936

34 11 Vol.34, No.11

2014 11 Nov. 2014 Reproduction & Contraception

, : 81001535;

, KW-201346919

: ; Tel/Fax:+86-13818390984;

E-mail: chqyu81@163.com

1,2 1 1

(1. , , 200433)

(2. , , 201203)

(polycystic ovary syndrome, PCOS)

,

, PCOS ,

, , ,

, PCOS

: (PCOS); ;

: R271.1 : A : 0253-357X(2014)11-0936-04

doi: 10.7669/j.issn.0253-357X.2014.11.0936

E-mail: randc_journal@163.com

(polycystic ovary syndrome,

PCOS)

,

,

, [1,2], PCOS

,

(IR)

PCOS

, PCOS

,

PCOS

1 PCOS

PCOS[3], 50%~70% PCOS

, ;

PCOS ,

, ,

,

PCOS

, - - ,

(luteinizing hormone, LH)

, LH[4] , PCOS

LH 17α /17~20

, 17α /17~20

, [5] [6], PCOS

Uncoupling protein 2(UCP2) ,

937

(T3) P450

(T) , PCOS

UCP2

2 PCOS

, PCOS ,

C (C reactive

protein, CRP) (interleukin, IL)-6 IL-18

α(tumor necrosis factor, TNF-α)

(macrophage migration inhibitory

factor, MIF) (INH)

PCOS CRP TNF-α IL-6

PCOS ,

, PCOS[9] [8], PCOS

PCOS

, ,

, ,

PCOS

,

TNF-α PCOS

, PCOS [9] MIF

, PCOS

MIF ,

PCOS ; MIF

PCOS[10] PCOS

3

(reactive oxygen

species, ROS) , PCOS

[11],

: ,

3.1

T ,

TNF-α -1 ,

-κB(nuclear factor-κB, NF-κB) ,

NF-κB , [12]

PCOS , ,

NF-κB , TNF-α IL-1[13,14],

ROS , p 4 7

(p47phox) (TBARS)

,

NADPH NOX2 NOX4 P22phox ,

ROS , NADPH DPI

Apocynin[15] , PCOS

: , ROS ,

NF-κB , TNF-α IL-1

(DHEA) PCOS

, TNF-α IL-6

, PCOS CD4+

, -1

(VCAM-1) , VCAM

, ,

P C O S [ 1 6 ] ,

VCAM-1 PCOS

[17,18],

,

(DHT) FOXO1

(SOD)2 , FOXO1 SOD2[17] GnRH

, PCOS IL-6

, PCOS[18]

,

, PCOS

3.2 [19], PCOS

(IR) ,

TNF-α PCOS TNF-α, TNF-α

938

-1 , -4

, ,

IR IR

,

, PCOS[20,21],

- ,

CYP17 ,

IL-18 [22], CYP19

mRNA , , IL-

18

,

,

, LH

CYP17 , ,

,

, PCOS[23]

4

, PCOS

, PCOS

, PCOS

PCOS ,

, PCOS ,

IR

, PCOS

[1] Ibrahim A, Cihangir ME, Mehmet S, et al. A macrophage

activation marker chitotriosidase in women with PCOS:

does low-grade chronic inflammation in PCOS relate to

PCOS itself or obesity? Arch Gynecol Obstet, 2012, 286

(4):1065-71.

[2] Ayse GK, Mehmet GT, Suleyman HI. Cornea in PCOS

patients as a possible target of IGF-1 action and insulin

resistance. Arch Gynecol Obstet, 2014, 290(6):1255-63.

[3] Huang A, Brennan K, Azziz A. Prevalence of hyperan-

drogenemia in the polycystic ovary syndrome diagnosed by

the NIH 1990 criteria. Fertil Steril, 2010, 93(6):1938-41.

[4] Burt Solorzano CM, Beller JP, Abshire MY, et al. Neuroendo-

crine dysfunction in polycystic ovary syndrome. Steroids,

2012, 77(4):332-7.

[5] Comim FV, Teerds K, Hardy K, et al. Increased protein

expression of LHCG receptor and 17α-hydroxylase/ 17-20-

lyase in human polycystic ovaries. Hum Reprod, 2013, 28

(11):3086-92.

[6] Liu Y, Jiang H, Xing FQ, et al. Uncoupling protein 2 expression

affects androgen synthesis in polycystic ovary syndrome.

Endocrine, 2013, 43(3):714-23.

