ONCE-DAILY β BLOCKERS SIMPLIFY TREATMENT FOR HYPERTENSIVES
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ONCE-DAILY SIMPLIFY TREATMENT FOR HYPERTENSIVES A daily dose of nadolol may have the edge on propranolol in lowering systolic BP After an initial wash-out period of 5 weeks, 75 hypertensive patients (mean supine diastolic BP , 18mm Hg) received either nadolal 40mg once daily or propranolol 1 Omg qid for 12 weeks in a double-blind, randomil .ed. comparative study. Doses were increased stepwise unt il supine diastolic BP was reduced to 90mm Hg or lower. Final daily doses ranged from SO-320mg; nadol ol 240 mg was most effective, while propranolol doses varied widely. The supine diastolic BP was normalized ( .... 90mm Hg) in 33 of 45 patients given nadol o] (7 J %) and in 17 of the 30 patients given pro pranolol (5 7 96 ). The average decrease in supine systoli c BP was 43mm Hg ( 22 .2% drop) for nadolal and 32 mm Hg (16.8 % drop) for propranolol (p <"0.0 1 ), indicating a greater effect of nadolol on th is parameter. Heart rates decreas ed by about 25 %' with each drug. The only adverse reactions thaI occurred in this series were slight weight gain in 2 patients treated with nadolol and moderate dizziness in I patient lreated with propranolol. EI Mehairy. M.M. el aL Journal of In ternational Medical Re:search 8: 193 (No J. (980) Once-daily atenolol and metoprolollower BP similarly over 12 weeks In a 12 -week double-blind, placebo-controlled, randomized trial, 2 groups of hypertensive outpati ents (mean supine diastolic BP IIOmm Hg)co mpleted treatment with either atenolol I OOmg or metopro lol I OOmg daily. 67 % of the patients achieved a target diastolic BP of95mm Hg or lower dur ing the trial. with no significant diff erences between the 2 agents. The greatest fall in BP occurred dur ing the first 4 weeks of drug treatment , with li ttle change after tha t. Increases in heart rate and systolic BP af ter exerci se teslS were similar at 3 and 23 hours, although in all cases the values for metoprolol were slightly lower than Ihose for alenolol. The increase in systoli c BP at 23 hours was twice that observed at 3 hours. Two patients developed sk in er uptions d ur ing therapy. although a relationsh ip to drug treatment was suggested o nl y for the palient on metoprolol. Adarns-Strurnp. B.J . et a1. : l' rac1ilioner 224: 54 I (May 1980) 0156-2703/80/0809·0CJ09 $00,50/0 C ADIS Press INPHARMA 9 Aug 1980 9
Transcript of ONCE-DAILY β BLOCKERS SIMPLIFY TREATMENT FOR HYPERTENSIVES
ONCE-DAILY ~-BLOCKERS SIMPLIFY TREATMENT FOR HYPERTENSIVES
A daily dose of nadolol may have the edge on propranolol in lowering systolic BP After an initial wash-out period of 5 weeks, 75 hypertensive patients (mean supine diastolic BP , 18mm Hg) received either nadolal 40mg once daily or propranolol 1 Omg qid for 12 weeks in a double-blind, randomil.ed. comparative study. Doses were increased stepwise until supine diastolic BP was reduced to 90mm Hg or lower. Final daily doses ranged from SO-320mg; nadolol 240mg was most effective, while propranolol doses varied widely. The supine diastolic BP was normalized ( .... 90mm Hg) in 33 of 45 patients given nadolo] (7 J % ) and in 17 of the 30 patients given propranolol (5 7 96 ). The average decrease in supine systolic BP was 43mm Hg (22 .2 % drop) for nadolal and 32mm Hg (16.8 % drop) for propranolol (p <"0.0 1), indicating a greater effect of
nadolol on th is parameter. Heart ra tes decreased by about 25 %' with each drug. The only adverse reactions thaI occurred in this series were slight weight gain in 2 patients treated with nadolol and moderate dizziness in I patient lreated with propranolol. EI Mehairy. M.M. el aL Journal of In ternational Medical Re:search 8: 193 (No J . (980)
Once-daily atenolol and metoprolollower BP similarly over 12 weeks In a 12-week double-blind, placebo-controlled, randomized trial, 2 groups of hypertensive outpatients (mean supine diastolic BP IIOmm Hg)completed treatment w ith either atenolol I OOmg or metoprolol I OOmg daily. 67 % of the patients achieved a target diastolic BP of95mm Hg or lower during the tr ial. with no significant differences between the 2 agents. The greatest fall in BP occurred during the first 4 weeks of drug treatment , wi th li ttle change after tha t. Increases in heart rate and systolic BP after exercise teslS were similar at 3 and 23 hours, although in all cases the values for metoprolol were slightly lower than Ihose for a lenolol. The increase in systolic BP at 23 hours was twice that observed at 3 hours. Two patients developed skin eruptions during therapy. a lthough a relat ionship to drug treatment was suggested only for the palient on metoprolol. Adarns-Strurnp. B.J. et a1. : l' rac1ilioner 224: 54 I (May 1980)
0156-2703/80/0809·0CJ09 $00,50/0 C ADIS Press INPHARMA 9 Aug 1980 9
