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PHASE 1 - CHEMISTRY OPTIMIZATION \^Λ NH /=N s=o ,o o' N: — ,J HN—^ φ = ArgoPore™-NH 2 0~ N v/ = ESQ! ΕΞΞΙ 2. BnBr, 4h ^ // -s=o o ΗΝ—Κ 1.TMSCHN 2 , 2h \_ R 2. BuNH 2 Ph QBS3 B \ _J> ~ r Ph PHASE 2 - FOCUSED LIBRARY PREPARATION S^^V V ^ // s=o ρ \ F 1. ΕΚΕΙ C #-NH ^ / s=o o ΗΝ 2. R^or^Br, 4h -• 1.TMSCHN 25 2h 2. R 2 NH 2 n 2 ο Ri Run 24 Different Temperatures Increase your production with the ability to use different trial temperatures in the same run. Run Different Reaction Times Optimize results quickly by testing chemistries at sev- eral different reac- tion times. Argon Pressurized System Use air or moisture sensitive reagents & solvents, including PtKPPhjXi, alkyllith- iums and Grignards. Monitor your Reactions Large, visible reac- tion vessels make it easy to monitor your chemistries. 0 7 C How to Create FOCUSED LIBRARIES Using the Nautilus™ 2400 Organic Synthesizer If you have ever used the Nautilus 2400 Organic Synthesizer in your lab, you've probably realized that it dramatically cuts down the time it takes to perform chemistry development and reaction opti- mization experiments. Nautilus users can simultaneously optimize their choice of reagents, solvents, temperatures and reaction times. What you may not know is that the Nautilus 2400 is also being used to create successful, focused libraries. Illustrated above is a tandem chemistry optimization and trial library study performed by chemists at Argonaut Technologies. Compared to man- ual methods this study was com- pleted in 1/3 the time. Are you looking to save time on chemistry development? Or planning to synthesize a focused library? Call our product and application specialists today to learn how the Nautilus 2400 can increase your productivity. <c Accelerating Organic Synthesis ARGONAUT TECHNOLOGIES San Carlos, CA · 887 Industrial Rd., Suite G, San Carlos, CA 94070 · (415) 598-1350 · (888) 598-1350 (Toll Free U.SA) Muttenz, Switzerland · St. Jakob-Strasse 148, R0. Box 43,4132 Muttenz 2, Switzerland · (41) 61465 98 98 In Japan: Sumitomo/Biott Coip. · 03 3260 0415 · Fax 03 3260 0407 · h^://www.ai'gotech.com CIRCLE 1 ON READER SERVICE CARD
Transcript of Partial Page Advertisements
PHASE 1 - CHEMISTRY OPTIMIZATION
\^Λ NH / = N s=o ,o
o' N:—,J HN—^
φ = ArgoPore™-NH2
0~Nv/=
ESQ! ΕΞΞΙ 2. BnBr, 4h
^ // -s=o o ΗΝ—Κ
1.TMSCHN2, 2h
\ _ R 2. BuNH2
Ph QBS3
B\ _J>
~ r Ph
PHASE 2 - FOCUSED LIBRARY PREPARATION
S^^V V
^ // s=o ρ
\ F
1. ΕΚΕΙ C #-NH
^ / s=o o ΗΝ
2. R ^ o r ^ B r , 4h - •
1.TMSCHN252h
2. R2NH2
n2 ο
Ri
Run 24 Different Temperatures
Increase your production with the ability to use different trial temperatures in the same run.
Run Different Reaction Times
Optimize results quickly by testing chemistries at several different reaction times.
Argon Pressurized System
Use air or moisture sensitive reagents & solvents, including PtKPPhjXi, alkyllith-iums and Grignards.
Monitor your Reactions
Large, visible reaction vessels make it easy to monitor your chemistries.
0
7
C
H o w to Create FOCUSED LIBRARIES Using the Nautilus™ 2400 Organic Synthesizer
If you have ever used the Nautilus 2400 Organic Synthesizer in your lab, you've probably realized that it dramatically cuts down the time it takes to perform chemistry development and reaction optimization experiments. Nautilus users can simultaneously optimize their choice of reagents, solvents, temperatures and reaction times.
What you may not know is that the Nautilus 2400 is also being used to create successful, focused libraries. Illustrated above is a tandem chemistry optimization and trial library study performed by chemists at Argonaut Technologies. Compared to manual methods this study was completed in 1/3 the time.
Are you looking to save time on chemistry development? Or planning to synthesize a focused library? Call our product and application specialists today to learn how the Nautilus 2400 can increase your productivity.
<c Accelerating Organic Synthesis
ARGONAUT TECHNOLOGIES San Carlos, CA · 887 Industrial Rd., Suite G, San Carlos, CA 94070 · (415) 598-1350 · (888) 598-1350 (Toll Free U.SA) Muttenz, Switzerland · St. Jakob-Strasse 148, R0. Box 43,4132 Muttenz 2, Switzerland · (41) 61465 98 98 In Japan: Sumitomo/Biott Coip. · 03 3260 0415 · Fax 03 3260 0407 · h^://www.ai'gotech.com
CIRCLE 1 ON READER SERVICE CARD
