The Use of GHB and Analogs to Facilitate Sexual Assaultforensicsciencereview.com/Abstract/22-5...
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The Use of GHB and Analogs to Facilitate Sexual Assault REFERENCE: Marinetti L, LeBeau MA: The use of GHB and analogs to facilitate sexual assault; Forensic Sci Rev 22:41; 2010. ABSTRACT: γ-Hydroxybutyric acid (GHB) and its metabolic precursors, γ-butyrolactone (GBL) and 1,4- butanediol (1,4-BD), may be among the most favored drugs used to commit drug-facilitated sexual assault (DFSA). In fact, federal legislation was enacted in the form of the Hillory J. Farias and Samantha Reid Date-Rape Drug Prohibition Act of 2000 to control and penalize use and distribution of GHB, GBL, and 1,4 BD. Unfortunately, solid proof of their use in many cases is difficult to obtain because GHB, GBL, and 1,4-BD have strong sedative and memory-impairing effects and are rapidly eliminated after ingestion. To further complicate the matter, GHB is a metabolite of γ-aminobutyric acid (GABA), a naturally occurring neurotransmitter in humans. This review focuses on the chemistry and pharmacology of these drugs and their use in DFSA. An overview of analytical techniques used to identify their presence is provided, as well as guidance on the toxicological interpretation of findings of GHB in biological specimens. KEY WORDS: 1,4-BD, 1,4-butanediol, γ-butyrolactone, drug-facilitated sexual assault, GBL, GHB, γ-hydroxy- butyrate.
Transcript of The Use of GHB and Analogs to Facilitate Sexual Assaultforensicsciencereview.com/Abstract/22-5...
The Use of GHB and Analogs to Facilitate Sexual Assault
REFERENCE: Marinetti L, LeBeau MA: The use of GHB and analogs to facilitate sexual assault; Forensic Sci
Rev 22:41; 2010.
ABSTRACT: γ-Hydroxybutyric acid (GHB) and its metabolic precursors, γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), may be among the most favored drugs used to commit drug-facilitated sexual assault (DFSA).In fact, federal legislation was enacted in the form of the Hillory J. Farias and Samantha Reid Date-Rape DrugProhibition Act of 2000 to control and penalize use and distribution of GHB, GBL, and 1,4 BD. Unfortunately, solidproof of their use in many cases is difficult to obtain because GHB, GBL, and 1,4-BD have strong sedative andmemory-impairing effects and are rapidly eliminated after ingestion. To further complicate the matter, GHB is ametabolite of γ-aminobutyric acid (GABA), a naturally occurring neurotransmitter in humans. This review focuseson the chemistry and pharmacology of these drugs and their use in DFSA. An overview of analytical techniquesused to identify their presence is provided, as well as guidance on the toxicological interpretation of findings ofGHB in biological specimens.
KEY WORDS: 1,4-BD, 1,4-butanediol, γ-butyrolactone, drug-facilitated sexual assault, GBL, GHB, γ-hydroxy-butyrate.
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