Alzheimer’s Disease

Your Antibody ExpertsCustomAlzheimer’s Disease

sAPPα

ADAM10

ADAM17

Fe65GAPDH

APPBP1

APP Processing

IntracellularGlycoticActivity

α secretase

β secretase

sAPPβ

CD147PSEN

PEN2NCSTNAPH1

CD147γ secretase

Aβ 40/42

LPL APOE

AβAggregation

Casp7Casp3 MAPT

NeurofibrillaryTangles

PairedHelical

Filaments

OligomericAβ

HyperphosphorylatedTau

Activation ofKinases:

PKC, ERK2, Src, RTk

Ca2+Ca2+

Calpain

p25Cdk5

p35Cdk5

Amyloid Plaque(Senile Plaque)

CytC APAF1

CellDeath

Apoptosis

TAUP P P P

Your Antibody ExpertsCustom

Alzheimer’s Related Products

APO-E AntibodyCat. No.: 7333Host: Rabbit (Polyclonal)Applications: E, WB, IHC-PSpecies Reactivity: HU, MS, RAT

ProSci’s Product HighlightsAPP AntibodyCat. No.: 5143Host: Rabbit (Polyclonal)Applications: E, WB, IHC-P, IFSpecies Reactivity - HU, MS, RAT

BACE AntibodyCat. No.: 2253Host: Rabbit (Polyclonal)Applications: E, WB, IHC-P, ICC, IFSpecies Reactivity: HU, MS

Product Cat. No. Applications SpeciesReactivity Product Cat. No. Applications Species

Reactivity

Detection Sets & Lysates Cat. No.

• 2051 P E, WB, ICC, IF HU• 1131 P E, WB, ICC, IF, FACS HU, MS, RAT• 2013 P E, WB, IHC-P, IF HU, MS, RAT• PM-2015 M E, WB, IHC-P HU, MS, RAT• 45-261 P E, WB HU, MS• 4003 P E, WB, IHC-P HU, MS, RAT• 7333 P E, WB, IHC-P HU, MS, RAT• 2136 P E, WB, IHC-P, IF HU, MS, RAT• 5143 P E, WB, IHC-P, IF HU, MS, RAT• 3683 P E, WB, ICC HU, MS• 2253 P E, WB, IHC-P, ICC, IF HU, MS• 2247 P E, WB, IHC-P HU, MS, RAT• 3343 P E, WB, IHC-P, IF HU, MS, RAT• 49-100 M WB, IHC, FACS, IP HU• 3353 P E, WB, IHC-P, IF HU, MS• 51-614 M E, WB, IHC, IP HU, MS, RAT, OTH• 3445 P E, IHC-P HU• 3465 P E, WB, IHC-P HU, MS, RAT• 3473 P E, WB, IHC-P, ICC, IF HU, MS, RAT• 2073 P E, WB, ICC, IF, IP HU• 3195 P E, WB, IHC-P, IF HU, MS, RAT• 3197 P E, WB, IHC-P HU, MS, RAT• 51-626 M WB, IHC, ICC, IP HU, MS, RAT• 32-127 M E, IHC HU• 49-408 P E, WB, IHC, IF, IP HU, MS, RAT• 49-095 M WB, IHC HU, MS, RAT, OTH• 31-008 P E, WB, IHC HU• 36-167 M WB, FACS,IP, FUNC HU• 3781 P E, WB, IHC, IF HU, MS, RAT• PM-7569 M E, WB HU, MS, RAT• 70-434 P E, WB, IHC HU, MS, RAT• XPS-2024 P WB, IHC, IP HU, RAT• 70-332 M WB, IHC, ICC, IP HU, MS, RAT• 28-230 P E, WB HU, MS, RAT• 46-670 P E HU