[7] Xiong YL, Liang XY, Yang X, et al. Low-grade chronic

inflammation in the peripheral blood and ovaries of women

with polycystic ovarian syndrome. Eur J Obstet Gynecol

Reprod Biol, 2011, 159(1):148-50.

[8] Wang YX, Zhu WJ. Evaluation of adiponectin, resistin, IL-

6, TNF-α in obese and non-obese women with polycystic

ovary syndrome. J Reprod Contracep, 2012, 23(4):237-44.

[9] Choi YS, Yang HI, Cho S, et al. Serum asymmetric

dimethylarginine, apelin, and tumor necrosis factor-α levels

in non-obese women with polycystic ovary syndrome.

Steroids, 2012, 77(13):1352-8.

[10] González F, Rote NS, Minium J, et al. Elevated circulating

levels of macrophage migration inhibitory factor in poly-

cystic ovary syndrome. Cytokine, 2010, 51(3):240-4.

[11] , , , .

-κB β1

. , 2013, 33(8):529-33.

[12] , , , . RAW264.7

-α -1

. , 2009, 89(35):2500-3.

[13] González F, Sreekumaran Nair K, Daniels J, et al.

Hyperandrogenism sensitizes mononuclear cells to promote

glucose-induced inflammation in lean reproductive-age

women. Endocrinol Metab, 2012, 302(3):E296-306.

[14]González F, Sreekumaran Nair K, Daniels J, et al.

Hyperandrogenism sensitizes leukocytes to hyperglycemia

to promote oxidative stress in lean reproductive-age women.

J Clin Endocrinol Metab, 2012, 97(8):2836-43.

[15] Lu JP, Monardo L, Bryskin L, et al. Androgens induce

oxidative stress and radiation resistance in prostate cancer

cells though NADPH oxidase. Prost Cancer Prost Dis, 2010,

939

13(1):39-46.

[16] Solano ME, Sander VA, Ho H, et al. Systemic inflammation,

cellular influx and up-regulation of ovarian VCAM-1 expres-

sion in a mouse model of polycystic ovary syndrome (PCOS).

Reprod Immunol, 2011, 92(1/2):33-44.

[17] Kajihara T, Tochigi H, Prechapanich J, et al. Androgen

signaling in decidualizing human endometrial stromal cells

enhances resistance to oxidative stress. Fertil Steril, 2012, 97

(1):185-91.

[18] Gonzalez F, Sia CL, Stanczyk FZ, et al. Hyperandrogenism

exerts an anti-inflammatory effect in obese women with poly-

cystic ovary syndrome. Endocrine, 2012, 42(3):726-35.

[19] , , , . TNF-α

INSIG2 SCAP .

, 2009, 25(5):929-33.

[20] Piotrowski PC, Rzepczynska IJ, Kwintkiewicz J, et al.

Oxidative stress induces expression of CYP11A, CYP17,

STAR and 3bHSD in rat theca-interstitial cells. J Soc Gynecol

Invest, 2005, 12(2 Suppl):319A.

[21] Ortega I, Cress AB, Villanueva AJ, et al. Resveratrol potentiates

effects of simvastatin on inhibition of rat ovarian theca-

interstitial cellsteroidogenesis. Fertil Steril, 2011, 96(3 Suppl):

S40-1.

[22] , , , .

. , 2013, 280(11):1796-9.

[23] Comim FV, Hardy K, Franks S. Adiponectin and its recep-

tors in the ovary: further evidence for a link between obesity

and hyperandrogenism in polycystic ovary syndrome. PLOS,

2013, 8(11):1-9.

(2014 2 12 )

Study of the Correlation between Hyperandrogenism and

Chronic Inflammation in Polycystic Ovary Syndrome

Li-hong HUANG1,2, Chao-qin YU1, Dan-ying ZHANG1

(1. Department of Traditional Chinese Medicine, Changhai Hospital, the Second Military Medical University, Shanghai, 200433)

(2. Shanghai University of Traditional Chinese Medicine, Shanghai, 201203)

ABSTRACT Polycystic ovary syndrome (PCOS) is a disease of endocrine and metabolic disorder, which

is mainly characterized by hyperandrogenism. It has always been the hot and difficult topic in the reproductive

endocrine field. Recently, a large number of studies have shown that PCOS is a chronic low-grade inflammation.

Moreover, there is a co-relationship between this inflammation and hyperandrogenism: either the hyperandrogenism

inducing the inflammation, or the inflammation stimulating the ovary to produce more androgen. They may

influence each other, and promote the occurrence and development of PCOS together.

Key words: polycystic ovary syndrome (PCOS); hyperandrogenism; chronic inflammation