Proteins | Peptides
peptide/proteins
Analytes
IGF-1 Study 1 | Study 2
rheumatoid factors | anti-IgM RF, anti-IgA RF, anti-CCP, anti-MCV
Volumetric Absorptive Micro Sampler (VAMS or Mitra) in Clinical Diagnostic
hepcidinHepcidin Determination in Dried Blood by Microfluidic LC-MS/MS: Comparison of DBS And VAMS for Matrix Effect And Recovery.
proteomics | β-galactosidase, HSA, APO A-I, APO C-I, APO C-III, APO E, CRP, cystatin C, periostin
Volumetric Absorptive Microsampling Integrated Into an Automated Bottom-Up Proteomics Workflow
HbA1c Study 1 | Study 2
protein mix | β-lactoglobulin, myoglobin, cy-tochrome c, albumin
Volumetric absorptive MicroSampling vs. other blood sam-pling materials in LC-MS-based protein analysis - prelimi-nary investigations.
C-peptide Microsampling Collection Methods for Measurement of C-peptide in Whole Blood. Journal of Diabetes Science and Technology
therapeutic mAbs | dalimumab, infliximab, ustekinumab, vedolizumab, tocilizumab, natali-zumab, rituximab
Capillary blood microsampling to determine serum bio-pharmaceutical concentration: Mitra microsampler vs dried blood spot
therapeutic mAbs | trastuzumab, daclizumab Application of Mitra® microsampling for pharmacokinetic bioanalysis of monoclonal antibodies in rats
multidimensional anti-influenza IgG antibodiesApplication of volumetric absorptive microsampling VAMS) to measure multidimensional anti-influenza IgG antibodies by the mPlex-Flu assay
apolipoproteins (apo) Early Detection of Atrial Fibrillation-Atrial Flutter Using Remote Patient Monitoring
hemaglobinPrediction of haematocrit in dried blood spots from the measurement of haemoglobin using commercially avail-able sodium lauryl sulphate
cardiovascular biomarkers | hsCRP, NT-proB-NP, and u-hs-cTnI
A protocol integrating remote patient monitoring patient reported outcomes and cardiovascular biomarkers
SARS-CoV-2 antibodies | IgG, IgMStandardization of enzyme-linked immunosorbent assays for serosurveys of the SARS-CoV-2 pandemic using clini-cal and at-home blood sampling
proteomics | APOA1, APOA2, APOA4, APOB, APOC1, APOC2, APOC3, APOE, and APOJ/CLUS, HBA, ALBU
Quality Control and Outlier Detection of Targeted Mass Spectrometry Data from Multiplex Protein Panels
therapeutic mAb | vedolizumab Evaluating an easy sampling method using dried blood spots to determine vedolizumab concentrations
Reference
The Mitra Device is a single-use, non-sterile device used as a specimen collector and for the storage and transport of blood or other biological fluids. It is not specific to any clinical test, and is not for use in diagnostic procedures. Use of the Mitra Device in Laboratory Developed Tests (LDTs) requires further processing including the establishment of performance characteristics and successful validation by the laboratory in a manner consistent with CLIA and/or other regulatory requirements.
analytes analyzed from Mitra® samples The blood microsampling innovator
™
June 2020 Edition
Small Molecule DrugsAnalytes
therapeutic drugs
antibiotics | piperacillin, tazobactam, mero-penem, linezolid and ceftazidime
Application of Mitra Microsampling For The Quantifica-tion of Antibiotics
antibiotic | fosfomycin Quantitative Bioanalytical Validation of Fosfomycin in Human Whole Blood With VAMS
antibiotics | beta-lactams (amoxicillin, penicillin G, piperacillin, flucloxacillin, ampicillin)
Evaluation of the Mitra Device For Pharmacokinetic / Pharmacodynamic Study of Beta-Lactams
antibiotic | vancomycin, creatinine Study 1 | Study 2
antibiotic | cefepime
Development and validation of a volumetric absorptive microsampling- liquid chromatography mass spectrome-try method for the analysis of cefepime in human whole blood: Application to pediatric pharmacokinetic study
anti-cancer | hydroxyureaStable-Isotope Dilution HPLC-Electrospray Ionization Tandem Mass Spectrometry Method for Quantifying Hydroxyurea in Dried Blood Samples
anti-cancer | mitotaneA method for the minimally invasive drug monitoring of mitotane by means of volumetric absorptive microsam-pling for a home-based therapeutic drug monitoring
antidepressants | fluoxetine, norfluoxetineantidiabetic | glipzide
Evaluation of Two Blood Microsampling Approaches For Drug Discovery PK Studies in Rats
anti-depressants | venlafaxine, desvenlafaxine
Clinical validation study to derive conversion factors from capillary blood concentration to plasma concentra-tion for venlafaxine and desvenlafaxine.
