0.05. RESULTS All implants survived until one month after insertion. The mean insertion torque for the 4 mm implants was 38.1 ± 1.2 Ncm, while for the 10 mm implants was 42.4 ± 2.1 Ncm (table 1). Using a paired two-sample t-test, no significant difference between the average in-sertion torques was found (p=0.005) (Fig. 6). Most of the patients had D2 bone (88%), while fewer patients had class D1 (8 %) or D3 (4 %) bone. DISCUSSION AND CONCLUSIONShort implants should be used by experts with skillfull hands to avoid implant failures. The preliminary results of this study demonstrate that 4 mm long TiZr implants with an hydrophilic surface can be safely inserted in re-sorbed mandibles with insertion torques comparable to longer implants, thereby avoiding vertical augmen-tation procedures. Unlike the mandible (McGill Con-sensus meeting, Montreal, 2003), there is no consensus today regarding the number of implants for a maxillary overdenture. However, a recent systematic review re-vealed that a maxillary overdenture, supported by six implants, connected with a bar, is the most successful treatment regarding the survival of both the implants and the overdenture (6). Four additional extrashort implants, as proposed by the present study, implicate an additional cost, altought they may help the long im-plants, by increasing the stability of fixed resin pro-

stheses, due to the wider spread of the implants within the arch. A second advantage might be that posterior bone resorption could be prevented, implicating less relinings of the prosthesis and avoiding mental nerve damage. Pieri et al. suggested that even in quality IV bone, a suc-cessful treatment can be expected with two additional short implants, early loaded, supporting an overdentu-re (7). The lower bone quality/density in the posterior areas may be compensated by splinting of all implants with a cad-cam bar. The loading, in the present study, was avoided in the early stages and after the final re-storation; moreover, unfrequent relining during the first weeks was performed to reduce crestal bone loss. Van Assche et al., studied the lack of information on the for-ces applied by different opposite arch conditions. Since the patient population of the study was limited, it was not possible to evaluate the influence of the applied forces of the opposing arch. They also showed that short implants can be a successful alternative to bone augmentation techniques for this treatment concept, also in type III or IV bone (8). The provision of short implant-supported prostheses in patients with atrophic alveolar ridges appears to be a successful treatment option in the short term; however, more scientific evi-dence is needed for the long term.

REFERENCES1. Annibali S, Cristalli MP, Dell’Aquila D, Bignozzi I, La Mo-naca G, Pilloni A. Short dental implants: a systematic re-view. J Dent Res 2012;91(1):25-32.2. Anitua E, Alkhraist MH, Piñas L, Begoña L, Orive G. Im-plant survival and crestal bone loss around extra-short implants supporting a fixed denture: the effect of crown height space, crown-to-implant ratio, and offset place-ment of the prosthesis. Int J Oral Maxillofac Implants 2014;29(3):682-689.3. Grandin M, Berner S, Dard M. A review of titanium zirco-nium (TiZr) alloys for use in endosseous dental implants. Materials, 2012, 5: 1348-1360.4. Kim DG, Christopherson GT, Dong XN, Fyhrie DP, Yeni YN. The effect of microcomputed tomography scanning and reconstruction voxel size on the accuracy of stereo-logical measurements in human cancellous bone. Bone 2004;35(6):1375-82.5. Slotte C, Gronningsaeter A, Halmoy AM, Ohrnell LO, Stroh G, Isaksson S, Johansson LA, Mordenfeld A, Eklund J, Embring J. Four-millimeter implants supporting fixed partial dental prostheses in the severely resorbed poste-rior mandible: two-year results. Clin Implant Dent Rel Res 2011;14:46-58.6. Slot W, Raghoebar GM, Vissink A, Huddleston Slater JJ, Meijer HJA. A systematic review of implant-supported maxillary overdentures after a mean observation period of at least 1 year. J Clin Periodontol 2010;37:98-110.7. Pieri F, Aldini NN, Fini M, Marchetti C, Corinaldesi G. Im-mediate functional loading of dental implants supporting a bar-retainedmaxillary overdenture: preliminary 12-mon-th results. J Periodontol 2009;80:1883-1893.8. Van Assche N, Michels S, Quirynen M, Naert I. Extra short dental implants supporting an overdenture in the edentulous maxilla: a proof of concept. Clin Oral Impl Res 2012;23:567-576.

PATIENT P1 P2 P3 P4 P5 P6 P7 P8 P9

Ncm 35 41 36 54 52 39 39 48 36SD 0 11 5.6 6.4 14 7.2 1.5 7.5 7.5

Fig.6 Mean insertion torque values per patient, recorded during the insertion of the 4mm implants.

Table 1 Mean insertion torque values (Ncm)+/- stan-dard deviation (SD) per patient (P1 to P9), recorded during the insertion of the 4mm implants.

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SCIENTIFIC UPDATE 长4毫米的种植体在下颚无齿且垂直骨量受限患者中的运用评估。手术初步结果


引言在全无齿患者的口腔修复中，运用传统的可移动假牙可能会由于以下原因使患者不满意，不稳定性、不适、挤压神经和影响吃饭与说话的能力。在这种情况下，一个用螺丝固定在种植体上的假牙可以作为一个可行的替代方案。然而，缺乏充足的骨量和过于接近下齿槽神经，可能会给骨内种植造成一个临床上的难题。通过运用短种植体来避免这些难题的话，初步稳定性可能会由于减少了骨结合的接触面积而受限制。况且，成功地在密致骨中放置短种植体还需要用一个精确的手术技巧来避免孔位过大和骨位被过分加热的情况。传统上，临床医生们已经避免了在受损骨中运用短种植体(如后置、低密度骨质、薄边等)。然而通过建立新的表面，短种植体的手术和临床性能可能变得和标准长度种植体非常相似。此短论的主要目的是对这种4毫米短种植体的手术性能进行评估和报道，该种植体由钛锆合金制成，其表面具有亲水性。

材料和方法我们招募了六个女性和三个男性进行下颌牙修复，三男六女的平均年龄为64岁（最小年龄为44岁最大年龄为86岁）在告知该实验的目的后，我们给每位测试者详尽地讲解了所有需要遵循的要求和治疗过程，包括治疗的原计划和替代程序。还给研究对象解释了潜在风险、可能出现的并发症、和被推荐的治疗的好处，然后，他们都签下了一个意向书。研究对象是根据以下两条标准筛选出来的：需要达到的标准：研究对象年龄在18岁以上，承诺参与研究3年以上；下颌全无齿，可以植入6根种植体（尖牙区的两根10毫米和四根4毫

米长的在颏神经后面的再吸收区域）；全牙和部分牙列不适合种植体的植入。种植部位的无齿时间需多于两个月，并且伤口已痊愈，有骨再吸收和萎缩状态；残留骨的重量必须与尖牙区所需标准一致，后面的区域至少有8毫米。排除标准：有血液、代谢、内分泌、肾脏或肿瘤性疾病的人，有人类免疫缺陷病毒感染者，每天抽烟超过10支者，酗酒者；以及所有可能妨碍参与正常研究实验或干扰分析结果的条件；有粘膜疾病者；有放射治疗史者；或在手术预期植入部位有过修复、挫骨、骨再生失败的人；有严重的夜磨牙症或咬牙习惯者；不充分的口腔卫生或无意在家护理口腔卫生者；缺乏初步稳定性者；骨量不足或有任何一种不支持种植手术的异常条件者。

疗前处理程序对研究对象的口腔进行了临床和影像检查，包括全景X光线 (图 1) （由美国纽约Carestream公司生产的8000C全景和X线头影数字系统）和锥束扫描（由美国纽约Carestream公司生产的CS9300系统）。通过利用启发式分割法，骨和非骨的三维像素被分离，这种专门用于骨组织而研发的分割方，是通过利用不均匀的CT衰减密度而研发出来的。

研究规划每位患者被植入六根种植体：尖牙区两根长 1 0 毫米的种植体和后部四根有亲水性表面长4毫米的种植体( 瑞士巴塞尔Strauman-nAG士卓曼研究所研发的Tissue Leval系标准RN，Roxolid,SLActive4.1毫米的种植体),以便于

长4毫米的种植体在下颚无齿且垂直骨量受限患者中的运用评估。手术初步结果文章来源: Calvo-Guirado JL, Mallaun M, Dard M, López Torres JA. Evaluation of 4 mm implants in mandibular edentulous patients with reduced bone height. Surgical preliminary results. J Osseointegr 2014;6(2):43-45.

