Charge Density Rules For Nature-Inspired Materials

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We acknowledge the support of: Perry Group, Dubin Group, Charge Density Rules For Nature-Inspired Materials Hansen Tjo, Sarah L. Perry Department of Chemical Engineering, University of Massachusetts Amherst Polycation (+) Polyanion (-) Surfactant amphilicity -> flexible environments, e.g., hydrophobic drug encapsulation for release in polar physiological system Charged micelle isotropy ~ ideal colloidal systems How does molecular chemistry inform coacervate phase behavior? Comple x Coacervation 100μm 100μm 100μm Surfactant Steric Repulsion Effects On Phase Behavior 100μm 100μm Y(-) ~ 0.6 Precipitation Predominates Y(-) ~ 0.8 100μm Spherical Droplets (Coacervates) Y(-) ~ 0.3 100μm L-to-S Phase Transition 100μm Y(-) ~ 0.6 Increase in Polymer Charge Density Decreases Critical Micelle Surface Charge Density Increase in neutral surfactant head PEG length effectively decreases micelle surface charge density Taylor et al., Soft Matter, 2016, 12, 9142. Applications: Drug delivery Vaccines stabilizers Sustainable oil recovery Electrostatically driven, associative liquid-liquid phase separation (LLPS) Charge density studies inform molecular design of polymer-micelle slug injections High-throughput optimization of slug parameters using porous microfluidic media Bridging systems chemistry and microfluidic platforms for energy sustainability Adapted from He et al., ACS Crystal Growth & Design, 2020, 20, 1021. PDADMAC-SDS/TX-100 Phase Diagram Surfactant Steric Hindrance Polymer Charge Density Design Rules = No Phase Separation Increasing Micelle Surface Charge Density Surfactant amphilicity forms adsorbed film lowering oil/slug interfacial tension Microfluidic Gradient-Tree Approach Increasing surfactant PEG-length increases (−) of turbidity jump scales with increasing micelle steric repulsion Negative correlation between polymer charge density and Determined the effects of polymer and micelle charge densities in driving complex coacervation Charge density design framework can be generalized to broad classes of ionic colloids, e.g., charged proteins, nanoparticles etc. and broaden array of coacervate-based platforms Further exploration into nanoscale chemistry affects on coacervate mechanical properties for renewable energy applications Polyethylene Glycol (PEG) tail on neutral surfactant head = Well-plate assays for turbidity, optical microscopy, kinetics studies
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Transcript of Charge Density Rules For Nature-Inspired Materials

PowerPoint PresentationWe acknowledge the support of: Perry Group, Dubin Group,
Charge Density Rules For Nature-Inspired Materials Hansen Tjo, Sarah L. Perry Department of Chemical Engineering, University of Massachusetts Amherst
Polycation (+) Polyanion (-)
hydrophobic drug encapsulation for release in polar
physiological system
How does molecular chemistry inform
coacervate phase behavior?
100μm
100μm
Applications:
• Charge density studies inform molecular design of polymer-micelle slug injections
• High-throughput optimization of slug parameters using porous microfluidic media
• Bridging systems chemistry and microfluidic platforms for energy sustainability
Adapted from He et al., ACS Crystal Growth & Design, 2020, 20, 1021.
PDADMAC-SDS/TX-100 Phase Diagram
steric repulsion
Negative correlation
driving complex coacervation
be generalized to broad classes of
ionic colloids, e.g., charged proteins,
nanoparticles etc. and broaden array
of coacervate-based platforms
surfactant head
microscopy, kinetics studies