Interferon-α-2b
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Reactions 728 - 21 Nov 1998 ★ S Interferon-α-2b First report of amoebic liver abscess in an elderly patient with previously subclinical Entamoeba histolytica infection: case report An amoebic liver abscess developed in a 65-year-old woman during treatment with interferon-α-2b for chronic hepatitis C infection; the woman was a latent carrier of Entamoeba histolytica infection. The woman developed a fever 14 days after the start of treatment with interferon-α-2b 6 MU/day. Tests showed an increased leucocyte count. Interferon-α-2b therapy was discontinued and she was treated with cefbuperazone, ceftazidime, minocycline, piperacillin and imipenem. However, the fever persisted and abdominal scans suggested a liver abscess. The abscess was drained, but she developed disseminated intravascular coagulation and died. At autopsy, trophozoites of E. histolytica were found in the liver abscess. The woman’s anti-E. histolytica antibody titre was 100-fold (positive) 1 year before and at the start of treatment with interferon-α-2b and increased to 4096-fold at the onset of the liver abscess. Author comment: ‘It was possible that IFN [interferon-α-2b] increased the gene expression of cystein proteinase and released cystein proteinases, which contributed to the development of invasive amoebiasis in this patient.’ Matsuo T, et al. A patient who developed an amoebic liver abscess during treatment with interferon. Journal of Gastroenterology and Hepatology 13: 1068-1071, Oct 1998 - Japan 800717654 » Editorial comment: A search of AdisBase and Medline did not reveal any previous case reports of amoebic liver abscess associated with interferon-α-2b therapy. 1 Reactions 21 Nov 1998 No. 728 0114-9954/10/0728-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Interferon-α-2b
Reactions 728 - 21 Nov 1998
★ SInterferon-α-2b
First report of amoebic liver abscess in an elderlypatient with previously subclinical Entamoebahistolytica infection: case report
An amoebic liver abscess developed in a 65-year-old womanduring treatment with interferon-α-2b for chronic hepatitis Cinfection; the woman was a latent carrier of Entamoebahistolytica infection.
The woman developed a fever 14 days after the start oftreatment with interferon-α-2b 6 MU/day. Tests showed anincreased leucocyte count. Interferon-α-2b therapy wasdiscontinued and she was treated with cefbuperazone,ceftazidime, minocycline, piperacillin and imipenem.However, the fever persisted and abdominal scans suggested aliver abscess. The abscess was drained, but she developeddisseminated intravascular coagulation and died.
At autopsy, trophozoites of E. histolytica were found in theliver abscess. The woman’s anti-E. histolytica antibody titrewas 100-fold (positive) 1 year before and at the start oftreatment with interferon-α-2b and increased to 4096-fold atthe onset of the liver abscess.
Author comment: ‘It was possible that IFN [interferon-α-2b]increased the gene expression of cystein proteinase andreleased cystein proteinases, which contributed to thedevelopment of invasive amoebiasis in this patient.’Matsuo T, et al. A patient who developed an amoebic liver abscess duringtreatment with interferon. Journal of Gastroenterology and Hepatology 13:1068-1071, Oct 1998 - Japan 800717654
» Editorial comment: A search of AdisBase and Medline didnot reveal any previous case reports of amoebic liver abscessassociated with interferon-α-2b therapy.
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Reactions 21 Nov 1998 No. 7280114-9954/10/0728-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