摘要目的：越来越多的迹象表明了短种植体在垂直骨量受限口腔修复过程中的运用。此短论的目的是评估小于10毫米的种植体在临床中的运用，并找出短种植体支撑的假牙在下颚萎缩患者中的成功运用方案。材料和方法：我们招募了六个女性和三个男性进行接受下颌牙的修复，在每位患者的下颌中植入六根种植体:其中两根常规种植体在前部，4根4毫米钛锆合金的种植体在后部。并对种植体的插入扭矩和骨密度进行了评估。结果：4毫米种植体的插入扭矩的平均值低于常规种植体的插入扭矩，但没有很明显的差异。此外大部分患者 (88%)显现出D2骨型。结论：从短期来讲，给萎缩牙槽嵴的患者植入短种植体支撑的假牙似乎是一个成功的治疗选择；不过，从长期来看，我们还需要更多的科学依据。

J.L. CALVO-GUIRADO1, M. MALLAUN2, M. DARD3, J.A. LÓPEZ TORRES4 1西班牙穆尔西亚大学2瑞士巴塞尔士卓曼研究所3美国纽约大学4西班牙穆尔西亚大学

关键词 : 骨密度、插入扭矩、短种植体、成功率


安装螺丝固定式的假牙。

手术过程用单次手术植入种植体。用下牙槽神经阻滞和注射含有1:100.000肾上腺素的牙用阿提卡因进行了局部麻醉。在第一磨牙远端面的牙槽嵴上切开了中切线，整个厚度的黏骨膜襟翼被翻起，并在后部用两个释放切口标出颏孔的路劲走向(图2).种植部位的准备工作按照精确的顺序进行(图3)。术后立即通过记录4毫米植入物的插入扭矩评估了种植体的初始稳定性。压盖螺丝被安装在种植体上，襟翼被重新定位后缝合(图4)。医师经过斟酌定量开了抗生素服用处方，为了控制疼痛给出了止痛药。并指导患者用0.12%的洗必泰溶液冲洗口腔（该溶液由西班牙巴塞罗那Dentaid公司生产），每天2次，坚持1到2周，直到拆线为止。拆线后，患者被要求以正确的动作用1%的氯己定胶凝涮洗植入物直到种植部位最终修复为止。利用临时植入物上的结构，把一个可移动的临时修复体安装在颌骨上（该临时修复体由德国库克斯的VOCO有限公司提供）。为了避免在愈合期间给最终植入物过大的压力和负荷，手术前后都进行了全景X摄影(图5).

统计分析统计所用软件名为StatXact(该软件由美国马塞诸塞州剑桥市的Cytel公司开发 )，我们还用Excel进行了描述性统计（Excel由美国华盛顿

州雷德蒙德市的微软公司开发）。在测试中病人被用作分析的个体单位，为了后续的数据，我们为每个患者计算出了平均值。在计算中使用了配对样本 t-检验法，最后显著性水平显示为0.05.

结果直到植入一个月后，所有的种植体都存活了下来，4毫米种植棒的插入扭矩为38.1 ± 1.2 Ncm,，长度为10毫米的种植棒的插入扭矩为42.4 ± 2.1 Ncm（表1）。运用配对样本 t-检验法，平均插入扭矩之间没有显著差异(p=0.005) (图6) 。

讨论和结论为了避免种植失败，应该由技术娴熟的专家来种植短种植体，这项研究的初步结果表明，长4毫米由钛锆合金制成且具有亲水性表面的种植体，可以安全地植入有再吸收性情况的下颌骨中，它的插入扭矩与更长的种植体插入扭矩不相上下。因此也可以避免用垂直扩充的程序。与下颌骨（2013年，在蒙特利尔市麦吉尔大学的一个会议上总结出一个关于下颌骨义齿种植体数量的共识）不同的是，如今没有针对上腭义齿种植体数量的共识。然而，最近的一个系统综述表明，根据上颚上的种植体和义齿的存活率来看，由六根种植体连着一根横着的铁丝来固定义齿是最为成功的治疗方案(6)。本实验提议的4根超短种植体的使用，可能会导致成本增加，但是，通过增加固定树脂义齿的稳定性，它们对长种植体是不无裨益的，因

Fig.1 Fig.2

Fig.3 Fig.4

图1 术前全景X线片。图2 植入种植体前粘骨膜瓣被翻起。图3 给4毫米种植体的钻孔顺序：兰斯型钻(设计成尖钻利于打破皮骨质)；2,2毫米钻(为了初始植入种植体); 种植体深度记； 2.8毫米钻；种植体深度记；3.5毫米钻；种植体深度计。图4 六根种植体被种植在无牙颌上，两根10毫米长的种植棒和四根4毫米种植棒在后面心智神经的两侧。

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SCIENTIFIC UPDATE 长4毫米的种植体在下颚无齿且垂直骨量受限患者中的运用评估。手术初步结果


为它们有更高的拱形接触面积。它还有一个优点是可以防止后期骨再吸收情况，这意味着可以少换几次义齿，并且可以防止颏神经受损。 Pieri 等人建议，通过用加短种植体、早期负载来支撑假牙的方案，甚至在IV类骨质中都有可能取得成功的修复(7)。后部低骨质/密度的区域，可以通过一个固定甲板把种植体捆版在一起来得到弥补（8）。就短期而言，给下颚萎缩的患着放置用短种植体支撑的义齿似乎是个成功的治疗选择；但是，在本次实验中，不管是在早期阶段还是在最终修复后都没有用辅助铁丝和早期的负载；此外，为了降低牙槽骨的损失，在手术后的最初几周内进行了偶尔的更换义齿。Van Assche等学者认为还缺乏关于不同方向的拱形条件所产生的力度的信息。由于研究中的患者数量有限，无法评估反向拱形所产生的力度的影响。根据此治疗概念，他们还认为短种植体可以成功地替代骨增量技术，包括在III类骨质和IV类骨质中，但从长期而言，还需要更多的科学依据。

参考文献 1. Annibali S, Cristalli MP, Dell’Aquila D, Bignozzi I, La Monaca G, Pilloni A. Short dental implants: a systema-tic review. J Dent Res 2012;91(1):25-32.2. Anitua E, Alkhraist MH, Piñas L, Begoña L, Orive G. Implant survival and crestal bone loss around

extra-short implants supporting a fixed denture: the effect of crown height space, crown-to-implant ratio, and offset placement of the prosthesis. Int J Oral Maxillofac Implants 2014;29(3):682-689.3. Grandin M, Berner S, Dard M. A review of titanium zirconium (TiZr) alloys for use in endosseous dental implants. Materials, 2012, 5: 1348-1360.4. Kim DG, Christopherson GT, Dong XN, Fyhrie DP, Yeni YN. The effect of microcomputed tomo-graphy scanning and reconstruction voxel size on the accuracy of stereological measurements in human cancellous bone. Bone 2004;35(6):1375-82.5. Slotte C, Gronningsaeter A, Halmoy AM, Ohrnell LO, Stroh G, Isaksson S, Johansson LA, Mordenfeld A, Eklund J, Embring J. Four-millimeter implants suppor-ting fixed partial dental prostheses in the severely resorbed posterior mandible: two-year results. Clin Implant Dent Rel Res 2011;14:46-58.6. Slot W, Raghoebar GM, Vissink A, Huddleston Slater JJ, Meijer HJA. A systematic review of implant-sup-ported maxillary overdentures after a mean obser-vation period of at least 1 year. J Clin Periodontol 2010;37:98-110.7. Pieri F, Aldini NN, Fini M, Marchetti C, Corinaldesi G. Immediate functional loading of dental implants supporting a bar-retainedmaxillary overdenture: preli-minary 12-month results. J Periodontol 2009;80:1883-1893.8. Van Assche N, Michels S, Quirynen M, Naert I. Extra short dental implants supporting an overdenture in the edentulous maxilla: a proof of concept. Clin Oral Impl Res 2012;23:567-576.

