2008

Indole derivativesR 0140 1-Toluene-sulfonyl-3-[(3'-hydroxy-5'-substituted)-γ-butyrolactone]-indoles: Syn-

thesis, COX-2 Inhibition and Anticancer Activities. — The target molecules (VIII) are synthesized by indium-mediated diastereoselective allylation of indoleglyoxylate (I), diastereoselective iodocyclization and nucleophilic replacement of the iodo group. Compounds (VIII) are highly potent and selective COX-2 inhibitors. The same com-pounds are also highly effective towards various cancer cell lines of human tumor cell panels. — (SINGH*, P.; MITTAL, A.; BHARDWAJ, A.; KAUR, S.; KUMAR, S.; Bioorg. Med. Chem. Lett. 18 (2008) 1, 85-89; Dep. Chem., Guru Nanak Dev Univ., Amritsar 143 005, India; Eng.) — H. Hoennerscheid

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