WHAT SETS ACTIVEFOCUS™

DESIGN APART?THE DIFFERENCE IS IN THE DISTANCE.

The ACTIVEFOCUS™ optic is the only multifocal featuring a central portion 100% dedicated to distance

UNCOMPROMISED DISTANCE

Contrast sensitivity is comparable to a monofocal IOL1,3

ACTIVEFOCUS™ Optical Design: Committed to long-range vision1,2

*Scaled to mm from microns (μ) for readability. † Surface profile of the TECNIS** Symfony 28.0 D IOL was measured using Bruker Contour white light interferometer

on the posterior surface and the diffraction efficiency calculated. Optical profile of the ReSTOR® +2.5 D IOL, model SV25T0 is based on its design profile.

**Trademarks are the property of their respective owners.

Symfony†,**

Radius (mm)

Step

Hei

ght (

mm

)*

-2 -1 -0.5 0.5-1.5-2.5 1.5 2.50 1 2-4

-2

0

2

4x 10-3*

ReSTOR® +2.5 D

x 10-3*

Radius (mm)

Step

Hei

ght (

mm

)*

-2 -1 -0.5 0.5-1.5-2.5 1.5 2.50 1 2-4

-2

0

2

4

Spatial Frequency (Cycles per Degree)

Mea

n Co

ntra

st S

ensi

tivi

ty (L

og U

nits

)

0

2.50

1.50

1.25

1.00

0.75

0.50

0.25

1.75

2.25

2.00

1.5 cpd (n=127/130) 3 cpd (n=129/132) 6 cpd (n=116/128) 12 cpd (n=103/117)

AcrySof® IQ Monofocal IOL AcrySof® IQ ReSTOR® +2.5 D IOL Standard Deviation

Binocular Mesopic Contrast Sensitivity*,3

4–6 Months Post-op

ACTIVEFOCUS™ Optical Design contrast sensitivity is comparable to that of AcrySof® IQ IOLs.1,3

Central portion 100% dedicated to distance1,2

ACTIVEFOCUS™ Optical Design: Contrast at distance†,4

3 mm pupil 4.5 mm pupil

Acry

Sof®

IQ

Mon

ofoc

alAc

rySo

f® IQ

Re

STO

R® +

2.5

DTE

CNIS

**

Mul

tifoc

al +

2.75

D

†�Images�derived�from�Vega,�et�al.�figure�2�(fn�5).� Slit�pattern�bench�test�displayed�in�logarithmic�scale� of�intensity�for�halo�assessment�at�distance�vision.� Only�IOLs�approved�in�the�U.S.�are�displayed.

**Trademarks�are�the�property�of�their�respective�owners.*With�glare.�Descriptive�statistics�only.

69.4% of light distributed to distance focal point1

40.5% of light distributed to distance focal point2

TECNIS† Toric �1.86%�off�target�≥5°,� by estimated market usage*,7 n=1,953

TECNIS† Toric

2.5Xmore likely to

rotate than AcrySof® IQ

Toric7

AcrySof® IQ Toricn=3,556

50% 50%

Counterclockwise

Clockwise

TECNIS† Toricn=1,953p<0.01

65%

35%

Counterclockwise

Clockwise

Direction of Rotation for IOLs ≥5° off Target7

*�Astigmatismfix.com�is�an�online�calculator�to�help�surgeons�determine�if�a�previously�placed�toric�IOL�is�ideally�aligned.�The�analysis�dataset�includes�5,674�entries,�with�each�unique�lens�and�intended�orientation�identified,�in�addition�to�post-operative�IOL�orientation�≥5°�from�intended�axis.�The�dataset�was�weighted�based�on�the�estimated�market�usage�of�each�lens.�The�full�evaluation�included�AcrySof® IQ Toric, TECNIS† Toric, Trulign† Toric and Staar† Toric IOLs.7 †Trademarks�are�the�property�of�their�respective�owners.

††Evaluated�studies�included�misorientation�data�from�1�to�approximately�12�months�post-op.§AcrySof®�IQ�Toric�IOLs�that�rotated�≥5°�off�target�showed�no�bias�for�rotational�direction�(51%�counterclockwise�and�49%�clockwise,�n=3,556,�p=0.33).

Proven Real-World Performance

In�evidence�from�thousands�of�cases�entered�into�AstigmatismFix.com,* TECNIS†�Toric�IOLs�were�more�likely�to�rotate�≥�5°�post-op�than�AcrySof® IQ Toric IOLs.7

Your outcomes are only as stable as the IOL you choose

AcrySof® IQ Toric IOLs: proven rotational stability8

• 13 studies• More than 900 patients•��<�5°�mean�rotation�from�baseline�for�all�

AcrySof® IQ Toric IOLs studied††

Built on the same proven platform as AcrySof® IQ Toric IOLs

Choose the proven stability of the AcrySof® IQ IOL platform

UNRIVALED STABILITY

Just 5° rotation of a T6 lens results in: –�0.42�D�residual�astigmatism5 – Residual astigmatism can compromise visual acuity

in presbyopia correction6

AcrySof®�IQ�Toric�IOLs�show�no bias for rotational direction, unlike TECNIS† Toric IOLs.§,7

If the ratio of clockwise to counterclockwise rotation differs significantly from 50:50, the IOL is likely rotating in one direction more often after implantation.

