Comparison of Pulmonary Function Testing with Distribution ...apacity was adm cquired during a ......
1
Hoom 1 Radio State INTRO obstruc structu with po diffusi human each gr METH twenty p A O 2 a subject 20% in pulse 8.3×8.3 was do values= (6.25× Lung C were a p A O 2 a γ ADC ) f calcula tailed A in orde smoker RESU and AD and AD were in of p A O observ correla μ pAO2 s not sho 95% C averag Lung V Fig.2. Residu betwee smalle CONC physio FEV 1 /F Comparison man Hamedani 1 , Ki ology, University o es, 3 Otolaryngolog ODUCTION: Con ctive and interstiti ure. The use of hyp otentially higher s on coefficient (AD n subjects and asym roup of measurem HODS: Ten healt y asymptomatic sm and ADC MRI st ts. p A O 2 imaging nterslice gap, usin sequence [Ham 3×15.3mm 3 , TR/T one using an interl =0,1.6 s/cm 2 with 6.25×15.3mm 3 ). A Capacity was adm acquired during a and ADC mean (μ for each subject w ated for each comp ANNOVA test wa er to compare the rs and nonsmokers Fig.2- The co ULTS & DISCUS DC maps for a rep DC distributions fo n the range of 102 O 2 among all subj ved between ADC ation between μ ADC shows a significan ow any correlation CI: −0.73, −0.17), ge alveolar oxygen Volume (r = −0.5 The mean values ual Volume and D en the two groups st overlap and mo CLUSION: Regio logical relevance. FVC). The richer i of Pulmonary Coe arash Emami 1 , Ste of Pennsylvania, P gy - Head and Nec U nventional pulmon ial lung diseases. perpolarized (HP) sensitivity. In this DC) of 3 He obtain mptomatic smoker ments in differentiat thy non-smokers mokers (13 M, 53± tudies. Before MR was performed o ng an interleaved o medani et al. TE=6.7/3.2ms, FO leaved diffusion-w similar imaging p A normoxic mixt ministered at end-e a 12-sec end-inspi μ pAO2 , μ ADC ), dispe were compared to parison to relate th as performed on bo sensitivity of MR s. rrelation plots of PFT SION: Fig.1(a, b presentative subjec or both groups. Th 2.1±11.9 Torr and jects ranged over and p A O 2 measur C and γ pAO2 (r = −0 nt variability amon n with any of the P suggesting that th n tension. Skewnes 7, P = 0.001, 95% of 3 He ADC (μ ADC DLCO. γ ADC also a for two key PFT st discrimination p onal distributions . However specifi information embed y Function Te efficient in Asy ephen J. Kadlecek 1 Philadelphia, PA, U k Surgery, Johns H United States, 5 Med nary function tests PFT however is c gas MRI has been study we compare ed with oxygen- a rs to highlight und ting the subject gr (5 F, 56±8 yrs. ±12 yrs., BMI=25 RI session, PFT w over twelve 13-m oxygen-weighted MRM 2011] OV=30×40cm 2 , α= weighted gradient parameters except ture of 3 He:N 2 :O 2 expiration in a sin iratory breath-hold ersion (σ pAO2, σ ADC PFT results. Pea he global values o oth PFT and MRI RI and PFT param T versus imaged p A O b) shows a represe ct from each group he overall p A O 2 and d 0.22±0.04 cm 2 /s, 33.9±6.1 Torr. N rement and their d 0.37, P = 0.06). As ng all subjects. Th PFT metrics either he heterogeneity o ss of the p A O 2 distr % CI: 0.27, 0.77). C ) showed a signif associated with DL metrics, and p A O 2 power between two of oxygen tensio ic MRI metrics, i dded in regional lu sting with Dis ymptomatic S 1 , Yi Xin 1 , Puttisar Milton Rossm United States, 2 Bio Hopkins University dicine, University s (PFT) provide a g considered to hav n under investigatio ed common PFT m and diffusion-weig derlying physiolog oups and to evalua , BMI=27.3±6.6) 5.3±8.4) participate was performed o m coronal slices gradient echo ima (spatial resolu =5˚) and ADC ima echo sequence wi t for spatial resolu based on 12% T ngle breath and im d. Imaged whole- ) and skewness (γ arson’s coefficient f PFT with MRI. results for both gr meters in differenti O 2 and ADC. entative coronal sli p. Fig.1(c–f) summ d ADC values for respectively. The No apparent assoc derivatives except s can be seen from he global average r. σ pAO2 on the othe of p A O 2 distributio ribution also show γ pAO2 also correla ficant correlation w LCO (r = 0.52, P 2 dispersion. Amon o groups and its P n and diffusivity including p A O 2 dis ung measurements stribution of A mokers Using rn Mongkolwisetw man 5 , and Rahim R ological Basis of B y, Baltimore, MD, of Pennsylvania, P global measure ov ve a poor sensitivi on for probing bot measurement with ghted HP gas MRI ical relationships b ate the potential of and ed in n all with aging ution aging ith b- ution Total mages -lung γ pAO2, t was One- roups ating ice of p A O 2 marize p A O 2 all subjects e dispersion ciation was for a weak m Fig.1(c,d), e p A O 2 does er hand associates on can be a more ws an interesting tre ated with