2005

AlcoholsQ 0230 Direct, Pyrrolidine Sulfonamide Promoted Enantioselective Aldol Reactions of

α,α-Dialkyl Aldehydes: Synthesis of Quaternary Carbon-Containing β-Hydroxy Carbonyl Compounds. — A bifunctional (S)-pyrrolidine trifluoromethanesulfon-amide is an effective organocatalyst for the direct asymmetric aldol reaction ofα,α-dialkyl aldehydes. β-Hydroxyaldehydes with an α-quaternary center are obtained. — (WANG*, W.; LI, H.; WANG, J.; Tetrahedron Lett. 46 (2005) 30, 5077-5079; Dep. Chem., Univ. N. Mex., Albuquerque, NM 87131, USA; Eng.) — Mais

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