CDs w metal complexes
2
CD top view side view Cyclodextrins as vehicles top view side view TRIMEB TRIMEB 1 2 3 0 20 40 60 U n -V ia b le ce lls (% ) D ays Example 1 Metal drug Cp 2 MoCl 2 Free Metal Drug TRIMEB-encapsulated Metal Drug Cytotoxicity enhancment by TRIMEB Human adenocarcinoma cells methylation
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Transcript of CDs w metal complexes
CD
top view
side view
Cyclodextrins as vehicles
top view
side view
TRIMEB
TRIMEB
1 2 30
20
40
60
Un-V
iable
cells (
%)
Days
Example 1
Metal drug Cp2MoCl2
Free Metal Drug
TRIMEB-encapsulated Metal Drug
Cytotoxicity enhancment by TRIMEB
Human adenocarcinoma cellsHuman adenocarcinoma cells
methylation
DIMEB
1 2 30
20
40
60
80
100
Un-V
iable
cells (
%)
Days
Example 2
Metal drug CpMobiim(CO)2BF4
Free Metal Drug
DIMEB-encapsulated Metal Drug
Cytotoxicity enhancment by DIMEB
Mouse melanoma cellsMouse melanoma cells
From powder XRD to theoretical structure
What is at work?
Active fragment
more available!!
Where does it work?
The drug affects mitocondria first ultimately leading to cell death
![A topological analysis of the bonding in [M2(CO)10] and [M3 ......function (SF) · Transition metal carbonyl complexes · Multicenter bonding 1 Introduction In the last two decades,](https://static.fdocument.org/doc/165x107/61284c34ccc7f66b051135f1/a-topological-analysis-of-the-bonding-in-m2co10-and-m3-function-sf.jpg)