Thoracic with DL/VA (r = = 0.006, 95% C ng all measuremen -value was signific in lungs show to spersion showed a therefore advocat Fig.1- Re p A O 2 and respective Fi HP Alveolar Oxyg g Hyperpolari wara 1 , Biao Han 1 , H R. Rizi 1 Behavior Program, United States, 4 Ra Philadelphia, PA, ver the entire lung ity for detecting lo th microstructural distributions of al I respectively. Thi between the two m f MRI metrics as i s with Maximum F sensitive marker end as it significan c Gas Volume, Fo −0.65, P < 0.001, CI: 0.15, 0.71). Fin nts performed, σ pA cantly less than an o have significant an even more dis tes their suitability epresentative maps o 3 He ADC measurem ely. ig. 3- Discrimination P MRI metrics. gen Tension an ized 3 He MRI Harrison McAdam , University of Pen adiology, Univers United States as a tool for diagn ocalized, early or and functional asp lveolar partial pre is comparison was methods. We also imaging biomarker Forced Expiratory to smoking-relate ntly correlates with orced Inspiratory F , 95% CI: −0.33, − nally Fig. 3 summ AO2 (dispersion of ny other PFT meas t correlations with scriminatory powe y for further invest of (a) p A O 2 and (b) 3 H ments in (c,d) healthy n of smokers and non nd Apparent D ms 2 , Masaru Ishii 3 , nnsylvania, Philad ity of Virginia, Ch nosis and monitori small changes in pects of lungs on a essure of oxygen (p s performed in two attempted to asses rs in monitoring ac Flow, FEF max (r = ed changes in the h DL/VA - Diffus Flow and FEV 1 /F −0.84) and a weak marized the results oxygen tension in surements as well h key PFT metric er compared to g tigation as respirat He ADC in a healthy y subjects and (e,f) as n-smokers with key re Diffusion G. Wilson Miller 4 delphia, PA, United harlottesville, VA, ing of a majority o n lung function an a regional basis an p A O 2 ) and apparen o groups of health ss the sensitivity o ctive smokers... = −0.51, P = 0.004 lungs compared t sion per unit area o FVC as is shown i ker association wit s of ANNOVA tes n the lungs) had th as ADC values. cs supporting the gold standards (e.g tory biomarkers. y subject. Summary o symptomatic smoker epresentative PFT an 4 , d of nd nd nt hy of 4, to of n th st he ir g. of s, nd 3994 Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)
Transcript of Comparison of Pulmonary Function Testing with Distribution ...apacity was adm cquired during a ......
Hoom
1RadioState
INTROobstrucstructuwith podiffusihumaneach grMETHtwentypAO2 asubject20% inpulse 8.3×8.3was dovalues=(6.25×Lung Cwere apAO2 aγADC) fcalculatailed Ain ordesmoker
RESUand ADand ADwere inof pAOobservcorrelaμpAO2 snot sho95% CaveragLung VFig.2. ResidubetweesmalleCONCphysioFEV1/F
Comparison
man Hamedani1, Ki
ology, University oes, 3Otolaryngolog
ODUCTION: Conctive and interstiti
ure. The use of hypotentially higher son coefficient (AD
n subjects and asymroup of measurem
HODS: Ten healty asymptomatic smand ADC MRI stts. pAO2 imaging nterslice gap, usin
sequence [Ham3×15.3mm3, TR/Tone using an interl=0,1.6 s/cm2 with 6.25×15.3mm3). ACapacity was admacquired during aand ADC mean (μfor each subject wated for each compANNOVA test waer to compare the rs and nonsmokers
Fig.2- The coULTS & DISCUS
DC maps for a repDC distributions fon the range of 102
O2 among all subjved between ADC ation between μADC
shows a significanow any correlation
CI: −0.73, −0.17), ge alveolar oxygenVolume (r = −0.5The mean values
ual Volume and Den the two groups st overlap and mo
CLUSION: Regiological relevance.FVC). The richer i
of PulmonaryCoe
arash Emami1, Ste
of Pennsylvania, Pgy - Head and Nec
U
nventional pulmonial lung diseases. perpolarized (HP) sensitivity. In this DC) of 3He obtainmptomatic smoker
ments in differentiatthy non-smokers
mokers (13 M, 53±tudies. Before MRwas performed o
ng an interleaved omedani et al.
TE=6.7/3.2ms, FOleaved diffusion-wsimilar imaging p
A normoxic mixtministered at end-ea 12-sec end-inspiμpAO2, μADC), dispewere compared toparison to relate thas performed on bo
sensitivity of MRs.
rrelation plots of PFTSION: Fig.1(a, b
presentative subjecor both groups. Th2.1±11.9 Torr andjects ranged over and pAO2 measur
C and γpAO2 (r = −0nt variability amonn with any of the Psuggesting that th
n tension. Skewnes7, P = 0.001, 95%of 3He ADC (μADC
DLCO. γADC also afor two key PFT
st discrimination ponal distributions . However specifiinformation embed
y Function Teefficient in Asyephen J. Kadlecek1
Philadelphia, PA, Uk Surgery, Johns H
United States, 5Med
nary function testsPFT however is cgas MRI has beenstudy we compareed with oxygen- ars to highlight undting the subject gr(5 F, 56±8 yrs.