Fig.5

PATIENT P1 P2 P3 P4 P5 P6 P7 P8 P9

Ncm 35 41 36 54 52 39 39 48 36SD 0 11 5.6 6.4 14 7.2 1.5 7.5 7.5

图5 种植后的术后X线片。

图6 每位患者的平均插入扭矩，插入4毫米种植体时的记录。表1 平均插入扭矩(Ncm)+/,标准偏差(SD)，每位患者（患者1到患者9), 4毫米种植体插入过程中的记录。


通过计算机导航骨浓缩后，聚合了PEEK（聚醚醚酮）的临时义齿的即时

作者: Alfredo Natali学士（牙科医生，自由职业者）

在治疗过程中，我们总是试图找到最好的诊断概念；在这个阶段，从制定治疗计划到实际治疗操作中，通过运用各种学科的实际帮助，可以使用很多种不同的方法。

每个手术都是为了解决一种实际的需求，需要仔细规划来更好的达到手术目的。尽可能完整的康复、正常的口颌功能、最小的创伤、最短的的时间、最少的成本和最小的困扰，是牙科领域中一直以来在追求的理想目标。在过去的十几年中，由于技术的进步和数字化工作流程的演变，使从诊断到治疗康复的无缝工作流程的制定和执行变成了可能，其适应症和可能性变得越来越大。

在牙种植中，我们看到了计算机导航种植的发展。由B&B DENTAL牙科新推出的计算机导航外科导板在数字光纤上提供了更多的简化处理，这一步接一步地帮助了诊所在全面学习过程中一些不可避免的弯路。此过程可以整合里面的各个阶段，从概念上来讲是属于不同场的，但是通过相关的顺序建立，在规划过程中，不同区域之间的不断回归，使你能够正确地管理和规划接下来的步骤。

一般来讲，规划过程可以分为三个宏观阶段：1. 诊断阶段2. 手术阶段3. 修复阶段接下来展示一个临床案例，里边介绍了主要的手术步骤：

1.诊断阶段我们可以看到第一个诊断区域，在这里我们收集了患者的所有信息和客观数据，包括X射线和锥束CT（图片1）。为了诊断预计种植区域骨的必要条件，和是否有足够宽度和厚度的牙龈组织；以便于确认是否可以进行实施无翻瓣手术。此外，患者还需要具备一个良好的开口状态，以便于容易地放入专用的刀具和种植体。在进行CT锥束扫描之前，应该进行初步的研究，从中得出一个全景不透射性面膜(图片2)。

通过光学扫描或双放射性扫描获取面膜，可以获得经过数字定位的解剖学参考（图片3）。

这些解剖学数据可以使牙医为患者做出一个预期的牙齿解剖，并具有大量关于数量、位置、倾斜度、所有固定件和有可能需要的基台的类型的信息（图片4）。这些是规划过程中基本和必要的参数，但不止这些，事实上还需要考虑手术因素和修复因素的相互影响。

图 1

图 2

图 3

图 4

图 5

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INDUSTRY NEWS B&B Dental


2 .手术阶段即时负载要想获得一个好的康复，种植体需要具有一个较好的初期稳定性（插入扭矩≥ 35 Ncm）；对于上颚来说，即使进行了种植部位的准备并且种植体的形状也有助于保证必要的初期稳定性，具有合适的骨可能会变得非常困难，这是个此行业中的典型特征。为了克服这个难题，B&B DENTAL牙科公司的Duravit 系统提供了手术导航系统和传统的手术用具，有一系列的骨填充器。进行局部扩大可以提高骨的局部密度并提高初期稳定性。

这种技术的优点也应用在了由B&B牙科公司所提供的3D指导下的手术中(图片5). 把EV种植体的位置从理论转移到实际操作中还需要一个面膜来指导（图片6）。比起手术导航这个过程更为人所知，但我们必须考虑到影响手术计划的具体措施要求。

比如，由B&B Dental牙科设计的特别型导筒具有特别的六角形状，并具有高精确度，所以有一个给定的体积，在几个种植体邻近的情况下可能会有干扰。此外，还需要考虑到导航还有不可还原性的垂直影响，这有可能使种植体沉入超过一定的限度。软件由3diemme创建，通过对干扰信号的适当控制和套用来执行。

3.修复阶段多亏了第一个得到CE认证的3diemme的规划软件，可以在手术前就得到临时伪影，因此不需要等待义齿的制造结束，因为我们已经知道种植体的位置。

显然，由于可能存在于材料和黏膜中的弹性，在种植体定位过程中会有一定的偏差。这个方法的另一个优势表现在型导筒的六角形状，它突出了连接种植体的位置(图片6)。如果把键盘的六角放置在导航指示的位置中可以预见非旋转基态假牙的位置，例如多用途六角形（MUA）骨填充器(图片7)。还可以进行规划减少钛制零时插管的咬合面，并用一个专门制造的树脂来帮助定位（图片7）。

3diemme的规划软件和B&B牙科快速成型实验室的3D CAD/CAM的结合给临时义齿的制造提供了无限的可能和选择。有必要让计划符合于实际的生产可能性和每个临川情况下可采用材料的特性。在制作了PEEK框架涂有丙烯酸类树脂的临床试验中，这种规划可以认为是完整的并可以过度到实际操作流程上。

手术操作阶段通过血管收缩(阿提卡因 1:100.000)的局部麻醉后，在用倒置的别针把面膜固定在前面板上之前，先进行黏膜切除，这样更易于去除唇状纤维和黏膜厚度的评估（图片9）。

B&B DENTAL牙科提供一整套便于临床工作的特别手术套装。B&B 3D试验室的面膜的固定，是个不容易的操作，需要极为谨慎的进行（图片10）。然后，用钻枪在所需位置

图 6

图 7

图 8

图 9

图 10

图 11 图 12


创建第一截骨（图片11）。在这个阶段，最易于测试骨的一致性，因此根据骨的一致性可以适当地调整外科手术方案来增加获得初期稳定性的可能。

为了增强面膜的稳定性，可以先植入两边最远端的种植体。位置准备补充分并且骨头没有随着钻头被取出，而是被压实，这多亏了骨填充器（图12）。在有更多的骨显露不一致时，这个过程就显得更有必要，而上颌的远端部位经常具有这些特点。

B&B DENTAL牙科生产的Duravit EV系列种植体，是固定在种植体架上的，他有显著的提高整体稳定性的功能（图13）。用间接视野来检查确定套筒的六边形与固定架的六角是否完全对齐是很有用的（图14）。骨填充和不充分准备的过程被运用于所有被计划种植的部位，并取得了令人满意的稳定性。具体而言，在大部分的操作中是用直键来代替装载架(图15)。在手术结束时去除了面膜(图16)。

安装义齿阶段

决定不给第13号牙的位置安装义齿，因为只具有刚好足够的稳定性和小直径的夹具。在该种植体上放置了用PEEK做的无菌黏膜愈合帽，它被包装在在B&B Dental牙科的所有种植器械里边。在其他种植体上安装了MUA桩和Il MUA斜桩，为了正确安装在种植体上，可能会使用到磨骨棒（图17）。

结束安装MUA时，决定做了一个位置印记，以便于促进骨梁的自行适应（图18）。这个阶段在口内也很容易操作，但要给患者留下几个小时来休息。

经过休息后，先从近中的两根,直接把义齿下调到口腔内，并固定位置（图19）。之后继续填满剩余的缝隙，拧紧义齿固定位置注入丙烯酸类树脂并完成锁定。义齿在实验室里完成加工并经过抛光（图21）。最后到义齿的临床应用，调整咬合面并进行审美抛光（图22）。

术后持续大约24小时中等程度的疼痛，出现了轻微的水肿，无出血症状，患者对治疗有高满意度。为了调整咬合，在7到14天的时候对临时义齿进行了检查，在1到2个月和3个月时（图23）。没有出现任何并发症。对临时义齿保持了长时间的维护，并等待换上最终的义齿。

[email protected] more information: [email protected]

图 13 图 14

图 15 图 15

图 16 图 17

图 18 图 19

图 21图 20

图 22 图 23

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INDUSTRY NEWS Silfradent


CGF-(Concentrated Growth Factors)

Salient features of the CGF:• Simple, safe and economic• Natural - 100% autologous• Thick Fibrin Matrix • Leukocytes, Platelets and Growth factors• Variable kinetics release• Matrix for Bone Graft Material

The CGF may be a valuable aid in the field of regenerative medicine, to speed up the process of regeneration. In fact this growth factor concentrate, showed great regenerative properties and versatility (Sohn et al. 2009). Its use has been proposed in various situations ranging from filling of extraction sockets (Tadić et al., 2014) to the filling of the cavity after cystectomy (Mirković et al., 2015), or in the sinus lift procedure (Kim et al., 2014; Del Fabbro et al., 2013; Sohn et al., 2011). Moreover, it can be used alone or with autologous bone particles or biomaterials (Gheno et al., 2014). Some authors suggest wet the surface of the implants with CGF in order to accelerate the bone-integration (Sie-brecht et al., 2002).• Scanning Electron Microscopy (SEM) studies, have shown that the CGF presents a fibrin network formed by thin and thick fibrillar ele-ments (Rodella et al., 2014).• Histo-morphological studies (Borsani, Bonazza et al., 2015 submit-ted) have allowed to see the fibrin network structure and the distri-bution of blood cells (leukocytes, erythrocytes and platelets) in the CGF.• Finally, in vitro studies using different human cell lines (Borsani, Bonazza et al., 2015 submitted), have shown that the addition of the CGF to the culture medium, stimulated cell proliferation (Borsani, Bonazza et al., 2015, submitted).