anti-depressants (next gen) | sertraline, fluoxetine, citalopram and vortioxetine
Whole blood and oral fluid microsampling for the mon-itoring of patients under treatment with antidepressant drugs
antidiabetic | exenatideLarge Molecule Application of VAMS For The Determi-nation of a Single-Rodent PK Profile for Exenatide by LC-MS/MS
antifungal | itraconazoleSampling Only Ten Microliters of Whole Blood For The Quantification of Poorly Soluble Drugs: Itraconazole as Case Study
antifungal | voriconazole, voriconazole n-oxideDevelopment and validation of a volumetric absorptive microsampling assay for analysis of voriconazole and voriconazole N-oxide in human whole blood
Reference
The Mitra Device is a single-use, non-sterile device used as a specimen collector and for the storage and transport of blood or other biological fluids. It is not specific to any clinical test, and is not for use in diagnostic procedures. Use of the Mitra Device in Laboratory Developed Tests (LDTs) requires further processing including the establishment of performance characteristics and successful validation by the laboratory in a manner consistent with CLIA and/or other regulatory requirements.
analytes analyzed from Mitra® devices | page 2
Drugs of Abuse
illicit drugs
Analytes
cathinones | methylone, ethylone, butylone, mephedrone, 4-MEC, MDPV
LC-MS/MS and VAMS for quantitative bioanalysis of cathinone analogues in dried urine, plasma and oral fluid samples
cannabinoids (natural and synthetic) Dried Haematic Microsamples And LC-MS/MS for The Analysis of Natural And Synthetic Cannabinoids
opioids | oxycodone, noroxycodone, oxymor-phone
Determination of oxycodone and its major metabolites in haematic and urinary matrices: Comparison of tradi-tional and miniaturised sampling approaches
30 common drugs of abuse Quantitative Swab Touch Spray Mass Spectrometry for Oral Fluid Drug Testing
cannabinoids | THC, CBD, CBN
A patient-centric liquid chromatography-tandem mass spectrometry microsampling assay for analysis of can-nabinoids in human whole blood: Application to pediat-ric pharmacokinetic study
cocaine and metabolites Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS/MS for the Forensic Assess-ment of Cocaine Consumption
Reference
anti-inflammatory | acetominophen Study 1 | Study 2 | Study 3
anti-inflammatory | paracetemol Study 1 | Study 2 | Study 3
anti-inflammatory | aspirinQuantitative analysis of acetylsalicylic acid in human blood using volumetric absorptive microsampling. Transl Clin Pharmacol. 2018 Mar;26(1):32-38
anti-inflammatory | naproxen Volumetric absorptive microsampling combined with im-pact-assisted extraction for hematocrit effect free assays
anti-parasitic | miltefosineVAMS as an Alternative to Conventional DBS Cards in The Quantification of Miltefosine in Dried Blood Sam-ples
anti-parasitic | albendazole, albendazole sulf-oxide, albendazole sulfone
Pharmacokinetics of albendazole, albendazole sulfox-ide and albendazole sulfone determined from plasma, blood, dried blood spots and Mitra® samples of hook-worm-infected adolescents
anti-rheumatic | hydroxychloroquine Capillary Blood Collected on VAMS Device For Monitor-ing Hydroxychloroquine in Rheumatoid Arthritis Patients
visual cycle modulators | emixustat Bioanalysis of emixustat in whole blood collected with VAMS by LC-MS/MS
cardiovascular drugs | amlodipine, atenolol, atorvastatin, bisoprolol, diltiazem, lisinopril, losartan, ramipril, simvastatin, valsartan
Volumetric absorptive microsampling (VAMS) coupled with high-resolution, accurate-mass (HRAM) mass spectrometry as a simplified alternative to dried blood spot (DBS) analysis for therapeutic drug monitoring of cardiovascular drugs
stimulants | paraxanthineDoes Volumetric Absorptive Microsampling Eliminate The Hematocrit Bias for Caffeine And Paraxanthine in Dried Blood Samples? A Comparative Study
sedative | midazolam, phenobarbital Supporting a paediatric study using wet and dry sam-ples Analytical Considerations
GSKA | proprietary small molecule drug cur-rently under clinical development
Drug monitoring by volumetric absorptive microsampling: method development considerations to mitigate hematocrit effects
antidiabetic | sitagliptin
Extractability-mediated stability bias and hematocrit im-pact: High extraction recovery is critical to feasibility of volumetric adsorptive microsampling (VAMS) in regulat-ed bioanalysis
antiretroviral | raltegravir
Extractability-mediated stability bias and hematocrit im-pact: High extraction recovery is critical to feasibility ofvolumetric adsorptive microsampling (VAMS) in regulat-ed bioanalysis.