AcrySof® IQ Toric 0.75%�off�target�≥5°,� by estimated market usage*,7 n=3,556

Excellent capsular adhesion9,10

*Trademarks�are�the�property�of�their�respective�owners.

†�In�vitro�fibronectin�protein�adhesion�assay�comparing�the�amount�of�fibronectin�adsorbed to AcrySof®, HOYA* and TECNIS*�acrylic�IOLs,�as�well�as�polymethacrylate�IOLs.�Fibronectin�adsorption�was�quantified�using�the�Thermo�Scientific* Micro BCATM Protein Assay kit.*

Engineered for optimal refractive predictability

UNRIVALED STABILITY

AcrySof® TECNIS*

Persistent �bronectin adsorption after sodium dodecyl sulfate treatment

Fibronectinadsorption

p<0.001

ug P

rote

in

1.00

0.00

2.00

3.00

4.00

5.00

6.00

n=11 n=11n=12 n=12

Fibronectin Adhesion Comparison†,9

AcrySof® BioMaterial�Advantage:�greater�fibronectin�binding�than�TECNIS* IOL material�to�promote�excellent�capsule�adhesion,9,10�with�low�Nd:YAG rates.11,12�

AcrySof® IOL BioMechanics�Advantage:�exceptional�axial�stability18,19

• STABLEFORCE® Haptics – Conforms to the capsular bag for precise centration18,19

AcrySof® IQ IOL Toric•���Excellent�axial�positioning�and�rotational�

stability for refractive predictability13-15,18,19

• No observed rotational bias7

TECNIS* Toric IOL•��Observed�bias�toward� counterclockwise�rotation7

•��Offset�haptic�design�may� increase risk of hyperopic shift17

Refractive Index: 1.47

Posterior Side

Refractive Index: 1.55

AcrySof® IQ Toric IOL Profile15

Offset haptics may be more prone to hyperopic shift.17

Refractive Index: 1.47

Posterior Side

Refractive Index: 1.55

TECNIS* Toric IOL Profile16Delivers the BioMaterial and BioMechanics�benefits� of AcrySof® IQ Toric IOLs

1615

IQ IQ Toric IQ ReSTOR Toric 2.5

IQ ReSTOR 2.5

IQ ReSTOR Toric 3.0

IQ ReSTOR 3.0

© 2017 Novartis 8/17 US-RES-17-E-1743b* Theoretical A-constant from product labeling (optical biometry/SRK-T formula at 6m)** Clinically derived from US clinical study results of 294 eyes at 14 clinical sites (optical biometry/SRK-T formula at 4m)

Take a look at ACTIVEFOCUS™ Optical Design

The difference is in the distance.Uncompromised distance1,3,4 • Unrivaled stability7,8,14

Physical Characteristics Model

Model Number SV25T3 SV25T4 SV25T5 SV25T6

IOL Cylinder Power (Diopters) 1.5 D 2.25 D 3.00 D 3.75 D

Corneal Plane 1.03 D 1.55 D 2.06 D 2.57 D

Add-Power +2.5 D

Add-Power Spectacle Plane +2.0 D

Number of Diffractive Steps 7 steps (Apodized)