CGF - MATERIALS

BLOOD COLLECTION1. Antiseptic swab2. Complete butterfly3. Tourniquet4. Gauzes5. Patches6. Vacuette Test Tubes (Greiner Bio-One GmbH, Kremsmunster, Austria)7. Tube rack

CGF is obtained using polyethylene tubes (Vacuette Test Tubes), coat-ed with silica micro particles and without the addition of exogenous substances. After collection, the blood samples are immediately cen-trifuged using a special centrifuge device (Medifuge, Silfradent, Italy).

CGF Concentrated Growth Factors: Protocol and characterization

The CGF is an autologous platelet concentrate, developed by Sacco, in 2006 and obtained from blood samples through a simple and standardized separation protocol, by means of a specific centrifuge (MEDIFUGE 200, Sil-

fradent srl, Forli, Italy), without the addition of exogenous substances. The main feature of the CGF resides in its consistency: it is an organic matrix rich in fibrin, able to “trap” platelets, leukocytes and growth factors; elements

that play an important role in the regenerative processes.


CGF MEDIFUGE (Silfradent)Characteristics• Benchtop centrifuge dedicated to the CGF production, equipped with an appropriate rotor with alternate and controlled speed and with an acceleration always below 300 RCF.• The medical device MEDIFUGE allows for the use of up to 8 test tubes for the creation of CGF (fibrin);• A microprocessor control system allows for the maintaining of a constant speed;• The exception rotor system with self-ventilation protects the blood sample from heat exposure;•The rotor-holding compartment, the closing door and the test tube-holding jackets guarantee biological safety in terms of bio-con-tainment, in the event of test tube breakage;•The test tube-holding jackets and rotor are built from thermal, an-tistatic material that is easy to clean, extract and sterilize in an autoclave at 135°;•MEDIFUGE is equipped with a decontamination cycle with UVC reflected light;•Cycle duration 5 minutes at 1,000 revs;•The electronic control engine and its internal parts require no main-tenance;•Noise levels fall below the standards required and do not exceed 57 dBa.

CGF centrifugation protocol (One step protocol)30’’ acceleration 2’ 2,700 rpm/ 735 g 4’ 2,400 rpm/ 580 g 4’ 2,700 rpm/ 735 g 3’ 3,000 rpm/ 905 g33’’ deceleration and stop

At the end of the process, three blood fractions were identified: (1) the upper layer, representing the liquid phase of plasma named plate-let poor plasma (PPP); (2) the lower layer, representing red blood cells (RBC) because of mainly contains erythrocytes; (3) the middle layer, representing the solid CGF consisting in three parts: the upper white part, the downer red part (about 0,5 cm from RBC) and the middle “buffy coat*” part (interface between white and red part) (Figure 1 A,B,C).

Fig.1A,B,C: phases of CGF

CGF- Morphological characterization

FIBRIN NETWORKThe use of electron microscopy (SEM), allowed to observe that the CGF fibrin network of the is constituted by thin and thick fibrillar elements (Figure 2A).

Fig.2A: SEM analysis of CGF, fibrin network

Hematoxylin-eosin staining, allowed to observe the architecture of the CGF fibrin network (Figure 3). The images showed that the fibrin network and architecture changed moving from the buffy coat* to the white part. In particular, near the buffy coat* the fibrin network was strictly compact (Figure 3A) while far from the buffy coat* be-came with a larger mesh (Figure 3B).

Fig.3: Architecture of the fibrin network:A) near the buffy coat; B) far from the buffy coat;

BLOOD CELLSThe May Grunwald Giemsa histological staining (Figure 4A) and He-matoxylin-eosin (Figure 4B), allowed to localize blood cells present in the CGF. White blood cells are mainly located in the buffy coat* and dispersed in it, especially in the red part of the CGF; the red blood cells are present only in the red part of the CGF.

Figure 4: A) May Grunwald Giemsa; B) Hematoxylin-Eosin

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INDUSTRY NEWS Silfradent


CGF-（浓缩生长因子）

CGF的突出特点：•操作简单, 安全, 经济•天然- 100％的自体•粗纤维蛋白基质•白细胞、血小板和生长因子•可变的释放动能•用于骨移植材料矩阵结构中

CGF可以给再生医学领域的操作提供有价值的帮助, 以加快再生的过程。其实这种生长因子浓缩显示出极大的可再生性和通用性（Sohn等人, 于2009年）。它的用途已经被使用于各种不同的情况下和范围内, 从填充拔牙窝（Tadić等人, 于2014年）, 到填充膀胱切除后的空腔（Mir-ković等人, 于2015年）, 或用于上颌窦的抬高手术中（Kim等人 , 于2014年, Del Fabbro等人, 于2013; Sohn等人, 于2011年）。此外, 它还可以单独使用, 或与自体骨粒子或生物材料一起使用（Gheno等人, 于2014年）。一些学者建议与CGF一起弄湿植入物的表面, 来加速骨整合（Siebrecht等人，于2002年）。•用扫描电子显微镜（SEM）研究表明, CGF是一个由薄纤维状元素和厚纤维状元素够成的纤维蛋白网（Rodella等人, 在2014年提出）。•组织形态学的研究（由BORSANI, Bonazza等人在2015年提出）已经使人们能够看到CGF网状纤维蛋白的结构和CGF中血细胞（白细胞、红细胞和血小板）的分布。•最后, 对不同的人类细胞系进行体外实验（由BORSANI, Bonazza等人在2015年提出）的结果证明, 在培养基中加入CGF, 可以起到刺激细胞增殖的作用（由BORSANI, Bonazza等人, 在2015年提出）。

CGF- 材料血样采集

1.防腐拭子2.全套蝴蝶针3.止血带4.纱布5.补丁6.Vacuette血液收集管（由奥地利克雷姆斯明斯特的Greiner Bio-One国际有限公司生产）7.试管架

CGF是在不添加任何外源性物质的情况下, 在涂有二氧化硅微粒的聚乙烯试管中（Vacuette试管）制造出来的。采血后, 立即使用一种特殊的离心机（MEDIFUGE200离心机, 由意大利Forli的Silfradent 有限公司生产）将血液样品进行离心而得。

CGF浓缩生长因子：学术方案和性质特征CGF是自体血小板浓缩液，由Sacco在2006年研发, 他借助一个离心机装置（该装置是由意大利

Forli的Silfradent 有限公司生产的MEDIFUGE200离心机）用一个标准化的简易分离法，在没有任何外源附加物质的情况下, 将它从血液样本中分离出来。该CGF的主要特点在于它的一致性: 是一个富含纤维蛋白的有机基体, 它可以“捕捉” 血小板、白血球和生长因子, 在再生过程中, 这些

元素都起着很重要的作用。


CGF MEDIFUGE离心机（Silfradent有限公司生产）

特点•台式离心机为了专门用于CGF的制备, 该机配备了一个可以替换可稳速的转子, 并且在加速时始终低于300 RCF。•MEDIFUGE离心机可以一次放置多达8个用于制造 CGF（纤维蛋白）的试管;•由一个微处理器控制系统来维持恒定的速度;•外加一个具有自通风功能的转子系统, 该系统避免了血液样品暴露在热源之中;•在试管破裂的情况下, 转子仓、关闭的门和试管夹套子, 都可以在生物防护方面提供可靠的生物安全性;•试管夹套子和转子都是由易散热、抗静电的材料制成, 因此, 易于清洗和提取, 置于135℃高压灭菌器内消毒即可;•MEDIFUGE离心机还配备了一个利用UVC反射光的净化循环系统;•净化时间为在转速1000下持续5分钟;•电子控制发动机及其内部部件无需维护;•噪音水平低于所要求的标准, 不超过57分贝。 CGF离心方法（一次离心法）30’’加速2’2700转/735克4’2400转/580克4’2700转/735克3’3000转/905克33’减速和停车离心过程结束时, 血液被分成了三个层次:（1）上层, 有被叫做贫血小板血浆的液态血浆（PPP）; （2）红色的下层, 是由于包含了大部分的红细胞所至（RBC）; （3）中间层, 由三个部分组成的固体CGF: 上部白色, 下边红色部分（至红细胞的距离约0.5厘米）和中间的“血沉棕黄层*”部分（就是连接白色部分和红色部分的那一段）（图1 A，B，C）。

图1ＡＢＣ：CGF的分层示意图

CGF-形态特征网状纤维蛋白利用电子显微镜（SEM）, 可以观察到网状的纤维蛋白CGF由薄纤维状元素和厚纤维状元素（图2A）构成。

图2A: 电子显微镜下看到的CGF网状纤维蛋白

苏木精 - 伊红染色体, 使我们能够观察到CGF网状纤维蛋白的结构（图3）。图像显示, 网状纤维蛋白的结构在血沉棕黄层和白色层中是不一样的。邻近血沉棕黄层的网状纤维蛋白的网格显得特别严密紧凑（图3A）, 而远离棕黄层的网状纤维蛋白的网格则比较粗大（图3B）。

网状纤维蛋白的结构 A）邻近血沉棕黄层；B) 远离棕黄层

血细胞用迈格林华染色液（图4A）和苏木精 - 伊红（图4B）, 可以定位到CGF中存在的血细胞。白细胞主要分部在血沉棕黄层中, 并零散分散在CGF中的其它部分; 尤其是在CGF的红色部分中; 而红细胞则只存在于CGF的红色部分内。

图4：A）迈格林华染色液 B）苏木精-曙红

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INDUSTRY NEWS GCOMM


Tell us something about G.COMM’s history.

