Copyright © 2017 Abcam, All rights reserved. Poster compiled with help from Dr John-Ioannis Sotiropoulos, ICVS.

Neuroinflammation and Alzheimer’s disease

β-secretase

Release of proinflammatory mediatorsIL-1β, IL-6, TNFα, IFNγ, MIP-1α, MIP-1β, RANTES, MCP1, M-CSF

Infiltration of monocytes and macrophages

Reactiveastrocytes

GFAP

Aβ plaque

Aβ clearance Activemicroglia

TREM2

Neuronaldamage

and death

Migratingmicroglia

Microglialcomplement

activation

Tau onmicrotubules

Tau mislocalizationto dendritic spine

Synapseloss

AmyloidogenicAPP processing

Blood brainbarrier

C99 OligomericTau

Tau paired helicalfilaments (PHFs)

Tau

Tau neurofibrillarytangles (NFTs)

AICD

APP

γ-secretase

Aβ

Axon terminal

Axon Dendritic spine

Ca2+Ca2+

Ca2+

Ca2+ overload

Ca2+

Ca2+

Ca2+Ca2+

Ca2+

Ca2+ Ca2+

Ca2+

GlutamateSoluble Aβoligomer

AMPAreceptor

Membranedamage

Apoptosis

CR3MCP-1

gradient

NMDAreceptor

Ca2+

Ca2+PSD95

Caspase 3

Calpain

GSK3βCaspase 7

Cdk5

p35

Cdk5

p25

Clq C3

FYN

FYN

P

P

Proteosomaldegradation

Ubiquitin

Autophagy

Tauhyperphosphorylation ROS

CCR2gradient

P

P

P

P

P PP

PP

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

PP

PP

P

PP

PP

P

P

PP

FYNP

P

P

P

P

P

P

P

P

P

P

To find out more, please visit www.abcam.com/neuroinflammation

Get to the root cause of neurodegeneration with these tools

Amyloid beta

Aβ peptide (1-42)

Quickly induce neurotoxicity and neurodegeneration with this high purity Aβ fragment. ab120301

CRANAD-58 Image Aβ in real time with this non-toxic, cell-permeable probe suitable for in vitro and in vivo imaging. ab146926

To find out more about amyloid beta probes, visit www.abcam.com/amyloid-probes

Tau

Anti-Tau (phospho S396) antibody

Quickly detect phospho S396 tau with this versatile antibody. Available in 10 μl trial format. ab109390

LMTX Target tau tangles and facilitate aggregate clearance with this tau aggregation inhibitor. ab223882

To learn about other products to study tau, visit www.abcam.com/tau

Glia

Anti-TMEM119 antibody

Distinguish microglia from macrophages and other immune cells with this stable and specific microglial marker.

ab209064

Anti-GFAP antibody

Effortlessly label astrocytes with this highly-cited astrocyte marker. ab7260

For more help choosing neural markers, visit www.abcam.com/glia

Proinflammatory mediators

Mouse TNF alpha ELISA Kit

Detect proinflammatory mediators, such as TNF-alpha, in just 90 minutes with a SimpleStep ELISA® kit. ab208348

To discover the range of SimpleStep ELISA kits, visit www.abcam.com/simplestep-elisa

Mouse and human key cytokine panels

Profile multiple cytokines at once with a multiplex panel or design your own.

ab213392ab213397

To learn more about Fireplex immunoassays, visit www.abcam.com/fireplex-immunoassays