• GSK3B / GSK3 Beta Antibody 71-366 P WB, IHC, IF HU, MS, RAT, OTH• IRE1p Antibody 3655 P E, WB, ICC, IF HU, MS, RAT• LRP1 Antibody 49-863 M E, WB, IHC, FACS, IP HU• MAPK1 Antibody [3F8] 51-396 M E, WB, IHC, FACS HU, MS• MAPK3 Antibody [3C9] 51-981 M E, WB, IHC, IF HU• Nicastrin Antibody 3985 P E, WB, IHC-P, IF HU, MS, RAT• Nicastrin Antibody [AT3B2] 49-072 M E, WB, IHC HU, MS• PEN2 Antibody 3981 P E, WB, IHC-P, IF HU, MS, RAT• Presenilin 1 Antibody 4203 P E, WB, IHC-P, IF HU, MS, RAT• Presenilin 1 Antibody XG-6101 P WB HU, MS• Presenilin 2 Antibody 29-978 P E, WB, IHC HU, MS, RAT, OTH• Presenilin 2 Antibody XG-6102 P WB HU, MS• SNCA Antibody 7911 P E, WB, IHC-P, IF HU, MS, RAT• sTNF Receptor Type I Antibody XP-5276 P E, WB, Neut HU• Tau (phospho Ser262) Antibody 79-152 P WB, IHC, IF HU, MS, RAT• Tau (phospho Ser404) Antibody 79-153 P WB, IHC, IF HU, MS, RAT• Tau Antibody 8077 P E, WB, IHC-P HU, MS, RAT• TP53 Antibody 49-495 M E, WB, IHC, IP HU

Alzheimers Disease B-Amyloid Protein Detection Set PSI-1812 APP; APP; BACE; BACE2Alzheimers Disease gamma-Secretase Detection Set PSI-1820 APH1; Nicastrin; PEN2; PSENAmygdala (Alzheimer’s Disease) Lysate XBL-10274Amygdala (Alzheimer’s Disease) Membrane Lysate XBL-10272Corpus Callosum (Alzheimer’s Disease) Lysate XBL-10278Frontal Lobe (Alzheimer’s Disease) Lysate XBL-10282Hippocampus (Alzheimer’s Disease) Cytoplasmic Lysate XBL-10283Hippocampus (Alzheimer’s Disease) Lysate XBL-10286Hippocampus (Alzheimer’s Disease) Membrane Lysate XBL-10284Occipital lobe (Alzheimer’s Disease) Lysate XBL-10290Parietal Lobe (Alzheimer’s Disease) Lysate XBL-10294Pons (Alzheimer’s Disease) Lysate XBL-10298Postcentral Gyrus (Alzheimer’s Disease) Lysate XBL-10302Precentral Gyrus (Alzheimer’s Disease) Lysate XBL-10306Temporal Lobe (Alzheimer’s Disease) Lysate XBL-10314Temporal Lobe (Alzheimer’s Disease) Membrane Lysate XBL-10312Thalamus (Alzheimer’s Disease) Lysate XBL-10310Antibody color in pathway

KEYAntibody not displayed in pathway• ••••••••

Alzheimer’s Disease - Caltag Medsystems · 2017. 7. 27. · Amygdala (Alzheimer’s Disease)...

Documents

Transcript of Alzheimer’s Disease - Caltag Medsystems · 2017. 7. 27. · Amygdala (Alzheimer’s Disease)...

aA Journal of Alzheimer’s Disease & Parkinsonism...J Alzheimer’s Disease & Parkinsonism o u r n a l o f a A lz h e i m e r s Dis a s e & P r k i n s o n i s m ISSN: 2161-0460 Citation:

er sDi aDenise Alheimers Dis Parkinsonism 214 4: Journal of ......Citation: Denis PA (2014) The Continuum of Metabolic Stress According to the Gas Model of Alzheimer’s Disease. J

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Nephrin, Podocin 6õ4relapsing nephrotic syndrome. Kidney Int. 2007 May;71(9):946-51. Rat renal glomerular lysate Human renal glomeruli ラット腎糸球体 lysate (7.5% ゲル )

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No Slide Title...Source: Hebert, L.E., et al. Alzheimer’s Disease in the U.S. Population: Prevalence Estimates Using the 2000 Census. Arch. Neurol., Vol. 60, Aug. 2003, 1119-1122

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THE PATHOPHYSIOLOGY OF ALZHEIMER’S … Vol. 3, No. 8 October 2005 ABSTRACT The pathophysiology of Alzheimer’s disease (AD) is complex, involving several neurotransmit-ter systems