Filtration Ultraviolet and blue light filtering

Optic Material Acrylate/Methacrylate Copolymer

Central Optic Zone Refractive

Optic Diameter 6.00

Overall Length 13.0 mm

Starting A-constant 119.1*/ 119.3**

Index of Refraction 1.55

Haptic Angulation 0°

Haptic Configuration STABLEFORCE® Haptic

1. Alcon Data on File. (April 11, 2016). 2. Alcon Data on File. (Oct 17, 2016). 3. AcrySof® IQ ReSTOR® +2.5 D IOL Directions for Use. 4. Vega F, Alba-Bueno F, Millán MS, et al. Halo and through-focus performance of four diffractive multifocal and intraocular lenses. Invest Ophthalmol Vis Sci. 2015;56;3967-3975. 5. Ferreira TB, Marques EF, Rodrigues A, et al. Visual and optical outcomes of a diffractive multifocal toric intraocular lens. J Cataract Refract Surg. 2013; 39:1029–1035. 6. Hayashi K, Manabe S, Yoshida M, Hayashi H. Effect of astigmatism on visual acuity in eyes with a diffractive multifocal intraocular lens. J Cataract Refract Surg. 2010;36(8):1323-1329. 7. Potvin R, et al. Toric intraocular lens orientation and residual refractive astigmatism: an analysis. Clin Ophthalmol. 2016;10:1829-1836. 8. Visser N, Bauer NJ, Nuijts RM. Toric intraocular lenses: historical overview, patient selection, IOL calculation, surgical techniques, clinical outcomes, and complications. J Cataract Refract Surg. 2013;39(4):624-637. 9. Ong M, Wang L, Karakelle M. Fibronectin adhesive properties of various intraocular lens materials. Alcon Laboratories, Fort Worth, TX, USA. ARVO 2013. 10. Linnola RJ, Sund M, Ylonen R, et al. Adhesion of soluble fibronectin, laminin, collagen type IV to intraocular lens materials. J Cataract Refract Surg. 1999;25(11):1486-1491. 11. Boureau C, et al. Incidence of Nd:YAG laser capsulotomies after cataract surgery: comparison of 3 square edge lenses of different composition. Can J Ophthalmol. 2009;44:165-170. 12. Apple DJ, Peng Q, Visessook N, et al. Eradication of posterior capsule opacification: documentation of a marked decrease in Nd:YAG laser posterior capsulotomy rates noted in an analysis of 5,416 pseudophakic human eyes obtained postmortem. Ophthalmology. 2001;108(3):505-518. 13. Nejima R, et al. Prospective intrapatient comparison of 6.0-millimeter optic single-piece and 3-piece hydrophobic acrylic foldable intraocular lenses. Ophthalmology. 2006;113(4):585- 590. 14. Wirtitsch MG, et al. Effect of haptic design on change in axial lens position after cataract surgery. J Cataract Refract Surg. 2004;30(1):45-51. 15. AcrySof® IQ Toric IOL Directions for Use. 16. TECNIS® Toric 1-Piece Aspheric IOL Specification Sheet. Abbott Medical Optics. 2015. 17. Eldaly MA, Mansour KA. Personal A-constant in relation to axial length with various intraocular lenses. Indian J Ophthalmol. 2014;62(7):788-791. 18. Lane SS, Ernest P, Miller KM, Hileman KS, Harris B, Waycaster CR. Comparison of clinical and patient reported outcomes with bilateral AcrySof® Toric or spherical control intraocular lenses. J Refract Surg. 2009;25(10):899-901. 19. Lane SS, Burgi P, Milios GS, Orchowski MW, Vaughan M, Schwarte E. Comparison of the biomechanical behavior of foldable intraocular lenses. J Cataract Refract Surg. 2004;30:2397-2402.

AcrySof® IQ ReSTOR®�Family�of�Multiflocal�IOLs�Important�Product�InformationCAUTION: Federal (USA) law restricts this device to the sale by or on the order of a physician. INDICATIONS: The AcrySof® IQ ReSTOR® Posterior Chamber Intraocular Multifocal IOLs include AcrySof® IQ ReSTOR® and AcrySof® ReSTOR® Toric and are intended for primary implantation for the visual correction of aphakia secondary to removal of a cataractous lens in adult patients with and without presbyopia, who desire near, intermediate and distance vision with increased spectacle independence. In addition, the AcrySof IQ ReSTOR Toric IOL is intended to correct pre-existing astigmatism. The lenses are intended to be placed in the capsular bag. WARNINGS/PRECAUTIONS: Careful preoperative evaluation and sound clinical judgment should be used by the surgeon to decide the risk/benefit ratio before implanting a lens in a patient with any of the conditions described in the Directions for Use labeling for each IOL. Physicians should target emmetropia, and ensure that IOL centration is achieved. Care should be taken to remove viscoelastic from the eye at the close of surgery. The ReSTOR Toric IOL should not be implanted if the posterior capsule is ruptured, if the zonules are damaged, or if a primary posterior capsulotomy is planned. Rotation can reduce astigmatic correction; if necessary lens repositioning should occur as early as possible prior to lens encapsulation. Some patients may experience visual disturbances and/or discomfort due to multifocality, especially under dim light conditions. A reduction in contrast sensitivity may occur in low light conditions. Visual symptoms may be significant enough that the patient will request explant of the multifocal IOL. Spectacle independence rates vary; some patients may need glasses when reading small print or looking at small objects. Posterior capsule opacification (PCO), when present, may develop earlier into clinically significant PCO with multifocal IOLs. Prior to surgery, physicians should provide prospective patients with a copy of the Patient Information Brochure available from Alcon informing them of possible risks and benefits associated with the AcrySof® IQ ReSTOR® IOLs. Do not resterilize; do not store over 45° C; use only sterile irrigating solutions such as BSS® or BSS PLUS® Sterile Intraocular Irrigating Solutions. ATTENTION: Reference the Directions for Use labeling for each IOL for a complete listing of indications, warnings and precautions.