Cladribine/interferon-α
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Reactions 876 - 3 Nov 2001 ★ Cladribine/interferon-α First report of gynaecomastia?: case report Gynaecomastia occurred in a 42-year-old man after he received treatment with interferon-α and then cladribine for hairy cell leukaemia. The man initially received SC interferon-α 3MU on alternate days for 20 months. Four months after stopping interferon-α, he began receiving treatment with cladribine 0.1 mg/kg/day as a 7-day continuous infusion. Following antineoplastic therapy, he also received ceftazidime and amikacin for febrile neutropenia. Nine months after receiving cladribine, he noticed that a firm, nontender mass had developed in his left breast. Mammography revealed an ill-defined, asymmetrical mass, representing glandular tissue. He also had epigastric burning, for which he received omeprazole. [Patient outcome not stated.] Author comment: ‘We wish to highlight the development of gynecomastia in a case of hairy cell leukaemia treated by interferon and cladribine . . . The possible mechanism involved is indeed difficult to identify.’ Abhyankar D, et al. Gynecomastia in a case of hairy cell leukaemia - cladribine induced? Leukemia and Lymphoma 42: 243-246, Jun 2001 - India 807207039 » Editorial comment: A search of AdisBase and Medline did not reveal any previous case reports of gynaecomastia associated with cladribine or interferon-α. 1 Reactions 3 Nov 2001 No. 876 0114-9954/10/0876-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Cladribine/interferon-α
Reactions 876 - 3 Nov 2001
★Cladribine/interferon-αFirst report of gynaecomastia?: case report
Gynaecomastia occurred in a 42-year-old man after hereceived treatment with interferon-α and then cladribine forhairy cell leukaemia.
The man initially received SC interferon-α 3MU on alternatedays for 20 months. Four months after stopping interferon-α,he began receiving treatment with cladribine 0.1 mg/kg/day asa 7-day continuous infusion. Following antineoplastic therapy,he also received ceftazidime and amikacin for febrileneutropenia. Nine months after receiving cladribine, henoticed that a firm, nontender mass had developed in his leftbreast. Mammography revealed an ill-defined, asymmetricalmass, representing glandular tissue. He also had epigastricburning, for which he received omeprazole. [Patient outcomenot stated.]
Author comment: ‘We wish to highlight the development ofgynecomastia in a case of hairy cell leukaemia treated byinterferon and cladribine . . . The possible mechanism involvedis indeed difficult to identify.’Abhyankar D, et al. Gynecomastia in a case of hairy cell leukaemia - cladribineinduced? Leukemia and Lymphoma 42: 243-246, Jun 2001 - India 807207039
» Editorial comment: A search of AdisBase and Medline didnot reveal any previous case reports of gynaecomastiaassociated with cladribine or interferon-α.
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Reactions 3 Nov 2001 No. 8760114-9954/10/0876-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
