Karolinska Institutet – Weizmann Institute of Science 2nd Joint Meeting (June 13-15, 2014)

Program

Still subject to modifications

June 13, 2014 (Seminar Room at CMB, KI) Opening ceremony Chair: Ingemar Ernberg and Boris Zhivotovsky 09.00 – 09.15 Professor Kerstin Tham, Pro-Vice-Chancellor KI - Greetings Keynote lecture: 09.15 – 09.40 Hugo Lagercrantz (KI): The preterm brain Session 1: Epigenetic regulation in cancer 09.45 – 10.05 Sören Lehman (KI): Revealing the epigenetic code of acute leukemia 10.10 – 10.30 Tsvee Lapidot (WIS): Regulation of normal and leukemic human stem

cells 10.35 – 10.55 Coffee, Tea 10.55 – 11.15 Anita Göndör (KI): Circadian regulation of genome organization in 3D 11.20 – 11.40 Moshe Oren (WIS): RNF20 and H2Bub1: linking chromatin

modifications with cancer 11.45 – 12.05 Igor Ulitsky (WIS): Long noncoding RNAs: conserved functions and

mechanisms in embryonic development 12.10 – 13.30 Lunch Session 2: DNA damage, Cell death and Senescence Chair: Maria Masucci and Kristina Viktorsson 13.20 – 13.50 Zvi Livneh (WIS): DNA damage tolerance and Leukemia – an

unexpected relationship 13.55 – 14.15 Marianne Farnebo (KI): Roles of WRAP53 and noncoding RNA in

DNA repair 14.20 – 14.30 Petra Hååg (KI): Analysis of gene expression and DNA repair signaling

events in acute myeloid leukemia. 14.35 – 14.45 Short talk. Tamir Biezuner (WIS): Studying cancer dynamics using

NGS-based, single-cell lineage analysis platform. 14.50 – 15.10 Valery Krizhanovsky (WIS): Senescent cells communicate via

intercellular protein transfer 15.15 – 15.35 Vladimir Gogvadze (KI): Mitochondria as a target for cancer therapy

15.35 – 15.55 Coffee, Tea 15.55 – 16.15 Rivka Dikstein (WIS): The mechanism underlying translation tolerance

of mitochondrial genes to energy stress 16.15 – 16.35 Klas Blomgren (KI): Role of autophagy in neuronal cell death in the

immature brain after ischemia 16.40 – 17.00 Bertrand Joseph (KI): The return of the nucleus: epigenetic control of

autophagy 17.05 – 17.25 Staffan Strömblad (KI): Role of Pak4 in Cancer Progression 17.30 – 17.50 Ehud Shapiro (WIS): Lineage analysis via single-cell genomics 17.55 – 18.15 Rickard Sandberg (KI): Single-cell RNA-seq reveals principles of

allelic expression in mammalian cells 18.30 Dinner at Faculty Club Svarta Räfven June 14, 2014 Session 3: Cell Signaling Networks (Nanna Svartz Lecture Hall, Karolinska

Hospital) Chair: Staffan Strömblad and Arne Östman 09.00 – 09.20 Eytan Domany (WIS): Pathway-based analysis of cancer 09.25 – 09.45 Arne Östman (KI): Regulation of tyrosine kinase signaling by

reversible oxidation of phosphatases 09.50 – 10.10 Ari Elson (WIS): The role of the PTPRO tyrosine phosphatase in

chronic lymphocytic leukemia 10.15 – 10.35 Yossi Yarden (WIS): Receptor tyrosine kinases: Mechanisms and

opportunities for cancer therapy 10.35 – 11.00 Coffee, Tea Session 4: What is life-lecture Chair: Galina Selivanova 11.00 – 12.00 Andrei V. Gudkov (Department of Cell Stress Biology, Roswell Park

Cancer Institute, Buffalo, New York): Eukaryotes and prokaryotes: which came first or what is the price for progressive evolution?

12.00 - 13.30 Lunch Session 5: Tumor Genetics, Imaging and Therapy Chair: Katya Pokrovskaya and Tatiana Pavlova 13.30 – 13.50 Henrik Grönberg (KI): ClinSeq: Clinical Sequencing of cancer. 13.55 – 14.15 Thierry Soussi (KI): The TP53 gene: an oncogene in disguise

14.20 – 14.40 Stig Linder (KI): Inhibition of proteasome deubiquitinating activity as a novel cancer therapy

14.45 – 14.55 Short talk. Gil Diamant (WIS): Novel Functions of the Transcription Elongation Factor DSIF in Regulation of the NF-κB Pathway

15.00 – 16.30 Poster Session and Coffee, Tea 16.30 – 16.40 Short talk. Debora Rosa Bublik (WIS): A feedback triangle involving

p53, FGF13 and its host miRNA. 16.45 – 16.55 Joanna Zawacka-Pankau (KI): Novel allosteric mechanism of p53

activation by small molecules for targeted anticancer therapy. 17.00 – 17.20 Matthias Löhr (KI): New ways to treat pancreatic cancer 17.25 – 17.45 Yihai Cao (KI): Mechanistic challenges of angiogenesis in disease

therapy 17.50 – 18.20 Rolf Lewensohn (KI): Advances in radiotherapy of lung cancer- from

basic biology to clinical application 18.30 – 22.00 Boat trip (from Nybrokajen) and Dinner June 15, 2014 (Nanna Svartz Lecture Hall, Karolinska Hospital) Session 6: Tumor Genetics, Imaging and Therapy (cont.) Chair: Boris Zhivotovsky and Klas Wiman 09.00 – 09.20 Dževad Belkić (KI): Breakthrough in MRS for Breast Cancer

