Alzheimer’s Disease - Caltag Medsystems · 2017. 7. 27. · Amygdala (Alzheimer’s Disease)...

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Your Anbody Experts Custom Alzheimer’s Disease © 2016 ProSci Incorporated. All rights reserved. prosci-inc.com | orders@prosci-inc.com | (858) 513 2638 Learn more: APP sAPP α C83 ADAM10 ADAM17 Fe65 GAPDH APPBP1 APP Processing Intracellular Glycoc Acvity α secretase β secretase sAPP β CD147 PSEN PEN2 NCSTN APH1 CD147 γ secretase C99 Aβ 40/42 LPL APOE Aβ Aggregaon GSK Casp7 Casp3 MAPT Neurofibrillary Tangles Paired Helical Filaments Oligomeric Aβ ROS TNFR Hyperphosphorylated Tau Acvaon of Kinases: PKC, ERK2, Src, RTk Ca 2+ Ca 2+ Ca 2+ TAU Calpain p25 Cdk5 p35 Cdk5 Amyloid Plaque (Senile Plaque) Cam CHP Bad FADD Casp8 Bid CytC CytC APAF1 Casp9 Casp3 Cell Death Cell Death Cell Death Apoptosis BACE Apoptosis SNCA NMDAR VDCC P LRP TAU P P P P P P P

Transcript of Alzheimer’s Disease - Caltag Medsystems · 2017. 7. 27. · Amygdala (Alzheimer’s Disease)...

Page 1: Alzheimer’s Disease - Caltag Medsystems · 2017. 7. 27. · Amygdala (Alzheimer’s Disease) Membrane Lysate XBL-10272 Corpus Callosum (Alzheimer’s Disease) Lysate XBL-10278 Frontal

Your Antibody ExpertsCustomAlzheimer’s Disease

© 2016 ProSci Incorporated. All rights reserved. prosci-inc.com | [email protected] | (858) 513 2638Learn more:

APP

sAPPα

C83

ADAM10

ADAM17

Fe65GAPDH

APPBP1

APP Processing

IntracellularGlycoticActivity

α secretase

β secretase

sAPPβ

CD147PSEN

PEN2NCSTNAPH1

CD147γ secretase

C99

Aβ 40/42

LPL APOE

AβAggregation

GSK

Casp7Casp3 MAPT

NeurofibrillaryTangles

PairedHelical

Filaments

OligomericAβ

ROS

TNFR

HyperphosphorylatedTau

Activation ofKinases:

PKC, ERK2, Src, RTk

Ca2+Ca2+

Ca2+

TAU

Calpain

p25Cdk5

p35Cdk5

Amyloid Plaque(Senile Plaque)

Cam

CHP

Bad

FADD

Casp8

Bid

CytC

CytC APAF1

Casp9

Casp3

CellDeath

CellDeath

CellDeath

Apoptosis

BACE

Apoptosis

SNCA

NM

DAR

VDCC

P

LRP

TAUP P P P

P PP

Page 2: Alzheimer’s Disease - Caltag Medsystems · 2017. 7. 27. · Amygdala (Alzheimer’s Disease) Membrane Lysate XBL-10272 Corpus Callosum (Alzheimer’s Disease) Lysate XBL-10278 Frontal

Your Antibody ExpertsCustom

© 2016-1 ProSci Incorporated. All rights reserved. prosci-inc.com | [email protected] | (858) 513 2638Order now:

Alzheimer’s Related Products

APO-E AntibodyCat. No.: 7333Host: Rabbit (Polyclonal)Applications: E, WB, IHC-PSpecies Reactivity: HU, MS, RAT

ProSci’s Product HighlightsAPP AntibodyCat. No.: 5143Host: Rabbit (Polyclonal)Applications: E, WB, IHC-P, IFSpecies Reactivity - HU, MS, RAT

BACE AntibodyCat. No.: 2253Host: Rabbit (Polyclonal)Applications: E, WB, IHC-P, ICC, IFSpecies Reactivity: HU, MS

Product Cat. No. Applications SpeciesReactivity Product Cat. No. Applications Species

Reactivity

Detection Sets & Lysates Cat. No.

