METABOLISM OF COMPLEX LIPIDS Dr. Vijay Marakala, MBBS, MD.

Assistant professor BIOCHEMISTRY SIMS & RC

OUTLINE

Biosynthesis of phospholipids

Degradation of phospholipids

Disorders of complex lipid metabolism

BIOSYNTHESIS OF PHOSPHOLIPIDS

1960

BIOSYNTHESIS OF PHOSPHOLIPIDS

DEGRADATION OF PHOSPHOLIPIDS

LIPID STORAGE DISEASE

DISORDERS OF COMPLEX LIPID METABOLISM

SPINGOLIPIDOSIS

RESPIRATORY DISTRESS SYNDROME

Deficiency of Glucocerbrosidase or β-glucosidaseGaucher’s disease

Deficiency of Spingomyelinase Niemann-Pick disease

Deficiency of β-galactosidaseGeneralized

gangliosidosis

GM1 ganglioside

Deficiency of hexosaminidase ATay-Sachs disease

Deficiency of hexosaminedase BSandhoff’s

disease

Deficiency of α-galactosidase Fabry’s disease