antiretroviral | ritonavir Volumetric absorptive microsampling combined with im-pact-assisted extraction for hematocrit effect free assays
antihelmintics | praziquantel
Evaluation of a novel micro-sampling device, Mitra™, in comparison to dried blood spots, for analysis of praziquan-tel in Schistosoma haematobium-infected children in rural Côte d’Ivoire
bronchodilator | salbutamolQuantitation of salbutamol using micro-volume blood sampling – applications to exacerbations of pediatric asthma
antisetics | amisulpride, aripiprazole, clozap-ine, olanzapine, quetiapine, risperidone, ziprasidone
TDM by Means of Novel Sampling (VAMS) And Ex-traction Procedures - A Comparative Study
anti-seizure | radiprodilA pharmacokinetic study of radiprodil oral suspension in healthy adults comparing conventional venous blood sampling with two microsampling techniques
anti-epileptics Study 1 | Study 2 | Study 3 | Study 4 | Study 5 | Study 6
Small Molecule Drugs continued
ReferenceAnalytes
analytes analyzed from Mitra® devices | page 3
The Mitra Device is a single-use, non-sterile device used as a specimen collector and for the storage and transport of blood or other biological fluids. It is not specific to any clinical test, and is not for use in diagnostic procedures. Use of the Mitra Device in Laboratory Developed Tests (LDTs) requires further processing including the establishment of performance characteristics and successful validation by the laboratory in a manner consistent with CLIA and/or other regulatory requirements.
methotrexate polyglutamateTransition of Methotrexate Polyglutamate Drug Monitoring Assay from Venipuncture to Capillary Blood-Based Collec-tion Method in Rheumatic Diseases
infliximab (IFX)Dried blood samples can support monitoring of infliximab concentrations in patients with inflammatory bowel dis-ease: A clinical validation
gamma-hydroxybutyric acid(GHB)Development and validation of volumetric absorptive mi-crosampling coupled with UHPLC–MS/MS for the analysis of gamma‐hydroxybutyric acid in human blood
midazolamValidation of methods for determining pediatric midazolam using wet whole blood and volumetric absorptive microsa-mpling
phenobarbital
Dried blood microsampling-based therapeutic drug monitoring of anti-epileptic drugs in children with nodding syndrome and epilepsy in Uganda and the Democratic Republic of the Congo.
Small Molecule Drugs continued
ReferenceAnalytes
analytes analyzed from Mitra® devices | page 4
The Mitra Device is a single-use, non-sterile device used as a specimen collector and for the storage and transport of blood or other biological fluids. It is not specific to any clinical test, and is not for use in diagnostic procedures. Use of the Mitra Device in Laboratory Developed Tests (LDTs) requires further processing including the establishment of performance characteristics and successful validation by the laboratory in a manner consistent with CLIA and/or other regulatory requirements.