• 2051 P E, WB, ICC, IF HU• 1131 P E, WB, ICC, IF, FACS HU, MS, RAT• 2013 P E, WB, IHC-P, IF HU, MS, RAT• PM-2015 M E, WB, IHC-P HU, MS, RAT• 45-261 P E, WB HU, MS• 4003 P E, WB, IHC-P HU, MS, RAT• 7333 P E, WB, IHC-P HU, MS, RAT• 2136 P E, WB, IHC-P, IF HU, MS, RAT• 5143 P E, WB, IHC-P, IF HU, MS, RAT• 3683 P E, WB, ICC HU, MS• 2253 P E, WB, IHC-P, ICC, IF HU, MS• 2247 P E, WB, IHC-P HU, MS, RAT• 3343 P E, WB, IHC-P, IF HU, MS, RAT• 49-100 M WB, IHC, FACS, IP HU• 3353 P E, WB, IHC-P, IF HU, MS• 51-614 M E, WB, IHC, IP HU, MS, RAT, OTH• 3445 P E, IHC-P HU• 3465 P E, WB, IHC-P HU, MS, RAT• 3473 P E, WB, IHC-P, ICC, IF HU, MS, RAT• 2073 P E, WB, ICC, IF, IP HU• 3195 P E, WB, IHC-P, IF HU, MS, RAT• 3197 P E, WB, IHC-P HU, MS, RAT• 51-626 M WB, IHC, ICC, IP HU, MS, RAT• 32-127 M E, IHC HU• 49-408 P E, WB, IHC, IF, IP HU, MS, RAT• 49-095 M WB, IHC HU, MS, RAT, OTH• 31-008 P E, WB, IHC HU• 36-167 M WB, FACS,IP, FUNC HU• 3781 P E, WB, IHC, IF HU, MS, RAT• PM-7569 M E, WB HU, MS, RAT• 70-434 P E, WB, IHC HU, MS, RAT• XPS-2024 P WB, IHC, IP HU, RAT• 70-332 M WB, IHC, ICC, IP HU, MS, RAT• 28-230 P E, WB HU, MS, RAT• 46-670 P E HU

• GSK3B / GSK3 Beta Antibody 71-366 P WB, IHC, IF HU, MS, RAT, OTH• IRE1p Antibody 3655 P E, WB, ICC, IF HU, MS, RAT• LRP1 Antibody 49-863 M E, WB, IHC, FACS, IP HU• MAPK1 Antibody [3F8] 51-396 M E, WB, IHC, FACS HU, MS• MAPK3 Antibody [3C9] 51-981 M E, WB, IHC, IF HU• Nicastrin Antibody 3985 P E, WB, IHC-P, IF HU, MS, RAT• Nicastrin Antibody [AT3B2] 49-072 M E, WB, IHC HU, MS• PEN2 Antibody 3981 P E, WB, IHC-P, IF HU, MS, RAT• Presenilin 1 Antibody 4203 P E, WB, IHC-P, IF HU, MS, RAT• Presenilin 1 Antibody XG-6101 P WB HU, MS• Presenilin 2 Antibody 29-978 P E, WB, IHC HU, MS, RAT, OTH• Presenilin 2 Antibody XG-6102 P WB HU, MS• SNCA Antibody 7911 P E, WB, IHC-P, IF HU, MS, RAT• sTNF Receptor Type I Antibody XP-5276 P E, WB, Neut HU• Tau (phospho Ser262) Antibody 79-152 P WB, IHC, IF HU, MS, RAT• Tau (phospho Ser404) Antibody 79-153 P WB, IHC, IF HU, MS, RAT• Tau Antibody 8077 P E, WB, IHC-P HU, MS, RAT• TP53 Antibody 49-495 M E, WB, IHC, IP HU

Alzheimers Disease B-Amyloid Protein Detection Set PSI-1812 APP; APP; BACE; BACE2Alzheimers Disease gamma-Secretase Detection Set PSI-1820 APH1; Nicastrin; PEN2; PSENAmygdala (Alzheimer’s Disease) Lysate XBL-10274Amygdala (Alzheimer’s Disease) Membrane Lysate XBL-10272Corpus Callosum (Alzheimer’s Disease) Lysate XBL-10278Frontal Lobe (Alzheimer’s Disease) Lysate XBL-10282Hippocampus (Alzheimer’s Disease) Cytoplasmic Lysate XBL-10283Hippocampus (Alzheimer’s Disease) Lysate XBL-10286Hippocampus (Alzheimer’s Disease) Membrane Lysate XBL-10284Occipital lobe (Alzheimer’s Disease) Lysate XBL-10290Parietal Lobe (Alzheimer’s Disease) Lysate XBL-10294Pons (Alzheimer’s Disease) Lysate XBL-10298Postcentral Gyrus (Alzheimer’s Disease) Lysate XBL-10302Precentral Gyrus (Alzheimer’s Disease) Lysate XBL-10306Temporal Lobe (Alzheimer’s Disease) Lysate XBL-10314Temporal Lobe (Alzheimer’s Disease) Membrane Lysate XBL-10312Thalamus (Alzheimer’s Disease) Lysate XBL-10310Antibody color in pathway

KEYAntibody not displayed in pathway• ••••••••


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