Diagnostics Aided by Advanced Signal Processing 09.25 – 09.45 Hadassa Degani (WIS): Multi-Parametric Magnetic Resonance of

Cancer: Integration of Anatomical, Functional and Metabolic studies 09.50 – 10.15 Eva Klein (KI): Control of EBV infection in cancer 10.20 – 10.40 Andrei Chagin (KI): G-proteins control the fate of chondrocyte

progenitors

10.40 – 11.00 Coffee, Tea 11.00 – 11.10 Short talk: Edna Haran (WIS): Exploring Breast Tissue and Cancer by

Diffusion MRI 11.15 – 11.25 Short talk. Omer Ziv (WIS): NPM1 regulates DNA damage tolerance:

Implications for Acute Myeloid Leukemia 11.30 – 11.50 Eliezer Zelzer (WIS): New perspectives in bone development 12.00 - 12.30 Georg Klein (KI) Future perspectives 12.35 – 14.00 Lunch

14.00 – 17.00 Excursion “Stockholm and City Hall” 3 h. Busses from Karolinska hospital

Posters: 1. Dževad Belkić & Karen Belkić (KI): New Mechanistic Radiobiological

Models for Cell Response to Radiation 2. Johanna Dzieran, Oscar Vickes, Ulrica K. Westermark, and Marie Arsenian

Henriksson (KI): MYCN induced miR-18a interferes with neuroblastoma cell differentiation by inhibition of estrogen and NGF signaling

3. Limin-Ma, Barry Wolahan, Wessen Maruwge, Angela Scramli, Catharine Drumond, Angelo de Milito, Sonia Lain, and Bertha Brodin (KI): Sirtuin Expression, Activity and Inhibition.

4. Inga Müller, Karin Larsson, Anna Frenzel, Ganna Oliynyk, Hanna Zirath, Edward V. Prochownik, Nicholas Westwood and Marie Arsenian Henriksson (KI). Targeting of the MYCN oncoprotein with c-MYC inhibitors.

5. Yakimchuk, K., Hasni, M.S., Guan, J., Berglund, M., Sander, B, Lagercrantz, S., Enblad, G., Amini, R.-M. and Okret, S. (KI): Lymphomas as estrogen-regulated cancers.

6. Ganna Oliynyk, Hanna Zirath, Henrik Johansson, Marcus D.R. Klarqvist, Christer Einvik, Janne Lehtiö and Marie Arsenian Henriksson (KI): Role of MYCN-induced mitochondrial metabolism in childhood neuroblastoma.

7. Diogo Ribeiro, Ulrica Westermark, Marcus D. R. Klarqvist, Jacob Lovén and Marie Arsenian Henriksson (KI): Regulation of the nuclear hormone receptor family by MYCN-driven miRNAs affects differentiation and survival in neuroblastoma.

8. My Björklund, Mikael Engskog, Jakob Haglöf, Maria Shoshan, Torbjörn Arvidsson, Curt Petterson (KI): Optimization of cell quenching for 1H- NMR metabolomic analysis.

9. Marike Gabrielson, My Björklund, Joseph Carlson and Maria Shoshan (KI): Expression of mitochondrial regulators PGC1α and TFAM as putative markers of subtype and chemoresistance in epithelial ovarian carcinoma.

10. Apostolos Zaravinos and Qiang Pan-Hammarström (KI): Gene set enrichment analysis highlights the relationships of the NF-κB/Snail/YY1/RKIP circuitry genes in multiple myeloma.

11. Joanna Zawacka-Pankau, Vera V. Grinkevich, Mikhail Burmakin, Anna Kostecka, Aparna Vema, Karin Ridderstråle, Natalia Issaeva, Virginia Andreotti, Eleanor Dickinson, Elisabeth Hedström, Clemens Spinnler, Alberto Inga, Lars-Gunnar Larsson, Anders Karlén, Olga Filz, Vladimir Poroikov, Sergey Lavrenov, Maria Preobrazhenskaya, Margareta Wilhelm, Perdita Barran, Andrei L. Okorokov, Galina Selivanova (KI): Novel allosteric mechanism of p53 activation by small molecules for targeted anticancer therapy.

12. Katarzyna Zielinska-Chomej, Moshe Giladi, Ailone Tichon, Jessica Tu, Petra Hååg, Yoram Palti, Kristina Viktorsson and Rolf Lewensohn (KI): Tumor treating fields (TTFields) combined with radiotherapy alter DNA repair capacity in non-small cell lung cancer and glioma cells.

13. Petra Hååg, Marita Lagergren Lindberg, Katarzyna Zielinska-Chomej, Lena Kanter, Rolf Lewensohn, Leif Stenke and Kristina Viktorsson (KI): Analysis of gene expression and DNA repair signaling events in acute myeloid leukemia.

14. Edna Haran (WIS): Exploring breast tissue and cancer by diffusion MRI. 15. Gil Diaman(WIS): Novel functions of the transcription elongation factor DSIF in

regulation of the NF-κB pathway.

16. Reut Yosef (WIS): Bcl-Xl and Bcl-w regulate the viability of senescent cells 17. Omer Ziv (WIS): NPM1 regulates DNA damage tolerance: Implications for acute

myeloid leukemia 18. Debora Rosa Bublik (WIS): A feedback triangle involving p53, FGF13 and its host

miRNA. 19. Tamir Biezuner (WIS): Sequencing-based single-cell lineage analysis platform.