Hormones | Steroids
Analytes
estetrolWhole Blood Microsampling For The Quantitation of Estetrol Without Derivatization by Liquid Chromatography-Tandem Mass Spectrometry
cortisol & testosterone
Measurement of Cortisol and Testosterone in Athletes: Accuracy of Liquid Chromatography-Tandem Mass Spectrometry Assays for Cortisol and Testosterone Measurement in Whole-Blood Microspecimens
anabolic steroids | testosterone, epites-tosterone, dihydrotestosterone, nandrolone, norethandrolone, androstenedione, mester-olone, methandrostenolone, danazol
Overcoming Biosampling Issues in Sport Drug Testing
estrogens
Comparison of nanofluidic and ultra-high performance liquid chromatography-tandem mass spectrometry for high sensitive pharmacokinetic studies of estrogens starting from whole blood microsampling
testosterone Androstenedione & 17-Hydroxy-progesterone
Quantification of Testosterone, Androstenedione and 17-Hydroxyprogesterone Collected Using Mitra®Micro Sampling Devices
corticosterone, dehydrocorticosterone progesterone
Influence of Low Protein Diet-Induced Fetal Growth Re-striction on the Neuroplacental Corticosterone Axis in the Rat
glucocorticoids | cortisol, corticosterone, cor-tisone, dexamethasone, methylprednisolone, fludrocortisone
Microsampling and LC–MS/MS for antidoping testing of glucocorticoids in urine
growth hormone doping biomarker | IGF-1 Use of capillary dried blood for quantification of intact IGF-I by LC–HRMS for antidoping analysis
Reference
analytes analyzed from Mitra® devices | page 5
Metabolomics & Metabolism
Metabolomics
Lactones
Esters
Lipid-Derived
Long-chain aldehydes
Phenolic volatiles
Analytes
breast cancer metabolites Comparative study on microsampling techniques in metabolic fingerprinting studies applying gas chroma-tography-MS analysis.
polar blood metabolome Pre-analytic evaluation of volumetric absorptive micro-sampling and integration in a mass spectrometry-based metabolomics workflow
urinary metabolites Evaluation of the Mitra microsampling device for use with key urinary metabolites in patients with Alkaptonuria)
amino acids, organic acids Targeted metabolomics of whole blood using volumetric absorptive microsampling
Iohexol as a GFR for chronic kidney disease Determination of iohexol by capillary blood microsampling and UHPLC-MS/MS
collecting metabolomic fluids w/ VAMS® (mini review)
Biofluid Collection in Metabolomics by the Application of the novel Volumetric Absorptive Microsampling Technolo-gy: a mini-Review
palmitate, stearate Quantitating fatty acids in dried blood spots on a common collection card versus a novel wicking sampling device
Reference
The Mitra Device is a single-use, non-sterile device used as a specimen collector and for the storage and transport of blood or other biological fluids. It is not specific to any clinical test, and is not for use in diagnostic procedures. Use of the Mitra Device in Laboratory Developed Tests (LDTs) requires further processing including the establishment of performance characteristics and successful validation by the laboratory in a manner consistent with CLIA and/or other regulatory requirements.