Our roots are in the Italian region known as Brianza, a land of estab-lished manufacturing traditions. G.COMM in 10 years of activity has gained a considerable reputation as a manufacturer of dental and electromedical equipment and supplies, focusing on components for dental units and in particular in the production of lamps and electric micromotors for the dental practice.

Your motto is “Quality, design, innovation”. How does it influence your activity?

These three words identify what today makes G.COMM a bench-mark among dental manufacturers. Thanks to our know-how, we can produce and sell with our own brand competitive, reliable, high-quali-ty products that make the dentist’s work easier and contribute to the patient’s well-being, at the same time fully complying with the sanitary regulations, hygiene standards and environmental safety. From the project development to its engineering and manufacturing, G.COMM manages all the production phases, giving to the company a high level of flexibility.

We guarantee an excellent pre- and post-sales assistance, but we also design and create custom-made products under the customers’ spe-cific, personal request to help them find the best and finest solution to their dental unit.Customer care and passion for our products are the basis of the growing success of G.COMM around the world, distributing today in more than 30 countries. But we are determined to expand ourselves and experience new markets all around the world. Dental lamps are your core products. How do the different models meet the dentist’s de-mands? In G.COMM we have put a special focus on the quality of the dentist’s work. This mission inspired the design and production of our lamps. For instance, the motto of our IRIS VIEW lamp is: “Our target: your work”.We believe that quality of work is strictly related to the possibility of perceiving the smallest details in the area of operations. Out of this belief comes Iris View, a dental light with a Full HD videocamera (1920x1080px) and autofocus that allows to view the area of treat-ment with a 30x optical zoom.

Interview with G.COMM


Iris View permits to have a detailed image of the operating area, high-lighting details which are difficult to see with naked eye, amplifying the visual capabilities of the professional and relieving eyestrain, leading to important progress in work methods.

The use of the videocamera improves communications both with the patient and specialized personnel. In the diagnosis phase diseases can be clearly shown on the monitor, making comprehension of the prob-lem simple and immediate. During the operating phase, specialised staff can follow the evolution of the operation in real time and at the end of the work results can be assessed.

Iris View allows recording and broadcasting the operation in Hi Defi-nition, making easy the connection to a wide range of devices. This opportunity is quite useful in various scientific contexts such as con-ferences, conventions and university lectures.

Iris View is expressly designed to improve the professionals’ well-being and work.The use of Monitor permits to work in complete comfort because the operating area can be observed in indirect vision. In fact, the den-tist is not forced to maintain an incorrect posture such as being bent over the patient, but can operate sitting upright. In this way, he can re-duce stress on the spinal column and consequentially decreasing the risk of professional ailments such as cervical problem, lumbar troubles and orthopaedic diseases.

Photo: Iris View dental lamp

Photo: The use of videocamera Photo: Complete Comfort

Photo: Connection to a wide range of devices

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INDUSTRY NEWS GCOMM


The lamp can be controlled both with the MyLight app and with the onboard keyboard to manage all the functions, according with the dentists’ needs. Using the iPad it’s possible to let an assistant set the parameters of the illumination with a Wi-Fi connection. In this way it’s possible to avoid touching the lamp, increasing hygiene and cleaning.

Colour temperature regulation: through a regulation system it’s pos-sible to adjust the colour temperature from 4.200° K to 6.000° K to improve the contrast on soft tissues. Recent studies demonstrate that dentists’ concentration increase through the rise of colour tempera-ture with the consequent reduction of their eyestrain. With the onboard keyboard or through the iPad it’s possible to set 3 different preset programs: Anty-Polymerisation Mode: minimises blue emissions, reducing the compound curing speed;Surgical Treatment: optimises the colour contrast on soft tissues, better distinguishing the shades of gums, blood and peridontium; Colour Capture: creates a combination of cool and warm LEDs that maximises the colour rendering index facilitating the dentists’ choices during tooth replacement operations.

Other important features included:Light intensity: it’s possible to adjust illuminance from 8.000 to 35.000 lux, as a function of the specific application in order to reduce eye-strain.

Scialytic Effects: the clearly geometry of reflectors, in combination with each LED source, allows to realize a luminous flux which is ho-mogenous, clean and without shadows.

Low energy consumption and high lifetime: low values of current and voltage (<20W) are present to supply the light source and to minimize the heat production, make the fan cooler not necessary. LED lifetimes are high in comparison with halogen light. Minimum LED lifetimes is about 50.000 hours, against the traditional 3.000 - 5.000. Soft lines and smooth surfaces, the possibility of an easy han-

dle’s extraction and sterilization allow to maintain an optimal cleaning and hygiene.

Absence of UV rays: there is no emission of UV rays, dangerous for biological tissues.

Ergonomics and italian design: Iris View is realized with a production process that assure robustness, harness and durability in terms of de-tachment and stretching.

Available in different RAL colours, for applications on the unit, ceiling, wall and floor.

New: available with 3rd axis movement to rotate Iris View in any directions. Then I would like to mention our high-performing dental LED lamp, POLARIS. Polaris established the new frontier of den-tal illumination LED technology: it shares many of the features of IRIS VIEW, namely the colour temperature regulation, the sci-alytic effect, low energy consumption and high lifetime, absence of UV rays, the ergonomic Italian design and movement flexibil-ity. POLARIS is available with the 3rd axis movement to rotate it in any direction and with a mirror and anti polymerization kit.

The functional and efficient bleaching LED light system COREWHITE can easily be applied directly to POLARIS just by removing a handle. Without any external supports and the power cord directly connect-ed to POLARIS, the operation area is free of any obstruction.

Through LED technology is possible to obtain the desired light intensity for different operation purposes. The maximum light power emitted is 2000 mW. Special filters are used to eliminate I.R. on the light pattern.

Photo: My Light app

Photo: Polaris dental LED light


G.COMM also produces the halogen dental light ISA. Dental light ISA has been designed to be ergonomic and modern at the same time and it is also very easy to clean. The results of the applied tech-nology are:- an operating light very easy to handle, stable and unique for its armonious lines and pleasant colours;- a perfect light pattern and cold white light- ergonomic and italian design: ISA is entirely made in aluminium; its structure is very solid, resistant and does not wear out after me-chanical use. The new resin reflector it’s easy to clean and resistant to brakes. ISA is available in different colours (RAL 9010, 9002, 9016, 7047 and others), and can be mounted on units, ceiling, wall or floor.

The halogen light range includes the VISION dental light. VISION is simple and functional, thanks to the coated reflector glass guarantees a light pattern without shadows and imperfections and a cold white light.It is available today in three versions:Vision Switch: allows to choose two light intensities: 15000 and 25000 luxVision with Potentiometer: the progressive regulation between 15000 and 25000 lux allows to select the more suitable light intensity for dentist’s needs.Vision with Optical Sensor: in order to comply with the sanitary regulations, this model allows to switch on-off the light just passing one hand.

