Neuroinammation and Alheimers disease -...
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Copyright © 2017 Abcam, All rights reserved. Poster compiled with help from Dr John-Ioannis Sotiropoulos, ICVS. Neuroinflammation and Alzheimer’s disease β-secretase Release of proinflammatory mediators IL-1β, IL-6, TNFα, IFNγ, MIP-1α, MIP-1β, RANTES, MCP1, M-CSF Infiltration of monocytes and macrophages Reactive astrocytes GFAP Aβ plaque Aβ clearance Active microglia TREM2 Neuronal damage and death Migrating microglia Microglial complement activation Tau on microtubules Tau mislocalization to dendritic spine Synapse loss Amyloidogenic APP processing Blood brain barrier C99 Oligomeric Tau Tau paired helical filaments (PHFs) Tau Tau neurofibrillary tangles (NFTs) AICD APP γ-secretase Aβ Axon terminal Axon Dendritic spine Ca2 + Ca2 + Ca2 + Ca 2+ overload Ca2 + Ca 2+ Ca2 + Ca2 + Ca2 + Ca2 + Ca2 + Ca2 + Glutamate Soluble Aβ oligomer AMPA receptor Membrane damage Apoptosis CR3 MCP-1 gradient NMDA receptor Ca2 + Ca2 + PSD95 Caspase 3 Calpain GSK3β Caspase 7 Cdk5 p35 Cdk5 p25 Clq C3 FYN FYN P P Proteosomal degradation Ubiquitin Autophagy Tau hyperphosphorylation ROS CCR2 gradient P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P P FYN P P P P P P P P P P P To find out more, please visit www.abcam.com/neuroinflammation Get to the root cause of neurodegeneration with these tools Amyloid beta Aβ peptide (1-42) Quickly induce neurotoxicity and neurodegeneration with this high purity Aβ fragment. ab120301 CRANAD-58 Image Aβ in real time with this non-toxic, cell-permeable probe suitable for in vitro and in vivo imaging. ab146926 To find out more about amyloid beta probes, visit www.abcam.com/amyloid-probes Tau Anti-Tau (phospho S396) antibody Quickly detect phospho S396 tau with this versatile antibody. Available in 10 μl trial format. ab109390 LMTX Target tau tangles and facilitate aggregate clearance with this tau aggregation inhibitor. ab223882 To learn about other products to study tau, visit www.abcam.com/tau Glia Anti-TMEM119 antibody Distinguish microglia from macrophages and other immune cells with this stable and specific microglial marker. ab209064 Anti-GFAP antibody Effortlessly label astrocytes with this highly-cited astrocyte marker. ab7260 For more help choosing neural markers, visit www.abcam.com/glia Proinflammatory mediators Mouse TNF alpha ELISA Kit Detect proinflammatory mediators, such as TNF-alpha, in just 90 minutes with a SimpleStep ELISA ® kit. ab208348 To discover the range of SimpleStep ELISA kits, visit www.abcam.com/simplestep-elisa Mouse and human key cytokine panels Profile multiple cytokines at once with a multiplex panel or design your own. ab213392 ab213397 To learn more about Fireplex immunoassays, visit www.abcam.com/fireplex-immunoassays
Transcript of Neuroinammation and Alheimers disease -...
Copyright © 2017 Abcam, All rights reserved. Poster compiled with help from Dr John-Ioannis Sotiropoulos, ICVS.
Neuroinflammation and Alzheimer’s disease
β-secretase
Release of proinflammatory mediatorsIL-1β, IL-6, TNFα, IFNγ, MIP-1α, MIP-1β, RANTES, MCP1, M-CSF
Infiltration of monocytes and macrophages
Reactiveastrocytes
GFAP
Aβ plaque
Aβ clearance Activemicroglia
TREM2
Neuronaldamage
and death
Migratingmicroglia
Microglialcomplement
activation
Tau onmicrotubules
Tau mislocalizationto dendritic spine
Synapseloss
AmyloidogenicAPP processing
Blood brainbarrier
C99 OligomericTau
Tau paired helicalfilaments (PHFs)
Tau
Tau neurofibrillarytangles (NFTs)
AICD
APP
γ-secretase
Aβ
Axon terminal
Axon Dendritic spine
Ca2+Ca2+
Ca2+
Ca2+ overload
Ca2+
Ca2+
Ca2+Ca2+
Ca2+
Ca2+ Ca2+
Ca2+
GlutamateSoluble Aβoligomer
AMPAreceptor
Membranedamage
Apoptosis
CR3MCP-1
gradient
NMDAreceptor
Ca2+
Ca2+PSD95
Caspase 3
Calpain
GSK3βCaspase 7
Cdk5
p35
Cdk5
p25
Clq C3
FYN
FYN
P
P
Proteosomaldegradation
Ubiquitin
Autophagy
Tauhyperphosphorylation ROS
CCR2gradient
P
P
P
P
P PP
PP
P
P
P
P
P
P
P
P
P
P
P
P
P
P
P
P
PP
PP
P
PP
PP
P
P
PP
FYNP
P
P
P
P
P
P
P
P
P
P
To find out more, please visit www.abcam.com/neuroinflammation
Get to the root cause of neurodegeneration with these tools
Amyloid beta
Aβ peptide (1-42)
Quickly induce neurotoxicity and neurodegeneration with this high purity Aβ fragment. ab120301
CRANAD-58 Image Aβ in real time with this non-toxic, cell-permeable probe suitable for in vitro and in vivo imaging. ab146926
To find out more about amyloid beta probes, visit www.abcam.com/amyloid-probes
Tau
Anti-Tau (phospho S396) antibody
Quickly detect phospho S396 tau with this versatile antibody. Available in 10 μl trial format. ab109390
LMTX Target tau tangles and facilitate aggregate clearance with this tau aggregation inhibitor. ab223882
To learn about other products to study tau, visit www.abcam.com/tau
Glia
Anti-TMEM119 antibody
Distinguish microglia from macrophages and other immune cells with this stable and specific microglial marker.
ab209064
Anti-GFAP antibody
Effortlessly label astrocytes with this highly-cited astrocyte marker. ab7260
For more help choosing neural markers, visit www.abcam.com/glia
Proinflammatory mediators
Mouse TNF alpha ELISA Kit
Detect proinflammatory mediators, such as TNF-alpha, in just 90 minutes with a SimpleStep ELISA® kit. ab208348
To discover the range of SimpleStep ELISA kits, visit www.abcam.com/simplestep-elisa
Mouse and human key cytokine panels
Profile multiple cytokines at once with a multiplex panel or design your own.
ab213392ab213397
To learn more about Fireplex immunoassays, visit www.abcam.com/fireplex-immunoassays
