2004

Oxazole derivativesR 0220 O-Protected 3-Hydroxy-oxazolidin-2,4-diones: Novel Precursors in the Synthesis

of α-Hydroxyhydroxamic Acids. — Title compounds of type (IV) are prepared in a one-pot procedure from cyanohydrins, CDI and the appropriate hydroxylamines. They are used as novel precursors for the synthesis of α-hydroxyhydroxamic acids. Decar-boxylation of (IV) is accomplished under mild conditions in the presence of different bases. Subsequent deprotection results in formation of final α-hydroxyhydroxamicacids. Deprotection of (Vc) leads to isolation of (VII). — (KURZ*, T.; WIDYAN, K.; Org. Biomol. Chem. 2 (2004) 14, 2023-2027; Inst. Pharm., Univ. Hamburg, D-20146 Hamburg, Germany; Eng.) — S. Adam

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