MASTER STUDENT POSITION AVAILABLECITI LABORATORY

DEPARTMENT OF CELL BIOLOGY, FACULTY OF SCIENCESUNIVERSITY OF GENEVA

Investigating the molecular basis of hypertension

E-cadherinIg-like-CAMs

(nectin, JAM,etc)

Claudins, MARVEL

ADHERENS JUNCTION TIGHT JUNCTION

ZOs

Polarity p.Afadin

p120

β-catenin

α-catenin

CINGULIN

PARACINGULIN

PLEKHA7

The Citi Laboratory investigates how junctional proteins in epithelial and endothelial cells control signaling, through the cytoskeleton, transcription factors, and mem-brane proteins. Our laboratory discovered PLEKHA7, a cytoplasmic component of adherens junctions, which binds to paracingulin and to other cytoplasmic junctional proteins to stabilize cadherin-based junctions. PLEKHA7 has been found to be involved in cardiovascular physiology, hypertension and glaucome, through GenomeW-ideAssociationStudies and genetic analysis. In rats Knock-Out for PLEKHA7, blood pressure is lower, and there is increased intracellular calcium and NO signaling by endothelial cells.The proposed project addresses the role of PLEKHA7 in endothelial cells, using CRISPR-KO cellular and mouse models, and state-of-the art biochemical and cell biological techniques, to discover how PLEKHA7 is implicated in hypertension and vascular physiology.For further information contact:Prof. Sandra Citi (sandra.citi@unige.ch)or visit website: http://www.unige.ch/sciences/biologie/bicel/citi/static/Sandra_Citi/Welcome.html

Shah, J., Guerrera, D., Vasileva, E., Sluysmans, S., Bertels, E., Citi, S. (2016) Int. J. Biochem. Cell Biol. 75: 112-116Citi, S., Spadaro, D., Schneider, Y., Stutz J. Pulimeno P. (2011). Mol. Membr. Biol. , 28:427-444.Pulimeno, P., Bauer, C., Stutz, J., Citi, S (2010) PLoS ONE 5(8): e12207Guillemot, L.,, Foglia, A., Paschoud, S., Pulimeno, P., Citi, S. (2008). Biochim Biophys Acta. 1778(3):601-13.Guillemot, L., Paschoud, S., Jond, L., Foglia, A., Citi, S. (2008). Mol. Biol. Cell, 19:4442-4453.Bordin, M., D’Atri, F., Guillemot, L. , Citi, S. (2004) Mol. Cancer Res. 2; 692-701.Cardellini, P., Cirelli A., Citi, S (2007). Cell Tissue Res. 330:247-56.

A PRODUCTIVE LAB!

BACHELOR AND MASTER STU-DENTS ALMOST ALWAYS

OBTAIN AT LEAST ONE PUBLI-CATION FROM THEIR STAY IN

THE CITI LABORATORY!!!

(some examples below)