±12 yrs., BMI=25RI session, PFT wover twelve 13-moxygen-weighted
MRM 2011] OV=30×40cm2, α=weighted gradient parameters except
ture of 3He:N2:O2
expiration in a siniratory breath-holdersion (σpAO2, σADC
PFT results. Peahe global values ooth PFT and MRI
RI and PFT param
T versus imaged pAOb) shows a represect from each grouphe overall pAO2 andd 0.22±0.04 cm2/s,
33.9±6.1 Torr. Nrement and their d0.37, P = 0.06). Asng all subjects. ThPFT metrics eitherhe heterogeneity oss of the pAO2 distr% CI: 0.27, 0.77).
C) showed a signifassociated with DL
metrics, and pAO2power between twoof oxygen tensio
ic MRI metrics, idded in regional lu
sting with Disymptomatic S1, Yi Xin1, Puttisar
Milton RossmUnited States, 2BioHopkins Universitydicine, University
s (PFT) provide a gconsidered to hav
n under investigatioed common PFT mand diffusion-weigderlying physiologoups and to evalua, BMI=27.3±6.6)
5.3±8.4) participatewas performed om coronal slices gradient echo ima
(spatial resolu=5˚) and ADC ima
echo sequence wit for spatial resolu based on 12% T
ngle breath and imd. Imaged whole-) and skewness (γ
arson’s coefficientf PFT with MRI. results for both gr
meters in differenti
O2 and ADC. entative coronal slip. Fig.1(c–f) summd ADC values for respectively. The
No apparent assocderivatives except s can be seen fromhe global averager. σpAO2 on the otheof pAO2 distributioribution also show
γpAO2 also correlaficant correlation wLCO (r = 0.52, P2 dispersion. Amono groups and its Pn and diffusivity including pAO2 disung measurements
stribution of Amokers Usingrn Mongkolwisetwman5, and Rahim Rological Basis of By, Baltimore, MD,of Pennsylvania, P
global measure ov
ve a poor sensitivion for probing botmeasurement with ghted HP gas MRIical relationships bate the potential of
and ed in n all with
aging ution aging ith b-ution Total
mages -lung γpAO2,
t was One-roups ating
ice of pAO2
marize pAO2 all subjects
e dispersion ciation was for a weak
m Fig.1(c,d), e pAO2 does er hand associates
on can be a more ws an interesting treated with Thoracicwith DL/VA (r = = 0.006, 95% C
ng all measuremen-value was significin lungs show to
spersion showed a therefore advocat
Fig.1- RepAO2 and respective
FiHP
Alveolar Oxygg Hyperpolariwara1, Biao Han1, HR. Rizi1
Behavior Program, United States, 4RaPhiladelphia, PA,
ver the entire lung ity for detecting loth microstructural distributions of al
I respectively. Thibetween the two mf MRI metrics as i
s with Maximum Fsensitive marker end as it significanc Gas Volume, Fo−0.65, P < 0.001,
CI: 0.15, 0.71). Finnts performed, σpAcantly less than ano have significantan even more distes their suitability
epresentative maps o3He ADC measurem
ely.
ig. 3- DiscriminationP MRI metrics.
gen Tension anized 3He MRI Harrison McAdam
, University of Penadiology, UniversUnited States
as a tool for diagnocalized, early or and functional asplveolar partial preis comparison wasmethods. We also imaging biomarker
Forced Expiratory to smoking-relatently correlates withorced Inspiratory F, 95% CI: −0.33, −nally Fig. 3 summAO2 (dispersion of ny other PFT meast correlations withscriminatory powey for further invest
of (a) pAO2 and (b) 3Hments in (c,d) healthy
n of smokers and non
nd Apparent D
ms2, Masaru Ishii3,
nnsylvania, Philadity of Virginia, Ch
nosis and monitorismall changes in
pects of lungs on aessure of oxygen (ps performed in twoattempted to assesrs in monitoring ac
Flow, FEFmax (r =ed changes in the h DL/VA - DiffusFlow and FEV1/F−0.84) and a weak
marized the resultsoxygen tension in
surements as well h key PFT metricer compared to gtigation as respirat
He ADC in a healthyy subjects and (e,f) as
n-smokers with key re
Diffusion
G. Wilson Miller4
delphia, PA, Unitedharlottesville, VA,
ing of a majority on lung function ana regional basis anpAO2) and appareno groups of healthss the sensitivity octive smokers...
= −0.51, P = 0.004lungs compared t
sion per unit area oFVC as is shown iker association wits of ANNOVA tesn the lungs) had thas ADC values. cs supporting the
gold standards (e.gtory biomarkers.
y subject. Summary osymptomatic smoker
epresentative PFT an
4,
d
of nd nd nt hy of
4, to of n
th st
he
ir g.
of s,
nd
3994Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)