Metals
metals
Analytes
biomarker | FeIron isotopic analysis of finger-prick and venous blood
by multi-collector inductively coupled plasma-mass spectrometry after volumetric absorptive microsampling
multi-element analysis Analysis of Whole Blood by ICP-MS Equipped With a High Temperature Total Sample Consumption System
prosthesis-related metals | Co, Cr, Al, Ti, V, Ni, Sr, Zr Study 1 | Study 2
elemental clinical analysis Dried matrix spots and clinical elemental analysis. Cur-rent status, difficulties, and opportunities
cobalt - metal-on-metal prosthesis
Development, validation and application of an inductively coupled plasma – Mass spectrometry method to deter-mine cobalt in metal-on-metal prosthesis patients using volumetric absorptive microsampling
mercury (Hg)
A simple and direct atomic absorption spectrometry meth-od for the direct determination of Hg in dried blood spots and dried urine spots prepared using various microsam-pling devices
Reference
DNA / RNA
dna/rna
Analytes
miRNA library, SNPs, qPCRTotal RNA/DNA Purification And Detection FromBlood Preserved on a Mitra® Microsampling Device
circulating RNA, NGS NGS analysis of total small non coding RNAs from low input RNA from dried blood sampling
small noncoding RNAs | miRNA, snoRNA, YRNA, tRNA
The sncRNA Zoo: a repository for circulating small non-coding RNAs in animals
Reference
analytes analyzed from Mitra® devices | page 6
Immunosuppressants
immunosuppressants
Analytes
methotrexateVolumetric Absorptive Micro Sampler(VAMS or Mitra) in Clinical Diagnostic
cyclosporin A, tacrolimus, ascomycin, sirolim-us, everolimus, temsirolimus Study 1 | Study 2
tacrolimus Study 1 | Study 2 | Study 3 | Study 4 | Study 5
cyclosporine A, everolimus, sirolimus, and tac-rolimus
Feasibility of Immunosuppressant Drug Monitoring by a Microsampling Device
everolimusValidation and clinical application of an LC-MS/MS meth-od for the quantification of everolimus using volumetric absorptive microsampling
cyclosporine A, tacrolimus
Volumetric Microsampling of Capillary Blood Spot vs Whole Blood Sampling for Therapeutic Drug Monitoring of Tacrolimus and Cyclosporin A: Accuracy and Patient Satisfaction
mycophenolic acid, tacrolimus, sirolimus, everolimus, cyclosporin A
VAMS for Assaying Immunosuppressants from Venous Whole Blood by LC-MS/MS Using a Novel Atmospheric Pressure Ionization Probe (Unispray™)
adalimumabMonitoring of Adalimumab Concentrations at Home in Patients with Inflammatory Bowel Disease Using Dried Blood Samples
Reference
The Mitra Device is a single-use, non-sterile device used as a specimen collector and for the storage and transport of blood or other biological fluids. It is not specific to any clinical test, and is not for use in diagnostic procedures. Use of the Mitra Device in Laboratory Developed Tests (LDTs) requires further processing including the establishment of performance characteristics and successful validation by the laboratory in a manner consistent with CLIA and/or other regulatory requirements.
Cytotoxins
cytotoxins
Analytes
sulfur mustard albumin adductsProcedures For Analysis of Dried Plasma Using Micro-sampling Devices to Detect Sulfur Mustard-Albumin Adducts For Verification of Poisoning
saxitoxin Quantification of Saxitoxin in Human Blood by ELISA
Reference
Vitamins / Supplements
supplements
Analyte
biomarker | 25-hydroxy vitamin D3Study 1 | Study 2
5-Methyltetrahydrofolic Acid (Folate)
Assessing VAMS Coupled with Stable Isotope Dilution Assay and Liquid Chromatography-Tandem Mass Spec-trometry as Potential Diagnostic Tool for Whole Blood 5-Methyltetrahydrofolic Acid
vitamin D metabolitesComparing Diene Derivatisation Methods of Dry Blood Samples For Vitamin D Metabolites Quantification by Liq-uid Chromatography-tandem Mass Spectrometry.
Reference
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The blood microsampling innovator
™
The Mitra Device is a single-use, non-sterile device used as a specimen collector and for the storage and transport of blood or other biological fluids. It is designed to be used by laboratory and healthcare profession-als, or end-users as a container to collect and transport blood or other biological fluids. It is not specific to any clinical test, and is not for use in diagnostic procedures. Use of the Mitra Device in Laboratory Developed Tests (LDTs) requires further processing including the establishment of performance characteristics and successful validation by the laboratory in a manner consistent with CLIA and/or other regulatory requirements. The Mitra Device is a FDA listed Class 1 exempt device, CE-IVD self-certified in the UK and EU, a Class I IVD in Australia, and registered with Health Canada. Neoteryx operates a Quality Management System (QMS) that is based on FDA good manufacturing practices, 21 CFR 820 regulations, and ISO-13485. Copyright © 2020 Neoteryx, LLC. All rights reserved.
neoteryx.com/freesampler
analytes analyzed from Mitra® devices | page 7
VAMS™ Technology Reviews
Metabolomics
Lactones
Esters
Lipid-Derived
Long-chain aldehydes
Phenolic volatiles
Keywords
sampling, drying, transportation, extraction Study 1 | Study 2 | Study 3
point-of-care device, minimally invasive Study 1 | Study 2
Reference
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