As well as ISA, VISION is available in different colours (RAL 9010, 9002, 9016, 7047 and others) and can be mounted on units, ceilings, walls or floors. (immagine VISION)

Photo: LED light system COREWHITE

Photo: Isa, halogen dental light Photo: Vision, halogen dental light

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INDUSTRY NEWS GCOMM


告诉我们关于GCOMM的历史？

GCOMM位于意大利布里安扎区，这是意大利传统制造业的基地。我们是一家牙科设备配件的制造商，尤其专注于研发和生产牙科口腔灯和电动马达。经过20多年的发展，我们赢得了客户的肯定和市场声誉。

GCOMM的座右铭是品质、设计、创新、它是如何影响你们的活动？

品质、设计、创新是我们今天区别于其他厂家的一个准则。在遵循国际卫生标准和环境安全准则的前提下，我们致力于为客户制造有竞争力，可靠的高质产品。在设计上方便医生操作的同时也考虑为病人提供一个舒适的治疗环境。为确保产品质量以及生产的灵活性，我们严格监控和协调项目部、技术部和生产部的各个环节。我们保障优质的售前售后服务。同时我们根据不同的客户需求设计和生产不同的产品。

关怀客户和对产品的热诚是我们成长并通向成功的基础，目前我们的产品远销到全球30多个国家和地区，我们决心把GCOMM品牌扩展到全球更多的区域。

口腔灯是你们的核心产品、不同的型号如何满足不同的需求？

我们特别关注医生的工作质量。这个使命激发了我们对口腔灯的设计和生产。例如，爱睿视(Iris View)手术灯的格言是：“ 我们的目标，您的工作” 我们相信口腔治疗的质量与能否观察到的操作区域内最细微的细节密切相关。基于这个理念，一个带有内置全高清(分辨率:1920x1080px)，自动对焦摄像功能，并可以30倍放大效果观察整个操作区域的口腔多功能操作灯爱睿视（Iris View）应运而生。

采访 G.COMM


爱睿视(Iris View)可以精密观察操作区域，重点突出裸眼难以观察到的细节，增强专业人员的视觉观察能力并可有效缓解眼部疲劳，改进工作方式和工作流程。

摄像机的使用促进了医生及相关专业人员之间的交流。在诊疗过程中，病患可以通过显示器清晰地展示出来，对问题的理解进而变得简单和直接。同时，在治疗期间，专业人员可实时地跟踪操作进展，并对最终的效果进行评定。

牙科临床流程不断地数字化，使得信息交互以及多媒体文件的分类和保存变的十分必要。爱睿视（Iris View）提供了一个以高分辨率记录并传输操作过程的机会。而且，视频信号可以和多种设备兼容。记录和查看操作过程在多种学术场合都十分有用，比如临床会诊，学术大会以及大学演讲等。

爱睿视（Iris View）提高了您每日工作的舒适度。通过显示器直视操作区域，您工作起来会非常舒适。牙医不需要长时间以不正确的姿势倾向病人，只需坐直操作，从而减少了脊柱压力和常见的因操作过程中姿势不正确而患上职业病的风险，如宫颈问题，腰部疼痛和畸形等。

根据医生的需求，通过下载Mylightapp的软件可以在IPAD进行操控手术灯，也可以在手术灯的按键板直接操控。连接手术灯的内置WIFI，护士可以通过IPAD设置光照度而避免手触手术灯按钮，达到卫生标准。

色温的常规范围是4200~6000开尔文 (K)，这个调整范围有利于更明显地区分软组织。最新的研究证明医生专注力随着色温的增加而加强，从而减少眼睛的过度疲劳。通过控制板或者IPAD可以方便地选择三个预设功能程序：

• 防树脂预先固化模式: 3000K，最大化减少蓝光发光，降低树脂固化速度。

• 外科治疗模式: 4500K，最佳地显示软组织的色差，更好的区分牙龈、血液和牙周组织的深浅。

• 比色模式: 5500K，结合冷LED光和暖LED光，使色温调整最大化，有助于牙医选择合适的波长进行牙齿镶复治疗。

图: 爱睿视(Iris View)手术灯

图: 摄像机的使用

图: 完全舒适

图: 视频信号可以和多种设备兼容

图: My Light app

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INDUSTRY NEWS GCOMM


其它重要特征:• 光照度：8000~35000勒克斯光照度范围有利于医生舒缓眼睛疲劳。• 无影效果：每个LED光源透过几何图形设计的反光镜照射出的光线柔均匀并且没有光影。• 低消耗和长寿命：低电流和电压（功率少于20瓦特）的输出减少热量的排放，减轻散热器的负荷。LED寿命比卤素灯长，大约50000小时，而传统的灯寿命只有3000~5000小时。手柄的线条柔和，表面光滑，可以轻易取出和消毒，保持干净和卫生。• 辐射：灯光没有紫外线辐射。• 人类工程学的意大利设计：生产的过程确保手术灯在拆离和伸展时候的坚固性和耐用性。• 根据治疗椅，吊顶和落地等不同的安装方法，手术灯有不同的RAL色号的选择。• 新：爱睿视(Iris View)的灯头有三位转轴，可以转向任意的方向。

然后介绍另一款LED口腔灯POLARIS。 POLARIS是口腔灯LED技术应用的先锋者：它包含了爱睿视的很多特征：色温调节范围，光学效应，低消耗长寿命，没有辐射，转向灵活，人类工程学的意大利设计。POLARIS还有其他选配功能：三位转轴运动方向，防树脂预先固化功能，以及加装多功能镜子。

高效的美白仪系统COREWHITE可以轻易地安装在 POLARIS上，只需要把其中一支手柄取出，不需要任何的配件支持，直接将美白仪安装上去就可以灵活使用。光照度可以满足不同的手术需要。最大的功率输出是2000兆瓦。特殊的过滤器可以减少光斑的红外线。

图: LED口腔灯POLARIS

GCOMM同时也生产卤素口腔灯 ISA。

它是人类工程学的设计，具有现代感，容易拆卸清洁。• 它是一款很容易操作的口腔灯，光线和谐，光色舒适。• 完美的光斑和冷光• 人类工程学的意大利设计: 生产材料主要是铝; 结构牢固耐用；树脂材料的反光片不容易断裂并且方便清洁。根据治疗椅，吊顶和落地等不同的安装方法，口腔灯有多种不同的RAL色号选择 (RAL 9010,9002,9016,7047 等)。

卤素口腔灯还包括型号 VISION。

VISION是基本型号，是GCOMM最早推出的第一款卤素灯，在市场已经20多年了。它简单，功能稳定可靠；特殊材料制造的反光片使光斑没有阴影和瑕疵，照射出冷白光。

有以下选配:• 调节光照度开关: 15000和25000勒克斯的转换。• 计电器的安装: 可以在15000和25000勒克斯之间选择适合的光照度。• 感应开关的安装: 口腔灯的开关可以通过感应控制。根据治疗椅，吊顶和落地等不同的安装方法，口腔灯有多种不同的RAL色号选择（RAL 9010,9002,9016,7047 等)。

图: 美白仪系统COREWHITE

图: 卤素口腔灯 ISA

图: 卤素口腔灯 VISION

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种植术前准备

口腔种植手术是一个简单的外科手术，它的要求与一般外科手术一样，要做好手术室环境、病人、器械及医护人员等的各项准备，保证种植手术的无菌原则。针对以上环节，简述其相应要求：

一、手术室环境

手术室必须至少准备一个单间，手术尽量安排在上午，术前一天做好手术室的清洁卫生，关好门窗，进行紫外灯消毒，保证手术室无菌。若在门诊手术，环境消毒和手术人员的无菌衣物一定要到位。手术当天患者戴好帽子，穿好脚套进入手术室。若有多台手术，要保证手术室的消毒时间和无菌环境。

二、患者手术术前准备要求

1、排除禁忌症，女性避开月经期 2、患者需拍好X片检查，取好模型3、术前做好口腔准备：拔除龋齿、残根，治疗好口腔疾病，口腔清洗；4、验血常规、肝功、血糖、出凝血时间。糖尿病患者术前2周控制糖化血红蛋白≤7%，术后10周内仍保证糖化血红蛋白≤7%5、术前一天吃抗菌素（常规抗菌药）6、术前测血压、脉搏、体温；对于高度紧张的患者术中监测指标7、术前口内口外消毒

三、器械及敷料准备

1、敷料：方巾（双层, 5块, 80cm*80cm或以上), 用于包裹病人头颈部洞巾（双层, 1块, 长度能从头遮盖到膝关节, 宽度要超过双肩）布套（双层，3个，1.5米/个，直径7cm左右，套种植机马达和吸唾管），若无布套可用一次性医用无菌保护套。若吸唾管是一次性无菌的，则可省去一个布套。

手术工具盒包布（双层，2块，根据诊所实际盛装手术器械的弯盘尺寸而定）种植器械盒包布（双层，2块，80cm*80cm，）手术人员口罩、帽子、洗手衣、洗手裤及无菌手术衣（一台手术2-3套）、无菌手套无菌生理盐水（1颗牙1-2瓶，视牙而定，夏季最好术前24-48小时放入冰箱冷却）小推车*2（放种植器械盒和手术工具盒用，视手术室整体配置而定）

