Download - CDs w metal complexes

Transcript
Page 1: CDs w metal complexes

CD

top view

side view

Cyclodextrins as vehicles

top view

side view

TRIMEB

TRIMEB

1 2 30

20

40

60

Un-V

iable

cells (

%)

Days

Example 1

Metal drug Cp2MoCl2

Free Metal Drug

TRIMEB-encapsulated Metal Drug

Cytotoxicity enhancment by TRIMEB

Human adenocarcinoma cellsHuman adenocarcinoma cells

methylation

Page 2: CDs w metal complexes

DIMEB

1 2 30

20

40

60

80

100

Un-V

iable

cells (

%)

Days

Example 2

Metal drug CpMobiim(CO)2BF4

Free Metal Drug

DIMEB-encapsulated Metal Drug

Cytotoxicity enhancment by DIMEB

Mouse melanoma cellsMouse melanoma cells

From powder XRD to theoretical structure

What is at work?

Active fragment

more available!!

Where does it work?

The drug affects mitocondria first ultimately leading to cell death