800-775-3295 animalnutrition@adm - Amazon S3 · Whole-yeast has Positive influence on health status...
Transcript of 800-775-3295 animalnutrition@adm - Amazon S3 · Whole-yeast has Positive influence on health status...
AnimAl nutrition
beef dAiry swine poultryAquA-culture
speciAltycompAnionAnimAl
ADM Alliance Nutrition, Inc.1000 N 30th St, PO Box C1
Quincy, IL 62305-3115
S9869D-0510
A whole-yeast source of mannan oligosaccharides (MOS) and β-glucans derived from ADM citric acid production.
Single-source consistency and research-proven efficacy for enhanced performance and active immune response.
What can you expect from citriStim?
ADM research studies document average performance improvements:
Receiving cattle: 10% ADG; 7% efficiency
Dairy calves: 12% ADG
Nursery pigs: 3% ADG; 2.5% efficiency
Poultry: 2% ADG; 5% efficiency
ADM field observations report the following:
Lower morbidity
With disease challenge, severity of scouring was reduced
Indications of better immune response as manifested by lower somatic cell count in lactating dairy cattle
Why ADM CitriStim?Consistency of single site production and process control
A unique strain of whole yeast (Pichia)
A highly biologically active source of MOS and β-glucan
Demonstrated efficacy
feeding suggestions
Swine: 1-4 lb/ton of complete feed
Poultry: 1-4 lb/ton of complete feed
Cattle: 2-8 lb/ton of milk replacer; 1-2 lb/ton of complete feed
Aquaculture: 2-4 lb/ton of complete feed
Companion Animals: 2-4 lb/ton of complete feed
For specific recommendations, contact your ADM Alliance Nutrition supplier.
To learn more about ADM CitriStim, consult with your ADM Alliance Nutrition supplier or contact ADM Alliance Nutrition at:
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www.admani.com 800-775-3295
Whole-yeast has Positive influence on health status of animalsinfection: Thirty years of research involving mannan oligosaccharides (MOS), which are provided in whole-yeast, have shown many fimbriated bacteria species readily bind with yeast surface MOS, thereby interfering with the infection process. Due to the pathogen binding effect of MOS, fewer patho-gens are available for intestinal colonization, resulting in lower infection rates (refer to #1 in Suggested Modes of Action). Pathogenic species that have shown possible binding include: E. coli, Salmonella, Proteus, and Klebsiella.
gut immunity: MOS and β-glucans provide conditioning for gut immunity. CitriStim is consistently high in MOS and β-glucan content. Research shows intestinal immune cells (Peyer’s Patches) are highly responsive to whole-yeast MOS and β-glucans. The result is elevated immune signaling and recruitment of macrophages and other immune cells to the intestine to counter anticipated pathogenic challenges (refer to #2 in Suggested Modes of Action).
SUGGESTED MODES OF ACTION
® ADM ALLIANCE NUTRITION
Fimbriatedpathogenic
bacteria
CitriStimwhole Pichiayeast cells
Pathogenic bacteriabind to yeast cells
protecting theintestinal villi
BINDING OF PATHOGENIC BACTERIA
INTESTINAL STIMULATION OF IMMUNE FUNCTION
(Surface carbohydrates on yeast cells arevery similar to binding sites on villi)
Colonizing andinfection of villiby pathogens
Mucosal immune cellsprocess yeast cell β-glucan
and MOS which elevatesoverall immune activity
1
1
2
2
SUGGESTED MODES OF ACTION
® ADM ALLIANCE NUTRITION
Fimbriatedpathogenic
bacteriaCitriStim
whole Pichiayeast cells
Pathogenic bacteriabind to yeast cells
protecting theintestinal villi
BINDING OF PATHOGENIC BACTERIA
INTESTINAL STIMULATION OF IMMUNE FUNCTION
(Surface carbohydrates on yeast cells arevery similar to binding sites on villi)
Colonizing andinfection of villiby pathogens
Mucosal immune cellsprocess yeast cell β-glucan
and MOS which elevatesoverall immune activity
1
1
2
2
ReseaRch-PRoven efficacy
• CitriStim has been extensively evaluated (ask for details).• Research has shown MOS will bind various fimbriated pathogens. CitriStim has
been shown to bind E. coli equal to or better than market-leading MOS and yeast products.
• Controlled research has been conducted with CitriStim in these production systems:
Neonatal animals- Dairy calves- Piglets - Chicks, ducklings, and turkey poults
Highly stressed animals- Receiving cattle- Heat stressed animals- Fescue toxicosis
High sensitivity production systems- Aquaculture
In VIVo PeRfoRmance
The impact of MOS on poultry has been reported extensively. Comparative trials of the effect of CitriStim versus a competitor MOS on gain, feed intake, and efficiency of nursery pigs (weaning to 60 lb) is noted in the accompanying graph. These trials demonstrate the higher efficacy of CitriStim.
CITRISTIM IS MORE EFFECTIVE IN BINDING OF K88 E. COLI IN VITRO THAN A LEADING MOS SOURCE
0 2 4
102%
100%
98%
96%
AVERAGE OF FOUR SWINE GROWTH TRIALS COMPARING CITRISTIM VERSUS A COMPETITOR MOS
104%
106%Note: Values are expressed as a percentage of control.
94%
92%
90%ADG ADFI F/G
50 days of age.
Co
mp
etit
ive
MO
S
Co
mp
etit
ive
MO
S
Co
mp
etit
ive
MO
S
0.00
-0.50
-1.00
-1.50
-2.00
COMPETITOR
INITIAL CONC. 3.65 X 107 CFU/G
HOURS OF INCUBATION
LOG S
CA
LE R
ED
UC
TIO
N Final K88 numbers were75% lower for CitriStim
CITRISTIM IS MORE EFFECTIVE IN BINDING OF K88 E. COLI IN VITRO THAN A LEADING MOS SOURCE
0 2 4
102%
100%
98%
96%
AVERAGE OF FOUR SWINE GROWTH TRIALS COMPARING CITRISTIM VERSUS A COMPETITOR MOS
104%
106%Note: Values are expressed as a percentage of control.
94%
92%
90%ADG ADFI F/G
50 days of age.
Co
mp
eti
tive
MO
S
Co
mp
eti
tive
MO
S
Co
mp
eti
tive
MO
S
0.00
-0.50
-1.00
-1.50
-2.00
COMPETITOR
INITIAL CONC. 3.65 X 107 CFU/G
HOURS OF INCUBATION
LOG S
CA
LE R
ED
UC
TIO
N Final K88 numbers were75% lower for CitriStim