2、口外手术工具盒：口镜*1~2、拉钩*1（可用口镜代替）持针器*1个、镊子*1、大小刮匙各*1、止血钳*2（弯\直）牙龈分离器*1 骨膜分离器*1 刀柄*1 尖刀片或小圆刀片*1 缝针5*12规格缝线0＃或1＃巾钳3-4个、眼科剪*1 纱布、棉球若干吸引头*1（最好是硬质的，同时起到牵拉作用）50ml注射器(含针头)加无菌盛物小碗*1或输液皮条加血压袖带（外冷却用）另：（针对个别病例准备）骨凿，骨锉，小锤子，咬骨钳，盛物小碗，骨粉，骨膜以上工具可集中在一起打包消毒

3、种植手术器械：种植机手术工具盒

4、其他：吸唾用强吸；洗手液，碘伏，酒精四、医护人员医生向患者讲解手术术中及术后注意事项，签手术同意书；医生、医助洗手穿衣，准备手术；巡回护士做好巡回工作。

刘双斌医生

全科资深医生，意大利安萨器械（ASA Dental）培训讲师。有十余年丰富的临床工作经验。毕业于天津医科大学，口腔医学硕士学位（牙周病及种植方面）。在牙体治疗、根管治疗、美学修复、以及复杂拔牙手术,种植牙等多学科具有相当丰富的临床经验。曾多年在涉外高端齿科诊所任职，工作中非常注重无痛治疗及微创治疗。擅长种植牙的修复治疗以及CAD/CAM微创修复、现代精细根管治疗并注重多学科的综合序列治疗。曾应邀参加首届全球华人口腔大会及多届国际口腔种植会议，赴多地交流学习，多次参加全国比赛并获得奖项.

作者: 刘双斌医生


1. 种植手术室相对独立的20㎡左右的手术室即可

2. 种植设备 • 必备设备：全景机• 种植机 • 选配设备：CT 、超声骨刀等

3. 种植工具盒和手术器械见附录• 种植系统工具盒 • 种植手术专用手术器械 4. 种植手术服包含手术衣，洞巾，包布，帽子（奥齿泰有手术衣套装：3个手术衣，1个洞巾，8个包布，3个帽子）

4. 种植消耗品无菌手套，口罩，无菌毛巾，12号及15号无菌刀片，一次性注射器，纱布，锡纸，洗手液，氯方己定含漱液，麻醉剂，金属注射器，碘伏棉球，缝合线，冰袋，生理盐水

种植外科基本步骤（一）一、一期手术（种植体植入）

1. 患者术前准备（1）术前用药– 抗生素、消炎药、抗焦虑药，氯己定

科室开展种植的前期准备工作

– 苯二氮类抗焦虑药：术前1小时服用– 抗生素：术前3～7天（2）消毒液冲洗（氯己定、聚烯吡酮磺）– 氯己定漱口：术前1分钟

2.外科手术器械和设备• 种植机、种植外科工具盒• 冷却盐水• 缝线、缝针• 骨移植材料• 屏障膜• 上颌窦提升工具• 常规外科器械 (推荐明细件附录)

3. 手术原则• 切口– 第一切口必须明确到位– 牵引骨膜时避免更大创伤（不要撕扯骨膜）– 充分但不必过度暴露• 翻瓣– 全层粘骨膜瓣翻开– 翻瓣– 去除骨面上的软组织

4. 种植窝制备

5. 缝合

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INDUSTRY NEWS Asa Dental


种植手术常规器械 - ASA Dental安萨

器械名称安萨产品编号备注

麻醉剂注射器

0480-3

麻醉

0481-7

0481-80483-3

牙探针0702L-15

牙周探诊0703L-1

金属吸唾管0902-M

吸唾2904-6

刀柄 0350-7

切开刀柄 0350-5

角刀 0351-12

小圆刀 0351-15C

拉钩2602-1

口角牵开2604

2616-1

牙龈分离器MV1851-2

翻瓣MV1850-9A

双面口镜头 2230-5

2231-5CS

口镜柄 ML2101

格雷西刮治器（准备几支即可）

LV1807-02 前前

刮治

LV1807-04 前前

LV1807-06 前前

LV1807-08 前前前前前



LV1807-14

线剪，牙龈剪

0307-1

缝合

0304-2TC

0309-2TC

缝合镊 0625-1

止血钳 0500-2

持针器 0415-15TC

骨刮匙2000-1

2000-3

巾钳 0550-3

骨盛放碗 1030-4

骨锉 1812-04S

组织镊 0621-1

18 cm ♂ ♀ 15 cmVS

专注优雅女士的定制器械。这是一个事实：女人的手与男人的手不同。从事牙科专业的女士需要使用特定的器械。截止目前，这些器械都以男人为出发点，他们的手掌较大，有着更长的手指和更强劲的握持力量。Asa Dental 认为是时候改变这种情形了。安萨公司要为牙科专业的女性员工提供更适于她们使用的手持器械。所以本公司创造了Asa优雅女士系列。根据女性手部结构和尺寸，量身设计了更适合女性使用的牙科器械。它具有更舒适的手柄和更轻盈的重量。出发点从10 到12 % 更精巧的手。从10 到12 % 更柔软的手指。差异适合的手柄。根据女性手掌尺寸重新设计的握持点。精巧以及更轻盈的把手。结果更简洁自然的操作性。更准确更安全的工作方式。肌腱和肌肉更舒适。

安萨单人股份有限公司. Asa Dental S.p.A. uninominale Via Valenzana di Sopra, 60 - Bozzano - 邮编 55054 Massarosa (Lu) - 意大利 Italy 电话 Tel +39 0584 938305 - 传真 Fax +39 0584 937167 - [email protected] - www.asadental.com

女士优雅系列AsaLady

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1 – Cut on dotted line. 削减虚线。

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Everytime you are looking for distributors.每当您寻找代理商。

For your advertising in international newspapers, special FDI and IDS issue, co-exhibitions, web and digital services write to [email protected]

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DENTECH CHINA EXHIBITION


Shanghai, 26 – 29 October 2016上海, 2016.10.26-29Infodent International for DenTech China: the living magazine project

Infodent International 为DenTech China开展互动杂志项目

During DenTech China 2016, Infodent International is proud to introduce a great experience for all visitors: the living magazine. Every year thousands of manufacturers and dealers are used to read Infodent International looking for connections and contents to improve their business. Next October, for the first time, they can “live the pages”.

在“第二十届中国国际口腔器材展览会暨学术研讨会”(DenTech China 2016)召开期间， Infodent International将向所有观众推出一份互动杂志，将绝佳的体验带给大家。每年有成千上万的生产商和经销商都习惯通过阅读Infodent International杂志，寻找有助于拓展其业务的内容和商机。今年10月，他们将在展会现场体验杂志互动项目。

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DENTECH CHINA EXHIBITION


Contents:How many times, after reading an article, you would like to ask something to its author? In DenTech China, finally, you can.Three conferences will entertain the audience about the two main Infodent International topics: developing business and scientific subjects.

您有多少次在阅读完一篇文章后，希望作者能解答您的一些疑问？在DenTech China 展会上，你就能实现这个愿望。我们将召开三场研讨会，会议围绕Infodent International的两个主要议题：业务拓展及新技术推介。

Distributors wall:The distributors wall is a must-read for all companies worldwide, a paper meeting point where to find dealers and new job opportunities.In DenTech China this wall will be real: a space continuously updated at the Infodent International booth to connect business and give our customers what they expect from their favourite magazine since 1994: the chance to improve.

Distributors Wall 是全球所有业内企业必读的一份刊物，该刊物告诉大家到哪里寻找经销商,并提供新的工作机会。在DenTech China展会上，我们将设立一面墙：在Infodent International主办方展台的空间里展示最新信息，帮助大家建立业务联系，并让我们的客户从这份于1994年创办的读者喜闻乐见的杂志中得到想要的：改进的机会。

Company highlights:Infodent International提供信息

Infodent International booth will offer to all distributors visiting DenTech China the best selection of opportunities they are used to find in highlights pages.Why do distributors visit a trade-show? For the same reason they read Infodent International: to discover the right companies in order to expand their business.The selection of companies considered eligible involved in this project will contribute to the satisfaction both of our readers and of all Den-Tech China visitors.Infodent International展台将向到访DenTech China展会的所有分销商提供一份最佳商机信息汇编；以往，我们在展会杂志的重点页面提供这些信息。为什么分销商会参加展会？是为了拓展自己的业务。他们阅读Infodent International杂志, 也是出于同样的原因。

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DENTECH CHINA EXHIBITION The Conferences Program


The conferences program:会议的内容:MyRay is a worldwide name in image-assisted diagnostics, a brand that has earned the trust of dental professionals and radiologists all over the world, offering a complete range of imaging products dedi-cated to digital dentistry. Innovative solutions designed to improve the surgery work flow by providing quality, reliability and user-friendliness.

