β-Carotene and retinol ineffective in preventing sputum atypia

18 THERAPY and retinol ineffective in preventing sputum atypia Teatment with and retinol [vitamin A] does not affect the incidence of sputum atypia, thought to be an intermediate marker in the development of lung cancer, researchers in the US report. In this randomised, double-blind trial, 755 former asbestos workers received either 50mg and retinol 25 OOOIU on alternate days, or placebo, for a minimum of 3 years. Sputum samples were analysed at 3-monthly intervals. At the end of treatment, sputum was classified as either normal or showing evidence of metaplasia, mild, moderate, or severe atypia, or malignancy. No significant difference in the incidence of any sputum abnormalities was seen between the treatment and placebo groups. McLarty JW, Holiday DB, Girard WM, Yanagihara RH, Kummet TD, et al. f}-Carotcne, vitamin A, and lung cancer chemoprevention: results of an intermediated endpoint study. American Joumal of Clinical Nutrition 62 (Suppl.): 1431·1438, Dec 1995 Il004'_ Editorial comment: This finding supports the view that supplements do not lower the incidence of lung cancer. Previous studies have indicated that such supplements may infact be detrimental [see lnpharma 1021: 14, 27 Jan 1996; 800417592]. 10 Feb 1996INPHARMA" 0156-270319611023-000181$01.00° Adls International Limited 1996. All rights reserved

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Transcript of β-Carotene and retinol ineffective in preventing sputum atypia

18 THERAPY

~-Carotene and retinol ineffective in preventing sputum atypia

Teatment with ~-carotene and retinol [vitamin A] does not affect the incidence of sputum atypia, thought to be an intermediate marker in the development of lung cancer, researchers in the US report.

In this randomised, double-blind trial, 755 former asbestos workers received either ~-carotene 50mg and retinol 25 OOOIU on alternate days, or placebo, for a minimum of 3 years. Sputum samples were analysed at 3-monthly intervals.

At the end of treatment, sputum was classified as either normal or showing evidence of metaplasia, mild, moderate, or severe atypia, or malignancy. No significant difference in the incidence of any sputum abnormalities was seen between the treatment and placebo groups. McLarty JW, Holiday DB, Girard WM, Yanagihara RH, Kummet TD, et al.

f}-Carotcne, vitamin A, and lung cancer chemoprevention: results of an intermediated endpoint study. American Joumal of Clinical Nutrition 62 (Suppl.): 1431·1438, Dec 1995 Il004'_ ~ Editorial comment: This finding supports the view that ~-carotene supplements do not lower the incidence of lung cancer. Previous studies have indicated that such supplements may infact be detrimental [see lnpharma 1021: 14, 27 Jan 1996; 800417592].