Investigating the molecular basis of hypertension · MASTER STUDENT POSITION AVAILABLE CITI...
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MASTER STUDENT POSITION AVAILABLE CITI LABORATORY DEPARTMENT OF CELL BIOLOGY, FACULTY OF SCIENCES UNIVERSITY OF GENEVA Investigating the molecular basis of hypertension E-cadherin Ig-like-CAMs (nectin, JAM,etc) Claudins, MARVEL ADHERENS JUNCTION TIGHT JUNCTION ZOs Polarity p. Afadin p120 β-catenin α-catenin CINGULIN PARACINGULIN PLEKHA7 The Citi Laboratory investigates how junctional proteins in epithelial and endothelial cells control signaling, through the cytoskeleton, transcription factors, and mem- brane proteins. Our laboratory discovered PLEKHA7, a cytoplasmic component of adherens junctions, which binds to paracingulin and to other cytoplasmic junctional proteins to stabilize cadherin-based junctions. PLEKHA7 has been found to be involved in cardiovascular physiology, hypertension and glaucome, through GenomeW- ideAssociationStudies and genetic analysis. In rats Knock-Out for PLEKHA7, blood pressure is lower, and there is increased intracellular calcium and NO signaling by endothelial cells. The proposed project addresses the role of PLEKHA7 in endothelial cells, using CRISPR-KO cellular and mouse models, and state-of-the art biochemical and cell biological techniques, to discover how PLEKHA7 is implicated in hypertension and vascular physiology. For further information contact: Prof. Sandra Citi ([email protected]) or visit website: http://www.unige.ch/sciences/biologie/bicel/citi/static/Sandra_Citi/Welcome.html Shah, J., Guerrera, D., Vasileva, E., Sluysmans, S., Bertels, E., Citi, S. (2016) Int. J. Biochem. Cell Biol. 75: 112-116 Citi, S., Spadaro, D., Schneider, Y., Stutz J. Pulimeno P. (2011). Mol. Membr. Biol. , 28:427-444. Pulimeno, P., Bauer, C., Stutz, J., Citi, S (2010) PLoS ONE 5(8): e12207 Guillemot, L.,, Foglia, A., Paschoud, S., Pulimeno, P., Citi, S. (2008). Biochim Biophys Acta. 1778(3):601-13. Guillemot, L., Paschoud, S., Jond, L., Foglia, A., Citi, S. (2008). Mol. Biol. Cell, 19:4442-4453. Bordin, M., D’Atri, F., Guillemot, L. , Citi, S. (2004) Mol. Cancer Res. 2; 692-701. Cardellini, P., Cirelli A., Citi, S (2007). Cell Tissue Res. 330:247-56. A PRODUCTIVE LAB! BACHELOR AND MASTER STU- DENTS ALMOST ALWAYS OBTAIN AT LEAST ONE PUBLI- CATION FROM THEIR STAY IN THE CITI LABORATORY!!! (some examples below)
Transcript of Investigating the molecular basis of hypertension · MASTER STUDENT POSITION AVAILABLE CITI...
MASTER STUDENT POSITION AVAILABLECITI LABORATORY
DEPARTMENT OF CELL BIOLOGY, FACULTY OF SCIENCESUNIVERSITY OF GENEVA
Investigating the molecular basis of hypertension
E-cadherinIg-like-CAMs
(nectin, JAM,etc)
Claudins, MARVEL
ADHERENS JUNCTION TIGHT JUNCTION
ZOs
Polarity p.Afadin
p120
β-catenin
α-catenin
CINGULIN
PARACINGULIN
PLEKHA7
The Citi Laboratory investigates how junctional proteins in epithelial and endothelial cells control signaling, through the cytoskeleton, transcription factors, and mem-brane proteins. Our laboratory discovered PLEKHA7, a cytoplasmic component of adherens junctions, which binds to paracingulin and to other cytoplasmic junctional proteins to stabilize cadherin-based junctions. PLEKHA7 has been found to be involved in cardiovascular physiology, hypertension and glaucome, through GenomeW-ideAssociationStudies and genetic analysis. In rats Knock-Out for PLEKHA7, blood pressure is lower, and there is increased intracellular calcium and NO signaling by endothelial cells.The proposed project addresses the role of PLEKHA7 in endothelial cells, using CRISPR-KO cellular and mouse models, and state-of-the art biochemical and cell biological techniques, to discover how PLEKHA7 is implicated in hypertension and vascular physiology.For further information contact:Prof. Sandra Citi ([email protected])or visit website: http://www.unige.ch/sciences/biologie/bicel/citi/static/Sandra_Citi/Welcome.html
Shah, J., Guerrera, D., Vasileva, E., Sluysmans, S., Bertels, E., Citi, S. (2016) Int. J. Biochem. Cell Biol. 75: 112-116Citi, S., Spadaro, D., Schneider, Y., Stutz J. Pulimeno P. (2011). Mol. Membr. Biol. , 28:427-444.Pulimeno, P., Bauer, C., Stutz, J., Citi, S (2010) PLoS ONE 5(8): e12207Guillemot, L.,, Foglia, A., Paschoud, S., Pulimeno, P., Citi, S. (2008). Biochim Biophys Acta. 1778(3):601-13.Guillemot, L., Paschoud, S., Jond, L., Foglia, A., Citi, S. (2008). Mol. Biol. Cell, 19:4442-4453.Bordin, M., D’Atri, F., Guillemot, L. , Citi, S. (2004) Mol. Cancer Res. 2; 692-701.Cardellini, P., Cirelli A., Citi, S (2007). Cell Tissue Res. 330:247-56.
A PRODUCTIVE LAB!
BACHELOR AND MASTER STU-DENTS ALMOST ALWAYS
OBTAIN AT LEAST ONE PUBLI-CATION FROM THEIR STAY IN
THE CITI LABORATORY!!!
(some examples below)