MyRay - 会议的官方合作伙伴MyRay是图像辅助诊断的全球名称, 已经赢得了全球的牙科专家及放射科医生的信任, 提供影像产品门类齐全的专用于数字牙科。创新的解决方案，以提高通过提供高质量，高可靠性和易用性手术的工作流程。

Scientific topic 新技术推介主题演讲

Speaker: Bingzhen Huang M.D.& Ph.D演讲人： Bingzhen Huang 医生/博士 Title: CGF&AFG: Basic principle and clinical application题目：CGF与AFG：基础原理及临床应用 Abstract:CGF (Concentrated Growth Factors) 、AF-

G（Autologous Fibrinogen Glue）are autologous fibrin and fibrino-gen without any additive (anticoagulant and activator). In this pre-sentation, I will show you how to make autologous fibrin, fibrinogen, thrombin easily and discuss with you the basic difference of autolo-gous blood production (PRP, PRGF, PRF, CGF, AFG) and how and why these productions work.内容提要：CGF (Concentrated Growth Factors) 和 AFG（Autologous Fibrino-gen Glue）是不加入任何其他成分（抗凝剂或促凝剂）情况下的自体纤维蛋白和纤维蛋白原。在这个演讲中，我将向大家展示如何轻松制作自体纤维蛋白、纤维蛋白原、凝血酶，并介绍各种自体血液制剂 (PRP, PRGF, PRF, CGF, AFG)基本区别，以及这些制剂的作用机制。

Speaker: Dr. Liu Shuangbin演讲人： Dr. Liu Shuangbin医生Title: Treatment of aesthetic and structural alterations of the Mucogingival Junction (MGJ)题目：牙龈黏膜交界( MGJ)的美观性和结构性改变治疗Abstract:

The purpose of this course is to provide a brief analysis of the gingival reconstruction of teeth and implant from an aesthetic and a structural point of view, according to scientific evidence and through the clinical experience of the operator. The course will provide a

wide range of information and procedures of reconstructive surgery. Limits, errors and possible complications will be analyzed supported by extensive clinical cases.

内容提要：本课程的目的，是依据科学证据和临床经验，从美观和结构的角度对牙龈重建和种植体进行一个简要分析。本课程的将广泛介绍重建手术领域的各种信息和程序。我们将通过丰富的临床案例，对相关的局限、失误和可能的并发症进行分析。

Business topic 业务拓展主题演讲

Speaker: Emanuele Elo Usai演讲人： Emanuele Elo UsaiTitle: 32 Dental marketing ideas for successful dentists题目： 32个牙科营销思路，让您的牙科职业生涯更成功

Abstract:Is being a good dentist enough to attract patients into your practice? The answer is no.This course aims to provide dentists some star-ting points needed to prepare and develop a marketing and com-munication strategy to improve their dental practice. A journey in 32 points across case histories and creative ideas, starting with the importance of identifying the business goals and continuing with tra-ditional, non-conventional and digital ideas to increase the revenue. 内容提要：牙医拥有精良的技术，就足以吸引患者前来自己诊所吗？答案是，这还不够。本课程旨在向牙医提供一些制定营销和沟通策略所需的基本知识，以帮助他们发展自己的诊所。我们将通过案例介绍32个创意思路。首先我们将从最重要的一点入手：找出自己的业务目标；持续地通过常规的、非常规思路，并使用数字化手段来增加收入。

Date and time: 27th of October, 2016 13.00 - 17.00时间: 2016 年 10月 27日, 13.00 - 17.00

Free entry, write to [email protected] to book your seat and your coffee break pass. 免费入场, 免费 coffee break。

联系邮箱[email protected]

For more, please visit www.infodent.com 如需了解更多信息，请访问

www.infodent.com

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WHAT’S NEXT Plan Ahead


Have you enjoyed reading DoctorOs by Infodent? 您喜不喜欢阅读”牙医 by Infodent”杂志？Waiting for the upcoming issue in September, 九月的下一个发行,等着吧!

Are you looking for more business opportunities? Get all our magazines.您是否正在寻找更多的商机？获取我们所有的杂志都。

• Inews The Infodent international special edition for the main dental trade-shows, distributed for free to all the exhibitors and visitors to reach the best audience ever and a lot of dentists.The next issues are for FDI Poznan and IDS 2017. Infodent International特刊为最重要的牙科贸易展, 在展会中免费发放。下一个发表: FDI Poznan 及 IDS 2017。• DoctorOs by InfodentChina is finally closer with this new B2C scientific magazine - in English and Chinese, of course - aimed to the most influential Chinese decision makers (hospitals directors, buyers, opinion leaders, trade and dentists) to connect the West with the East. 这本科学类季刊杂志（商家对客户）的出现会对中国牙医行业产生重要影响，旨在为中国最具影响力的龙头企业服务。所有文章都是中英双语。目标是中国牙医行业，医院院长，买家，意见领袖，企业高层及牙医为了东连西进。• ImplantBookThe first and only complete global guide about the implantology industry addressed to dentists and dealers, collecting in a single volume the widest offer never seen before.Book your free copy and get more info on implant-book.com 第一套关于种植业的全面丛书，为牙医及代理商都。立刻免费预订您的杂志! 如需了解更多信息，请问www.implant-book.com• Infomedix International Since 2002 the B2B magazine targeting distributors worldwide: a landmark for the medical industry, generating every year thousands of connections. Each issue reaches more than 36.000 dealers, manufacturers, importers, exporters, wholesalers, agents and trade associa-tions, circulating in the main exhibitions in 5 continents.Free on infomedixinternational.com. 自2002年以来这本科学类杂志（公对公）为全球的代理商。每一个发表送到36.000多代理商, 制造商, 买卖, 批发商, 代理人, 展览会都, 在五大洲的最重要展会发放。免费在infomedixinternational.com

Ask our staff for more info. We are happy to support you! 请跟我们的人员联系吧, 我们都很高兴帮助您!

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DoctorOs by Infodent International is the title of this magazine as well as an ap-plied for trademark. Any use there of without the publisher’s authorization is to be deemed illegal and shall be prosecuted.

• Publisher-Editore: Baldo Pipitone [email protected] • General Manager: Paola Uvini [email protected]• Editorial Director: Silvia Borriello [email protected]• Exhibition Manager: Alessia Murano [email protected] • Newsroom: Paola Uvini [email protected] Ragonesi [email protected]• Graphic Department: Silvia Piscopiello [email protected] • Marketing Department: Emanuele Usai [email protected] • Advertising: Riccardo Bonati [email protected] Stefano Santelmo [email protected] Claudia Ragonesi [email protected] • Account Department: Nadia Coletta [email protected] Mercuri [email protected]

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DoctorOs by Infodent è un supplemento di Infodent Internationaln°2/2016 - aut. trib. VT n°528 del 21-07-2004Quatrimestrale di informazione tecnico scientificaCosto copia - Euro 0.15

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Publishing deadline / Chiuso in tipografia: 27/05/2016

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1-2016

Management of impacted dilacerated maxillary incisor with

strategic positioning of a straightwire appliance


Post-extraction application of beta-tricalcium phosphate in

alveolar socketβ-磷酸三钙在拔牙后牙槽窝

中的应用

Immediate implants in extraction sockets with periapical lesions:

an illustrated review牙窝根尖周变病的即刻种植:一篇有插图说明的述评

Inside:

n°1/2016 Issue

Riccardo Bonati [email protected]

Baldo Pipitone CEO

[email protected]

Stefano Santelmo Advertising

[email protected]

Claudia Ragonesi Advertising

[email protected]

Alessia Murano Exhibition Manager

[email protected]

Emanuele Usai Marketing Manager

[email protected]

牙医

终于，第一套关于种植体的全面丛书到了。

The Chapters:Dental implants, Osteointegration & biomaterials, 3D printers,

Rotary instruments, Equipment & supplies for implants, Radiology, Piezosurgery, Software, Micromotors.

Implantbook is a trademark of Infodent Srl

Book now your free copy on implant-book.com!

Implantbook Cover Page.indd 1 27/05/16 12:53

DoctorOs 01 2016

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