About Synthetic CannabinoidsSynthetic cannabinoids are functionally similar to Δ9-tetrahydrocannabinol (THC), the active principle of cannabis. Like THC, they bind to the same cannabinoid receptors in the brain and other organs as the endogenous ligand anandamide. In late 2008, several cannabinoids were detected in herbal smoking mixtures or incense. They do not contain tobacco or cannabis but when smoked, produce effects similar to those of cannabis (EMCDDA, 2013).

The synthetic cannabinoids fall into seven major structural groups:

Naphthoylindoles (e.g. JWH-018, JWH-073 and JWH-398).Naphthylmethylindoles.Naphthoylpyrroles.Naphthylmethylindenes.Phenylacetylindoles (i.e. benzoylindoles, e.g. JWH-250).Cyclohexylphenols (e.g. CP 47,497 and homologues of CP 47,497).Classical cannabinoids (e.g. HU-210).

K2

Genie Yucatan Fire

Skunk

Sence

SmokeChillXHighdi’s Almdröhner

Earth Impact

Gorillaz

Galaxy Gold Space Truckin

Solar FlareMoon Rocks

Aroma

Blue Lotus

Scope

Sky

JWH-167 (Phenyl)JWH-203 (Phenyl)

JWH-250 (Phenyl) JWH-251 (Phenyl)JWH-320 (Phenyl)RCS-8 (Phenyl)

Naphthoylindoles

JWH-007 (Naph)JWH-015 (Naph)JWH-018 (Naph)JWH-019 (Naph)JWH-081 (Naph)JWH-098 (Naph)JWH-116 (Naph)MAM-2201AM-2201 (Naph)AM-1220AM-1235AM-2232

AM-1248 (Adam)AB-001 (Adam)

CP 47, 497 (non-classical) CP 55,244 (non-classical)CP 55,940 (non-classical)HU-308 (non-classical)

AM-2233 (benz)RCS-4 (Benz)AM-694 (benz)AM-630 (benzoil)

AM-630 AM-679 AM-694

AM-1241 AM-2233 RCS-4

ResearchInverse Agonist for CB2

Ki= 32.1nM at CB2

165x fold selectivity over CB1

ResearchAgonist for CB1 and CB2

Ki = 13.5nM at CB1

Ki = 49.5nM at CB2.

Designer DrugMap CB1 RreceptorSelective Agonist for CB1

Ki = ? 13.5nM at CB1

Peripheral CB receptorKi= 2.1nM at CB12

100 fold selectivity over CB1

Potent agonist Ki = 1.8nM at CB1

Ki = 2.2nM at CB2

JWH 018 analog Found in ‘herbal incense’ products

Naphthoylindoles

AM-1220 AM-1221 AM-1235

AM-2201AM-2232 JWH-007

ResearchAgonist for CB1

Ki = 3.88 nM CB1

Ki = 73.4 nM CB2

ResearchAgonist for CB2

Ki = 52.4 nM CB1

Ki = 0.28 nM CB2

ResearchAgonist for CB1

Ki = 1.50 nM CB1

Ki = 20.4 nM CB2

ResearchAgonist Ki = 1.0 nM CB1

Ki = 2.6 nM CB2

ResearchAgonist Ki = 0.28 nM CB1

Ki = 1.48 nM CB2

‘Herbal Synthetic’Agonist Ki = 9.0 nM CB1

Ki = 2.9 nM CB2

JWH-015 JWH-018 JWH-019

JWH-073 JWH-081 JWH-098

ResearchAgonist for CB2

Ki = 388 nM CB1

Ki = 13.9 nM CB2

Synthetic (herbal incense) Full Agonist Ki = 9.00 nM CB1

Ki = 2.94 nM CB2

Synthetic (herbal incense) Full Agonist Ki = 9.80 nM CB1

Ki = 5.60 nM CB2

Synthetic analgesic Full Agonist Ki = 8.9 nM CB1

Ki = 38 nM CB2

Synthetic analgesic Full Agonist Ki = 1.20 nM CB1

Ki = 12.4 nM CB2

Research Full Agonist Ki = 4.50 nM CB1

Ki = 1.88 nM CB2

JWH-116

JWH-149

JWH-193 JWH-198 JWH-200

Research Full Agonist Ki = 52 nM CB1

ResearchAgonist for CB2

Ki = 5.0 nM CB1

Ki = 0.73 nM CB2

ResearchAgonist for CB1

Ki = 10 nM CB1

ResearchAgonist for CB1

Ki = 6 nM CB1

ResearchAnalgesicAgonist for CB1

IC50 = 7.8 - 42 nM

JWH-210 JWH-398 JWH-424

MAM-2201

ResearchAgonist Ki = 0.46 nM CB1

Ki = 0.69 nM CB2

Found in ‘Herbal Incense’ AnalgesicAgonist Ki = 2.3 nM CB1

Ki = 2.8 nM CB2

ResearchAgonist Ki = 20.9 nM CB1

Ki = 5.40 nM CB2

ResearchAgonist Ki = 1.0 nM CB1

Ki = 2.6 nM CB2

CP 47,497 (cannabicyclohexanol) CP 55,940 HU-308

Agonist Ki = 2.2 nM CB1

AnalgesicMotor depresantAnticonvulsants

ResearchAgonist Ki = 0.58 nM CB1

Ki = 0.69 nM CB2

ResearchAgonist Ki = 10 uM CB1

Ki = 20 nM CB2

AgonistPotent analgesicFound in Spice Gold

Phenylacetylindoles

JWH-167 JWH-203 JWH-250

JWH 251

JWH-320

RCS-8

ResearchAgonist Ki = 90 nM CB1

Ki = 159 nM CB2

ResearchAgonist Ki = 8.0 nM CB1

Ki = 7.0 nM CB2

ResearchAgonist Ki = 11.0 nM CB1

Ki = 33.0 nM CB2

Synthetic Herbal

Adamantoylindoles

AB-001 AM-1248

Synthetic Herbal Synthetic Herbal